SG11201906853QA - Anti-rsv monoclonal antibody formulation - Google Patents
Anti-rsv monoclonal antibody formulationInfo
- Publication number
- SG11201906853QA SG11201906853QA SG11201906853QA SG11201906853QA SG11201906853QA SG 11201906853Q A SG11201906853Q A SG 11201906853QA SG 11201906853Q A SG11201906853Q A SG 11201906853QA SG 11201906853Q A SG11201906853Q A SG 11201906853QA SG 11201906853Q A SG11201906853Q A SG 11201906853QA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- monoclonal antibody
- formulation
- pct
- present
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 102220240796 rs553605556 Human genes 0.000 abstract 2
- 101100010343 Drosophila melanogaster lobo gene Proteins 0.000 abstract 1
- 229940126534 drug product Drugs 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1002—Coronaviridae
- C07K16/1003—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2 or Covid-19]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1027—Paramyxoviridae, e.g. respiratory syncytial virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1596X+99.62 — D 0.40C El 25C © 5C 1 3 4 97.5 0 2 TIME (MONTHS) = -0.0211X+99.638 Y = -0.5254+99.373 100 99.5 >_ 99 m • 98.5 O _ 98 W O 20 18/ 1607 22 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 07 September 2018 (07.09.2018) WIP0 I PCT Iiiimmomitiaonolomomioolimommom oimIE (10) International Publication Number WO 2018/160722 Al (51) International Patent Classification: C07K 16/08 (2006.01) A61K 39/395 (2006.01) C07K 16/10 (2006.01) A61P 31/12 (2006.01) A61K 38/16 (2006.01) A61P 31/14 (2006.01) A61K 39/42 (2006.01) (21) International Application Number: PCT/US2018/020264 (22) International Filing Date: 28 February 2018 (28.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/465,379 01 March 2017 (01.03.2017) US (71) Applicant: MEDIMMUNE LIMITED [GB/GB]; Mil- stein Building, Granta Park, Cambridge CB21 6GH (GB). (72) Inventors; and (71) Applicants: LOBO, Brian [US/US]; Medlmmune, LLC, One MedImmune Way, Gaithersburg, MD 20878 (US). GOLDBERG, Deborah [US/US]; 6219 Sutton Court, Elkridge, MD 21075 (US). (74) Agent: JOHNSON, Nancy, A.; Mueting, Raasch & Gebhardt, P.A., P.O. Box 581336, Minneapolis, MN 55458-1336 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: ANTI-RSV MONOCLONAL ANTIBODY FORMULATION MEDI8897 REPRESENTATIVE DRUG PRODUCT STABILITY Fig. 3 (57) : The present invention provides a formulation comprising: (i) an anti-RSV monoclonal antibody; and (ii) an ionic ex- cipient; wherein the monoclonal antibody is present at a concentration of about 50mg/m1 or greater and the ionic excipient is present at a concentration of between 50 and 150 mM and the formulation has a pH of about 5.5 to about 7.5. [Continued on next page] WO 2018/160722 Al D ill Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a))
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762465379P | 2017-03-01 | 2017-03-01 | |
| PCT/US2018/020264 WO2018160722A1 (en) | 2017-03-01 | 2018-02-28 | Anti-rsv monoclonal antibody formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201906853QA true SG11201906853QA (en) | 2019-09-27 |
Family
ID=61903153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201906853QA SG11201906853QA (en) | 2017-03-01 | 2018-02-28 | Anti-rsv monoclonal antibody formulation |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US10774133B2 (en) |
| EP (1) | EP3589648A4 (en) |
| JP (2) | JP7046088B2 (en) |
| KR (2) | KR102668158B1 (en) |
| CN (3) | CN116059343A (en) |
| AR (1) | AR111083A1 (en) |
| AU (2) | AU2018227502B2 (en) |
| BR (1) | BR112019017755A2 (en) |
| CA (1) | CA3051864A1 (en) |
| CL (1) | CL2019002478A1 (en) |
| CO (1) | CO2019009034A2 (en) |
| CR (1) | CR20190400A (en) |
| EA (1) | EA201991701A1 (en) |
| EC (1) | ECSP19062769A (en) |
| GB (1) | GB2564175B (en) |
| IL (2) | IL312499A (en) |
| MX (1) | MX2019010408A (en) |
| PH (1) | PH12019501979A1 (en) |
| SG (1) | SG11201906853QA (en) |
| TW (2) | TW202228779A (en) |
| UA (1) | UA128450C2 (en) |
| WO (1) | WO2018160722A1 (en) |
| ZA (1) | ZA202006797B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE048855T2 (en) | 2014-01-15 | 2020-08-28 | Medimmune Llc | Rsv-specific antibodies and functional parts thereof |
| JP2018535242A (en) * | 2015-11-30 | 2018-11-29 | メディミューン，エルエルシー | Optimal ratio of amino acids and sugars as amorphous stabilizing compounds in pharmaceutical compositions containing high concentrations of protein-based therapeutics |
| TW202228779A (en) * | 2017-03-01 | 2022-08-01 | 英商梅迪繆思有限公司 | Anti-rsv monoclonal antibody formulation |
| EP3589318A1 (en) * | 2017-03-01 | 2020-01-08 | MedImmune Limited | Formulations of monoclonal antibodies |
| JOP20190260A1 (en) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | Stable formulations of programmed death receptor 1 (pd-1) antibodies and methods of use thereof |
| BR112019022873A8 (en) | 2017-05-02 | 2023-04-11 | Merck Sharp & Dohme | FORMULATION, AND, INJECTION VESSEL OR DEVICE. |
| JP7467438B2 (en) | 2018-10-18 | 2024-04-15 | メルク・シャープ・アンド・ドーム・エルエルシー | Anti-RSV antibody formulations and methods of use thereof |
| BR112021015034A2 (en) | 2019-02-18 | 2021-10-05 | Eli Lilly And Company | THERAPEUTIC ANTIBODY FORMULATION |
| EP3956351A1 (en) * | 2019-04-18 | 2022-02-23 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Biological and synthetic molecules inhibiting respiratory syncytial virus infection |
| US12024553B2 (en) | 2019-04-30 | 2024-07-02 | Medimmune Limited | Dosage regimens for and compositions including anti-RSV antibodies |
| CN115960214A (en) * | 2021-10-12 | 2023-04-14 | 中国科学院分子细胞科学卓越创新中心 | Design and application of fully human antibody for neutralizing respiratory syncytial virus |
| TW202342510A (en) | 2022-02-18 | 2023-11-01 | 英商Ｒｑ生物科技有限公司 | Antibodies |
| CN116987183B (en) * | 2022-07-22 | 2024-10-15 | 北京智仁美博生物科技有限公司 | Neutralizing antibodies against respiratory syncytial virus and uses thereof |
| WO2024120516A1 (en) * | 2022-12-08 | 2024-06-13 | 南京诺唯赞生物科技股份有限公司 | Antibodies specifically binding to rsv |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5892019A (en) | 1987-07-15 | 1999-04-06 | The United States Of America, As Represented By The Department Of Health And Human Services | Production of a single-gene-encoded immunoglobulin |
| US5811524A (en) | 1995-06-07 | 1998-09-22 | Idec Pharmaceuticals Corporation | Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof |
| WO1997010846A1 (en) | 1995-09-18 | 1997-03-27 | Intracel Corporation | Neutralizing monoclonal antibodies to respiratory syncytial virus |
| GB0113179D0 (en) * | 2001-05-31 | 2001-07-25 | Novartis Ag | Organic compounds |
| CA2466034C (en) * | 2001-11-08 | 2012-12-18 | Protein Design Labs, Inc. | Stable aqueous pharmaceutical formulations of daclizumab antibodies |
| AU2013201261B2 (en) * | 2002-06-14 | 2016-06-23 | Medimmune, Llc | Stabilized liquid anti-RSV antibody formulations |
| US7132100B2 (en) | 2002-06-14 | 2006-11-07 | Medimmune, Inc. | Stabilized liquid anti-RSV antibody formulations |
| US7425618B2 (en) * | 2002-06-14 | 2008-09-16 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
| PL1610820T5 (en) * | 2003-04-04 | 2014-01-31 | Genentech Inc | High concentration antibody and protein formulations |
| TW200636064A (en) | 2004-10-28 | 2006-10-16 | Centocor Inc | Anti-respiratory syncytial virus antibodies, antigens and uses thereof |
| JP2009532336A (en) * | 2006-03-06 | 2009-09-10 | メディミューン，エルエルシー | Humanized anti-CD22 antibodies and their use in the treatment of tumors, transplants and autoimmune diseases |
| EP1997830A1 (en) | 2007-06-01 | 2008-12-03 | AIMM Therapeutics B.V. | RSV specific binding molecules and means for producing them |
| PE20091174A1 (en) * | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | LIQUID FORMULATION WITH HIGH CONCENTRATION OF ANTIBODY CONTENT |
| CA2742086A1 (en) | 2008-11-05 | 2010-05-14 | Merck Sharp & Dohme Corp. | Live, attenuated respiratory syncytial virus |
| US20120121580A1 (en) * | 2009-07-28 | 2012-05-17 | Merck Sharp & Dohme Corp. | Methods for producing high concentration lyophilized pharmaceutical formulations |
| EP2486053B1 (en) * | 2009-10-06 | 2017-01-18 | Medimmune Limited | Rsv-specific binding molecule |
| US8568726B2 (en) | 2009-10-06 | 2013-10-29 | Medimmune Limited | RSV specific binding molecule |
| CL2011003002A1 (en) | 2011-11-25 | 2012-05-25 | Univ Pontificia Catolica Chile | Monoclonal antibody or a fragment thereof that binds to the m2-1 protein of the human respiratory syncytial virus (RSV); nucleotide sequences; pharmaceutical composition; method of diagnosis of infection produced by vrs; kit; and use of said antibody to prepare a medicament. |
| BR122019026701B1 (en) * | 2012-03-26 | 2023-01-24 | Sanofi | STABLE IGG4-BASED BINDER FORMULATIONS, KIT, AND PRE-FILLED DEVICE OR CONTAINER |
| US20140004131A1 (en) | 2012-05-04 | 2014-01-02 | Novartis Ag | Antibody formulation |
| US8883979B2 (en) * | 2012-08-31 | 2014-11-11 | Bayer Healthcare Llc | Anti-prolactin receptor antibody formulations |
| LT2950886T (en) | 2013-02-01 | 2020-07-10 | Medimmune, Llc | Respiratory syncytial virus f protein epitopes |
| HUE048855T2 (en) * | 2014-01-15 | 2020-08-28 | Medimmune Llc | Rsv-specific antibodies and functional parts thereof |
| WO2016059512A1 (en) * | 2014-10-18 | 2016-04-21 | Pfizer Inc. | Anti-il-7r antibody compositions |
| KR102638978B1 (en) * | 2015-07-07 | 2024-02-22 | 얀센 백신스 앤드 프리벤션 비.브이. | Vaccine against RSV |
| JO3555B1 (en) | 2015-10-29 | 2020-07-05 | Merck Sharp & Dohme | Antibody neutralizing human respiratory syncytial virus |
| EP3589318A1 (en) * | 2017-03-01 | 2020-01-08 | MedImmune Limited | Formulations of monoclonal antibodies |
| TW202228779A (en) | 2017-03-01 | 2022-08-01 | 英商梅迪繆思有限公司 | Anti-rsv monoclonal antibody formulation |
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2018
- 2018-02-13 TW TW111113045A patent/TW202228779A/en unknown
- 2018-02-13 TW TW107105368A patent/TWI761453B/en active
- 2018-02-23 GB GB1802974.4A patent/GB2564175B/en active Active
- 2018-02-26 AR ARP180100448A patent/AR111083A1/en unknown
- 2018-02-28 JP JP2019547310A patent/JP7046088B2/en active Active
- 2018-02-28 SG SG11201906853QA patent/SG11201906853QA/en unknown
- 2018-02-28 CA CA3051864A patent/CA3051864A1/en active Pending
- 2018-02-28 US US15/907,876 patent/US10774133B2/en active Active
- 2018-02-28 IL IL312499A patent/IL312499A/en unknown
- 2018-02-28 KR KR1020227003517A patent/KR102668158B1/en active IP Right Grant
- 2018-02-28 CN CN202210988780.XA patent/CN116059343A/en active Pending
- 2018-02-28 EA EA201991701A patent/EA201991701A1/en unknown
- 2018-02-28 CR CR20190400A patent/CR20190400A/en unknown
- 2018-02-28 KR KR1020197025250A patent/KR102359181B1/en active IP Right Grant
- 2018-02-28 CN CN201880014929.6A patent/CN110418803B/en active Active
- 2018-02-28 EP EP18761614.9A patent/EP3589648A4/en active Pending
- 2018-02-28 AU AU2018227502A patent/AU2018227502B2/en active Active
- 2018-02-28 MX MX2019010408A patent/MX2019010408A/en unknown
- 2018-02-28 WO PCT/US2018/020264 patent/WO2018160722A1/en unknown
- 2018-02-28 CN CN202410036839.4A patent/CN117982637A/en active Pending
- 2018-02-28 BR BR112019017755A patent/BR112019017755A2/en not_active Application Discontinuation
- 2018-02-28 UA UAA201908966A patent/UA128450C2/en unknown
- 2018-02-28 IL IL268202A patent/IL268202B2/en unknown
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2019
- 2019-08-21 CO CONC2019/0009034A patent/CO2019009034A2/en unknown
- 2019-08-28 CL CL2019002478A patent/CL2019002478A1/en unknown
- 2019-08-29 PH PH12019501979A patent/PH12019501979A1/en unknown
- 2019-08-29 EC ECSENADI201962769A patent/ECSP19062769A/en unknown
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2020
- 2020-07-13 US US16/927,169 patent/US11667698B2/en active Active
- 2020-10-30 ZA ZA2020/06797A patent/ZA202006797B/en unknown
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2021
- 2021-06-18 US US17/351,348 patent/US11286294B2/en active Active
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2022
- 2022-03-22 JP JP2022045862A patent/JP7446356B2/en active Active
- 2022-11-04 AU AU2022263564A patent/AU2022263564A1/en active Pending
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2023
- 2023-04-28 US US18/309,475 patent/US20230399383A1/en active Pending
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