SG11201908786VA - Substituted indoline derivatives as dengue viral replication inhibitors - Google Patents
Substituted indoline derivatives as dengue viral replication inhibitorsInfo
- Publication number
- SG11201908786VA SG11201908786VA SG11201908786VA SG11201908786VA SG 11201908786V A SG11201908786V A SG 11201908786VA SG 11201908786V A SG11201908786V A SG 11201908786VA SG 11201908786V A SG11201908786V A SG 11201908786VA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- leuven
- dengue viral
- turnhoutseweg
- beerse
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) W I PO I ill mu °million °nolo VII IE (10) International Publication Number WO 2018/178240 Al PCT (51) International Patent Classification: CO7D 403/12 (2006.01) A61P 31/14 (2006.01) A61K 31/41 (2006.01) (21) International Application Number: PCT/EP2018/058079 (22) International Filing Date: 29 March 2018 (29.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17164048.5 31 March 2017 (31.03.2017) EP (71) Applicants: JANSSEN PHARMACEUTICALS, INC. [US/US]; 1125 Trenton-Harbourton Road, Titusville, NJ New Jersey 08560 (US). KATHOLIEKE UNIVERSITEIT LEUVEN [BE/BE]; Waaistraat 6, bus 5105, 3000 Leuven (BE). (72) Inventors: KESTELEYN, Bart Rudolf Romanie; c/o Janssen Pharmaceutica NV Turnhoutseweg 30, 2340 Beerse (BE). BONFANTI, Jean-Francois; c/o Janssen-Cilag 1 rue Camille Desmoulins, TSA 91003, 92787 Issy-les-Moulin- eaux Cedex 9 (FR). COESEMANS, Erwin; c/o Janssen Pharmaceutica NV Turnhoutseweg 30, 2340 Beerse (BE). RABOISSON, Pierre Jean-Marie Bernard; c/o Janssen Pharmaceutica NV Turnhoutseweg 30, 2340 Beerse (BE). MARCHAND, Arnaud Didier M; c/o Cistim Leuven vzw Gaston Geenslaan 2, 3001 Leuven (Heverlee) (BE). BARDIOT, Dorothee Alice Marie-Eve; c/o Cistim Leu- ven vzw Gaston Geenslaan 2, 3001 Leuven (Heverlee) (BE). (74) Agent: GHEDIRA, Rim; Johnson & Johnson Patent Law Department, Turnhoutseweg 30, 2340 Beerse (BE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.1700) Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) CZ el (54) Title: SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS I N (57) : The present invention relates to substituted indoline derivatives, methods to prevent or treat dengue viral infections by 1-1 ----. using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the © compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral N infections. The invention also relates to processes for preparation of the compounds.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17164048 | 2017-03-31 | ||
| PCT/EP2018/058079 WO2018178240A1 (en) | 2017-03-31 | 2018-03-29 | Substituted indoline derivatives as dengue viral replication inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201908786VA true SG11201908786VA (en) | 2019-10-30 |
Family
ID=58464340
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201908786V SG11201908786VA (en) | 2017-03-31 | 2018-03-29 | Substituted indoline derivatives as dengue viral replication inhibitors |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US11083707B2 (en) |
| EP (1) | EP3601266B1 (en) |
| JP (1) | JP7203752B2 (en) |
| KR (1) | KR102530832B1 (en) |
| CN (1) | CN110461831B (en) |
| AR (1) | AR111314A1 (en) |
| AU (1) | AU2018246301B2 (en) |
| BR (1) | BR112019020175A2 (en) |
| CA (1) | CA3055867C (en) |
| CL (1) | CL2019002745A1 (en) |
| CO (1) | CO2019010295A2 (en) |
| CR (1) | CR20190446A (en) |
| DK (1) | DK3601266T3 (en) |
| EA (1) | EA039784B1 (en) |
| EC (1) | ECSP19070369A (en) |
| ES (1) | ES2884151T3 (en) |
| HR (1) | HRP20210942T1 (en) |
| HU (1) | HUE054678T2 (en) |
| IL (1) | IL269658B (en) |
| JO (1) | JOP20180025B1 (en) |
| LT (1) | LT3601266T (en) |
| MX (1) | MX2019011606A (en) |
| NI (1) | NI201900099A (en) |
| PE (1) | PE20191650A1 (en) |
| PH (1) | PH12019502201A1 (en) |
| SG (1) | SG11201908786VA (en) |
| SI (1) | SI3601266T1 (en) |
| TW (1) | TWI795393B (en) |
| UA (1) | UA126288C2 (en) |
| UY (1) | UY37645A (en) |
| WO (1) | WO2018178240A1 (en) |
| ZA (1) | ZA201906395B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| JOP20160086B1 (en) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
| JO3633B1 (en) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
| JOP20160198B1 (en) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
| WO2017167950A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indole derivatives as dengue viral replication inhibitors |
| WO2017167953A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| JOP20170069B1 (en) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | Substituted indoline derivatives as dengue viral replication inhibitors |
| EA201892200A1 (en) | 2016-04-01 | 2019-03-29 | Янссен Фармасьютикалз, Инк. | SUBSTITUTED DERIVATIVE COMPOUNDS OF INDOL AS AN INGIBITORS FOR DENG VIRUS REPLICATION INHIBITORS |
| JOP20180026A1 (en) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | Substituted indoline derivatives as dengue viral replication inhibitors |
| JOP20180025B1 (en) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | Substituted indoline derivatives as dengue viral replication inhibitors |
| PE20200604A1 (en) | 2017-05-22 | 2020-03-10 | Janssen Pharmaceuticals Inc | INDOLINE DERIVATIVES SUBSTITUTED AS INHIBITORS OF DENGUE VIRAL REPLICATION |
| BR112019024311A2 (en) | 2017-05-22 | 2020-07-28 | Janssen Pharmaceuticals, Inc. | substituted indoline derivatives as dengue viral replication inhibitors |
| CN109485596A (en) * | 2018-12-19 | 2019-03-19 | 山东理工职业学院 | A kind of preparation method of the dengue virus inhibitor containing indoline |
| CN112159325B (en) * | 2020-10-10 | 2022-11-25 | 浙江工业大学 | Method for synthesizing 2-amino-3-nitrotoluene |
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| EP1039911B1 (en) | 1997-10-27 | 2005-05-25 | Eli Lilly And Company | MORPHOLINO-N-ETHYL ESTER PRODRUGS OF INDOLE sPLA 2 INHIBITORS |
| GB0110832D0 (en) | 2001-05-03 | 2001-06-27 | Virogen Ltd | Antiviral compounds |
| JP2005520795A (en) | 2001-12-12 | 2005-07-14 | コンフォーマ・セラピューティクス・コーポレイション | Purine analogs having HSP90 inhibitory activity |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| WO2005113516A1 (en) * | 2004-05-14 | 2005-12-01 | Neurocrine Biosciences, Inc. | Uracil-type gonadotropin-releasing hormone receptor antagonists and methods related thereto |
| US20060211698A1 (en) | 2005-01-14 | 2006-09-21 | Genelabs, Inc. | Bicyclic heteroaryl derivatives for treating viruses |
| US20060194835A1 (en) | 2005-02-09 | 2006-08-31 | Migenix Inc. | Compositions and methods for treating or preventing flaviviridae infections |
| MX338530B (en) | 2008-06-03 | 2016-04-21 | Siga Technologies Inc | Small molecule inhibitors for the treatment or prevention of dengue virus infection. |
| WO2010021878A1 (en) | 2008-08-19 | 2010-02-25 | Janssen Pharmaceutica Nv | Cold menthol receptor antagonists |
| TWI453207B (en) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | Aminotriazolopyridines, compositions thereof, and methods of treatment therewith |
| EP2393359A4 (en) | 2009-02-09 | 2012-10-03 | Enanta Pharm Inc | Linked dibenzimidazole derivatives |
| GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
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| RS58394B1 (en) | 2014-10-01 | 2019-04-30 | Janssen Pharmaceuticals Inc | Mono- or di-substituted indoles as dengue viral replication inhibitors |
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| JOP20150335B1 (en) | 2015-01-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | indole derivatives as dengue viral replication inhibitors |
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| JOP20160086B1 (en) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
| JO3633B1 (en) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
| JOP20160198B1 (en) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
| JP6864001B2 (en) | 2015-11-03 | 2021-04-21 | ゾエティス・サービシーズ・エルエルシー | Sol-gel polymer compositions and their use |
| WO2017167953A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| DK3436444T3 (en) | 2016-03-31 | 2020-07-27 | Takeda Pharmaceuticals Co | HETEROCYCLIC COMPOUND |
| WO2017167950A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indole derivatives as dengue viral replication inhibitors |
| WO2017173206A1 (en) | 2016-04-01 | 2017-10-05 | Signal Pharmaceuticals, Llc | Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith |
| PL3436457T3 (en) | 2016-04-01 | 2022-11-28 | Basf Se | Bicyclic compounds |
| IL296966A (en) | 2016-04-01 | 2022-12-01 | Amgen Inc | Chimeric receptors to flt3 and methods of use thereof |
| ES2930058T3 (en) | 2016-04-01 | 2022-12-05 | Kite Pharma Inc | Chimeric receptors and methods of using the same |
| EA201892200A1 (en) | 2016-04-01 | 2019-03-29 | Янссен Фармасьютикалз, Инк. | SUBSTITUTED DERIVATIVE COMPOUNDS OF INDOL AS AN INGIBITORS FOR DENG VIRUS REPLICATION INHIBITORS |
| JOP20170069B1 (en) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | Substituted indoline derivatives as dengue viral replication inhibitors |
| PT3436079T (en) | 2016-04-01 | 2021-10-06 | Kite Pharma Inc | Chimeric antigen and t cell receptors and methods of use |
| JOP20180025B1 (en) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | Substituted indoline derivatives as dengue viral replication inhibitors |
| JOP20180026A1 (en) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | Substituted indoline derivatives as dengue viral replication inhibitors |
| BR112019024311A2 (en) | 2017-05-22 | 2020-07-28 | Janssen Pharmaceuticals, Inc. | substituted indoline derivatives as dengue viral replication inhibitors |
| PE20200604A1 (en) | 2017-05-22 | 2020-03-10 | Janssen Pharmaceuticals Inc | INDOLINE DERIVATIVES SUBSTITUTED AS INHIBITORS OF DENGUE VIRAL REPLICATION |
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2018
- 2018-03-26 JO JOP/2018/0025A patent/JOP20180025B1/en active
- 2018-03-28 AR ARP180100776A patent/AR111314A1/en unknown
- 2018-03-29 CN CN201880022017.3A patent/CN110461831B/en active Active
- 2018-03-29 UA UAA201910701A patent/UA126288C2/en unknown
- 2018-03-29 US US16/493,768 patent/US11083707B2/en active Active
- 2018-03-29 MX MX2019011606A patent/MX2019011606A/en unknown
- 2018-03-29 CA CA3055867A patent/CA3055867C/en active Active
- 2018-03-29 EP EP18715612.0A patent/EP3601266B1/en active Active
- 2018-03-29 EA EA201992329A patent/EA039784B1/en unknown
- 2018-03-29 DK DK18715612.0T patent/DK3601266T3/en active
- 2018-03-29 AU AU2018246301A patent/AU2018246301B2/en active Active
- 2018-03-29 HU HUE18715612A patent/HUE054678T2/en unknown
- 2018-03-29 WO PCT/EP2018/058079 patent/WO2018178240A1/en active Application Filing
- 2018-03-29 SI SI201830307T patent/SI3601266T1/en unknown
- 2018-03-29 JP JP2019553169A patent/JP7203752B2/en active Active
- 2018-03-29 SG SG11201908786V patent/SG11201908786VA/en unknown
- 2018-03-29 BR BR112019020175-0A patent/BR112019020175A2/en unknown
- 2018-03-29 PE PE2019001933A patent/PE20191650A1/en unknown
- 2018-03-29 KR KR1020197031207A patent/KR102530832B1/en active IP Right Grant
- 2018-03-29 LT LTEP18715612.0T patent/LT3601266T/en unknown
- 2018-03-29 ES ES18715612T patent/ES2884151T3/en active Active
- 2018-03-29 TW TW107110872A patent/TWI795393B/en active
- 2018-03-29 CR CR20190446A patent/CR20190446A/en unknown
- 2018-04-02 UY UY0001037645A patent/UY37645A/en not_active Application Discontinuation
-
2019
- 2019-09-24 PH PH12019502201A patent/PH12019502201A1/en unknown
- 2019-09-24 CO CONC2019/0010295A patent/CO2019010295A2/en unknown
- 2019-09-25 IL IL269658A patent/IL269658B/en unknown
- 2019-09-26 CL CL2019002745A patent/CL2019002745A1/en unknown
- 2019-09-27 EC ECSENADI201970369A patent/ECSP19070369A/en unknown
- 2019-09-27 NI NI201900099A patent/NI201900099A/en unknown
- 2019-09-27 ZA ZA2019/06395A patent/ZA201906395B/en unknown
-
2021
- 2021-06-11 HR HRP20210942TT patent/HRP20210942T1/en unknown
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