SG11201903059SA - New anthelmintic quinoline-3-carboxamide derivatives - Google Patents
New anthelmintic quinoline-3-carboxamide derivativesInfo
- Publication number
- SG11201903059SA SG11201903059SA SG11201903059SA SG11201903059SA SG11201903059SA SG 11201903059S A SG11201903059S A SG 11201903059SA SG 11201903059S A SG11201903059S A SG 11201903059SA SG 11201903059S A SG11201903059S A SG 11201903059SA SG 11201903059S A SG11201903059S A SG 11201903059SA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- quinoline
- monheim
- str
- pounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 1111111111101110101011111 01111101 0 0111111011110 11111 001 101111110 1111 0111111 International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2018/087036 Al 17 May 2018 (17.05.2018) WIPO I PCT (51) International Patent Classification: C07D 215/54 (2006.01) C07D 405/14 (2006.01) CO7D 215/56 (2006.01) A61K 31/47 (2006.01) CO7D 405/12 (2006.01) A61P 33/10 (2006.01) KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (21) International Application Number: TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. PCT/EP2017/078319 (84) Designated States (unless otherwise indicated, for every (22) International Filing Date: 06 November 2017 (06.11.2017) kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (25) Filing Language: English TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (26) Publication Language: English EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (30) Priority Data: 16198550.2 11 November 2016 (11.11.2016) EP TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (71) Applicant: BAYER ANIMAL HEALTH GMBH Declarations under Rule 4.17: [DE/DE]; Kaiser-Wilhelm-Allee 10, 51373 Leverkusen — as to applicant's entitlement to apply for and be granted a (DE). patent (Rule 4.17(ii)) (72) Inventors: HUBSCH, Walter; Wildsteig 22, 42113 Wup- pertal (DE). KOBBERLING, Johannes; Azalienstr. 30, 41466 Neuss (DE). KOHLER, Adeline; Heimchenweg 9, 40764 Langenfeld (DE). SCHWARZ, Hans-Georg; Published: — with international search report (Art. 21(3)) Auf dem Beerenkamp 82b, 46282 Dorsten (DE). KULKE, Daniel; Dillinger Str. 13, 51375 Leverkusen (DE). WELZ, Claudia; An der Ziegelei 14, 40593 Diisseldor (DE). ILG, Thomas; Plotzenseer Strasse 16, 40789 Monheim (DE). BORNGEN, Kirsten; Feldhasenweg 23, 50859 Köln (DE). ZHUANG, Wei; StauffenbergstraBe 13, 40789 Monheim (DE). GRIEBENOW, Nils; Kurfiirstenstr. 39, 41541 Dor- magen (DE). BOHM, Claudia; Im Seefelde 4a, 30457 Hannover (DE). LINDNER, Niels; Bodelschwinghweg 4, 42115 Wuppertal (DE). HINK, Maike; Eugen-Eisele-Weg 6, 71665 Vaihingen/Enz (DE). GORGENS, Ulrich; Fester Str.37, 40882 Ratingen (DE). (74) Agent: BIP PATENTS; Alfred-Nobel-Str. 10, NRW, 40789 Monheim am Rhein (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, ,_ 1 (54) Title: NEW ANTHELMINTIC QUINOLINE-3-CARBOXAMIDE DERIVATIVES tD R 6 R 2 (57) : The present invention covers new quinoline com- pounds of general formula (I) in which A, R 1 , R, R 2 3 , R 4 , R 5 , M A © N' (I) R 6 , and Q are as defined herein, methods of preparing said com- IN 1 1 00 GC 0 ,„ 0 ei ... rl 4 R R pounds, intermediate compounds useful for preparing said cam- pounds, pharmaceutical compositions and combinations compris- ing said compounds and the use of said compounds for manufac- pharmaceutical compositions for the treatment, control and/ or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16198550 | 2016-11-11 | ||
| PCT/EP2017/078319 WO2018087036A1 (en) | 2016-11-11 | 2017-11-06 | New anthelmintic quinoline-3-carboxamide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201903059SA true SG11201903059SA (en) | 2019-05-30 |
Family
ID=57321155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201903059SA SG11201903059SA (en) | 2016-11-11 | 2017-11-06 | New anthelmintic quinoline-3-carboxamide derivatives |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US10889573B2 (en) |
| EP (1) | EP3538512B1 (en) |
| JP (1) | JP7165129B2 (en) |
| KR (1) | KR102595730B1 (en) |
| CN (1) | CN109890793B (en) |
| AU (1) | AU2017357503B2 (en) |
| BR (1) | BR112019009529A2 (en) |
| CA (1) | CA3043298A1 (en) |
| CL (1) | CL2019001292A1 (en) |
| CO (1) | CO2019004776A2 (en) |
| DK (1) | DK3538512T3 (en) |
| DO (1) | DOP2019000117A (en) |
| ES (1) | ES2884073T3 (en) |
| IL (1) | IL266407B (en) |
| MX (1) | MX2019005569A (en) |
| MY (1) | MY196327A (en) |
| NZ (1) | NZ752550A (en) |
| PH (1) | PH12019501034A1 (en) |
| PL (1) | PL3538512T3 (en) |
| PT (1) | PT3538512T (en) |
| SG (1) | SG11201903059SA (en) |
| SI (1) | SI3538512T1 (en) |
| TW (1) | TWI821165B (en) |
| UA (1) | UA126119C2 (en) |
| UY (1) | UY37480A (en) |
| WO (1) | WO2018087036A1 (en) |
| ZA (1) | ZA201903708B (en) |
Families Citing this family (19)
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| MX2019015895A (en) | 2017-06-30 | 2020-02-07 | Bayer Animal Health Gmbh | New azaquinoline derivatives. |
| US11254661B2 (en) * | 2017-08-04 | 2022-02-22 | Bayer Animal Health Gmbh | Quinoline derivatives for treating infections with helminths |
| CA3085675A1 (en) | 2017-12-15 | 2019-06-20 | Bayer Animal Health Gmbh | Process for preparing antihelmintic 4-amino-quinoline-3-carboxamide derivatives |
| BR112020022619A2 (en) * | 2018-05-09 | 2021-02-02 | Bayer Animal Health Gmbh | new quinoline derivatives |
| EP3643711A1 (en) * | 2018-10-24 | 2020-04-29 | Bayer Animal Health GmbH | New anthelmintic compounds |
| US20220064159A1 (en) * | 2018-12-18 | 2022-03-03 | Elanco Tiergesundheit Ag | Bicyclic derivatives |
| US20220064160A1 (en) * | 2018-12-18 | 2022-03-03 | Elanco Tiergesundheit Ag | Bicyclic derivatives |
| CN113825543A (en) | 2019-03-19 | 2021-12-21 | 勃林格殷格翰动物保健美国公司 | Anthelmintic aza-benzothiophene and aza-benzofuran compounds |
| US20220242857A1 (en) * | 2019-06-07 | 2022-08-04 | Elanco Tiergesundheit Ag | Bicyclic derivatives for treating endoparasites |
| TW202120490A (en) * | 2019-07-30 | 2021-06-01 | 德商拜耳動物保健有限公司 | New isoquinoline derivatives |
| BR112022012126A2 (en) | 2019-12-18 | 2022-08-30 | Intervet Int Bv | ANTELMINTHIC COMPOUNDS COMPRISING A QUINOLINE STRUCTURE |
| BR112022020315A2 (en) | 2020-04-09 | 2022-12-13 | Bayer Animal Health Gmbh | NEW ANTIHELMINTIC COMPOUNDS |
| MX2022015038A (en) | 2020-05-29 | 2023-01-04 | Boehringer Ingelheim Animal Health Usa Inc | Anthelmintic heterocyclic compounds. |
| US20240059680A1 (en) | 2020-11-18 | 2024-02-22 | Elanco Tiergesundheit Ag | N-(2,3-dihydro-1,4-benzoxazin-4-yl)-3-isopropyl-7-(2,3,5-trifluorophenyl)benzo-thiophene-2-carboxamide derivatives and similar compounds for the treatment of heartworm infections |
| TW202237600A (en) | 2020-12-04 | 2022-10-01 | 瑞士商禮藍動物保健股份有限公司 | Bicyclic derivatives |
| EP4259606A1 (en) | 2020-12-11 | 2023-10-18 | Intervet International B.V. | Anthelmintic compounds comprising a pyridine structure |
| AU2021395477A1 (en) | 2020-12-11 | 2023-06-22 | Intervet International B.V. | Anthelmintic compounds comprising a thienopyridine structure |
| EP4148052A1 (en) | 2021-09-09 | 2023-03-15 | Bayer Animal Health GmbH | New quinoline derivatives |
| AR127495A1 (en) | 2021-11-01 | 2024-01-31 | Boehringer Ingelheim Vetmedica Gmbh | PYRROLOPYRIDAZINE COMPOUNDS AS ANTIHELMINTICS |
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2017
- 2017-11-06 BR BR112019009529A patent/BR112019009529A2/en active Search and Examination
- 2017-11-06 PT PT177914389T patent/PT3538512T/en unknown
- 2017-11-06 MX MX2019005569A patent/MX2019005569A/en unknown
- 2017-11-06 DK DK17791438.9T patent/DK3538512T3/en active
- 2017-11-06 PL PL17791438T patent/PL3538512T3/en unknown
- 2017-11-06 SI SI201730854T patent/SI3538512T1/en unknown
- 2017-11-06 EP EP17791438.9A patent/EP3538512B1/en active Active
- 2017-11-06 KR KR1020197013186A patent/KR102595730B1/en active IP Right Grant
- 2017-11-06 MY MYPI2019002590A patent/MY196327A/en unknown
- 2017-11-06 NZ NZ752550A patent/NZ752550A/en unknown
- 2017-11-06 ES ES17791438T patent/ES2884073T3/en active Active
- 2017-11-06 US US16/348,797 patent/US10889573B2/en active Active
- 2017-11-06 JP JP2019524276A patent/JP7165129B2/en active Active
- 2017-11-06 WO PCT/EP2017/078319 patent/WO2018087036A1/en unknown
- 2017-11-06 AU AU2017357503A patent/AU2017357503B2/en active Active
- 2017-11-06 CA CA3043298A patent/CA3043298A1/en active Pending
- 2017-11-06 UA UAA201906455A patent/UA126119C2/en unknown
- 2017-11-06 SG SG11201903059SA patent/SG11201903059SA/en unknown
- 2017-11-06 CN CN201780069050.7A patent/CN109890793B/en active Active
- 2017-11-10 UY UY0001037480A patent/UY37480A/en not_active Application Discontinuation
- 2017-11-10 TW TW106138957A patent/TWI821165B/en active
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2019
- 2019-05-02 IL IL266407A patent/IL266407B/en unknown
- 2019-05-09 PH PH12019501034A patent/PH12019501034A1/en unknown
- 2019-05-10 CL CL2019001292A patent/CL2019001292A1/en unknown
- 2019-05-10 DO DO2019000117A patent/DOP2019000117A/en unknown
- 2019-05-10 CO CONC2019/0004776A patent/CO2019004776A2/en unknown
- 2019-06-10 ZA ZA2019/03708A patent/ZA201903708B/en unknown
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2020
- 2020-10-30 US US17/085,880 patent/US11505545B2/en active Active
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