AR055601A1 - Compuestos derivados de imidazopiridina como ligandos de receptores canabinoides - Google Patents
Compuestos derivados de imidazopiridina como ligandos de receptores canabinoidesInfo
- Publication number
- AR055601A1 AR055601A1 ARP060103437A ARP060103437A AR055601A1 AR 055601 A1 AR055601 A1 AR 055601A1 AR P060103437 A ARP060103437 A AR P060103437A AR P060103437 A ARP060103437 A AR P060103437A AR 055601 A1 AR055601 A1 AR 055601A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- substituted
- unsubstituted
- cycloalkyl
- membered
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Composicion farmacéutica que lo compende y su uso para la fabricacion de un medicamento util para el tratamiento de una afeccion mediada por la actividad de receptores de cannabinoides de tipo 2, tal como trastorno inmune, trastorno inflamatorio, dolor, artritis reumatoide, esclerosis multiple, osteoartritis u osteoporosis. Reivindicacion 1. un compuesto de imidazopiridina caracterizado porque es de formula (1) en la que: X1 es NR4 u O; R1 se selecciona entre H, alquilo C1-6, cicloalquilo C3-6 y halo-alquilo C1-6 sustituido; R2 es H o (CH2)mR3 donde m es 0 o 1; o R1 y R2 junto con el átomo de N al que están unidos forman un anillo heterociclilo de 4 a 8 miembros no aromático opcionalmente sustituido; R3 es un grupo heterociclilo de 4 a 8 miembros no aromático, un grupo cicloalquilo C3-8, alquilo C1-10 lineal o ramificado, alquenilo C2-10, cicloalquenilo C3-8, alquinilo C2-10, cicloalquinilo C3-8 o un grupo fenilo, pudiendo estar cualquiera de ellos sin sustituir o sustituido, o R5; R4 se selecciona entre H, alquilo C1-6, cicloalquilo C3-6, alquilo C1-6 sustituido con halo, COCH3, y SO2Me; R5 es como se muestra en formula (2) donde p es 0, 1 o 2, y X es CH2, O, S o SO2; R6 es fenilo sin sustituir o sustituido, cicloalquilo C3-6 sin sustituir o sustituido o un anillo heterociclilo no aromático de 4 a 8 miembros sin sustituir o sustituido; R7 es OH, alcoxi C1-6, NR8aR8b, NHCOR9, NHSO2R9 o SOqR9; R8a es H o alquilo C1-6; R8b es H o alquilo C1-6; R9 es alquilo C1-6; R10 es H, alquilo C1-6 sustituido o sin sustituir o Cl; R12 es H o alquilo C1-6; R13 es H o alquilo C1-6; q es 0, 1 o 2; o un derivado farmacéuticamente aceptable del mismo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0516380A GB0516380D0 (en) | 2005-08-09 | 2005-08-09 | Compounds |
GB0524324A GB0524324D0 (en) | 2005-11-29 | 2005-11-29 | Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AR055601A1 true AR055601A1 (es) | 2007-08-29 |
Family
ID=37192394
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060103437A AR055601A1 (es) | 2005-08-09 | 2006-08-07 | Compuestos derivados de imidazopiridina como ligandos de receptores canabinoides |
Country Status (17)
Country | Link |
---|---|
US (1) | US20080221097A1 (es) |
EP (1) | EP1912985A1 (es) |
JP (1) | JP2009504587A (es) |
KR (1) | KR20080034457A (es) |
AR (1) | AR055601A1 (es) |
AU (1) | AU2006278191A1 (es) |
BR (1) | BRPI0614272A2 (es) |
CA (1) | CA2618165A1 (es) |
CR (1) | CR9787A (es) |
EA (1) | EA200800562A1 (es) |
IL (1) | IL188924A0 (es) |
MA (1) | MA29694B1 (es) |
MX (1) | MX2008001935A (es) |
NO (1) | NO20081195L (es) |
PE (1) | PE20070239A1 (es) |
TW (1) | TW200734335A (es) |
WO (1) | WO2007017237A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0705803D0 (en) * | 2007-03-28 | 2007-05-02 | Glaxo Group Ltd | Novel compounds |
CA2757188A1 (en) | 2009-03-30 | 2010-10-07 | Astellas Pharma Inc. | Pyrimidine compound |
KR20130020881A (ko) | 2010-02-08 | 2013-03-04 | 알러간, 인코포레이티드 | 칸나비노이드-2 효능제로서 유용한 피리다진 유도체 |
PL2599774T3 (pl) * | 2010-07-29 | 2017-01-31 | Astellas Pharma Inc. | Skondensowane związki pirydynowe, jako ligandy receptorów kannabinoidowych cb2 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0113245B1 (en) * | 1982-12-29 | 1989-03-15 | Kureha Kagaku Kogyo Kabushiki Kaisha | Cephalosporin derivatives |
US5112820A (en) * | 1990-03-05 | 1992-05-12 | Sterling Drug Inc. | Anti-glaucoma compositions containing 2- and 3-aminomethyl-6-arylcarbonyl- or 6-phenylthio-2,3-dihydropyrrolo-(1,2,3-de)-1,4-benzoxazines and method of use thereof |
FR2692575B1 (fr) * | 1992-06-23 | 1995-06-30 | Sanofi Elf | Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
US6696448B2 (en) * | 1996-06-05 | 2004-02-24 | Sugen, Inc. | 3-(piperazinylbenzylidenyl)-2-indolinone compounds and derivatives as protein tyrosine kinase inhibitors |
EP0931872B1 (de) * | 1998-01-23 | 2003-04-09 | Voith Paper Patent GmbH | Verfahren zur Entfernung von feinen Verunreinigungen aus einer Faserstoffsuspension |
US6232320B1 (en) * | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
US7332494B2 (en) * | 2000-08-14 | 2008-02-19 | Janssen Pharmaceutica, N.V. | Method for treating allergies using substituted pyrazoles |
MXPA03001960A (es) * | 2000-09-06 | 2004-03-18 | Johnson & Johnson | Un metodo para tratar alergias. |
US20040063744A1 (en) * | 2002-05-28 | 2004-04-01 | Tao Wang | Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides |
EP1534687B1 (en) * | 2002-08-21 | 2006-09-27 | Glaxo Group Limited | 2-phenylamino-4-trifluoromethyl-5-(benzyl- or pyridin-4-ylmethyl)carbamoylpyrimidine derivatives as selective cb2 cannabinoid receptor modulators |
GB0222493D0 (en) * | 2002-09-27 | 2002-11-06 | Glaxo Group Ltd | Compounds |
TW200418830A (en) * | 2003-02-14 | 2004-10-01 | Wyeth Corp | Heterocyclyl-3-sulfonylazaindole or-azaindazole derivatives as 5-hydroxytryptamine-6 ligands |
US20040214856A1 (en) * | 2003-04-23 | 2004-10-28 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
PT1753764E (pt) * | 2004-06-09 | 2009-01-28 | Glaxo Group Ltd | Derivados de pirrolopiridina |
-
2006
- 2006-08-07 TW TW095128913A patent/TW200734335A/zh unknown
- 2006-08-07 AU AU2006278191A patent/AU2006278191A1/en not_active Abandoned
- 2006-08-07 EA EA200800562A patent/EA200800562A1/ru unknown
- 2006-08-07 AR ARP060103437A patent/AR055601A1/es unknown
- 2006-08-07 MX MX2008001935A patent/MX2008001935A/es unknown
- 2006-08-07 US US11/997,918 patent/US20080221097A1/en not_active Abandoned
- 2006-08-07 WO PCT/EP2006/007812 patent/WO2007017237A1/en active Application Filing
- 2006-08-07 JP JP2008525462A patent/JP2009504587A/ja not_active Withdrawn
- 2006-08-07 KR KR1020087003128A patent/KR20080034457A/ko not_active Application Discontinuation
- 2006-08-07 PE PE2006000952A patent/PE20070239A1/es not_active Application Discontinuation
- 2006-08-07 BR BRPI0614272-9A patent/BRPI0614272A2/pt not_active Application Discontinuation
- 2006-08-07 CA CA002618165A patent/CA2618165A1/en not_active Abandoned
- 2006-08-07 EP EP06763009A patent/EP1912985A1/en not_active Withdrawn
-
2008
- 2008-01-21 IL IL188924A patent/IL188924A0/en unknown
- 2008-02-08 MA MA30633A patent/MA29694B1/fr unknown
- 2008-02-29 CR CR9787A patent/CR9787A/es not_active Application Discontinuation
- 2008-03-06 NO NO20081195A patent/NO20081195L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2618165A1 (en) | 2007-02-15 |
BRPI0614272A2 (pt) | 2011-03-22 |
KR20080034457A (ko) | 2008-04-21 |
CR9787A (es) | 2008-05-05 |
EA200800562A1 (ru) | 2008-06-30 |
IL188924A0 (en) | 2008-08-07 |
US20080221097A1 (en) | 2008-09-11 |
EP1912985A1 (en) | 2008-04-23 |
MA29694B1 (fr) | 2008-08-01 |
WO2007017237A1 (en) | 2007-02-15 |
AU2006278191A1 (en) | 2007-02-15 |
PE20070239A1 (es) | 2007-04-01 |
TW200734335A (en) | 2007-09-16 |
MX2008001935A (es) | 2008-03-26 |
NO20081195L (no) | 2008-04-28 |
JP2009504587A (ja) | 2009-02-05 |
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