SG11201810366WA - 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamides - Google Patents
3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamidesInfo
- Publication number
- SG11201810366WA SG11201810366WA SG11201810366WA SG11201810366WA SG11201810366WA SG 11201810366W A SG11201810366W A SG 11201810366WA SG 11201810366W A SG11201810366W A SG 11201810366WA SG 11201810366W A SG11201810366W A SG 11201810366WA SG 11201810366W A SG11201810366W A SG 11201810366WA
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- SG
- Singapore
- Prior art keywords
- international
- berlin
- pct
- compounds
- co7d
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
- C07D237/16—Two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111101111 0 DOI 010111110101111 0 01010 1101 OH HI 111110 lil OE lil Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\"\") WO 2017/202816 Al 30 November 2017 (30.11.2017) WIPO I PCT (51) International Patent Classification: PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, CO7D 237/16 (2006.01) CO7D 405/12 (2006.01) SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, CO7D 237/20 (2006.01) A61P 35/00 (2006.01) TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. C07D 403/12 (2006.01) A61K 31/501 (2006.01) (84) Designated States (unless otherwise indicated, for every (21) International Application Number: kind of regional protection available): ARIPO (BW, GH, PCT/EP2017/062355 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (22) International Filing Date: UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 23 May 2017 (23.05.2017) TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (25) Filing Language: English MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (26) Publication Language: English TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (30) Priority Data: PCT/CN2016/083308 Declarations under Rule 4.17: 25 May 2016 (25.05.2016) CN — as to applicant's entitlement to apply for and be granted a PCT/CN2017/074408 patent (Rule 4.17(0 22 February 2017 (22.02.2017) CN Published: (71) Applicants: BAYER PHARMA AKTIENGESEL- — with international search report (Art. 21(3)) LSCHAFT [DE/DE]; MilllerstraBe 178, 13353 Berlin (DE). DEUTSCHES KREBSFORSCHUNGSZEN- TRUM (DKFZ) [DE/DE]; Im Neuenheimer Feld 280, 69120 Heidelberg (DE). (72) Inventors: SCHMEES, Norbert; Bondickstr.61, 13469 Berlin (DE). GUTCHER, Ilona; Paul-Robeson-Str. 28, 10439 Berlin (DE). IRLBACHER, Horst; Winsstrasse 47, 10405 Berlin (DE). BADER, Benjamin; Hillmannstr. 14, 13467 Berlin (DE). ZHAO, Na; Nanhai Community, Shan- haizi east Road, BDA, Beijng, 100076 (CN). PLATTEN, Michael; Cambridgestr. 7, 69115 Heidelberg (DE). (74) Agent: BIP PATENTS; Alfred-Nobel-Str. 10, 40789 Mon- heim am Rhein (DE). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, = (81) (54) Title: 3-OXO-2,6-DIPHENYL-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDES (57) : The present invention covers 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carbox- RS compounds of general formula (I): in which R1, R2, R3, R4, R5 and R6 are as defined here- R 4 R 6 pounds, pharmaceutical compositions and combinations comprising said compounds and the use of go in, methods of preparing said compounds, intermediate compounds useful for preparing said com- said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis 1-1 GC of diseases, in particular of cancer or conditions with 10 dysregulated immune responses or other N N' disorders associated with aberrant AHR signaling, as a sole agent or in combination with other ac- 0 ei /0 tive ingredients. IN Il 14111 H N. R 1 0 ei (I) O
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2016083308 | 2016-05-25 | ||
| CN2017074408 | 2017-02-22 | ||
| PCT/EP2017/062355 WO2017202816A1 (en) | 2016-05-25 | 2017-05-23 | 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201810366WA true SG11201810366WA (en) | 2018-12-28 |
Family
ID=58745251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201810366WA SG11201810366WA (en) | 2016-05-25 | 2017-05-23 | 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamides |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US11040035B2 (en) |
| EP (1) | EP3464248B1 (en) |
| JP (1) | JP6964096B2 (en) |
| KR (1) | KR20190009369A (en) |
| CN (1) | CN109863140B (en) |
| AU (1) | AU2017269870A1 (en) |
| BR (1) | BR112018074185A2 (en) |
| CA (1) | CA3025227A1 (en) |
| CL (1) | CL2018003345A1 (en) |
| CO (1) | CO2018012654A2 (en) |
| CR (1) | CR20180556A (en) |
| CU (1) | CU20180143A7 (en) |
| DO (1) | DOP2018000256A (en) |
| EA (1) | EA201892666A1 (en) |
| EC (1) | ECSP18087725A (en) |
| IL (1) | IL263046A (en) |
| MA (1) | MA45087A (en) |
| MX (1) | MX2018014443A (en) |
| NI (1) | NI201800124A (en) |
| PE (1) | PE20190509A1 (en) |
| PH (1) | PH12018502472A1 (en) |
| SG (1) | SG11201810366WA (en) |
| SV (1) | SV2018005787A (en) |
| TN (1) | TN2018000392A1 (en) |
| TW (1) | TW201742859A (en) |
| UY (1) | UY37256A (en) |
| WO (1) | WO2017202816A1 (en) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI759301B (en) | 2016-05-24 | 2022-04-01 | 美商安美基公司 | Pegylated carfilzomib compounds |
| JOP20190193A1 (en) * | 2017-02-09 | 2019-08-08 | Bayer Pharma AG | 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamides for the treatment of cancer |
| WO2019101647A1 (en) * | 2017-11-21 | 2019-05-31 | Bayer Aktiengesellschaft | 2-phenylpyrimidine-4-carboxamides as ahr inhibitors |
| EA037978B1 (en) * | 2017-11-21 | 2021-06-18 | Байер Акциенгезельшафт | 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamides for the treatment of cancer |
| US11591311B2 (en) | 2017-11-21 | 2023-02-28 | Bayer Aktiengesellschaft | 3-oxo-6-heteroaryl-2-phenyl-2,3-dihydropyridazine-4-carboxamides |
| CA3082856A1 (en) | 2017-11-21 | 2019-05-31 | Bayer Aktiengesellschaft | Sulphur substituted 3-oxo-2,3-dihydropyridazine-4-carboxamides |
| CA3110402A1 (en) | 2018-08-24 | 2020-02-27 | Jaguahr Therapeutics Pte Ltd | Tetrahydropyridopyrimidine derivatives as ahr modulators |
| EP3843853A1 (en) | 2018-08-31 | 2021-07-07 | Jaguahr Therapeutics Pte Ltd | Heterocyclic compounds as ahr modulators |
| CN109771437B (en) * | 2019-03-28 | 2023-03-17 | 西安交通大学医学院第一附属医院 | Application of trifluorothymidine in preparing medicine for treating triple negative breast cancer |
| EP3715471A1 (en) * | 2019-03-29 | 2020-09-30 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Ahr signature marker set |
| EP3721894A1 (en) | 2019-04-10 | 2020-10-14 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Interleukin-4-induced gene 1 (il4i1) as a biomarker and uses thereof |
| JPWO2021020362A1 (en) * | 2019-07-29 | 2021-02-04 | ||
| EP3835432A1 (en) | 2019-12-10 | 2021-06-16 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Interleukin-4-induced gene 1 (il4i1) and respective metabolites as biomarkers for cancer |
| WO2021122434A1 (en) * | 2019-12-16 | 2021-06-24 | Bayer Aktiengesellschaft | Combination of an ahr-inhibitor and an pd1-inhibitor antibody and its use in the treatment of cancer |
| JP2023510797A (en) | 2020-01-10 | 2023-03-15 | イケナ オンコロジー， インコーポレイテッド | AHR inhibitors and uses thereof |
| CN115244048A (en) | 2020-02-26 | 2022-10-25 | 捷豹治疗有限公司 | Pyridopyrimidine derivatives useful for modulating AhR signaling |
| BR112022019387A2 (en) * | 2020-03-27 | 2022-11-16 | Dong A St Co Ltd | AMINOPYRIMIDINE DERIVATIVES AND THEIR USE AS ARYL HYDROCARBON RECEPTOR MODULATORS |
| US11911376B2 (en) | 2020-03-30 | 2024-02-27 | The Regents Of The University Of Colorado | Methods for preventing and treating retinal damage |
| CN114181212B (en) * | 2020-09-15 | 2023-06-06 | 山东轩竹医药科技有限公司 | Pyridazinone AhR inhibitors |
| WO2022078356A1 (en) * | 2020-10-15 | 2022-04-21 | 山东轩竹医药科技有限公司 | Heteroaromatic ahr inhibitor |
| CN114685426A (en) * | 2020-12-28 | 2022-07-01 | 苏州泽璟生物制药股份有限公司 | Sulfonamide inhibitor and preparation method and application thereof |
| CN118234710A (en) * | 2021-09-14 | 2024-06-21 | 元启(苏州)生物制药有限公司 | 2-Aryl or heteroaryl-3-oxo-4-carboxamide-6-cyclo-dihydropyrazine aryl hydrocarbon receptor modulators and use thereof in the treatment of diseases and conditions |
| WO2024076300A1 (en) | 2022-10-03 | 2024-04-11 | Jaguahr Therapeutics Pte Ltd | Compounds useful in modulation of ahr signalling |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4134467A1 (en) | 1991-10-18 | 1993-04-22 | Thomae Gmbh Dr K | HETEROBIARYL DERIVATIVES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
| WO2000009488A1 (en) | 1998-08-14 | 2000-02-24 | Nihon Nohyaku Co., Ltd. | Pyridazinone derivatives |
| IL154709A0 (en) | 2000-09-18 | 2003-10-31 | Eisai Co Ltd | Pyridazinone and triazinone derivatives and pharmaceutical compositions containing the same |
| FR2847253B1 (en) | 2002-11-19 | 2007-05-18 | Aventis Pharma Sa | NOVEL DERIVATIVES OF PYRIDAZINONES AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM |
| FR2847235B1 (en) | 2002-11-20 | 2005-07-08 | Essilor Int | PROTECTIVE AND SETTING PACKAGING FOR CIRCULAR CONTOUR OBJECTS |
| WO2007058392A1 (en) | 2005-11-21 | 2007-05-24 | Japan Tobacco Inc. | Heterocyclic compound and medicinal application thereof |
| WO2009142732A2 (en) | 2008-05-20 | 2009-11-26 | Cephalon, Inc. | Substituted pyridazinone derivatives as histamine-3 (h3) receptor ligands |
| PE20100362A1 (en) | 2008-10-30 | 2010-05-27 | Irm Llc | PURINE DERIVATIVES THAT EXPAND HEMATOPOYETIC STEM CELLS |
| US10314810B2 (en) | 2010-07-27 | 2019-06-11 | Trustees Of Boston University | Aryl hydrocarbon receptor (AhR) modifiers as novel cancer therapeutics |
| US20170173008A1 (en) | 2014-03-19 | 2017-06-22 | President And Fellows Of Harvard College | Antimicrobial agents and screening methods |
-
2017
- 2017-05-23 SG SG11201810366WA patent/SG11201810366WA/en unknown
- 2017-05-23 MX MX2018014443A patent/MX2018014443A/en unknown
- 2017-05-23 WO PCT/EP2017/062355 patent/WO2017202816A1/en unknown
- 2017-05-23 PE PE2018003109A patent/PE20190509A1/en unknown
- 2017-05-23 TN TNP/2018/000392A patent/TN2018000392A1/en unknown
- 2017-05-23 EP EP17724833.3A patent/EP3464248B1/en active Active
- 2017-05-23 CN CN201780046149.5A patent/CN109863140B/en active Active
- 2017-05-23 KR KR1020187037050A patent/KR20190009369A/en not_active Application Discontinuation
- 2017-05-23 AU AU2017269870A patent/AU2017269870A1/en not_active Abandoned
- 2017-05-23 CR CR20180556A patent/CR20180556A/en unknown
- 2017-05-23 EA EA201892666A patent/EA201892666A1/en unknown
- 2017-05-23 US US16/303,539 patent/US11040035B2/en active Active
- 2017-05-23 CU CU2018000143A patent/CU20180143A7/en unknown
- 2017-05-23 MA MA045087A patent/MA45087A/en unknown
- 2017-05-23 BR BR112018074185-0A patent/BR112018074185A2/en not_active IP Right Cessation
- 2017-05-23 JP JP2018561224A patent/JP6964096B2/en active Active
- 2017-05-23 CA CA3025227A patent/CA3025227A1/en active Pending
- 2017-05-24 UY UY0001037256A patent/UY37256A/en not_active Application Discontinuation
- 2017-05-25 TW TW106117299A patent/TW201742859A/en unknown
-
2018
- 2018-11-15 IL IL263046A patent/IL263046A/en unknown
- 2018-11-23 SV SV2018005787A patent/SV2018005787A/en unknown
- 2018-11-23 EC ECSENADI201887725A patent/ECSP18087725A/en unknown
- 2018-11-23 CL CL2018003345A patent/CL2018003345A1/en unknown
- 2018-11-23 NI NI201800124A patent/NI201800124A/en unknown
- 2018-11-23 CO CONC2018/0012654A patent/CO2018012654A2/en unknown
- 2018-11-23 DO DO2018000256A patent/DOP2018000256A/en unknown
- 2018-11-23 PH PH12018502472A patent/PH12018502472A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019516744A (en) | 2019-06-20 |
| MA45087A (en) | 2021-05-26 |
| PE20190509A1 (en) | 2019-04-10 |
| EP3464248A1 (en) | 2019-04-10 |
| UY37256A (en) | 2018-01-02 |
| CR20180556A (en) | 2019-04-23 |
| SV2018005787A (en) | 2019-02-07 |
| MX2018014443A (en) | 2019-04-15 |
| PH12018502472A1 (en) | 2019-09-23 |
| TW201742859A (en) | 2017-12-16 |
| JP6964096B2 (en) | 2021-11-10 |
| CN109863140B (en) | 2023-02-21 |
| KR20190009369A (en) | 2019-01-28 |
| CL2018003345A1 (en) | 2019-03-15 |
| IL263046A (en) | 2018-12-31 |
| CA3025227A1 (en) | 2017-11-30 |
| US11040035B2 (en) | 2021-06-22 |
| EP3464248B1 (en) | 2021-09-08 |
| AU2017269870A1 (en) | 2018-12-06 |
| BR112018074185A2 (en) | 2019-03-06 |
| ECSP18087725A (en) | 2018-11-30 |
| CO2018012654A2 (en) | 2018-12-14 |
| CU20180143A7 (en) | 2019-07-04 |
| TN2018000392A1 (en) | 2020-06-15 |
| DOP2018000256A (en) | 2019-02-15 |
| CN109863140A (en) | 2019-06-07 |
| US20200237757A1 (en) | 2020-07-30 |
| EA201892666A1 (en) | 2019-08-30 |
| WO2017202816A1 (en) | 2017-11-30 |
| NI201800124A (en) | 2019-04-29 |
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