JPS5677259A - N-pyridoxyl 5,8,11,14,17-eicosapentaenoic acid amide, and its preparation - Google Patents

N-pyridoxyl 5,8,11,14,17-eicosapentaenoic acid amide, and its preparation

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Publication number
JPS5677259A
JPS5677259A JP15357479A JP15357479A JPS5677259A JP S5677259 A JPS5677259 A JP S5677259A JP 15357479 A JP15357479 A JP 15357479A JP 15357479 A JP15357479 A JP 15357479A JP S5677259 A JPS5677259 A JP S5677259A
Authority
JP
Japan
Prior art keywords
eicosapentaenoic acid
acid amide
pyridoxyl
preparation
eicosapentaenoic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15357479A
Other languages
Japanese (ja)
Other versions
JPS6318584B2 (en
Inventor
Mitsuo Mazaki
Takayuki Hara
Katsuhiko Arai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co Ltd filed Critical Nippon Chemiphar Co Ltd
Priority to JP15357479A priority Critical patent/JPS5677259A/en
Publication of JPS5677259A publication Critical patent/JPS5677259A/en
Publication of JPS6318584B2 publication Critical patent/JPS6318584B2/ja
Granted legal-status Critical Current

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  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:N-Pyridoxyl 5,8,11,14,17-eicosapentaenoic acid amide.
USE: A blood platelet coagulation inhibitor. It has higher stability and absorbability than 5,8,11,14,17-eicosapentaenoic acid.
PROCESS: 5,8,11,14,17-Eicosapentaenoic acid found abundantly in fish bodies or its reactive derivative (acid halide, an active acid amide with N-hydroxysuccinimide, etc.) is made to react with pyridoxamine to obtain N-pyridoxyl 5,8, 11,14,17- eicosapentaenoic acid amide. When said eicosapentaenoic acid is used as it is, the reaction is pref. carried out in the presence of N,N-dicyclohexylcarboxiimide, a 2- substituted pyridinium salt or a base (e.g. triethylamine, sodium carbonate, etc.).
COPYRIGHT: (C)1981,JPO&Japio
JP15357479A 1979-11-29 1979-11-29 N-pyridoxyl 5,8,11,14,17-eicosapentaenoic acid amide, and its preparation Granted JPS5677259A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15357479A JPS5677259A (en) 1979-11-29 1979-11-29 N-pyridoxyl 5,8,11,14,17-eicosapentaenoic acid amide, and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15357479A JPS5677259A (en) 1979-11-29 1979-11-29 N-pyridoxyl 5,8,11,14,17-eicosapentaenoic acid amide, and its preparation

Publications (2)

Publication Number Publication Date
JPS5677259A true JPS5677259A (en) 1981-06-25
JPS6318584B2 JPS6318584B2 (en) 1988-04-19

Family

ID=15565460

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15357479A Granted JPS5677259A (en) 1979-11-29 1979-11-29 N-pyridoxyl 5,8,11,14,17-eicosapentaenoic acid amide, and its preparation

Country Status (1)

Country Link
JP (1) JPS5677259A (en)

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Also Published As

Publication number Publication date
JPS6318584B2 (en) 1988-04-19

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