SG11201908691PA - Compounds and methods for the treatment of parasitic diseases - Google Patents
Compounds and methods for the treatment of parasitic diseasesInfo
- Publication number
- SG11201908691PA SG11201908691PA SG11201908691PA SG11201908691PA SG 11201908691P A SG11201908691P A SG 11201908691PA SG 11201908691P A SG11201908691P A SG 11201908691PA SG 11201908691P A SG11201908691P A SG 11201908691PA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- massachusetts
- cambridge
- treatment
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 27 September 2018 (27.09.2018) WIP0 I PCT °mono n o VIII VIII ium VII IE (10) International Publication Number WO 2018/175385 Al (51) International Patent Classification: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, A61K 31/395 (2006.01) CO7D 487/04 (2006.01) (21) International Application Number: PCT/US2018/023270 (22) International Filing Date: KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) 20 March 2018 (20.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/473,771 20 March 2017 (20.03.2017) US (71) Applicants: THE BROAD INSTITUTE, INC. [US/US]; 415 Main Street, Cambridge, Massachusetts 02142 (US). PRESIDENT AND FELLOWS OF HARVARD COL- LEGE [US/US]; 17 Quincy Street, Cambridge, Massachu- setts 02138-3876 (US). (72) Inventors: COMER, Eamon; C/o The Broad Institute, INC., 415 Main Street, Cambridge, Massachusetts 02142 (US). KATO, Nobutaka; C/o The Broad Institute, INC., 415 Main Street, Cambridge, Massachusetts 02142 (US). MORNINGSTAR, Marshall; C/o The Broad Institute, INC., 415 Main Street, Cambridge, Massachusetts 02142 (US). MELILLO, Bruno; c/o President and Fellows of Harvard College, 17 Quincy Street, Cambrifge, MA 02138 (US). (74) Agent: HUNTER-ENSOR, Melissa; C/o Greenberg Trau- rig, LLP, One International Place, Boston, Massachusetts 02110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 1-1 TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 1 1 MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 1 1 N 1-1 (54) Title: COMPOUNDS AND METHODS FOR THE TREATMENT OF PARASITIC DISEASES (57) : Provided herein are compounds useful for the treatment of various parasitic diseases. These compounds, as well as 0 pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compostions, veterinary compositions and may be used \" in methods of treatment and/or prophylaxis of diseases spread by parasites, including malaria and cryptosporidiosis.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762473771P | 2017-03-20 | 2017-03-20 | |
| PCT/US2018/023270 WO2018175385A1 (en) | 2017-03-20 | 2018-03-20 | Compounds and methods for the treatment of parasitic diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201908691PA true SG11201908691PA (en) | 2019-10-30 |
Family
ID=63586520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201908691P SG11201908691PA (en) | 2017-03-20 | 2018-03-20 | Compounds and methods for the treatment of parasitic diseases |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11174260B2 (en) |
| EP (1) | EP3600286B1 (en) |
| JP (1) | JP7306997B2 (en) |
| KR (1) | KR20190129968A (en) |
| CN (1) | CN110650738B (en) |
| AU (1) | AU2018240031B2 (en) |
| BR (1) | BR112019019494A2 (en) |
| CA (1) | CA3057087A1 (en) |
| CO (1) | CO2019011546A2 (en) |
| ES (1) | ES2966369T3 (en) |
| IL (1) | IL269390B (en) |
| MX (1) | MX2019011271A (en) |
| MY (1) | MY197171A (en) |
| PH (1) | PH12019502150A1 (en) |
| SG (1) | SG11201908691PA (en) |
| WO (1) | WO2018175385A1 (en) |
| ZA (1) | ZA201906213B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7306997B2 (en) | 2017-03-20 | 2023-07-11 | ザ・ブロード・インスティテュート・インコーポレイテッド | Compounds and methods for the treatment of parasitic diseases |
| WO2019051642A1 (en) * | 2017-09-12 | 2019-03-21 | 广州中科蓝华生物科技有限公司 | Kit for transfecting intracellular parasites and use thereof |
| US20210355522A1 (en) * | 2018-08-20 | 2021-11-18 | The Broad Institute, Inc. | Inhibitors of rna-guided nuclease activity and uses thereof |
| WO2020061167A1 (en) * | 2018-09-18 | 2020-03-26 | Washington University | Treatment of infections of toxoplasma gondii and closely related parasites |
| CN113661166A (en) * | 2019-01-09 | 2021-11-16 | 卫材R&D管理有限公司 | Process for the synthesis of diazabicyclo [6.2.0] decane-related compounds |
| WO2021081315A1 (en) * | 2019-10-25 | 2021-04-29 | The Broad Institute, Inc. | Compounds and methods for the treatment of cryptosporidiosis |
| WO2022067060A1 (en) * | 2020-09-24 | 2022-03-31 | The Broad Institute, Inc. | Apicomplexan parasite inhibition |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3176017A (en) * | 1963-02-26 | 1965-03-30 | American Home Prod | Aroylalkyl derivatives of diazabicyclo-nonanes and-decanes |
| US3542780A (en) | 1967-07-25 | 1970-11-24 | American Home Prod | 2-amidino-1,2,3,4-tetrahydropyrazine(1,2-a)indoles |
| US3531485A (en) | 1967-08-14 | 1970-09-29 | American Home Prod | Aryl-substituted diazabicycloalkanes |
| RU2236413C2 (en) | 1998-07-14 | 2004-09-20 | Байер Акциенгезельшафт | Derivatives of artemisinin, method for their preparing, pharmaceutical composition based on thereof and method for treatment |
| UA77515C2 (en) | 2002-04-04 | 2006-12-15 | Diazabicyclo alkane derivatives possessing neuroldnin-nk1 receptor antagonistic activity | |
| US7511159B2 (en) | 2003-12-25 | 2009-03-31 | Ono Pharmaceutical Co., Ltd. | Azetidine ring compounds and drugs comprising the same |
| ME03042B (en) * | 2012-11-19 | 2018-10-20 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
| EA027752B1 (en) | 2012-12-20 | 2017-08-31 | Юсб Биофарма Спрл | Therapeutically active pyrazolo-pyrimidine derivatives |
| UY35772A (en) | 2013-10-14 | 2015-05-29 | Bayer Cropscience Ag | NEW PESTICIDED COMPOUNDS |
| GB2533536B (en) | 2013-10-24 | 2021-05-19 | Toyota Motor Co Ltd | Cathode active material for sodium batteries, and sodium battery |
| JP6591429B2 (en) | 2013-11-11 | 2019-10-16 | ザ・ブロード・インスティテュート・インコーポレイテッド | Compounds and methods for the treatment of malaria |
| WO2015103583A1 (en) | 2014-01-06 | 2015-07-09 | President And Fellows Of Harvard College | Monobactams and methods of their synthesis and use |
| ES2719136T3 (en) | 2014-03-24 | 2019-07-08 | Novartis Ag | Organic monobactam compounds for the treatment of bacterial infections |
| EA033446B1 (en) | 2014-10-24 | 2019-10-31 | Takeda Pharmaceuticals Co | Heterocyclic compound for treating macular degeneration and/or stargardt's disease |
| US11040976B2 (en) | 2015-04-24 | 2021-06-22 | President And Fellows Of Harvard College | Substrate selective inhibitors of insulin-degrading enzyme (IDE) and uses thereof |
| JP7306997B2 (en) | 2017-03-20 | 2023-07-11 | ザ・ブロード・インスティテュート・インコーポレイテッド | Compounds and methods for the treatment of parasitic diseases |
| WO2020061167A1 (en) | 2018-09-18 | 2020-03-26 | Washington University | Treatment of infections of toxoplasma gondii and closely related parasites |
| WO2020219610A1 (en) | 2019-04-23 | 2020-10-29 | Washington University | Compounds and methods for the treatment of parasitic diseases |
-
2018
- 2018-03-20 JP JP2019551706A patent/JP7306997B2/en active Active
- 2018-03-20 CN CN201880033124.6A patent/CN110650738B/en active Active
- 2018-03-20 ES ES18771869T patent/ES2966369T3/en active Active
- 2018-03-20 SG SG11201908691P patent/SG11201908691PA/en unknown
- 2018-03-20 EP EP18771869.7A patent/EP3600286B1/en active Active
- 2018-03-20 WO PCT/US2018/023270 patent/WO2018175385A1/en unknown
- 2018-03-20 US US16/495,357 patent/US11174260B2/en active Active
- 2018-03-20 CA CA3057087A patent/CA3057087A1/en active Pending
- 2018-03-20 MX MX2019011271A patent/MX2019011271A/en unknown
- 2018-03-20 KR KR1020197030814A patent/KR20190129968A/en not_active Application Discontinuation
- 2018-03-20 BR BR112019019494A patent/BR112019019494A2/en unknown
- 2018-03-20 MY MYPI2019005496A patent/MY197171A/en unknown
- 2018-03-20 IL IL269390A patent/IL269390B/en unknown
- 2018-03-20 AU AU2018240031A patent/AU2018240031B2/en active Active
-
2019
- 2019-09-19 ZA ZA2019/06213A patent/ZA201906213B/en unknown
- 2019-09-19 PH PH12019502150A patent/PH12019502150A1/en unknown
- 2019-10-17 CO CONC2019/0011546A patent/CO2019011546A2/en unknown
-
2021
- 2021-07-28 US US17/387,639 patent/US11866441B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2018240031B2 (en) | 2022-07-14 |
| AU2018240031A1 (en) | 2019-10-10 |
| CO2019011546A2 (en) | 2020-02-28 |
| PH12019502150A1 (en) | 2020-07-06 |
| IL269390B (en) | 2022-08-01 |
| IL269390A (en) | 2019-11-28 |
| JP7306997B2 (en) | 2023-07-11 |
| BR112019019494A2 (en) | 2020-04-28 |
| EP3600286A1 (en) | 2020-02-05 |
| ES2966369T3 (en) | 2024-04-22 |
| CA3057087A1 (en) | 2018-09-27 |
| WO2018175385A1 (en) | 2018-09-27 |
| US11866441B2 (en) | 2024-01-09 |
| US20200095253A1 (en) | 2020-03-26 |
| US11174260B2 (en) | 2021-11-16 |
| MY197171A (en) | 2023-05-28 |
| EP3600286B1 (en) | 2023-08-16 |
| MX2019011271A (en) | 2020-01-20 |
| RU2019132950A3 (en) | 2021-06-29 |
| JP2020514381A (en) | 2020-05-21 |
| CN110650738A (en) | 2020-01-03 |
| KR20190129968A (en) | 2019-11-20 |
| EP3600286A4 (en) | 2020-12-02 |
| CN110650738B (en) | 2023-05-09 |
| ZA201906213B (en) | 2022-03-30 |
| US20220162211A1 (en) | 2022-05-26 |
| RU2019132950A (en) | 2021-04-21 |
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