SG11201809537VA - Urea motif containing compounds and derivatives thereof as antibacterial drugs - Google Patents
Urea motif containing compounds and derivatives thereof as antibacterial drugsInfo
- Publication number
- SG11201809537VA SG11201809537VA SG11201809537VA SG11201809537VA SG11201809537VA SG 11201809537V A SG11201809537V A SG 11201809537VA SG 11201809537V A SG11201809537V A SG 11201809537VA SG 11201809537V A SG11201809537V A SG 11201809537VA SG 11201809537V A SG11201809537V A SG 11201809537VA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- compounds
- miinchen
- pct
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/30—Derivatives containing the group >N—CO—N aryl or >N—CS—N—aryl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/38—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101/110 111010101111101011111 0 01010 111H11111111111111111111111111111111111 Organization 0 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/207556 A2 07 December 2017 (07.12.2017) WIP0 I PCT (51) International Patent Classification: CO7D 317/62 (2006.01) A61K 31/17 (2006.01) A01N 47/30 (2006.01) (21) International Application Number: PCT/EP2017/063014 (22) International Filing Date: 30 May 2017 (30.05.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16171906.7 30 May 2016 (30.05.2016) EP (71) Applicant: TECHNISCHE UNIVERSITAT MUNCHEN [DE/DE]; Arcisstr. 21, 80333 Miinchen (DE). (72) Inventors: KLEINER, Philipp; HardenbergstraBe 20, 80992 Miinchen (DE). SIEBER, Stephan; Olgartenweg 2, 86919 Utting am Ammersee (DE). KUNOLD, Elena; SchellingstraBe 106, 80798 Miinchen (DE). Agent: BOEHMERT & BOEHMERT ANWALTS- (74) PARTNERSCHAFT MBB; Markus Engelhard, Pet- tenkoferstraBe 20 - 22, 80336 Miinchen (DE). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (81) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (84) N Published: ..! — without international search report and to be republished V::+ upon receipt of that report (Rule 48.2(g)) in — in with sequence listing part of description (Rule 5.2(a)) IN 0 ei N (54) Title: UREA MOTIF CONTAINING COMPOUNDS AND DERIVATIVES THEREOF AS ANTIBACTERIAL DRUGS 1-1 0 (57) : The invention relates to compounds which are suitable for treating bacterial diseases and to pharmaceutical compositions \" containing such compounds. The invention further relates to a kit of parts comprising such compounds and to the use of such compounds 0 as disinfectants.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16171906 | 2016-05-30 | ||
PCT/EP2017/063014 WO2017207556A2 (en) | 2016-05-30 | 2017-05-30 | Urea motif containing compounds and derivatives thereof as antibacterial drugs |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201809537VA true SG11201809537VA (en) | 2018-12-28 |
Family
ID=56087197
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201809537VA SG11201809537VA (en) | 2016-05-30 | 2017-05-30 | Urea motif containing compounds and derivatives thereof as antibacterial drugs |
Country Status (11)
Country | Link |
---|---|
US (1) | US20210009550A1 (en) |
EP (1) | EP3464260B8 (en) |
JP (1) | JP7129085B2 (en) |
CN (1) | CN109890804A (en) |
CA (1) | CA3023040A1 (en) |
DK (1) | DK3464260T3 (en) |
ES (1) | ES2901164T3 (en) |
HU (1) | HUE057798T2 (en) |
PL (1) | PL3464260T3 (en) |
SG (1) | SG11201809537VA (en) |
WO (1) | WO2017207556A2 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108026027B (en) * | 2015-08-17 | 2020-10-02 | 邱浩杰 | Substituted malonamide compounds and their use as antibacterial agents |
CN108785306B (en) * | 2018-09-09 | 2021-02-19 | 东北农业大学 | Application of sorafenib in preparation of medicines for inhibiting bacteria and intervening pathogenic bacteria biofilm |
CN109456261A (en) * | 2018-12-05 | 2019-03-12 | 西安交通大学 | A kind of light Affinity Probes molecule and preparation method thereof based on VEGFR-2 inhibitor Sorafenib |
CN113061126A (en) * | 2021-03-16 | 2021-07-02 | 无锡海伦生物科技有限公司 | Preparation method and application of sorafenib photoaffinity probe molecule based on halogen intermediate |
US11648248B1 (en) | 2022-01-12 | 2023-05-16 | King Abdulaziz University | Potent antimicrobial compounds with a pyridazine nucleus |
TW202339708A (en) * | 2022-04-13 | 2023-10-16 | 國立臺灣大學 | Antimicrobial compositions, pharmaceutical compositions and use thereof |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
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NL254871A (en) * | 1959-08-14 | |||
US3503886A (en) * | 1967-10-27 | 1970-03-31 | Mary C Noel | Antiseptic compositions |
WO1989000563A1 (en) * | 1987-07-17 | 1989-01-26 | The Nutrasweet Company | High potency sweetening agents |
JPH10109912A (en) * | 1996-10-04 | 1998-04-28 | Akio Suganuma | Antimicrobial composition |
US6207679B1 (en) * | 1997-06-19 | 2001-03-27 | Sepracor, Inc. | Antimicrobial agents uses and compositions related thereto |
US6093742A (en) * | 1997-06-27 | 2000-07-25 | Vertex Pharmaceuticals, Inc. | Inhibitors of p38 |
US7517880B2 (en) | 1997-12-22 | 2009-04-14 | Bayer Pharmaceuticals Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
WO2000032196A2 (en) * | 1998-12-04 | 2000-06-08 | Influx, Inc. | Inhibitors of multidrug transporters |
AU2002243439A1 (en) | 2000-11-17 | 2002-07-24 | Smithkline Beecham Corporation | Fatty acid synthase inhibitors |
KR20030080509A (en) | 2002-04-09 | 2003-10-17 | 주식회사 엘지생명과학 | Antibacterial Compositions Containing Urea, Thiourea and Sulfamide Derivatives |
JP2008518014A (en) * | 2004-10-27 | 2008-05-29 | ニューロゲン コーポレイション | Diarylureas as CB1 antagonists |
EP1991215A1 (en) | 2006-03-09 | 2008-11-19 | Cenix Bioscience GmbH | Use of inhibitors of scavenger receptor class proteins for the treatment of infectious diseases |
GB2449973B8 (en) | 2007-05-31 | 2010-01-06 | Syntopix Group Plc | Antibacterial & anti-acne formulations containing dialkyl sulphosuccinates |
WO2009035951A2 (en) | 2007-09-11 | 2009-03-19 | Arete Therapeutics, Inc. | Soluble epoxide hydrolase inhibitors |
WO2009088549A2 (en) | 2007-10-19 | 2009-07-16 | The Board Of Regents Of The University Of Texas System | Methods of inhibiting bacterial virulence and compounds relating thereto |
EP2385831A4 (en) | 2009-01-09 | 2014-03-26 | Uab Research Foundation | Small molecule inhibitors of nads, namnat, and nmnat |
CN103130686B (en) | 2011-12-02 | 2016-09-14 | 天津市国际生物医药联合研究院 | N, N '-asymmetric diaryl substitute urea compound and its production and use |
WO2013142628A2 (en) | 2012-03-20 | 2013-09-26 | Fred Hutchinson Cancer Research Center | Antibiotic compounds and compositions, and methods for identification thereof |
US9951097B2 (en) * | 2012-12-04 | 2018-04-24 | The Board Of Trustees Of The University Of Illinois | Antibacterial compounds targeting isoprenoid biosynthesis |
WO2015051149A1 (en) | 2013-10-04 | 2015-04-09 | The Trustees Of Columbia University In The City Of New York | Sorafenib analogs and uses thereof |
US9387186B2 (en) | 2014-05-22 | 2016-07-12 | Muhammad Iqbal Choudhary | Thiourea derivatives |
-
2017
- 2017-05-30 PL PL17728481T patent/PL3464260T3/en unknown
- 2017-05-30 CA CA3023040A patent/CA3023040A1/en active Pending
- 2017-05-30 CN CN201780034569.1A patent/CN109890804A/en active Pending
- 2017-05-30 HU HUE17728481A patent/HUE057798T2/en unknown
- 2017-05-30 SG SG11201809537VA patent/SG11201809537VA/en unknown
- 2017-05-30 JP JP2018562297A patent/JP7129085B2/en active Active
- 2017-05-30 ES ES17728481T patent/ES2901164T3/en active Active
- 2017-05-30 EP EP17728481.7A patent/EP3464260B8/en active Active
- 2017-05-30 WO PCT/EP2017/063014 patent/WO2017207556A2/en unknown
- 2017-05-30 DK DK17728481.7T patent/DK3464260T3/en active
- 2017-05-30 US US16/304,521 patent/US20210009550A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20210009550A1 (en) | 2021-01-14 |
HUE057798T2 (en) | 2022-06-28 |
EP3464260B8 (en) | 2022-02-16 |
WO2017207556A2 (en) | 2017-12-07 |
WO2017207556A4 (en) | 2018-03-22 |
ES2901164T3 (en) | 2022-03-21 |
CA3023040A1 (en) | 2017-12-07 |
EP3464260B1 (en) | 2021-10-27 |
WO2017207556A3 (en) | 2018-01-11 |
JP2019524644A (en) | 2019-09-05 |
DK3464260T3 (en) | 2021-12-20 |
CN109890804A (en) | 2019-06-14 |
PL3464260T3 (en) | 2022-01-31 |
JP7129085B2 (en) | 2022-09-01 |
EP3464260A2 (en) | 2019-04-10 |
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