ATE552253T1 - 3-substituierte-6-aryl- pyridin derivate als liganden für c5a-rezeptoren - Google Patents

3-substituierte-6-aryl- pyridin derivate als liganden für c5a-rezeptoren

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Publication number
ATE552253T1
ATE552253T1 AT03768799T AT03768799T ATE552253T1 AT E552253 T1 ATE552253 T1 AT E552253T1 AT 03768799 T AT03768799 T AT 03768799T AT 03768799 T AT03768799 T AT 03768799T AT E552253 T1 ATE552253 T1 AT E552253T1
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Austria
Prior art keywords
receptors
substituted
compounds
aryl
ligands
Prior art date
Application number
AT03768799T
Other languages
English (en)
Inventor
Alan Hutchison
Jun Yuan
Kyungae Lee
George Maynard
Bertrand Chenard
Nian Liu
Qin Guo
Zihong Guo
Peter Hrnciar
Original Assignee
Novartis Int Pharm Ltd
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Publication of ATE552253T1 publication Critical patent/ATE552253T1/de

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
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    • A61P17/00—Drugs for dermatological disorders
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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AT03768799T 2002-11-08 2003-11-07 3-substituierte-6-aryl- pyridin derivate als liganden für c5a-rezeptoren ATE552253T1 (de)

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Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101928284A (zh) * 2003-03-14 2010-12-29 小野药品工业株式会社 含氮杂环衍生物以及包含所述化合物作为活性成分的药物
EP1780211A3 (de) * 2003-09-30 2007-06-06 Amgen Inc. vANILLOIDREZEPTORLIGANDEN UND DEREN VERWENDUNG IN BEHANDLUNGEN
MXPA06003615A (es) 2003-09-30 2006-06-05 Amgen Inc Ligandos del receptor vanilloide y su uso en tratamientos.
MXPA06011589A (es) * 2004-04-08 2006-12-20 Dow Agrosciences Llc Sulfoximinas n-sustituidas insecticidas.
AU2005244104B2 (en) * 2004-05-08 2012-03-15 Novartis International Pharmaceutical Ltd. 4,5-disubstituted-2-aryl pyrimidines
US8143404B2 (en) 2004-09-13 2012-03-27 Ono Pharmaceutical Co., Ltd Nitrogenous heterocylic derivative and medicine containing the same as an active ingredient
US7968574B2 (en) 2004-12-28 2011-06-28 Kinex Pharmaceuticals, Llc Biaryl compositions and methods for modulating a kinase cascade
US7300931B2 (en) 2004-12-28 2007-11-27 Kinex Pharmaceuticals, Llc Compositions for treating cell proliferation disorders
GT200600042A (es) * 2005-02-10 2006-09-27 Aventis Pharma Inc Compuestos de bis arilo y heteroarilo sustituido como antagonistas selectivos de 5ht2a
ES2540966T3 (es) 2005-02-16 2015-07-15 Anacor Pharmaceuticals, Inc. Compuestos biocidas de boronoftalida
WO2006124897A2 (en) * 2005-05-13 2006-11-23 Lexicon Genetics Incorporated Methods and compositions for improving cognition
ZA200709626B (en) 2005-05-13 2009-02-25 Lexicon Pharmaceuticals Inc Multicyclic compounds and methods of their use
EP1739078A1 (de) 2005-05-30 2007-01-03 Jerini AG C5a-Rezeptor-Antagonisten
CA2654440C (en) 2005-06-06 2013-09-03 Girish J. Kotwal Methods for treatment or prophylaxis of atherosclerosis and reperfusion injury
WO2007034406A1 (en) * 2005-09-22 2007-03-29 Actelion Pharmaceuticals Ltd Pyrrolidine-3-carboxylic acid amide derivatives and their use as inhibitors of renin
BRPI0620754A2 (pt) * 2005-12-29 2011-11-22 Novartis Ag derivados de amina de piridinila como inibidores de proteìna de transferência de éster de colesterila (cetp)
CN102532180B (zh) * 2005-12-30 2016-06-29 安纳考尔医药公司 含硼的小分子
BRPI0621279B1 (pt) 2005-12-30 2021-07-20 Anacor Pharmaceuticals, Inc Moléculas pequenas contendo boro
TW201309635A (zh) 2006-02-10 2013-03-01 Dow Agrosciences Llc 殺蟲性之ｎ-取代（６-鹵烷基吡啶-３-基）烷基磺醯亞胺（二）
US8003642B2 (en) 2006-03-10 2011-08-23 Ono Pharmaceutical Co., Ltd. Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient
PL2010528T3 (pl) 2006-04-19 2018-03-30 Novartis Ag 6-0-podstawione związki benzoksazolowe i benzotiazolowe i sposoby hamowania sygnalizacji csf-1r
MX2008014284A (es) 2006-05-10 2008-11-18 Novartis Ag Derivados biciclicos como inhibidores de cetp.
TWI381811B (zh) * 2006-06-23 2013-01-11 Dow Agrosciences Llc 用以防治可抵抗一般殺蟲劑之昆蟲的方法
AU2007265373B2 (en) 2006-06-29 2013-02-21 Atnx Spv, Llc Biaryl compositions and methods for modulating a kinase cascade
WO2008027539A1 (en) * 2006-09-01 2008-03-06 Dow Agrosciences Llc Insecticidal n-substituted (2- sudstituted-1,3-thiazol) alkyl sulfoximines
TWI387585B (zh) * 2006-09-01 2013-03-01 Dow Agrosciences Llc 殺蟲性之ｎ-取代（雜芳基）烷基烴基硫亞胺
TW200823193A (en) * 2006-11-07 2008-06-01 Lexicon Pharmaceuticals Inc (S)-phenyl(heterocycle)methanol-based compounds, compositions comprising them and methods of their use
TW200827345A (en) * 2006-11-07 2008-07-01 Lexicon Pharmaceuticals Inc (R)-phenyl(heterocycle)methanol-based compounds, compositions comprising them and methods of their use
TWI395736B (zh) * 2006-11-08 2013-05-11 Dow Agrosciences Llc 作為殺蟲劑之雜芳基（取代的）烷基ｎ-取代的磺醯亞胺（二）
DE102006059710A1 (de) * 2006-12-18 2008-06-19 Freie Universität Berlin Substituierte 4-Hydroxypyridine
EP1939180A1 (de) * 2006-12-20 2008-07-02 sanofi-aventis Heteroarylacrylamide und ihre Verwendung als Arzneimittel für die Stimulation der Expression der endothelialen NO-Synthase
US7939529B2 (en) 2007-05-17 2011-05-10 Kinex Pharmaceuticals, Llc Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof
US7935697B2 (en) 2006-12-28 2011-05-03 Kinex Pharmaceuticals, Llc Compositions for modulating a kinase cascade and methods of use thereof
US7709648B2 (en) * 2007-02-09 2010-05-04 Dow Agrosciences Llc Process for the preparation of 2-substituted-5-(1-alkylthio)alkylpyridines
AR066366A1 (es) * 2007-05-01 2009-08-12 Dow Agrosciences Llc Mezclas sinergicas plaguicidas
US8124605B2 (en) 2007-07-06 2012-02-28 Kinex Pharmaceuticals, Llc Compositions and methods for modulating a kinase cascade
CA2693253C (en) * 2007-07-20 2015-03-24 Jonathan Babcock Increasing plant vigor
DE102007042754A1 (de) 2007-09-07 2009-03-12 Bayer Healthcare Ag Substituierte 6-Phenylnikotinsäuren und ihre Verwendung
MX2010003621A (es) 2007-10-01 2010-04-14 Hoffmann La Roche N-heterociclil biaril carboxamidas como antagonistas del receptor ccr.
CN102015634B (zh) * 2008-03-03 2014-02-12 陶氏益农公司 杀虫剂
MX2010013109A (es) * 2008-06-18 2010-12-20 Hoffmann La Roche Nuevos derivados de heteroaril-carboxamida.
AU2009330194B2 (en) 2008-12-22 2015-07-09 Chemocentryx, Inc. C5aR antagonists
NZ596445A (en) 2009-06-24 2013-04-26 Boehringer Ingelheim Int New compounds, pharmaceutical composition and methods relating thereto
WO2010149685A1 (en) 2009-06-24 2010-12-29 Boehringer Ingelheim International Gmbh New compounds, pharmaceutical composition and methods relating thereto
BR112012014164A2 (pt) 2009-12-14 2016-05-17 Merck Patent Gmbh inibidores da esfingosina quinase
CA2796419C (en) 2010-04-16 2018-11-06 Kinex Pharmaceuticals, Llc Compositions and methods for the prevention and treatment of cancer
US8802058B2 (en) * 2010-04-19 2014-08-12 Gelmed, Llc Pharmaceutical compositions and methods for administering the same
RS56332B1 (sr) 2010-06-24 2017-12-29 Chemocentryx Inc Antagonisti c5ar
WO2012052540A1 (en) * 2010-10-21 2012-04-26 Universitaet Des Saarlandes Selective cyp11b1 inhibitors for the treatment of cortisol dependent diseases
CN102850321A (zh) * 2011-06-28 2013-01-02 中国科学院上海药物研究所 芳香氧基嘧啶甲酰胺或芳香氧基吡啶甲酰胺类化合物及其制备方法、药物组合物和用途
CA2842364A1 (en) * 2011-07-29 2013-02-07 Karyopharm Therapeutics, Inc. Nuclear transport modulators and uses thereof
DK3333164T3 (da) 2011-07-29 2023-09-18 Karyopharm Therapeutics Inc Hydrazide containing nuclear transport modulators and uses thereof
WO2013082458A1 (en) 2011-12-02 2013-06-06 The Regents Of The University Of California Reperfusion protection solution and uses thereof
LT2858991T (lt) 2012-05-09 2018-11-26 Biogen Ma Inc. Branduolinio transporto moduliatoriai ir jų panaudojimas
SG11201408237YA (en) * 2012-06-15 2015-01-29 Curegenix Inc Compound as wnt signaling inhibitor, composition, and use thereof
SI2890680T1 (en) 2012-08-30 2018-08-31 Athenex, Inc. Conventus Building N- (3-FLUOROBENZYL) -2- (5- (4-MORFOLINOPHENYL) PIRIDIN-2-IL) ACETAMIDE AS PROTEIN TIROZINE KINASE PROTECTORS
CA2905830C (en) 2013-03-12 2022-01-18 Curegenix Inc. Quinazoline and naphthyridine derivatives useful in the treatment of cancer
EP2968278B8 (de) 2013-03-15 2019-05-22 Karyopharm Therapeutics Inc. Verfahren zur förderung der wundheilung mit crm1-inhibitoren
CN105307651A (zh) 2013-04-22 2016-02-03 艾伯维公司 噻唑类化合物及其用途
KR102545732B1 (ko) 2013-06-21 2023-06-20 카리오팜 쎄라퓨틱스, 인코포레이티드 핵수송 조절인자 및 이의 용도
EP3099666B1 (de) * 2014-01-27 2018-12-12 Vertellus Holdings LLC Verfahren zur herstellung von 2-chlor-5-methylpyridin
CN107072992B (zh) 2014-08-15 2020-03-10 卡尔约药物治疗公司 赛灵克斯的多晶型物
BR112017006232B1 (pt) 2014-09-29 2022-10-11 Chemocentryx, Inc. Processos e intermediários na preparação de antagonistas de c5ar
AU2016226036B2 (en) * 2015-03-04 2020-06-04 Dana-Farber Cancer Institute, Inc. Salicylate inhibitors of MELK and methods of use
CA2997745A1 (en) * 2015-09-14 2017-03-23 Children's Hospital Medical Center Methods and compositions for treatment of gaucher disease via modulation of c5a receptor
TWI773657B (zh) 2015-12-18 2022-08-11 美商亞德利克斯公司 作爲非全身ｔｇｒ５促效劑之經取代之4-苯基吡啶化合物
US12084472B2 (en) 2015-12-18 2024-09-10 Ardelyx, Inc. Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists
WO2017117535A1 (en) 2015-12-31 2017-07-06 Karyopharm Therapeutics Inc. Nuclear transport modulators and uses thereof
WO2017117529A1 (en) 2015-12-31 2017-07-06 Karyopharm Therapeutics Inc. Nuclear transport modulators and uses thereof
MX2022006069A (es) 2016-01-14 2023-01-12 Chemocentryx Inc Metodo para tratar glomerulopatia c3.
CN109310686B (zh) 2016-04-04 2022-06-21 凯莫森特里克斯股份有限公司 可溶性C5aR拮抗剂
WO2018098472A1 (en) 2016-11-28 2018-05-31 Karyopharm Therapeutics Inc. Crm1 inhibitors for treating epilepsy
JP2017095498A (ja) * 2017-01-18 2017-06-01 キュアジェニックス インコーポレイテッド Ｗｎｔシグナリング阻害剤、組成物およびその用途としての化合物
US10562896B2 (en) 2017-05-31 2020-02-18 Chemocentryx, Inc. 6-5 fused rings as C5a inhibitors
ES2934507T3 (es) 2017-05-31 2023-02-22 Chemocentryx Inc Anillos fusionados en 5-5 como inhibidores de C5a
CA3077395A1 (en) 2017-10-30 2019-05-09 Chemocentryx, Inc. Deuterated compounds as immunomodulators
WO2019126424A1 (en) 2017-12-22 2019-06-27 Chemocentryx, Inc. DIARYL SUBSTITUTED 6,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS
JP7253557B2 (ja) 2017-12-22 2023-04-06 ケモセントリックス，インコーポレイティド Ｃ５ａＲ阻害剤としてのジアリール置換５，５－縮合環化合物
EP3765453A1 (de) * 2018-03-13 2021-01-20 Jubilant Prodel LLC Bicyclische verbindungen als inhibitoren der pd1/pd-l1-interaktion/aktivierung
IL277608B2 (en) 2018-04-02 2023-09-01 Chemocentryx Inc Prodrugs of conjugated c5ar antagonists

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1180268A (en) * 1967-09-26 1970-02-04 Ici Ltd Pharmaceutically Active Phenyl-Heterocyclic-Alkanol Derivatives
GB1188416A (en) * 1968-04-01 1970-04-15 Ici Ltd Heterocyclic Amines
FR2164482A1 (en) * 1971-12-21 1973-08-03 Aries Robert Phenyl pyridyl acylamino pyrazolones - antiinflammatories antipyretics and analgesics
JPH0710846B2 (ja) * 1985-01-18 1995-02-08 ダイセル化学工業株式会社 ４−置換オキシ−３−ピリジンカルボキサミド化合物
US4857527A (en) * 1985-12-12 1989-08-15 Fujisawa Pharmaceutical Co., Ltd. Morpholine containing pyridine compounds, compositions and use
US4990507A (en) * 1985-12-12 1991-02-05 Fujisawa Pharmaceutical Co., Ltd. N-containing heterocyclic compounds, and composition comprising the same
GB8530602D0 (en) * 1985-12-12 1986-01-22 Fujisawa Pharmaceutical Co Heterocyclic compounds
US5008168A (en) 1988-04-18 1991-04-16 Canon Kabushiki Kaisha Photosensitive member for electrophotography
US5283242A (en) * 1991-10-24 1994-02-01 American Home Products Corporation Substituted benzimidazoles and quinazolines as antihypertensives
US5807824A (en) 1993-12-06 1998-09-15 Ciba-Geigy Corporation C5A receptor antagonists having substantially no agonist activity
DE4427199A1 (de) 1994-08-01 1996-02-08 Hoechst Ag 3,4-Difluorpyridine und ihre Verwendung in flüssigkristallinen Mischungen
WO1999031062A1 (fr) 1997-12-17 1999-06-24 Shionogi & Co., Ltd. Nouveaux composes de pyridine
US6147085A (en) 1999-04-01 2000-11-14 Neurogen Corporation Aminoalkyl substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives
JP2000226372A (ja) 1999-02-01 2000-08-15 Nippon Soda Co Ltd アミド化合物、その製造方法及び農園芸用殺虫剤
US6627633B2 (en) * 1999-03-17 2003-09-30 Albany Molecular Research, Inc. 6-substituted biaryl purine derivatives as potent cyclin/CDK inhibitors and antiproliferative agents
US6355644B1 (en) 1999-06-14 2002-03-12 Neurogen Corporation Benzylpiperazinyl-indolinylethanones
US6482611B1 (en) 1999-09-23 2002-11-19 Neurogen Corporation Human capsaicin receptor and uses thereof
WO2002049993A2 (en) 2000-09-29 2002-06-27 Neurogen Corporation High affinity small molecule c5a receptor modulators
US6310212B1 (en) 2000-03-28 2001-10-30 Neurogen Corporation 4-substituted quinoline derivatives
CA2418652C (en) 2000-08-10 2010-03-23 Mitsubishi Pharma Corporation Novel 3-substituted urea derivatives and medicinal use thereof
KR20040015716A (ko) * 2001-05-22 2004-02-19 뉴로젠 코포레이션 Ｃｒｆ1 조절자로서의 5-치환된-2-아릴피리딘

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US20090176980A1 (en) 2009-07-09
WO2004043925A2 (en) 2004-05-27
AU2003291403A1 (en) 2004-06-03
US20110281837A1 (en) 2011-11-17
EP1565452B1 (de) 2012-04-04
AU2003291403A8 (en) 2004-06-03
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US7342115B2 (en) 2008-03-11
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