ATE461178T1 - Pyridazinyl-piperazine und deren verwendung als histamin-h3-rezeptorliganden - Google Patents
Pyridazinyl-piperazine und deren verwendung als histamin-h3-rezeptorligandenInfo
- Publication number
- ATE461178T1 ATE461178T1 AT04738980T AT04738980T ATE461178T1 AT E461178 T1 ATE461178 T1 AT E461178T1 AT 04738980 T AT04738980 T AT 04738980T AT 04738980 T AT04738980 T AT 04738980T AT E461178 T1 ATE461178 T1 AT E461178T1
- Authority
- AT
- Austria
- Prior art keywords
- histamine
- compounds
- receptor
- pyridazinyl
- piperazine
- Prior art date
Links
- 102000004384 Histamine H3 receptors Human genes 0.000 title abstract 4
- 108090000981 Histamine H3 receptors Proteins 0.000 title abstract 4
- MIPXOMNITKFHDA-UHFFFAOYSA-N 3-piperazin-1-ylpyridazine Chemical compound C1CNCCN1C1=CC=CN=N1 MIPXOMNITKFHDA-UHFFFAOYSA-N 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 230000001270 agonistic effect Effects 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000004885 piperazines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200301107 | 2003-07-29 | ||
| US49269303P | 2003-08-05 | 2003-08-05 | |
| PCT/DK2004/000483 WO2005009976A1 (en) | 2003-07-29 | 2004-07-06 | Pyridazinyl- piperazines and their use as histamine h3 receptor ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE461178T1 true ATE461178T1 (de) | 2010-04-15 |
Family
ID=34105630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04738980T ATE461178T1 (de) | 2003-07-29 | 2004-07-06 | Pyridazinyl-piperazine und deren verwendung als histamin-h3-rezeptorliganden |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7294626B2 (de) |
| EP (1) | EP1651615B1 (de) |
| JP (1) | JP4680903B2 (de) |
| KR (1) | KR20060054392A (de) |
| CN (1) | CN100584831C (de) |
| AT (1) | ATE461178T1 (de) |
| AU (1) | AU2004259263B2 (de) |
| BR (1) | BRPI0413048A (de) |
| CA (1) | CA2532236C (de) |
| DE (1) | DE602004026068D1 (de) |
| DK (1) | DK1651615T3 (de) |
| ES (1) | ES2342605T3 (de) |
| IL (1) | IL173161A0 (de) |
| MX (1) | MXPA06001053A (de) |
| NO (1) | NO20061003L (de) |
| PL (1) | PL1651615T3 (de) |
| PT (1) | PT1651615E (de) |
| RU (1) | RU2006101452A (de) |
| WO (1) | WO2005009976A1 (de) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030176437A1 (en) | 2001-08-31 | 2003-09-18 | D.M. Watterson | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death |
| US20030236259A1 (en) * | 2002-02-05 | 2003-12-25 | Rolf Hohlweg | Novel aryl- and heteroarylpiperazines |
| CN1972914A (zh) | 2004-03-31 | 2007-05-30 | 詹森药业有限公司 | 作为组胺h3受体配合体的非咪唑杂环化合物 |
| EP1595881A1 (de) * | 2004-05-12 | 2005-11-16 | Pfizer Limited | Tetrahydronaphthyridin-Derivate, verwendbar als Histamin H3 Rezeptor-Liganden |
| WO2006034441A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| TW200626138A (en) | 2004-09-20 | 2006-08-01 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
| CA2580857A1 (en) | 2004-09-20 | 2006-09-28 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| WO2006034440A2 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| WO2006034341A2 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
| MX2007003318A (es) | 2004-09-20 | 2007-05-18 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como agentes terapeuticos. |
| EP2316457A1 (de) * | 2004-09-20 | 2011-05-04 | Xenon Pharmaceuticals Inc. | Pyridin-Derivate zur Hemmung der menschlichen Stearoyl-Coa-Desaturase |
| JP5094398B2 (ja) | 2004-09-20 | 2012-12-12 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 複素環式誘導体およびステアロイル−ＣｏＡデサチュラーゼのメディエータとしてのそれらの使用 |
| WO2006050389A2 (en) | 2004-11-02 | 2006-05-11 | Northwestern University | Pyridazine compounds, compositions and methods |
| WO2006050359A2 (en) | 2004-11-02 | 2006-05-11 | Northwestern University | Pyridazine compounds and methods |
| AU2006343359A1 (en) | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| ES2375929T3 (es) | 2005-07-04 | 2012-03-07 | High Point Pharmaceuticals, Llc | Antagonistas del receptor histamina h3. |
| GB0517184D0 (en) * | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
| JO2769B1 (en) | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
| US8158673B2 (en) * | 2005-10-27 | 2012-04-17 | Pfizer Inc. | Histamine-3 receptor antagonists |
| WO2007127375A2 (en) * | 2006-04-28 | 2007-11-08 | Northwestern University | Formulations containing pyridazine compounds for treating neuroinflammatory diseases |
| CA2650711A1 (en) | 2006-04-28 | 2007-11-08 | Northwestern University | Compositions and treatments using pyridazine compounds and cholinesterase inhibitors |
| EP2038256A1 (de) | 2006-05-23 | 2009-03-25 | TransTech Pharma, Inc | 6-(4-cyclopropylpiperazin-1-yl)-2'-methyl-[3,4']-bipyridin und seine verwendung als arzneimittel |
| ATE538116T1 (de) * | 2006-05-29 | 2012-01-15 | High Point Pharmaceuticals Llc | 3-(1,3-benyodioxol-5-yl)-6- (4- cyclopropylpiperazin-1-yl)-pyridazin, dessen salze und solvate und dessen verwendung als histamin-h3-rezeptorantagonist |
| CN101495456B (zh) | 2006-05-30 | 2014-03-19 | 詹森药业有限公司 | 作为组胺h3受体的调节剂的取代的吡啶基酰胺化合物 |
| KR20090024811A (ko) | 2006-06-23 | 2009-03-09 | 아보트 러보러터리즈 | 히스타민 ｈ3 수용체 조절제로서의 사이클로프로필 아민 유도체 |
| US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| JO2642B1 (en) | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| JO2849B1 (en) | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| CN101663299A (zh) | 2007-04-23 | 2010-03-03 | 詹森药业有限公司 | 作为快速解离性多巴胺2受体拮抗剂的噻(二)唑类化合物 |
| EP2148873B1 (de) | 2007-04-23 | 2012-08-29 | Janssen Pharmaceutica, N.V. | 4-alkoxypyridazinderivate als schnell dissoziierende dopamin-2-rezeptorantagonisten |
| JP5603770B2 (ja) * | 2007-05-31 | 2014-10-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ２受容体拮抗薬およびその使用 |
| US9353170B2 (en) * | 2007-06-08 | 2016-05-31 | Sanofi-Aventis Deutschland Gmbh | Long-acting transient polymer conjugates of exendin |
| EP2014656A3 (de) | 2007-06-11 | 2011-08-24 | High Point Pharmaceuticals, LLC | Neue heterocyclische H3-Antagonisten |
| MY158253A (en) | 2007-11-20 | 2016-09-30 | Janssen Pharmaceutica Nv | Cycloalkyloxy- and heterocycloalkyloxypyridine compounds as modulators of the histamine h3 receptor |
| WO2010000456A1 (en) | 2008-07-03 | 2010-01-07 | Janssen Pharmaceutica Nv | Substituted 6- (1-piperazinyl) -pyridazines as 5-ht6 receptor antagonists |
| JP5457450B2 (ja) | 2008-07-31 | 2014-04-02 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 迅速解離性ドーパミン２受容体拮抗薬としてのピペラジン−１−イル−トリフルオロメチル−置換−ピリジン |
| JP2012512834A (ja) | 2008-12-19 | 2012-06-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 炎症、喘息及びｃｏｐｄの処置のためのｃｃｒ２受容体アンタゴニストとしての環状ピリミジン−４−カルボキサミド |
| US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| CN102933579B (zh) | 2009-12-17 | 2015-07-15 | 贝林格尔.英格海姆国际有限公司 | 新的ccr2受体拮抗剂及其用途 |
| WO2011141474A1 (en) | 2010-05-12 | 2011-11-17 | Boehringer Ingelheim International Gmbh | Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| WO2011141477A1 (en) | 2010-05-12 | 2011-11-17 | Boehringer Ingelheim International Gmbh | New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| EP2571870B1 (de) | 2010-05-17 | 2015-01-21 | Boehringer Ingelheim International GmbH | Ccr2-antagonisten und verwendungen dafür |
| JP5636094B2 (ja) * | 2010-05-25 | 2014-12-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ２受容体アンタゴニスト |
| WO2011151251A1 (en) | 2010-06-01 | 2011-12-08 | Boehringer Ingelheim International Gmbh | New ccr2 antagonists |
| WO2012037258A1 (en) | 2010-09-16 | 2012-03-22 | Abbott Laboratories | Processes for preparing 1,2-substituted cyclopropyl derivatives |
| JP5786258B2 (ja) | 2011-07-15 | 2015-09-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規かつ選択的なｃｃｒ２拮抗薬 |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| FR2999427B1 (fr) * | 2012-12-17 | 2015-01-30 | Metabolys | Composition et kit comprenant des derives de piperazine et de la metformine, leur utilisation dans le traitement du diabete |
| ES2811098T3 (es) | 2015-07-02 | 2021-03-10 | Centrexion Therapeutics Corp | Citrato de (4-((3r,4r)-3-metoxitetrahidro-pirano-4-ilamino)piperidin-1-il)(5-metil-6-(((2r, 6s)-6-(p-tolil)tetrahidro-2hpirano-2-il) metilamino)pirimidin-4il) metanona |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4144346A (en) | 1977-01-31 | 1979-03-13 | Janssen Pharmaceutica N.V. | Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles |
| FR2573075B1 (fr) | 1984-09-14 | 1987-03-20 | Innothera Lab Sa | Nouvelles (pyridyl-2)-1 piperazines, leur procede de preparation et leur application en therapeutique |
| HUP0004512A3 (en) | 1997-10-27 | 2003-01-28 | Agouron Pharmaceuticals Inc La | 4-aminothiazole derivatives, their preparation and their use as inhibitors of cyclin-dependent kinases |
| WO2000066578A1 (en) | 1999-04-30 | 2000-11-09 | Pfizer Products Inc. | Compounds for the treatment of obesity |
| WO2001066534A2 (en) | 2000-03-09 | 2001-09-13 | Abbott Laboratories | Cyclic and bicyclic diamino histamine-3 receptor antagonists |
| AU2001251083A1 (en) | 2000-03-31 | 2001-10-15 | Ortho-Mcneil Pharmaceutical, Inc. | Method for using 2-aryloxyalkylaminobenzoxazoles and 2-aryloxyalkylaminobenzothiazoles as h3 antagonists |
| US6316475B1 (en) | 2000-11-17 | 2001-11-13 | Abbott Laboratories | Aminoalkoxybiphenylcarboxamides as histamine-3 receptor ligands and their therapeutic applications |
| EP1474401A2 (de) * | 2002-02-05 | 2004-11-10 | Novo Nordisk A/S | Neue aryl- und heteroarylpiperazine |
-
2004
- 2004-07-06 BR BRPI0413048-0A patent/BRPI0413048A/pt not_active IP Right Cessation
- 2004-07-06 DK DK04738980.4T patent/DK1651615T3/da active
- 2004-07-06 EP EP04738980A patent/EP1651615B1/de not_active Expired - Lifetime
- 2004-07-06 MX MXPA06001053A patent/MXPA06001053A/es active IP Right Grant
- 2004-07-06 CN CN200480021891A patent/CN100584831C/zh not_active Expired - Fee Related
- 2004-07-06 PT PT04738980T patent/PT1651615E/pt unknown
- 2004-07-06 JP JP2006521396A patent/JP4680903B2/ja not_active Expired - Fee Related
- 2004-07-06 ES ES04738980T patent/ES2342605T3/es not_active Expired - Lifetime
- 2004-07-06 AU AU2004259263A patent/AU2004259263B2/en not_active Ceased
- 2004-07-06 KR KR1020067002114A patent/KR20060054392A/ko not_active Application Discontinuation
- 2004-07-06 PL PL04738980T patent/PL1651615T3/pl unknown
- 2004-07-06 AT AT04738980T patent/ATE461178T1/de active
- 2004-07-06 DE DE602004026068T patent/DE602004026068D1/de not_active Expired - Lifetime
- 2004-07-06 RU RU2006101452/04A patent/RU2006101452A/ru not_active Application Discontinuation
- 2004-07-06 WO PCT/DK2004/000483 patent/WO2005009976A1/en active Application Filing
- 2004-07-06 CA CA2532236A patent/CA2532236C/en not_active Expired - Fee Related
-
2006
- 2006-01-16 IL IL173161A patent/IL173161A0/en unknown
- 2006-01-18 US US11/334,207 patent/US7294626B2/en not_active Expired - Fee Related
- 2006-02-28 NO NO20061003A patent/NO20061003L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2342605T3 (es) | 2010-07-09 |
| CA2532236C (en) | 2011-08-23 |
| DK1651615T3 (da) | 2010-05-25 |
| PT1651615E (pt) | 2010-04-29 |
| CN100584831C (zh) | 2010-01-27 |
| DE602004026068D1 (de) | 2010-04-29 |
| WO2005009976A1 (en) | 2005-02-03 |
| MXPA06001053A (es) | 2006-04-11 |
| JP2007500135A (ja) | 2007-01-11 |
| US7294626B2 (en) | 2007-11-13 |
| EP1651615B1 (de) | 2010-03-17 |
| AU2004259263A1 (en) | 2005-02-03 |
| PL1651615T3 (pl) | 2010-08-31 |
| RU2006101452A (ru) | 2006-06-27 |
| IL173161A0 (en) | 2006-06-11 |
| CN1829699A (zh) | 2006-09-06 |
| BRPI0413048A (pt) | 2006-10-17 |
| CA2532236A1 (en) | 2005-02-03 |
| US20060173012A1 (en) | 2006-08-03 |
| NO20061003L (no) | 2006-04-26 |
| JP4680903B2 (ja) | 2011-05-11 |
| EP1651615A1 (de) | 2006-05-03 |
| KR20060054392A (ko) | 2006-05-22 |
| AU2004259263B2 (en) | 2010-12-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE461178T1 (de) | Pyridazinyl-piperazine und deren verwendung als histamin-h3-rezeptorliganden | |
| DE60237528D1 (de) | Neue aminoazetidin-, aminopyrrolidin- und aminopiperidinderivative | |
| WO2003066604A3 (en) | Novel aryl- and heteroarylpiperazines | |
| EA200601897A1 (ru) | Производные тетрагидронафтиридина, пригодные в качестве лигандов рецептора н3 гистамина | |
| NO20075624L (no) | Nye histamin H3-reseptorligander og deres terapeutiske anvendelser | |
| DE602005018758D1 (de) | Am histamin-h3-rezeptor wirksame mittel, herstellung und therapeutische anwendungen | |
| DK1725536T3 (da) | Imidazolin-derivater med CB1-antagonistisk aktivitet | |
| NO20043637L (no) | Amider av aminoalkylsubstituerte azetidiner, pyrrolidiner, piperidiner og azepaner | |
| EA200500342A1 (ru) | Гетероциклические замещённые пиперазины для лечения шизофрении | |
| NO20070347L (no) | Modulatorer av alfa7 nikotinske acetylkolinreseptorer og terapeutiske anvendelser | |
| TW200800946A (en) | Substituted piperazines as metabotropic glutamate receptor antagonists | |
| ATE450508T1 (de) | Substituierte piperidinen mit selektiver bindungsfähigkeit zu histamin h3-rezeptoren | |
| ATE442846T1 (de) | Piperidin- und pyrrolidin-derivate alsantagonisten des histamin-h3-rezeptors | |
| ATE467636T1 (de) | Pyrazoloä3 , 4-düazepinderivate als histamin-h3- antagonisten | |
| ATE407119T1 (de) | Pyridinderivate und deren verwendung als modulatoren des cb2-rezeptors | |
| ATE481972T1 (de) | Chinazolinon-derivate als vanilloid-antagonisten | |
| DE60308699D1 (en) | 2-phenylamino-4-trifluoromethyl-5-(benzyl- oder pyridin-4-ylmethyl)carbamoylpyrimidin-derivate als selektive cb2 cannabinoid-rezeptor modulatoren | |
| ATE523488T1 (de) | Histamin-h3-rezeptor-mittel, deren herstellung und therapeutische verwendung | |
| DE60135158D1 (de) | Antagonisten des ige-rezeptors | |
| ATE486078T1 (de) | 5,6-disubstituierte oxadiazolopyrazine und thiadiazolopyrazine als liganden des cxc- chemokinrezeptors | |
| EA200800562A1 (ru) | Производные имидазопиридина в качестве лигандов каннабиноидного рецептора | |
| DE60319989D1 (de) | Diazabicylononan - und decanderivate und ihre verwendung als opioid-rezeptorligande | |
| DE60224509D1 (de) | Imidazolderivate verwendbar als histamin h3 rezeptorliganden | |
| UA83187C2 (en) | Aryl- and heteroarylpiperazines | |
| ITMI20041231A1 (it) | Antagonisti del recettore dei vanilloidi trpv1 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1651615 Country of ref document: EP |