SG11201809126RA - Aromatic sulfonamide derivatives - Google Patents

Aromatic sulfonamide derivatives

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Publication number
SG11201809126RA
SG11201809126RA SG11201809126RA SG11201809126RA SG11201809126RA SG 11201809126R A SG11201809126R A SG 11201809126RA SG 11201809126R A SG11201809126R A SG 11201809126RA SG 11201809126R A SG11201809126R A SG 11201809126RA SG 11201809126R A SG11201809126R A SG 11201809126RA
Authority
SG
Singapore
Prior art keywords
co7d
berlin
international
str
rule
Prior art date
Application number
SG11201809126RA
Inventor
Stefan Werner
Stefanie Mesch
Arwed Cleve
Nico Bräuer
Simon Herbert
Markus Koch
Henrik Dahllöf
Maren Osmers
Elizabeth Hardaker
Anton Lishchynskyi
Original Assignee
Bayer Pharma AG
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Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of SG11201809126RA publication Critical patent/SG11201809126RA/en

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 1111111111111111111111111111111111111111 01111111111111111111111111111111111110111111 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/191000 Al 09 November 2017 (09.11.2017) W I P0 I P C T (51) International Patent Classification: (72) Inventors: WERNER, Stefan; EhrenbergstraBe 8, 10245 C07D 213/85 (2006.01) C07D 207/333 (2006.01) Berlin (DE). MESCH, Stefanie; Ulmenallee 45, 14050 C07D 231/12 (2006.01) C07D 207/416 (2006.01) Berlin (DE). CLEVE, Arwed; Konstanzer Str. 8, 10707 C07D 231/14 (2006.01) C07D 213/40 (2006.01) Berlin (DE). BRAUER, Nico; Ruppiner Str. 103, C07D 231/16 (2006.01) C07D 213/61 (2006.01) 14612 Falkensee (DE). HERBERT, Simon, Anthony; C07D 231/18 (2006.01) C07D 213/64 (2006.01) ChausseestraBe 88D, 10115 Berlin (DE). KOCH, Markus; C07D 233/16 (2006.01) C07D 213/65 (2006.01) Eschengraben 16, 13189 Berlin (DE). DAHLLOF, Henrik; C07D 233/61 (2006.01) CO7D 213/74 (2006.01) Sagargatan 6c, 753 17 Uppsala (SE). OSMERS, Maren; CO7D 233/64 (2006.01) CO7D 231/38 (2006.01) Zum Exerzierhaus 12, 14469 Potsdam (DE). HARDAK- CO7D 233/68 (2006.01) CO7D 231/56 (2006.01) ER, Elizabeth; 90 Mellison Road, Tooting SW17 9AY CO7D 401/04 (2006.01) CO7D 239/30 (2006.01) (GB). LISHCHYNSKYI, Anton; Benrather SchloBallee CO7D 235/06 (2006.01) CO7D 249/06 (2006.01) 15, 40597 Diisseldorf (DE). C07C 311/40 (2006.01) C07D 249/18 (2006.01) C07D 403/04 (2006.01) C07D 249/20 (2006.01) CO7D 237/08 (2006.01) CO7D 263/32 (2006.01) (74) Agent: BIP PATENTS; Alfred-Nobel-Str. 10, 40789 Mon- heim am Rhein (DE). CO7D 405/04 (2006.01) CO7D 271/04 (2006.01) (81) Designated States (unless otherwise indicated, for every CO7D 239/26 (2006.01) CO7D 275/02 (2006.01) kind of national protection available): AE, AG, AL, AM, CO7D 405/06 (2006.01) CO7D 277/26 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CO7D 239/34 (2006.01) CO7D 277/34 (2006.01) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, CO7D 239/42 (2006.01) CO7D 277/56 (2006.01) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, - CO7D 249/08 (2006.01) CO7D 213/60 (2006.01) HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, CO7D 249/10 (2006.01) A61K 31/41 (2006.01) KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, = CO7D 249/12 (2006.01) A61P 35/00 (2006.01) MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, CO7D 249/14 (2006.01) A61P 37/00 (2006.01) PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, CO7D 471/04 (2006.01) A61P 25/02 (2006.01) SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, = CO7D 261/08 (2006.01) A61P 25/28 (2006.01) TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. CO7D 271/06 (2006.01) A61P 25/16 (2006.01) (84) Designated States (unless otherwise indicated, for every (21) International Application Number: PCT/EP2017/059882 kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = International Filing Date: ZM, ZW), Eurasian AZ, BY, KG, KZ, RU, TJ, UG, (AM, = (22) 26 April 2017 (26.04.2017) TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, _ _ EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Filing Language: English MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, = (25) Publication Language: English TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). = - (26) = (30) Priority Data: = 16167996.4 03 May 2016 (03.05.2016) EP Declarations under Rule 4.17: - as to applicant's entitlement to apply for and be granted a (71) Applicant: BAYER PHARMA AKTIENGESEL- LSCHAFT [DE/DE]; Miillerstr. 178, 13353 Berlin (DE). patent (Rule 4.17(H)) = = = (54) Title: AROMATIC SULFONAMIDE DERIVATIVES (57) : Substituted aromatic sulfonamides of formula (I) pharmaceutical 0 1-1 I I compositions and combinations comprising said compounds and the use of said 0 =S -N H 2 compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease. © R 2 c 2 © 0 R 1-1 (I ) O\ X 1-1 „.......--„,,::::..., - N IN 1-1 I R 5 R 2b © ei O [Continued on next page] WO 2017/191000 Al MIDEDIMOMMIDIRMEMOMOIHMOIONNIHMEMOIMIE Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event amendments (Rule 48.2(h)) of receipt of
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Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112018072549A2 (en) * 2016-05-03 2019-02-19 Bayer Pharma Aktiengesellschaft aromatic sulfonamide derivatives
BR112019006490B1 (en) * 2016-10-24 2023-11-28 Fmc Corporation COMPOUND, FUNGICIDAL COMPOSITIONS AND METHODS FOR CONTROLLING VEGETABLE DISEASES
WO2018104307A1 (en) * 2016-12-09 2018-06-14 Bayer Pharma Aktiengesellschaft Aromatic sulfonamide derivatives and their use as anatagon i sts or negative allosteric modulators of p2x4
WO2018210729A1 (en) * 2017-05-18 2018-11-22 Bayer Pharma Aktiengesellschaft Aromatic sulfonamide derivatives as antagonists or negative allosteric modulators of p2x4 receptor
JOP20190278A1 (en) * 2017-05-31 2019-11-28 Novartis Ag 5,6-fused-bicyclic compounds and compositions for the treatment of parasitic diseases
MA50448A (en) * 2017-10-29 2020-09-02 Bayer Ag AROMATIC SULPHONAMIDE DERIVATIVES FOR THE TREATMENT OF ISCHEMIC Cerebral Injury
AU2019331005B2 (en) 2018-08-31 2024-03-28 Xenon Pharmaceuticals Inc. Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents
AU2020390377B2 (en) * 2019-11-29 2023-12-21 Wuhan Ll Science And Technology Development Co., Ltd. Compound containing benzene ring and application thereof
CN113082023B (en) * 2019-12-23 2024-03-01 武汉朗来科技发展有限公司 Pharmaceutical combination of P2X3 inhibitor and P2X4 inhibitor and application thereof
CA3163440A1 (en) * 2019-12-30 2021-07-08 Jun LOU Fused ring compound and application thereof
JP2023533496A (en) 2020-06-30 2023-08-03 バイエル アクチェンゲゼルシャフト Use of N-phenylacetamide with P2X4 receptor antagonist activity to treat certain eye diseases
IL299346A (en) 2020-06-30 2023-02-01 Bayer Ag Substituted n-phenylacetamides having p2x4 receptor antagonistic activity
CN111743864B (en) * 2020-08-05 2022-04-01 牡丹江医学院 Sports trauma spray and preparation method thereof
WO2022049253A1 (en) 2020-09-07 2022-03-10 Bayer Aktiengesellschaft Substituted n-heteroaryl-n-pyridinylacetamides as p2x4 modulators
TW202239748A (en) * 2021-01-27 2022-10-16 大陸商武漢朗來科技發展有限公司 A kind of aromatic compound, pharmaceutical composition thereof, preparation method therefor and use thereof
WO2022186133A1 (en) 2021-03-01 2022-09-09 日本農薬株式会社 Fused heterocycle compound having sulfonamide group or salt thereof, agricultural/horticultural pesticide and external or internal parasite controlling agent for animals containing said compound or salt thereof, and method of use therefor
US11878269B2 (en) 2022-03-17 2024-01-23 International Business Machines Corporation Cyclopropeneimines for capture and transfer of carbon dioxide
WO2023190826A1 (en) * 2022-03-31 2023-10-05 学校法人 高崎健康福祉大学 Pharmaceutical composition for preventing or suppressing or treating symptoms accompanying pseudo-allergic reactions

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5011472A (en) 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
US5770615A (en) 1996-04-04 1998-06-23 Bristol-Myers Squibb Company Catecholamine surrogates useful as β3 agonists
US5994398A (en) * 1996-12-11 1999-11-30 Elan Pharmaceuticals, Inc. Arylsulfonamides as phospholipase A2 inhibitors
CA2772642C (en) * 2009-09-03 2017-08-29 Bristol-Myers Squibb Company Quinazolines as potassium ion channel inhibitors
WO2011120026A1 (en) 2010-03-26 2011-09-29 Glaxo Group Limited Pyrazolyl-pyrimidines as kinase inhibitors
WO2011145035A1 (en) 2010-05-17 2011-11-24 Indian Incozen Therapeutics Pvt. Ltd. Novel 3,5-disubstitued-3h-imidazo[4,5-b]pyridine and 3,5- disubstitued -3h-[1,2,3]triazolo[4,5-b] pyridine compounds as modulators of protein kinases
CN103080094B (en) * 2010-07-13 2015-06-24 日本化学医药株式会社 P2X4 receptor antagonist
SG10201605325TA (en) 2012-01-13 2016-08-30 Nippon Chemiphar Co P2x4 receptor antagonist
US9872822B2 (en) 2013-06-21 2018-01-23 L'oreal Process for dyeing in the presence of oxidation bases comprising at least one sulfonic, sulfonamide, sulfone, amid or acid group and a metal catalyst, device and ready-to-use composition
EP3020707B1 (en) 2013-07-12 2019-08-21 Nippon Chemiphar Co., Ltd. P2x4 receptor antagonist
AU2014288116B2 (en) 2013-07-12 2018-05-17 Kyushu University P2X4 receptor antagonist
WO2015088564A1 (en) 2013-12-13 2015-06-18 Sunovion Pharmaceuticals Inc. P2x4 receptor modulating compounds
WO2015088565A1 (en) 2013-12-13 2015-06-18 Sunovion Pharmaceuticals Inc. P2x4 receptor modulating compounds and methods of use thereof
JP2018528159A (en) * 2015-06-10 2018-09-27 バイエル・ファルマ・アクティエンゲゼルシャフト Aromatic sulfonamide derivatives
BR112018072549A2 (en) 2016-05-03 2019-02-19 Bayer Pharma Aktiengesellschaft aromatic sulfonamide derivatives
US9988367B2 (en) 2016-05-03 2018-06-05 Bayer Pharma Aktiengesellschaft Amide-substituted pyridinyltriazole derivatives and uses thereof
KR20230075528A (en) 2016-05-03 2023-05-31 갈레라 랩스, 엘엘씨 Combination therapy for cancer treatment
WO2018104307A1 (en) * 2016-12-09 2018-06-14 Bayer Pharma Aktiengesellschaft Aromatic sulfonamide derivatives and their use as anatagon i sts or negative allosteric modulators of p2x4
WO2018104305A1 (en) * 2016-12-09 2018-06-14 Bayer Pharma Aktiengesellschaft Field of application of the invention
WO2018210729A1 (en) * 2017-05-18 2018-11-22 Bayer Pharma Aktiengesellschaft Aromatic sulfonamide derivatives as antagonists or negative allosteric modulators of p2x4 receptor
MA50448A (en) * 2017-10-29 2020-09-02 Bayer Ag AROMATIC SULPHONAMIDE DERIVATIVES FOR THE TREATMENT OF ISCHEMIC Cerebral Injury

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