MX2017002013A - Polimorfos de selinexor. - Google Patents

Polimorfos de selinexor.

Info

Publication number
MX2017002013A
MX2017002013A MX2017002013A MX2017002013A MX2017002013A MX 2017002013 A MX2017002013 A MX 2017002013A MX 2017002013 A MX2017002013 A MX 2017002013A MX 2017002013 A MX2017002013 A MX 2017002013A MX 2017002013 A MX2017002013 A MX 2017002013A
Authority
MX
Mexico
Prior art keywords
structural formula
crystalline forms
compound
compositions
selinexor
Prior art date
Application number
MX2017002013A
Other languages
English (en)
Inventor
G Roe David
Clinton Austad Brian
Original Assignee
Karyopharm Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karyopharm Therapeutics Inc filed Critical Karyopharm Therapeutics Inc
Publication of MX2017002013A publication Critical patent/MX2017002013A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invencion se refiere a formas cristalinas del compuesto representado por la Formula estructural I y a composiciones que comprenden formas cristalinas del compuesto representado por la Formula estructural I descrita en la presente. Las formas cristalinas del compuesto de Formula estructural I y las composiciones que comprenden las formas cristalinas del compuesto de Formula estructural I proporcionadas en la presente, en particular, la Forma cristalina unica A, se pueden incorporar en composiciones farmaceuticas, las cuales se pueden utilizar para tratar varios trastornos asociados con la actividad de CRM1, incluido el cancer. En la presente tambien se describen metodos para preparar el compuesto de Formula estructural I y sus formas cristalinas unicas.
MX2017002013A 2014-08-15 2015-08-14 Polimorfos de selinexor. MX2017002013A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462038069P 2014-08-15 2014-08-15
PCT/US2015/045395 WO2016025904A1 (en) 2014-08-15 2015-08-14 Polymorphs of selinexor

Publications (1)

Publication Number Publication Date
MX2017002013A true MX2017002013A (es) 2017-05-12

Family

ID=53969460

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017002013A MX2017002013A (es) 2014-08-15 2015-08-14 Polimorfos de selinexor.
MX2021014128A MX2021014128A (es) 2014-08-15 2017-02-14 Polimorfos de selinexor.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2021014128A MX2021014128A (es) 2014-08-15 2017-02-14 Polimorfos de selinexor.

Country Status (18)

Country Link
US (6) US10519139B2 (es)
EP (2) EP4112615A1 (es)
JP (3) JP6777626B2 (es)
KR (1) KR102608259B1 (es)
CN (3) CN107072992B (es)
AU (4) AU2015301484B2 (es)
CA (1) CA2957266A1 (es)
CO (1) CO2017001884A2 (es)
DK (1) DK3180331T3 (es)
EA (1) EA201790384A1 (es)
ES (1) ES2926377T3 (es)
IL (1) IL250328B (es)
MA (1) MA40254B1 (es)
MX (2) MX2017002013A (es)
SG (2) SG11201700789SA (es)
UA (1) UA123535C2 (es)
WO (1) WO2016025904A1 (es)
ZA (1) ZA201700880B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2736887T3 (pl) 2011-07-29 2018-03-30 Karyopharm Therapeutics, Inc. Modulatory transportu jądrowego zawierające ugrupowanie hydrazydu i ich zastosowania
LT3404027T (lt) 2012-05-09 2020-07-10 Biogen Ma Inc. Branduolių transporto moduliatoriai ir jų panaudojimas
US10202366B2 (en) 2013-03-15 2019-02-12 Karyopharm Therapeutics Inc. Methods of promoting wound healing using CRM1 inhibitors
SG11201510036TA (en) 2013-06-21 2016-01-28 Karyopharm Therapeutics Inc Nuclear transport modulators and uses thereof
WO2016025904A1 (en) 2014-08-15 2016-02-18 Karyopharm Therapeutics Inc. Polymorphs of selinexor
WO2017117529A1 (en) 2015-12-31 2017-07-06 Karyopharm Therapeutics Inc. Nuclear transport modulators and uses thereof
US10709706B2 (en) 2015-12-31 2020-07-14 Karopharm Therapeutics Inc. Nuclear transport modulators and uses thereof
WO2017118940A1 (en) * 2016-01-08 2017-07-13 Dr. Reddy's Laboratories Limited Solid forms of selinexor and process for their preparation
US11602530B2 (en) 2016-11-28 2023-03-14 Biogen Ma Inc. CRM1 inhibitors for treating epilepsy
WO2018129227A1 (en) 2017-01-05 2018-07-12 Watson Laboratories Inc. Novel crystalline forms of selinexor and process for their preparation
CN106831731B (zh) * 2017-01-17 2019-11-08 广州市闻皓生物科技有限公司 一种Selinexor原料药的合成方法
WO2019232724A1 (en) * 2018-06-06 2019-12-12 Xw Laboratories, Inc. Compounds as nuclear transport modulators and uses thereof
WO2020072008A1 (en) * 2018-10-04 2020-04-09 Deva Holding Anonim Sirketi Novel solid dispersions of selinexor
EP3941588A1 (en) 2019-03-20 2022-01-26 Johnson Matthey Public Limited Company Co-crystal forms of selinexor
MA55808A (fr) 2019-05-01 2022-03-09 Karyopharm Therapeutics Inc Procédé de préparation d'inhibiteurs de xpo1 et intermédiaires destinés à être utilisés dans la préparation d'inhibiteurs de xpo1
EP3968987A4 (en) * 2019-05-16 2022-10-26 Mayo Foundation for Medical Education and Research METHODS AND SUBSTANCES FOR THE TREATMENT OF CANCER
EP3808742A1 (en) 2019-10-16 2021-04-21 Sandoz AG Polymorph of selinexor
WO2022087218A1 (en) 2020-10-21 2022-04-28 Karyopharm Therapeutics Inc. Crystalline form of selinexor
CN112679477B (zh) * 2020-12-17 2021-10-26 佛山奕安赛医药科技有限公司 塞利尼索及其中间体的制备方法
US20230192563A1 (en) * 2021-12-20 2023-06-22 Raytheon Technologies Corporation Particle enhancement of ceramic matrix composites, method of manufacture thereof and articles comprising the same
CN116675677B (zh) * 2023-08-02 2023-09-26 中国林业科学研究院林产化学工业研究所 一种c8漆酚衍生物及其制备方法和应用

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1017398A (en) 1911-01-16 1912-02-13 John E Folsom Telegraph-key.
KR840000529A (ko) 1981-07-07 1984-02-25 콘스탄틴 루이스 클레멘트 인돌 유도체의 제조방법
CS229934B2 (en) 1981-07-07 1984-07-16 Pfizer Production method subst.indolylacryte acid derivative
US4778796A (en) 1985-07-19 1988-10-18 Dainippon Pharmaceutical Co., Ltd. ω-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same
JP3111321B2 (ja) 1990-02-23 2000-11-20 武田薬品工業株式会社 縮合チアゾール化合物
IL97249A (en) 1990-02-23 1995-01-24 Takeda Chemical Industries Ltd Compounds of 7,6,5,4-tetrahydrothiazole] B-5,4 [pyridine and compounds of 5,6-dihydro-H4-pyrrolo] D-3,2 [thiazole, their manufacture, and pharmaceutical compositions including or
US5541213A (en) 1993-06-24 1996-07-30 Eisai Co., Ltd. Propenoic acid derivatives diazole propenoic acid compounds which have useful pharmaceutical utility
US5468353A (en) 1994-05-05 1995-11-21 Minnesota Mining And Manufacturing Company Mist suppressant for solvent extraction metal electrowinning
AU4368996A (en) 1994-11-23 1996-06-17 Neurogen Corporation Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligands
US20030018025A1 (en) 1995-06-07 2003-01-23 Neurogen Corporation, Corporation Of The State Of Delaware Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives: new classes of dopamine receptor subtype specific ligands
JPH11513382A (ja) 1995-10-20 1999-11-16 ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング ５員複素環化合物、これらの化合物を含む医薬品、それらの使用及びそれらの調製方法
ATE341554T1 (de) 1996-04-04 2006-10-15 Shionogi & Co Cephemverbindungen und medikamente die diese verbindungen enthalten
JP4054992B2 (ja) 1996-04-25 2008-03-05 日産化学工業株式会社 エチレン誘導体および有害生物防除剤
TW449460B (en) 1996-04-25 2001-08-11 Nissan Chemical Ind Ltd Ethylene derivatives and pest controlling agents
DE19624659A1 (de) 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab Neue Pyridylalken- und Pyridylalkinsäureamide
US5994398A (en) 1996-12-11 1999-11-30 Elan Pharmaceuticals, Inc. Arylsulfonamides as phospholipase A2 inhibitors
JP4416198B2 (ja) 1997-12-19 2010-02-17 武田薬品工業株式会社 アニリド誘導体、その製造法および用途
WO1999050264A1 (fr) 1998-03-30 1999-10-07 Kyowa Hakko Kogyo Co., Ltd. Derives de quinazoline
AR029803A1 (es) 2000-02-21 2003-07-16 Smithkline Beecham Plc Imidazoles sustituidos con piridilo y composiciones farmaceuticas que las comprenden
ES2257441T3 (es) 2000-09-29 2006-08-01 Topotarget Uk Limited Compuestos de acido carbonico que comprenden un enlace amino como inhibidores hdac.
AU2002327627B2 (en) 2001-09-14 2006-09-14 Methylgene Inc. Inhibitors of histone deacetylase
AU2003287965A1 (en) 2002-10-24 2004-05-13 Carex Sa Modulation of peroxisome proliferator activated receptors activity
DE10250743A1 (de) 2002-10-31 2004-05-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Amid-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
JP4145230B2 (ja) 2002-11-01 2008-09-03 武田薬品工業株式会社 神経障害の予防・治療剤
ZA200503967B (en) 2002-11-01 2006-11-29 Takeda Pharmaceutical Agent for preventing or treating neuropathy
ATE552253T1 (de) 2002-11-08 2012-04-15 Novartis Int Pharm Ltd 3-substituierte-6-aryl- pyridin derivate als liganden für c5a-rezeptoren
EP1599447A1 (en) 2003-02-28 2005-11-30 Galderma Research & Development, S.N.C. Ligands that modulate lxr-type receptors
EP1757591A4 (en) 2004-05-26 2010-05-05 Eisai R&D Man Co Ltd ZIMTSÄUREAMIDVERBINDUNG
KR20070050475A (ko) 2004-08-11 2007-05-15 교린 세이야꾸 가부시키 가이샤 신규 환상 아미노 안식향산 유도체
WO2006019020A1 (ja) 2004-08-16 2006-02-23 Sankyo Company, Limited 置換されたウレア化合物
US20100130737A1 (en) 2005-02-18 2010-05-27 Takeda Pharmaceutical Company Limited Regulating Agent of GPR34 Receptor Function
JP5305914B2 (ja) 2005-11-15 2013-10-02 大塚製薬株式会社 オキサゾール化合物及び医薬組成物
JP2007210929A (ja) 2006-02-09 2007-08-23 Sankyo Co Ltd ウレア化合物を含有する医薬
CA2643796A1 (en) 2006-03-09 2007-09-13 Eisai R & D Management Co., Ltd. Polycyclic cinnamide derivatives
ES2452820T3 (es) 2006-04-07 2014-04-02 Methylgene, Inc. Derivados de benzamida como inhibidores de histona desacetilasa
BRPI0710266B8 (pt) 2006-04-18 2021-05-25 Nippon Chemiphar Co composto, medicamento, e, uso de um composto
US8653115B2 (en) 2006-06-13 2014-02-18 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Heterocyclic non-nucleoside compounds, their preparation, pharmaceutical composition and their use as antiviral agents
KR101410318B1 (ko) 2006-07-27 2014-06-27 (주)아모레퍼시픽 바닐로이드 수용체 길항제로서의 신규 화합물, 그의 이성질체, 또는 약제학적으로 허용가능한 그의 염, 및 이를함유하는 약제학적 조성물
WO2008029825A1 (fr) 2006-09-05 2008-03-13 Kyowa Hakko Kirin Co., Ltd. Dérivé d'imidazole
EP1939180A1 (en) 2006-12-20 2008-07-02 sanofi-aventis Heteroarylacrylamides and their use as pharmaceuticals for the stimulation of the expression of endothelial NO synthase
EP1942104A1 (en) 2006-12-20 2008-07-09 sanofi-aventis Heteroarylcyclopropanecarboxamides and their use as pharmaceuticals
CN101711154A (zh) 2007-02-26 2010-05-19 科森生物科学公司 氨基甲酸酯化合物
EP2003118A1 (de) 2007-06-13 2008-12-17 Bayer Schering Pharma Aktiengesellschaft Zimtsäurederivate als Modulatoren des EP2-Rezeptors
EP2323737A2 (en) 2008-08-08 2011-05-25 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
CN102480969A (zh) 2009-07-09 2012-05-30 科锐医疗有限公司 伤口愈合和瘢痕调制方法
US8518968B2 (en) 2009-12-04 2013-08-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hydrazone and diacyl hydrazine compounds and methods of use
CA2791914C (en) 2010-03-05 2019-01-15 Karyopharm Therapeutics, Inc. Nuclear transport modulators and uses thereof
WO2012099807A1 (en) 2011-01-17 2012-07-26 Karyopharm Therapeutics, Inc. Olefin containing nuclear transport modulators and uses thereof
EA201490406A1 (ru) 2011-07-29 2014-07-30 Кариофарм Терапевтикс, Инк. Модуляторы ядерного транспорта и их применение
PL2736887T3 (pl) 2011-07-29 2018-03-30 Karyopharm Therapeutics, Inc. Modulatory transportu jądrowego zawierające ugrupowanie hydrazydu i ich zastosowania
WO2013020024A2 (en) 2011-08-03 2013-02-07 Karyopharm Therapeutics, Inc. Maleimide compounds and methods of treatment
LT3404027T (lt) 2012-05-09 2020-07-10 Biogen Ma Inc. Branduolių transporto moduliatoriai ir jų panaudojimas
US20160016916A1 (en) 2013-03-15 2016-01-21 Karyopharm Therapeutics Inc. Exo Olefin-Containing Nuclear Transport Modulators and Uses Thereof
US10202366B2 (en) * 2013-03-15 2019-02-12 Karyopharm Therapeutics Inc. Methods of promoting wound healing using CRM1 inhibitors
SG11201510036TA (en) 2013-06-21 2016-01-28 Karyopharm Therapeutics Inc Nuclear transport modulators and uses thereof
WO2014205393A1 (en) 2013-06-21 2014-12-24 Karyopharm Therapeutics Inc. Nuclear transport modulators and uses thereof
WO2015073908A1 (en) * 2013-11-15 2015-05-21 H. Lee Moffitt Cancer Center And Research Institute, Inc. Method for selecting cancer treatment regimen
CN105294681B (zh) * 2014-07-26 2017-07-07 广东东阳光药业有限公司 Cdk类小分子抑制剂的化合物及其用途
WO2016025904A1 (en) * 2014-08-15 2016-02-18 Karyopharm Therapeutics Inc. Polymorphs of selinexor
WO2017117529A1 (en) 2015-12-31 2017-07-06 Karyopharm Therapeutics Inc. Nuclear transport modulators and uses thereof
US10709706B2 (en) 2015-12-31 2020-07-14 Karopharm Therapeutics Inc. Nuclear transport modulators and uses thereof
WO2017118940A1 (en) * 2016-01-08 2017-07-13 Dr. Reddy's Laboratories Limited Solid forms of selinexor and process for their preparation
JP6765198B2 (ja) 2016-03-10 2020-10-07 パナソニック株式会社 潜熱蓄熱材及びそれを用いる蓄熱システム
US11602530B2 (en) 2016-11-28 2023-03-14 Biogen Ma Inc. CRM1 inhibitors for treating epilepsy
WO2018129227A1 (en) * 2017-01-05 2018-07-12 Watson Laboratories Inc. Novel crystalline forms of selinexor and process for their preparation

Also Published As

Publication number Publication date
SG11201700789SA (en) 2017-02-27
JP6777626B2 (ja) 2020-10-28
AU2021286266A1 (en) 2022-01-06
WO2016025904A1 (en) 2016-02-18
KR20170043561A (ko) 2017-04-21
NZ728850A (en) 2024-03-22
AU2021286266B2 (en) 2024-02-01
CN111481553B (zh) 2023-09-01
CN111484483B (zh) 2023-05-26
US11078190B2 (en) 2021-08-03
US20180215733A1 (en) 2018-08-02
CA2957266A1 (en) 2016-02-18
UA123535C2 (uk) 2021-04-21
CN111481553A (zh) 2020-08-04
EP3180331A1 (en) 2017-06-21
EA201790384A1 (ru) 2017-08-31
AU2020203246A1 (en) 2020-06-04
CN107072992A (zh) 2017-08-18
SG10201808624VA (en) 2018-11-29
US11753401B2 (en) 2023-09-12
AU2020203246B2 (en) 2021-09-16
AU2024202835A1 (en) 2024-05-23
US20240208943A1 (en) 2024-06-27
US11807629B2 (en) 2023-11-07
JP2017527549A (ja) 2017-09-21
EP4112615A1 (en) 2023-01-04
MA40254A (fr) 2021-05-19
IL250328B (en) 2022-05-01
AU2015301484A1 (en) 2017-03-02
JP7558310B2 (ja) 2024-09-30
US20200283419A1 (en) 2020-09-10
IL250328A0 (en) 2017-03-30
US20220135545A1 (en) 2022-05-05
CN107072992B (zh) 2020-03-10
US10519139B2 (en) 2019-12-31
ZA201700880B (en) 2020-01-29
JP2023052622A (ja) 2023-04-11
US11746102B2 (en) 2023-09-05
MX2021014128A (es) 2022-01-04
ES2926377T3 (es) 2022-10-25
JP2020143144A (ja) 2020-09-10
US20230242517A1 (en) 2023-08-03
AU2015301484B2 (en) 2020-02-20
MA40254B1 (fr) 2022-09-30
CN111484483A (zh) 2020-08-04
KR102608259B1 (ko) 2023-11-29
EP3180331B1 (en) 2022-06-08
DK3180331T3 (da) 2022-09-12
JP7218323B2 (ja) 2023-02-06
US20230242516A1 (en) 2023-08-03
CO2017001884A2 (es) 2017-07-19

Similar Documents

Publication Publication Date Title
MX2021014128A (es) Polimorfos de selinexor.
EA201691442A1 (ru) N-азаспироциклоалканзамещенные n-гетероарильные соединения и композиции для ингибирования активности shp2
PH12018500071A1 (en) Plinabulin compositions
MD20160136A2 (ro) Compuşi dihidroizochinolinonici substituiţi
MY197698A (en) Oxysterols and methods of use thereof
IN2014CH00247A (es)
PH12017500401A1 (en) Therapeutic compounds as inhibitors of the orexin-1 receptor
MX2021014663A (es) Il-23a y tnf-alfa orientados y compuesto y sus usos.
TN2017000031A1 (en) Imidazopyridazine compounds
PH12017500459A1 (en) Azetidinyloxyphenylpyrrolidine compounds
MX2017005578A (es) Métodos de administración de composiciones de amantadina.
PH12017500089A1 (en) Aldosterone synthase inhibitors
PH12017500595A1 (en) Aldosterone synthase inhibitors
EA033423B1 (ru) Циклопропанбензофуранилпиридопиразиндионы
MD20160111A2 (ro) Derivaţi diheterociclici legaţi de cicloalchil
MD4780B1 (ro) Urei asimetrice p-substituite şi utilizările medicale ale acestora
GB2564185A (en) Process for the preparation of derivatives of benzodioxole
PH12015502703A1 (en) Pharmaceutical compositions
NZ767083A (en) Polymorphs of selinexor
MX2017005669A (es) Derivados de hidroxido de bencilo, preparacion de los mismos y uso terapeutico de los mismos.
IN2014MU00070A (es)