SG11201407303SA - Compositions and methods for treatment of neuromuscular disorders and neurodegenerative disorders - Google Patents
Compositions and methods for treatment of neuromuscular disorders and neurodegenerative disordersInfo
- Publication number
- SG11201407303SA SG11201407303SA SG11201407303SA SG11201407303SA SG11201407303SA SG 11201407303S A SG11201407303S A SG 11201407303SA SG 11201407303S A SG11201407303S A SG 11201407303SA SG 11201407303S A SG11201407303S A SG 11201407303SA SG 11201407303S A SG11201407303S A SG 11201407303SA
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- SG
- Singapore
- Prior art keywords
- international
- compositions
- disorders
- treatment
- methods
- Prior art date
Links
- 208000018360 neuromuscular disease Diseases 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 208000015122 neurodegenerative disease Diseases 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000004770 neurodegeneration Effects 0.000 abstract 2
- 102220240796 rs553605556 Human genes 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 206010070538 Gestational hypertension Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000005793 Restless legs syndrome Diseases 0.000 abstract 1
- 206010039710 Scleroderma Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 201000011461 pre-eclampsia Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 239000006188 syrup Substances 0.000 abstract 1
- 235000020357 syrup Nutrition 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/10—Hydrazines
- C07C243/12—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms
- C07C243/16—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C243/18—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/02—Compounds containing any of the groups, e.g. carbazates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 14 November 2013 (14.11.2013) WIPOIPCT (10) International Publication Number WO 2013/168021 A1 (51) International Patent Classification: C07C 57/48 (2006.01) C07C 233/49 (2006.01) C07C 233/87 (2006.01) C07D 339/04 (2006.01) A61K31/16 (2006.01) A61K31/385 (2006.01) A61K31/185 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/IB2013/052239 21 March 2013 (21.03.2013) English English (30) Priority Data: 1779/CHE/2012 7 May 2012 (07.05.2012) IN (72) Inventor; and (71) Applicant : KANDULA, Mahesh [IN/IN]; Door No. 11- 61, Samalkot Mandal, East Godavari Dist, G.Medapadu 533 434, Andhra Pradesh (IN). (72) Inventor: KANDULA, Mahesh; Door No. 11-61, Samalkot Mandal, East Godavari Dist, Andhra Pradesh, G.Medapadu 533434 (IN). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) CJ o (54) Title: COMPOSITIONS AND METHODS FOR TREATMENT OF NEUROMUSCULAR DISORDERS AND NEURODE- i-H GENERATIVE DISORDERS i-H o CJ (57) Abstract: The invention relates to the compounds of formula (I) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of com pounds of formula (I), and methods for treating or preventing neuromuscular disorders and neurodegenerative diseases may be for mulated for oral, buccal, rectal, topical, transdermal, transmucosaf intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment or management of neuromuscular disorders and neurodegenerative diseases such as Parkin son's disease, scleroderma, restless leg syndrome, hypertension and gestational hypertension.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1779CH2012 | 2012-05-07 | ||
PCT/IB2013/052239 WO2013168021A1 (en) | 2012-05-07 | 2013-03-21 | Compositions and methods for treatment of neuromuscular disorders and neurodegenerative disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201407303SA true SG11201407303SA (en) | 2014-12-30 |
Family
ID=54193686
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201407303SA SG11201407303SA (en) | 2012-05-07 | 2013-03-21 | Compositions and methods for treatment of neuromuscular disorders and neurodegenerative disorders |
Country Status (8)
Country | Link |
---|---|
US (1) | US9642915B2 (en) |
EP (1) | EP2847158A4 (en) |
JP (1) | JP2015522531A (en) |
CN (1) | CN104603096A (en) |
AU (1) | AU2013257742A1 (en) |
CA (1) | CA2873093A1 (en) |
SG (1) | SG11201407303SA (en) |
WO (1) | WO2013168021A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2014233168B2 (en) * | 2013-03-15 | 2018-11-22 | Cancer Research Technology, Llc | Methods and compositions for Gamma-glutamyl cycle modulation |
CN108495626A (en) * | 2015-09-02 | 2018-09-04 | 塞尔利克斯生物私人有限公司 | Composition for treating Parkinson's disease and method |
KR101842948B1 (en) * | 2016-10-13 | 2018-03-28 | 연세대학교 산학협력단 | Composition comprising Decanal or as active ingredients for Preventing or treating muscle disease |
WO2019155464A1 (en) | 2018-02-08 | 2019-08-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Dopamine precursors |
CN111467385B (en) * | 2019-01-24 | 2022-05-17 | 深圳市华大农业应用研究院 | Use of composition in preventing or treating neurodegenerative disease |
CN110041300A (en) | 2019-02-18 | 2019-07-23 | 海南大学 | A kind of pharmaceutical intermediate compound and its synthetic method |
CN110511159B (en) * | 2019-09-20 | 2022-12-30 | 上海倍殊生物科技有限公司 | Synthesis method of benserazide hydrochloride |
Family Cites Families (136)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2807644A (en) | 1954-08-20 | 1957-09-24 | Parke Davis & Co | Pantethine inhibitors |
DE1205972B (en) | 1963-08-20 | 1965-12-02 | Merck Ag E | Process for the production of a lipoic acid derivative |
US4011342A (en) | 1971-06-02 | 1977-03-08 | Seperic | Method and composition for the treatment of hypertension with ortho-disubstituted arylguanidines |
JPS5677259A (en) | 1979-11-29 | 1981-06-25 | Nippon Chemiphar Co Ltd | N-pyridoxyl 5,8,11,14,17-eicosapentaenoic acid amide, and its preparation |
JPS57500432A (en) | 1980-03-20 | 1982-03-11 | ||
US4404366A (en) | 1980-05-06 | 1983-09-13 | Miles Laboratories, Inc. | Beta-galactosyl-umbelliferone-labeled hapten conjugates |
US4412992A (en) | 1980-07-21 | 1983-11-01 | Biorex Laboratories Limited | 2-Hydroxy-5-phenylazobenzoic acid derivatives and method of treating ulcerative colitis therewith |
US4440763A (en) | 1981-03-18 | 1984-04-03 | Block Drug Company, Inc. | Use of 4-aminosalicyclic acid as an anti-inflammatory agent |
IT1190727B (en) | 1982-03-10 | 1988-02-24 | Ausonia Farma Srl | COMPOUND WITH ANALGESIC, ANTI-INFLAMMATORY AND MUCOREGULATING ACTIVITY PROCEDURE FOR ITS PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS |
FR2528038B2 (en) | 1982-06-04 | 1985-08-09 | Lafon Labor | BENZHYDRYLSULFINYLACETAMIDE DERIVATIVES AND THEIR THERAPEUTIC USE |
US4564628A (en) | 1983-01-03 | 1986-01-14 | Nelson Research & Development Co. | Substituted 2-aminotetralins |
US5104887A (en) | 1983-02-04 | 1992-04-14 | University Of Iowa Research Foundation | Topical ophthalmic imino substituted 2-imino-3-methyl-delta4-1,3,4-thiadiazoline-5-sulfonamides carbonic anhydrase inhibitors |
JPS6089474A (en) | 1983-10-20 | 1985-05-20 | Toyo Pharma- Kk | Morphinan derivative, production thereof and antitumor agent containing said compound |
IL73293A (en) | 1983-11-04 | 1988-02-29 | Abbott Lab | Methyl 2-(alkanamidoalkylsulfonic)ethylthiophosphonate derivatives |
IT1213132B (en) | 1984-02-02 | 1989-12-14 | Yason Srl | ANTIBRONCOPNEUMOPATHIC AGENT. |
US4550109A (en) | 1984-05-31 | 1985-10-29 | The Board Of Regents, The University Of Texas System | Lipoidal biopterin compounds |
JPS61277618A (en) | 1985-06-04 | 1986-12-08 | Suntory Ltd | Remedy for autism |
YU213587A (en) | 1986-11-28 | 1989-06-30 | Orion Yhtymae Oy | Process for obtaining new pharmacologic active cateholic derivatives |
US4873259A (en) | 1987-06-10 | 1989-10-10 | Abbott Laboratories | Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds |
HU207287B (en) * | 1989-01-17 | 1993-03-29 | Biosignal Kutato Fejlesztoe Kf | Polyene fatty acid derivatives of tyrozine-quinaze inhibiting activity and pharmaceutical composition containing them as active component |
DE69016335T2 (en) | 1989-10-06 | 1995-06-01 | Fujirebio Kk | Pantothenic acid derivatives. |
US5242937A (en) | 1990-03-19 | 1993-09-07 | Research Corporation Technologies, Inc. | Topically active ocular thiadiazole sulfonamide carbonic anhydrase inhibitors |
IT1248702B (en) | 1990-06-06 | 1995-01-26 | Yason Srl | ANTITUSSIVE AGENT AND MUCOREGULATOR, ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS |
FR2699077B1 (en) | 1992-12-16 | 1995-01-13 | Rhone Poulenc Rorer Sa | Application of anticonvulsants in the treatment of neurological lesions linked to trauma. |
FR2707637B1 (en) | 1993-06-30 | 1995-10-06 | Lafon Labor | New acetamide derivatives, their preparation process and their use in therapy. |
JPH09511496A (en) | 1994-02-18 | 1997-11-18 | セル・セラピューティックス・インコーポレーテッド | Intracellular messenger |
SE9401727D0 (en) | 1994-05-18 | 1994-05-18 | Astra Ab | New compounds I |
FR2722199B3 (en) | 1994-07-11 | 1996-09-06 | Univ Picardie Jules Verne Etab | VALPROIC ACID DERIVATIVES AND THEIR APPLICATIONS AS MEDICAMENTS |
US6156777A (en) | 1994-12-15 | 2000-12-05 | Pharmacia & Upjohn Company | Use of pramipexole as a neuroprotective agent |
US5795909A (en) * | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
NZ334389A (en) | 1996-08-28 | 2001-05-25 | Ube Industries | Cyclic amine derivatives |
ID22499A (en) | 1996-11-22 | 1999-10-21 | Elan Pharmaceuticals Inc Cs | AMINO N-AMIDA (ARIL / HETEROARIL / ALCILACETYL) AMINO, PHARMACY COMPOSITION CONSISTING FROM AMINO ACID AMIDO, AND METHODS TO RESPOND TO THE B-AMILOID PEPTIDES AND / OR THE MAKING OF THESE PEOPLE. |
US6414008B1 (en) | 1997-04-29 | 2002-07-02 | Boehringer Ingelheim Pharma Kg | Disubstituted bicyclic heterocycles, the preparation thereof, and their use as pharmaceutical compositions |
GB9710351D0 (en) | 1997-05-20 | 1997-07-16 | Scotia Holdings Plc | Glucosamine fatty acids |
NZ333474A (en) | 1998-01-02 | 1999-06-29 | Mcneil Ppc Inc | A chewable tablet containing ibuprofen, fumaric acid and a non hydrocolloid binder e.g. a wax or a fat |
TR200002505T2 (en) | 1998-02-27 | 2000-12-21 | Sankyo Company Limited | Cyclic amino compounds |
JP3761324B2 (en) | 1998-05-15 | 2006-03-29 | ヤンマー農機株式会社 | Passenger rice transplanter |
KR200226089Y1 (en) | 1998-08-13 | 2001-06-01 | 구자홍 | Condenser chiller of refrigerator |
US6846495B2 (en) | 1999-01-11 | 2005-01-25 | The Procter & Gamble Company | Compositions having improved delivery of actives |
PL350924A1 (en) | 1999-04-06 | 2003-02-10 | Sepracor Inc | Derivatives of venlafaxine and methods of preparing and using the same |
US6262118B1 (en) | 1999-06-04 | 2001-07-17 | Metabolex, Inc. | Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia |
HUP0202797A3 (en) | 1999-09-29 | 2004-05-28 | Procter & Gamble | Compositions having improved stability |
US6429223B1 (en) | 2000-06-23 | 2002-08-06 | Medinox, Inc. | Modified forms of pharmacologically active agents and uses therefor |
WO2002009769A2 (en) | 2000-07-27 | 2002-02-07 | Rutgers, The State University Of New Jersey | Therapeutic azo-compounds for drug delivery |
AU2001296703A1 (en) * | 2000-10-06 | 2002-04-15 | Xenoport, Inc. | Bile acid prodrugs of l-dopa and their use in the sustained treatment of parkinsonism |
MXPA03003575A (en) | 2000-10-24 | 2003-07-14 | Ajinomoto Kk | Process for producing b-form nateglinide crystal. |
DE10103506A1 (en) | 2001-01-26 | 2002-08-14 | Ingo S Neu | Pharmaceutical composition for the treatment of multiple sclerosis |
UA81224C2 (en) | 2001-05-02 | 2007-12-25 | Euro Celtic S A | Dosage form of oxycodone and use thereof |
WO2003018004A2 (en) | 2001-08-29 | 2003-03-06 | Endo Pharmaceuticals, Inc. | Analgetic pyrroline derivatives |
US7138133B2 (en) | 2001-10-10 | 2006-11-21 | The Procter & Gamble Company | Orally administered liquid compositions |
US20040010038A1 (en) | 2002-02-27 | 2004-01-15 | Eran Blaugrund | Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors |
US20030220344A1 (en) | 2002-04-04 | 2003-11-27 | Luiz Belardinelli | Method of treating arrhythmias |
AU2003242520A1 (en) | 2002-04-15 | 2003-10-27 | Novartis Ag | Crystal forms of n-(trans-4-isopropylcyclohexylcarbonyl)-d-phenylalanine |
EP1494669A1 (en) | 2002-04-16 | 2005-01-12 | Fujisawa Pharmaceutical Co., Ltd. | Medicament for preventing and/or treating chronic rejection |
US7060725B2 (en) | 2002-05-13 | 2006-06-13 | Janssen Pharmaceutica N.V. | Substituted sulfamate anticonvulsant derivatives |
GB0223224D0 (en) | 2002-10-07 | 2002-11-13 | Novartis Ag | Organic compounds |
US7101912B2 (en) | 2002-12-06 | 2006-09-05 | Xenoport, Inc. | Carbidopa prodrugs and derivatives, and compositions and uses thereof |
ES2373639T3 (en) | 2002-12-19 | 2012-02-07 | The Scripps Research Institute | COMPOSITIONS AND USES TO STABILIZE TRANSTIRETIN AND INHIBIT THE ABNORMAL FOLDING OF TRANSTIRETIN. |
MXPA05008652A (en) | 2003-02-14 | 2005-10-18 | Pf Medicament | Use of the enantiomer (1s, 2r) of milnacipran for the preparation of a medicament. |
UA81657C2 (en) | 2003-03-04 | 2008-01-25 | Орто-Макнейл Фармасьютикел, Инк. | Normal;heading 1;heading 2;PROCESS FOR THE PREPARATION OF ANTICONVULSANT DERIVATIVES OF TOPIRAMATE |
NZ601780A (en) | 2003-07-29 | 2012-10-26 | Signature R & D Holdings Llc | Amino Acid Prodrugs |
KR101096480B1 (en) | 2003-10-14 | 2011-12-20 | 제노포트 인코포레이티드 | Crystalline form of gamma-aminobutyric acid analog |
US7470435B2 (en) | 2003-11-17 | 2008-12-30 | Andrx Pharmaceuticals, Llc | Extended release venlafaxine formulation |
KR20060108691A (en) | 2003-11-28 | 2006-10-18 | 상꾜 가부시키가이샤 | Cyclic amine derivative having heteroaryl ring |
DE10361259A1 (en) | 2003-12-24 | 2005-07-28 | Schwarz Pharma Ag | Use of Rotigotine in Early Stage Parkinson's Disease to Prevent Further Neuronal Loss |
CN1953660A (en) | 2004-04-07 | 2007-04-25 | 佐治亚州大学研究基金会 | Glucosamine and glucosamine/anti-inflammatory mutual prodrugs, compositions, and methods |
UA88464C2 (en) | 2004-04-29 | 2009-10-26 | Колдуэлл Гейлер, Инк. | Method of topical methadone administration providing systemic effect |
CN1672678A (en) | 2004-05-03 | 2005-09-28 | 深圳微芯生物科技有限责任公司 | Separation and extraction of natural active long-chain fatty acid component for preventing and treating prostatosis and the prepn and application of its medicine prepn |
NZ551511A (en) * | 2004-06-04 | 2010-09-30 | Xenoport Inc | Levodopa prodrugs, and compositions and uses thereof |
CN100455560C (en) | 2004-06-09 | 2009-01-28 | 中国人民解放军军事医学科学院放射医学研究所 | Medicine precursor containing long chain fatty acyl group substituted venlafaxine and its prepn and use |
AU2006225005A1 (en) | 2005-03-18 | 2006-09-21 | Ripped Formulations Ltd. | Compositions and methods for increasing metabolism, thermogenesis and/or muscular definition |
KR20080005601A (en) | 2005-05-11 | 2008-01-14 | 니코메드 게엠베하 | Combination of the pde4 inhibitor roflumilast and a tetrahydrobiopterin derivative |
DE102005022276A1 (en) * | 2005-05-13 | 2006-11-16 | Ellneuroxx Ltd. | Derivatives of dihydroxyphenylalanine |
US20060270635A1 (en) | 2005-05-27 | 2006-11-30 | Wallace John L | Derivatives of 4- or 5-aminosalicylic acid |
CA2609852A1 (en) | 2005-05-27 | 2006-11-30 | Daiichi Sankyo Company, Limited | Cyclic amine derivative having substituted alkyl group |
WO2006125293A1 (en) | 2005-05-27 | 2006-11-30 | Antibe Therapeutics Inc. | Derivatives of 4- or 5-aminosalicylic acid |
WO2007045620A1 (en) | 2005-10-18 | 2007-04-26 | Boehringer Ingelheim International Gmbh | Use of pramipexol for treating moderate to severe restless legs syndrome (rls) |
KR20080091261A (en) | 2006-01-27 | 2008-10-09 | 아사히 가세이 파마 가부시키가이샤 | Medicine for transnasal administration |
US20070259930A1 (en) | 2006-04-10 | 2007-11-08 | Knopp Neurosciences, Inc. | Compositions and methods of using r(+) pramipexole |
EP1870395A1 (en) | 2006-06-19 | 2007-12-26 | KRKA, D.D., Novo Mesto | Process for preparation of o-desmethylvenlafaxine and its analogue |
US7943666B2 (en) | 2006-07-24 | 2011-05-17 | Trinity Laboratories, Inc. | Esters of capsaicin for treating pain |
US7645767B2 (en) | 2006-08-31 | 2010-01-12 | Trinity Laboratories, Inc. | Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy |
TW200817048A (en) | 2006-09-08 | 2008-04-16 | Wyeth Corp | Dry powder compound formulations and uses thereof |
CN100573950C (en) | 2006-12-14 | 2009-12-23 | 财团法人工业技术研究院 | Phase change memory apparatus and manufacture method thereof |
AU2007333050B2 (en) | 2006-12-14 | 2013-08-29 | Knopp Biosciences Llc | Compositions and methods of using (R)-pramipexole |
CA2673511A1 (en) | 2006-12-22 | 2008-07-03 | Combinatorx, Incorporated | Pharmaceutical compositions for treatment of parkinson's disease and related disorders |
CA2675134A1 (en) | 2007-01-12 | 2008-07-24 | Biomarin Pharmaceutical Inc. | Pterin analogs |
ES2319024B1 (en) | 2007-02-13 | 2009-12-11 | Quimica Sintetica, S.A. | PROCEDURE FOR OBTAINING ENTACAPONA SUBSTANTIALLY FREE OF ISOMERO Z, ITS SYNTHESIS INTERMEDIATES AND NEW CRYSTAL FORM. |
AU2008224844B2 (en) | 2007-03-14 | 2012-08-09 | Knopp Neurosciences, Inc. | Synthesis of chirally purified substituted benzothiazole diamines |
AU2008247818B2 (en) | 2007-05-01 | 2011-10-20 | Sun Pharmaceutical Industries, Inc. | Morphinan compounds |
EP1997493A1 (en) | 2007-05-28 | 2008-12-03 | Laboratorios del Dr. Esteve S.A. | Combination of a 5-HT7 receptor ligand and an opioid receptor ligand |
EP2190853A4 (en) | 2007-06-22 | 2011-08-31 | Gluconova Llc | Halide-free glucosamine-acidic drug complexes |
US20090075942A1 (en) | 2007-09-13 | 2009-03-19 | Protia, Llc | Deuterium-enriched fosamprenavir |
CN101390854A (en) | 2007-09-21 | 2009-03-25 | 北京德众万全药物技术开发有限公司 | Medical composition containing riluzole |
WO2009056791A1 (en) | 2007-11-02 | 2009-05-07 | Pliva Hrvatska D.O.O. | Processes for preparing pharmaceutical compounds |
TW200936123A (en) | 2007-11-06 | 2009-09-01 | Xenoport Inc | Use of prodrugs of GABAb agonists for treating neuropathic and musculoskeletal pain |
CN101186583B (en) | 2007-12-20 | 2011-05-11 | 吉林大学 | Methyl 2-(2-(2,6-dichlorophenylamino)phenyl)acetate and its synthesizing method and application |
US20100081713A1 (en) | 2008-03-19 | 2010-04-01 | CombinatoRx, (Singapore) Pte. Ltd. | Compositions and methods for treating viral infections |
CN101569618B (en) | 2008-04-30 | 2011-11-09 | 上海医药工业研究院 | Application of long-chain fatty acid derivative or plant extracts containing same in inhibiting the activity of aromatizing enzyme |
KR100990949B1 (en) | 2008-06-09 | 2010-10-29 | 엔자이텍 주식회사 | Method for Preparing Clopidogrel and Derivatives Thereof |
SG192488A1 (en) | 2008-07-08 | 2013-08-30 | Catabasis Pharmaceuticals Inc | Fatty acid acetylated salicylates and their uses |
MX2011001341A (en) | 2008-08-19 | 2011-03-29 | Xenoport Inc | Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof, and methods of use. |
EP2328565B1 (en) | 2008-08-22 | 2014-06-04 | Wockhardt Limited | An extended release pharmaceutical composition of entacapone or salts thereof |
WO2010073124A2 (en) | 2008-12-26 | 2010-07-01 | Actavis Group Ptc Ehf | Processes for preparing highly pure rotigotine or a pharmaceutically acceptable salt thereof |
GB0904300D0 (en) * | 2009-03-12 | 2009-04-22 | Amarin Neuroscience Ltd | Essential fatty acid compounds |
BRPI0901298A2 (en) | 2009-04-06 | 2011-01-04 | Ems Sa | phthalimide derivatives of nonsteroidal antiinflammatory compounds and / or modulators of tnf- (alpha), process for obtaining them, pharmaceutical compositions containing them and their uses in the treatment of inflammatory diseases |
EP2424521A4 (en) | 2009-04-29 | 2015-03-04 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
WO2010147666A1 (en) | 2009-06-19 | 2010-12-23 | Memorial Sloan-Kettering Cancer Center | Compounds useful as carbonic anhydrase modulators and uses thereof |
WO2011017800A1 (en) | 2009-08-10 | 2011-02-17 | Bellus Health (International) Limited | Methods, compounds, and compositions for delivering 1,3-propan ed isulfonic acid |
CN102002053A (en) | 2009-09-02 | 2011-04-06 | 陕西合成药业有限公司 | Tetrahydro thienopyridine derivative for treating |
CN101717392A (en) | 2009-10-09 | 2010-06-02 | 苏州凯达生物医药技术有限公司 | Method for preparing rotigotine and derivative thereof |
CN102050815B (en) | 2009-11-06 | 2014-04-02 | 北京美倍他药物研究有限公司 | Dabigatran ester derivatives as prodrug |
CN101724934B (en) | 2009-11-10 | 2012-07-04 | 东华大学 | Medicinal fibre used for treating cutaneous inflammation and pain, preparation and application thereof |
ES2364011B1 (en) | 2009-11-20 | 2013-01-24 | Gp Pharm, S.A. | CAPSULES OF PHARMACEUTICAL ACTIVE AND ESTERS OF POLYINSATURATED FATTY ACIDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES. |
JP5771627B2 (en) | 2010-01-08 | 2015-09-02 | カタバシス ファーマシューティカルズ,インコーポレイテッド | Fatty acid fumarate derivatives and their use |
US9062094B2 (en) | 2010-01-22 | 2015-06-23 | Ascendis Pharma As | Dipeptide-based prodrug linkers for aliphatic amine-containing drugs |
RU2436772C2 (en) | 2010-01-28 | 2011-12-20 | Закрытое акционерное общество "НПК ЭХО" | 4[(4'-nicotinoylamino)butyroylamino]butanoic acid, exhibiting nootropic activity, and method of producing said compound |
US20130190327A1 (en) | 2010-02-26 | 2013-07-25 | Catabasis Pharmaceuticals Inc | Bis-fatty acid conjugates and their uses |
JP5885085B2 (en) | 2010-06-08 | 2016-03-15 | クリサニ バイオサイエンシーズ プライベート リミテッド | Cysteamine derivatives and their use in the treatment of nonalcoholic steatohepatitis |
KR101943812B1 (en) | 2010-07-12 | 2019-01-31 | 사노피-아벤티스 도이칠란트 게엠베하 | Aqueous composition comprising bromhexine |
AR082499A1 (en) | 2010-08-23 | 2012-12-12 | Gruenenthal Gmbh | USEFUL COMPOUNDS FOR NERVOUS SYSTEM, INFLAMMATORY, STOMACH AND AS ANALGESIC DISORDERS |
WO2012027543A1 (en) | 2010-08-25 | 2012-03-01 | Teva Pharmaceuticals Usa, Inc. | Solid state forms of dabigatran etexilate, dabigatran etexilate mesylate and processes for preparation thereof |
CN101921245B (en) | 2010-08-30 | 2012-04-18 | 中国人民解放军军事医学科学院卫生学环境医学研究所 | Sulfonamides compound for inhibiting carbonic anhydrase II and synthesis method and application thereof |
WO2012055567A2 (en) | 2010-10-29 | 2012-05-03 | Algiax Pharmaceuticals Gmbh | Use of malononitrilamides in neuropathic pain |
EP2450039A1 (en) | 2010-11-08 | 2012-05-09 | PAION UK Ltd. | Dosing regimen for sedation with CNS 7056 (Remimazolam) |
WO2012115695A1 (en) | 2011-02-25 | 2012-08-30 | Catabasis Pharmaceuticals, Inc. | Bis-fatty acid conjugates and their uses |
WO2013008182A1 (en) | 2011-07-10 | 2013-01-17 | Mahesh Kandula | Prodrugs of gaba analogs |
CN102336767A (en) | 2011-07-11 | 2012-02-01 | 华东理工大学 | Method for preparing high-purity chiral alpha-substituted-6,7-thiaindan[3,2-c]pyridine derivative |
WO2013017974A1 (en) | 2011-07-30 | 2013-02-07 | Mahesh Kandula | Compositions and methods for the treatment of neuromuscular disorders and neurodegenerative diseases |
WO2013024376A1 (en) | 2011-08-16 | 2013-02-21 | Mahesh Kandula | Compositions and methods for the treatment of atherothrombosis |
WO2013027150A1 (en) | 2011-08-21 | 2013-02-28 | Mahesh Kandula | Compositions and methods for the treatment of parkinson's disease |
CN102633799B (en) | 2012-04-10 | 2014-06-25 | 凯莱英医药集团(天津)股份有限公司 | Method for synthesizing sapropterin dihydrochloride from racemate intermediate separation route |
US20150133533A1 (en) | 2012-05-08 | 2015-05-14 | Mahesh Kandula | Compositions and methods for the treatment of cough |
US9434704B2 (en) | 2012-05-08 | 2016-09-06 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological degenerative disorders |
WO2013168022A1 (en) | 2012-05-08 | 2013-11-14 | Mahesh Kandula | Compositions and methods for treating atherothrombosis |
EP2847152A4 (en) | 2012-05-10 | 2016-03-23 | Cellix Bio Private Ltd | Compositions and methods for the treatment of metabolic syndrome |
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2013
- 2013-03-21 CA CA2873093A patent/CA2873093A1/en not_active Abandoned
- 2013-03-21 US US14/533,118 patent/US9642915B2/en active Active
- 2013-03-21 AU AU2013257742A patent/AU2013257742A1/en not_active Abandoned
- 2013-03-21 JP JP2015510900A patent/JP2015522531A/en active Pending
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- 2013-03-21 EP EP13788032.4A patent/EP2847158A4/en not_active Withdrawn
- 2013-03-21 SG SG11201407303SA patent/SG11201407303SA/en unknown
- 2013-03-21 CN CN201380030631.1A patent/CN104603096A/en active Pending
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US9642915B2 (en) | 2017-05-09 |
WO2013168021A1 (en) | 2013-11-14 |
EP2847158A4 (en) | 2015-12-30 |
CN104603096A (en) | 2015-05-06 |
AU2013257742A1 (en) | 2014-11-27 |
CA2873093A1 (en) | 2013-11-14 |
US20160122293A1 (en) | 2016-05-05 |
EP2847158A1 (en) | 2015-03-18 |
JP2015522531A (en) | 2015-08-06 |
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