EA200800562A1 - Производные имидазопиридина в качестве лигандов каннабиноидного рецептора - Google Patents

Производные имидазопиридина в качестве лигандов каннабиноидного рецептора

Info

Publication number
EA200800562A1
EA200800562A1 EA200800562A EA200800562A EA200800562A1 EA 200800562 A1 EA200800562 A1 EA 200800562A1 EA 200800562 A EA200800562 A EA 200800562A EA 200800562 A EA200800562 A EA 200800562A EA 200800562 A1 EA200800562 A1 EA 200800562A1
Authority
EA
Eurasian Patent Office
Prior art keywords
derivatives
imidazopiridine
canonabinoid
receptor ligand
diseases
Prior art date
Application number
EA200800562A
Other languages
English (en)
Inventor
Эндрю Джон Итертон
Джерард Мартин Пол Гиблин
Уилльям Леонард Митчелл
Алан Нэйлор
Ли Уилльям Пэйдж
Мартин Сварбрик
Дженнифер Энн Свитинг
Original Assignee
Глаксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0516380A external-priority patent/GB0516380D0/en
Priority claimed from GB0524324A external-priority patent/GB0524324D0/en
Application filed by Глаксо Груп Лимитед filed Critical Глаксо Груп Лимитед
Publication of EA200800562A1 publication Critical patent/EA200800562A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Настоящее изобретение относится к новым производным имидазопиридина, фармацевтическим композициям, содержащим эти соединения и к их применению при лечении болезней, особенно боли, где болезни вызываются, прямо или косвенно, увеличением или уменьшением активности каннабиноидного рецептора.
EA200800562A 2005-08-09 2006-08-07 Производные имидазопиридина в качестве лигандов каннабиноидного рецептора EA200800562A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0516380A GB0516380D0 (en) 2005-08-09 2005-08-09 Compounds
GB0524324A GB0524324D0 (en) 2005-11-29 2005-11-29 Compounds
PCT/EP2006/007812 WO2007017237A1 (en) 2005-08-09 2006-08-07 Imidazopyridine derivatives as cannabinoid receptor ligands

Publications (1)

Publication Number Publication Date
EA200800562A1 true EA200800562A1 (ru) 2008-06-30

Family

ID=37192394

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200800562A EA200800562A1 (ru) 2005-08-09 2006-08-07 Производные имидазопиридина в качестве лигандов каннабиноидного рецептора

Country Status (17)

Country Link
US (1) US20080221097A1 (ru)
EP (1) EP1912985A1 (ru)
JP (1) JP2009504587A (ru)
KR (1) KR20080034457A (ru)
AR (1) AR055601A1 (ru)
AU (1) AU2006278191A1 (ru)
BR (1) BRPI0614272A2 (ru)
CA (1) CA2618165A1 (ru)
CR (1) CR9787A (ru)
EA (1) EA200800562A1 (ru)
IL (1) IL188924A0 (ru)
MA (1) MA29694B1 (ru)
MX (1) MX2008001935A (ru)
NO (1) NO20081195L (ru)
PE (1) PE20070239A1 (ru)
TW (1) TW200734335A (ru)
WO (1) WO2007017237A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0705803D0 (en) * 2007-03-28 2007-05-02 Glaxo Group Ltd Novel compounds
EP2415765A4 (en) 2009-03-30 2012-08-15 Astellas Pharma Inc PYRIMIDINE COMPOUND
WO2011097553A1 (en) 2010-02-08 2011-08-11 Allergan, Inc. Pyridazine derivatives useful as cannabinoid - 2 agonists
EP2599774B1 (en) * 2010-07-29 2016-07-06 Astellas Pharma Inc. Condensed pyridine compounds as cb2 cannabinoid receptor ligands

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0113245B1 (en) * 1982-12-29 1989-03-15 Kureha Kagaku Kogyo Kabushiki Kaisha Cephalosporin derivatives
US5112820A (en) * 1990-03-05 1992-05-12 Sterling Drug Inc. Anti-glaucoma compositions containing 2- and 3-aminomethyl-6-arylcarbonyl- or 6-phenylthio-2,3-dihydropyrrolo-(1,2,3-de)-1,4-benzoxazines and method of use thereof
FR2692575B1 (fr) * 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
US6696448B2 (en) * 1996-06-05 2004-02-24 Sugen, Inc. 3-(piperazinylbenzylidenyl)-2-indolinone compounds and derivatives as protein tyrosine kinase inhibitors
ATE237023T1 (de) * 1998-01-23 2003-04-15 Voith Paper Patent Gmbh Verfahren zur entfernung von feinen verunreinigungen aus einer faserstoffsuspension
US6232320B1 (en) * 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
US7332494B2 (en) * 2000-08-14 2008-02-19 Janssen Pharmaceutica, N.V. Method for treating allergies using substituted pyrazoles
US6579896B2 (en) * 2000-09-06 2003-06-17 Ortho-Mcneil Pharmaceutical, Inc. Method for treating allergies using substituted pyrazoles
US20040063744A1 (en) * 2002-05-28 2004-04-01 Tao Wang Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides
AU2003260436A1 (en) * 2002-08-21 2004-03-11 Glaxo Group Limited Pyrimidine compounds
GB0222493D0 (en) * 2002-09-27 2002-11-06 Glaxo Group Ltd Compounds
MXPA05008441A (es) * 2003-02-14 2005-10-19 Wyeth Corp Derivados de heterociclil-3-sulfonilindazol o azaindazol como ligandos de 5-hidroxitriptamina-6.
US20040214856A1 (en) * 2003-04-23 2004-10-28 Pfizer Inc Cannabinoid receptor ligands and uses thereof
DE602005010698D1 (de) * 2004-06-09 2008-12-11 Glaxo Group Ltd Pyrrolopyridinderivate

Also Published As

Publication number Publication date
AU2006278191A1 (en) 2007-02-15
JP2009504587A (ja) 2009-02-05
MX2008001935A (es) 2008-03-26
US20080221097A1 (en) 2008-09-11
IL188924A0 (en) 2008-08-07
CA2618165A1 (en) 2007-02-15
EP1912985A1 (en) 2008-04-23
CR9787A (es) 2008-05-05
BRPI0614272A2 (pt) 2011-03-22
MA29694B1 (fr) 2008-08-01
PE20070239A1 (es) 2007-04-01
KR20080034457A (ko) 2008-04-21
WO2007017237A1 (en) 2007-02-15
AR055601A1 (es) 2007-08-29
NO20081195L (no) 2008-04-28
TW200734335A (en) 2007-09-16

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