SG11201808138YA - Substituted indole derivatives as dengue viral replication inhibitors - Google Patents
Substituted indole derivatives as dengue viral replication inhibitorsInfo
- Publication number
- SG11201808138YA SG11201808138YA SG11201808138YA SG11201808138YA SG11201808138YA SG 11201808138Y A SG11201808138Y A SG 11201808138YA SG 11201808138Y A SG11201808138Y A SG 11201808138YA SG 11201808138Y A SG11201808138Y A SG 11201808138YA SG 11201808138Y A SG11201808138Y A SG 11201808138YA
- Authority
- SG
- Singapore
- Prior art keywords
- leuven
- international
- dengue viral
- compounds
- janssen
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 1111111011110110101011111010111110110111100111111110011111111111111011111 International Bureau .. .... ..Yejd (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/167950 Al 5 October 2017 (05.10.2017) IN I PO I P CT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every CO7D 209/14 (2006.01) A61P 31/14 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 31/4045 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/EP2017/057660 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (22) International Filing Date: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, 31 March 2017 (31.03.2017) MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (25) Filing Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (26) Publication Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 16163312.8 31 March 2016 (31.03.2016) EP (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicants: JANSSEN PHARMACEUTICALS, INC. GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, [US/US]; 1125 Trenton-Harbourton Road, Titusville, NJ TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, New Jersey 08560 (US). KATHOLIEKE UNI- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, VERSITEIT LEUVEN [BE/BE]; Waaistraat 6, bus 5105, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, 3000 Leuven (BE). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (72) Inventors: BARDIOT, Dorothee Alice Marie-Eve; c/o SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, — Cistim Leuven vzw Gaston Geenslaan 2, 3001 Leuven GW, KM, ML, MR, NE, SN, TD, TG). — (Heverlee) (BE). BONFANTI, Jean-Francois; c/o Declarations under Rule 4.17: _ Janssen-Cilag 1 rue Camille Desmoulins, TSA 91003, — as to applicant's entitlement to apply for and be granted a 92787 Issy-les-Moulineaux Cedex 9 (FR). KESTELEYN, 4.1700) = Bart Rudolf Romanie; Pharmaceutica NV patent (Rule c/o Janssen Turnhoutseweg 30, 2340 Beerse MARCHAND, Published: (BE). = Arnaud Didier M; c/o Cistim Leuven vzw Gaston Geens- = - with international search report (Art. 21(3)) = laan 2, 3001 Leuven (Heverlee) (BE). RABOISSON, Pierre Jean-Marie Bernard; c/o Janssen Pharmaceutica — with sequence listing part of description (Rule 5.2(a)) NV Turnhoutseweg 30, 2340 Beerse (BE). (74) Agent: VERBERCKMOES, Filip; J&J Patent Law De- = partment Turnhoutseweg 30, 2340 Beerse (BE). = = = = = = = = 1-1 © kr) 0\ IN 1-1 (54) Title: SUBSTITUTED INDOLE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS 1-1 C (57) : The present invention concerns substituted indole derivatives, methods to prevent or treat dengue viral infections by N using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or 0 prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination prepara- tions of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16163312 | 2016-03-31 | ||
PCT/EP2017/057660 WO2017167950A1 (en) | 2016-03-31 | 2017-03-31 | Substituted indole derivatives as dengue viral replication inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201808138YA true SG11201808138YA (en) | 2018-10-30 |
Family
ID=55650292
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201808138YA SG11201808138YA (en) | 2016-03-31 | 2017-03-31 | Substituted indole derivatives as dengue viral replication inhibitors |
Country Status (26)
Country | Link |
---|---|
US (1) | US10646469B2 (en) |
EP (1) | EP3436435B1 (en) |
JP (1) | JP6888021B2 (en) |
KR (1) | KR102359743B1 (en) |
CN (1) | CN108884033B (en) |
AU (1) | AU2017242893A1 (en) |
BR (1) | BR112018068676A2 (en) |
CA (1) | CA3013405A1 (en) |
CL (1) | CL2018002729A1 (en) |
CO (1) | CO2018009559A2 (en) |
CR (1) | CR20180495A (en) |
DK (1) | DK3436435T3 (en) |
EA (1) | EA201892214A1 (en) |
EC (1) | ECSP18073245A (en) |
ES (1) | ES2882488T3 (en) |
HK (1) | HK1258142A1 (en) |
HR (1) | HRP20210847T1 (en) |
HU (1) | HUE054936T2 (en) |
IL (1) | IL261944A (en) |
LT (1) | LT3436435T (en) |
MX (1) | MX2018011784A (en) |
PH (1) | PH12018502015A1 (en) |
SG (1) | SG11201808138YA (en) |
SI (1) | SI3436435T1 (en) |
WO (1) | WO2017167950A1 (en) |
ZA (1) | ZA201806473B (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
JOP20160086B1 (en) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
JOP20160198B1 (en) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
JO3633B1 (en) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
CA3013407A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
WO2017167950A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indole derivatives as dengue viral replication inhibitors |
CR20180494A (en) | 2016-04-01 | 2019-01-29 | Janssen Pharmaceuticals Inc | DERIVATIVES OF INDOL SUBSTITUTES SUBSTITUTED AS INHIBITORS OF THE VIRIC REPLICATION OF DENGUE |
JOP20170069B1 (en) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | Substituted indoline derivatives as dengue viral replication inhibitors |
JOP20180026A1 (en) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | Substituted indoline derivatives as dengue viral replication inhibitors |
JOP20180025B1 (en) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | Substituted indoline derivatives as dengue viral replication inhibitors |
PE20200604A1 (en) | 2017-05-22 | 2020-03-10 | Janssen Pharmaceuticals Inc | INDOLINE DERIVATIVES SUBSTITUTED AS INHIBITORS OF DENGUE VIRAL REPLICATION |
EA039702B1 (en) | 2017-05-22 | 2022-03-01 | Янссен Фармасьютикалз, Инк. | Substituted indoline derivatives as dengue viral replication inhibitors |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0110832D0 (en) | 2001-05-03 | 2001-06-27 | Virogen Ltd | Antiviral compounds |
JP2005520795A (en) | 2001-12-12 | 2005-07-14 | コンフォーマ・セラピューティクス・コーポレイション | Purine analogs having HSP90 inhibitory activity |
GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
MX2007008587A (en) | 2005-01-14 | 2007-09-07 | Genelabs Tech Inc | Indole derivatives for treating viral infections. |
JP2008530124A (en) | 2005-02-09 | 2008-08-07 | ミジェニックス インコーポレイテッド | Compositions and methods for treating or preventing flavivirus infections |
BRPI0909985A2 (en) | 2008-06-03 | 2015-08-25 | Siga Technologies Inc | Pharmaceutical composition and method for the treatment or prophylaxis of a viral infection or associated disease |
WO2010021878A1 (en) * | 2008-08-19 | 2010-02-25 | Janssen Pharmaceutica Nv | Cold menthol receptor antagonists |
WO2010091413A1 (en) * | 2009-02-09 | 2010-08-12 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
KR20120123678A (en) | 2010-01-15 | 2012-11-09 | 길리애드 사이언시즈, 인코포레이티드 | Inhibitors of flaviviridae viruses |
GB201116559D0 (en) * | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
ES2655518T3 (en) | 2013-10-23 | 2018-02-20 | Janssen Sciences Ireland Uc | Carboxamide derivatives and their use as medicines for the treatment of hepatitis B |
US9777001B2 (en) | 2014-01-31 | 2017-10-03 | Bristol-Myers Squibb Company | Macrocycles with aromatic P2′ groups as factor xia inhibitors |
NO2721243T3 (en) | 2014-10-01 | 2018-10-20 | ||
PT3201177T (en) | 2014-10-01 | 2019-02-12 | Univ Leuven Kath | Mono- or di-substituted indoles as dengue viral replication inhibitors |
ES2714074T3 (en) | 2014-10-01 | 2019-05-27 | Janssen Pharmaceuticals Inc | Mono- or disubstituted indole derivatives as inhibitors of dengue virus replication |
JOP20150335B1 (en) | 2015-01-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | indole derivatives as dengue viral replication inhibitors |
AR103680A1 (en) | 2015-02-23 | 2017-05-24 | Lilly Co Eli | BACE1 SELECTIVE INHIBITORS |
JOP20160086B1 (en) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
JO3633B1 (en) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
JOP20160198B1 (en) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
CA3002214C (en) | 2015-11-03 | 2022-01-04 | Zoetis Services Llc | Sol-gel polymer composites and uses thereof |
UY37174A (en) | 2016-03-31 | 2017-10-31 | Takeda Pharmaceuticals Co | A HETEROCYCLIC COMPOUND THAT HAS AN INHIBITING ACTION OF MONOACILGLICEROL LIPASA |
CA3013407A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
WO2017167950A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indole derivatives as dengue viral replication inhibitors |
CR20180518A (en) | 2016-04-01 | 2019-04-25 | Kite Pharma Inc | FLT3 CHEMICAL RECEPTORS AND SAME USE METHODS |
JOP20170069B1 (en) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | Substituted indoline derivatives as dengue viral replication inhibitors |
EP3436018A4 (en) | 2016-04-01 | 2019-11-13 | Signal Pharmaceuticals, LLC | Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith |
CR20180494A (en) | 2016-04-01 | 2019-01-29 | Janssen Pharmaceuticals Inc | DERIVATIVES OF INDOL SUBSTITUTES SUBSTITUTED AS INHIBITORS OF THE VIRIC REPLICATION OF DENGUE |
CN109641008B (en) | 2016-04-01 | 2021-03-23 | 凯德药业股份有限公司 | Chimeric receptors and methods and uses thereof |
IL261941B2 (en) | 2016-04-01 | 2023-11-01 | Kite Pharma Inc | Chimeric antigen and t cell receptors and methods of use |
BR112018068851B1 (en) | 2016-04-01 | 2022-11-22 | Basf Se | COMPOUND OF FORMULA I, COMPOSITION, METHODS FOR COMBAT OR CONTROL OF INVERTEBRATE PEST AND FOR PLANT PROTECTION, COATED SEED AND USE OF AT LEAST ONE COMPOUND |
JOP20180025B1 (en) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | Substituted indoline derivatives as dengue viral replication inhibitors |
JOP20180026A1 (en) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | Substituted indoline derivatives as dengue viral replication inhibitors |
EA039702B1 (en) | 2017-05-22 | 2022-03-01 | Янссен Фармасьютикалз, Инк. | Substituted indoline derivatives as dengue viral replication inhibitors |
PE20200604A1 (en) | 2017-05-22 | 2020-03-10 | Janssen Pharmaceuticals Inc | INDOLINE DERIVATIVES SUBSTITUTED AS INHIBITORS OF DENGUE VIRAL REPLICATION |
-
2017
- 2017-03-31 WO PCT/EP2017/057660 patent/WO2017167950A1/en active Application Filing
- 2017-03-31 US US16/087,800 patent/US10646469B2/en active Active
- 2017-03-31 CO CONC2018/0009559A patent/CO2018009559A2/en unknown
- 2017-03-31 KR KR1020187027072A patent/KR102359743B1/en active IP Right Grant
- 2017-03-31 DK DK17714750.1T patent/DK3436435T3/en active
- 2017-03-31 MX MX2018011784A patent/MX2018011784A/en unknown
- 2017-03-31 HU HUE17714750A patent/HUE054936T2/en unknown
- 2017-03-31 SG SG11201808138YA patent/SG11201808138YA/en unknown
- 2017-03-31 CN CN201780021395.5A patent/CN108884033B/en active Active
- 2017-03-31 SI SI201730800T patent/SI3436435T1/en unknown
- 2017-03-31 AU AU2017242893A patent/AU2017242893A1/en not_active Abandoned
- 2017-03-31 LT LTEP17714750.1T patent/LT3436435T/en unknown
- 2017-03-31 EA EA201892214A patent/EA201892214A1/en unknown
- 2017-03-31 JP JP2018549441A patent/JP6888021B2/en active Active
- 2017-03-31 BR BR112018068676A patent/BR112018068676A2/en not_active Application Discontinuation
- 2017-03-31 ES ES17714750T patent/ES2882488T3/en active Active
- 2017-03-31 CA CA3013405A patent/CA3013405A1/en not_active Abandoned
- 2017-03-31 CR CR20180495A patent/CR20180495A/en unknown
- 2017-03-31 EP EP17714750.1A patent/EP3436435B1/en active Active
-
2018
- 2018-09-20 PH PH12018502015A patent/PH12018502015A1/en unknown
- 2018-09-26 CL CL2018002729A patent/CL2018002729A1/en unknown
- 2018-09-26 IL IL261944A patent/IL261944A/en unknown
- 2018-09-28 ZA ZA2018/06473A patent/ZA201806473B/en unknown
- 2018-09-28 EC ECSENADI201873245A patent/ECSP18073245A/en unknown
-
2019
- 2019-01-14 HK HK19100496.8A patent/HK1258142A1/en unknown
-
2021
- 2021-05-27 HR HRP20210847TT patent/HRP20210847T1/en unknown
Also Published As
Publication number | Publication date |
---|---|
EA201892214A1 (en) | 2019-03-29 |
CR20180495A (en) | 2018-12-06 |
IL261944A (en) | 2018-10-31 |
EP3436435B1 (en) | 2021-05-12 |
HRP20210847T1 (en) | 2021-07-23 |
EP3436435A1 (en) | 2019-02-06 |
BR112018068676A2 (en) | 2019-01-15 |
US10646469B2 (en) | 2020-05-12 |
CO2018009559A2 (en) | 2018-09-20 |
JP6888021B2 (en) | 2021-06-16 |
KR20180130498A (en) | 2018-12-07 |
ZA201806473B (en) | 2020-05-27 |
ECSP18073245A (en) | 2018-10-31 |
CL2018002729A1 (en) | 2018-11-23 |
SI3436435T1 (en) | 2021-08-31 |
PH12018502015A1 (en) | 2019-07-15 |
US20190274999A1 (en) | 2019-09-12 |
KR102359743B1 (en) | 2022-02-07 |
MX2018011784A (en) | 2019-02-13 |
HK1258142A1 (en) | 2019-11-08 |
JP2019510024A (en) | 2019-04-11 |
CN108884033B (en) | 2021-03-09 |
CA3013405A1 (en) | 2017-10-05 |
HUE054936T2 (en) | 2021-10-28 |
ES2882488T3 (en) | 2021-12-02 |
DK3436435T3 (en) | 2021-08-09 |
LT3436435T (en) | 2021-08-25 |
WO2017167950A1 (en) | 2017-10-05 |
AU2017242893A1 (en) | 2018-08-09 |
CN108884033A (en) | 2018-11-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG11201808270PA (en) | Substituted indoline derivatives as dengue viral replication inhibitors | |
SG11201808138YA (en) | Substituted indole derivatives as dengue viral replication inhibitors | |
SG11201808237UA (en) | Substituted indole compound derivatives as dengue viral replication inhibitors | |
SG11201908786VA (en) | Substituted indoline derivatives as dengue viral replication inhibitors | |
SG11201908465QA (en) | Substituted indoline derivatives as dengue viral replication inhibitors | |
SG11201900163PA (en) | Macrocycle kinase inhibitors | |
SG11201909955XA (en) | Formulations of anti-lag3 antibodies and co-formulations of anti-lag3 antibodies and anti-pd-1 antibodies | |
SG11201811564QA (en) | Methods of treating ovarian cancer | |
SG11201810280YA (en) | Spiro-lactam nmda receptor modulators and uses thereof | |
SG11201810628XA (en) | Nasal pharmaceutical compositions with a porous excipient | |
SG11201900546UA (en) | Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof | |
SG11201811442UA (en) | Formulation of a peptide vaccine | |
SG11201900551WA (en) | Spiro-lactam nmda receptor modulators and uses thereof | |
SG11201900443VA (en) | Spiro-lactam nmda receptor modulators and uses thereof | |
SG11201807784SA (en) | 3-desoxy derivative and pharmaceutical compositions thereof | |
SG11201900554YA (en) | Spiro-lactam nmda modulators and methods of using same | |
SG11201900558RA (en) | Spiro-lactam nmda receptor modulators and uses thereof | |
SG11201900349VA (en) | Somatostatin modulators and uses thereof | |
SG11201408318RA (en) | Compositions and methods for transmucosal absorption | |
SG11201908517XA (en) | Pyrimidinyl-pyridyloxy-naphthyl compounds and methods of treating ire1-related diseases and disorders | |
SG11201907804QA (en) | Pharmaceutical composition comprising selexipag | |
SG11201901534VA (en) | Combination therapy with controlled-release cnp agonists | |
SG11202000333UA (en) | Bicyclic ketone compounds and methods of use thereof | |
SG11201900238UA (en) | Compounds and methods for modulation of smn2 | |
SG11201906436VA (en) | Novel heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same |