ATE486078T1 - 5,6-disubstituierte oxadiazolopyrazine und thiadiazolopyrazine als liganden des cxc- chemokinrezeptors - Google Patents
5,6-disubstituierte oxadiazolopyrazine und thiadiazolopyrazine als liganden des cxc- chemokinrezeptorsInfo
- Publication number
- ATE486078T1 ATE486078T1 AT06785619T AT06785619T ATE486078T1 AT E486078 T1 ATE486078 T1 AT E486078T1 AT 06785619 T AT06785619 T AT 06785619T AT 06785619 T AT06785619 T AT 06785619T AT E486078 T1 ATE486078 T1 AT E486078T1
- Authority
- AT
- Austria
- Prior art keywords
- oxadiazolopyrazine
- thiadiazolopyrazine
- disubstituted
- ligands
- chemokine receptor
- Prior art date
Links
- 108091008928 CXC chemokine receptors Proteins 0.000 title 1
- 102000054900 CXCR Receptors Human genes 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- DLHRAOSKUZJSEB-UHFFFAOYSA-N oxadiazolo[4,5-b]pyrazine Chemical class C1=CN=C2ON=NC2=N1 DLHRAOSKUZJSEB-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000019034 Chemokines Human genes 0.000 abstract 1
- 108010012236 Chemokines Proteins 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Vascular Medicine (AREA)
- Virology (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69516205P | 2005-06-29 | 2005-06-29 | |
PCT/US2006/024908 WO2007005403A1 (en) | 2005-06-29 | 2006-06-27 | 5,6-di-substituted oxadiazolopyrazines and thiadiazolopyrazines as cxc-chemokine receptor ligands |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE486078T1 true ATE486078T1 (de) | 2010-11-15 |
Family
ID=37137404
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06785619T ATE486078T1 (de) | 2005-06-29 | 2006-06-27 | 5,6-disubstituierte oxadiazolopyrazine und thiadiazolopyrazine als liganden des cxc- chemokinrezeptors |
Country Status (10)
Country | Link |
---|---|
US (1) | US7897606B2 (de) |
EP (1) | EP1907399B1 (de) |
JP (1) | JP2009500328A (de) |
CN (1) | CN101253180B (de) |
AT (1) | ATE486078T1 (de) |
CA (1) | CA2613428A1 (de) |
DE (1) | DE602006017849D1 (de) |
ES (1) | ES2353401T3 (de) |
MX (1) | MX2008000367A (de) |
WO (1) | WO2007005403A1 (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20070011475A (ko) * | 2004-05-12 | 2007-01-24 | 쉐링 코포레이션 | Cxcr1 및 cxcr2 케모카인 길항제 |
CA2613607A1 (en) * | 2005-06-29 | 2007-01-04 | Schering Corporation | Di-substituted oxadiazoles as cxc-chemokine receptor ligands |
ES2784223T3 (es) | 2012-06-20 | 2020-09-23 | Univ Virginia Patent Foundation | Composiciones y procedimientos para regular la homeostasis de glucosa y la acción de insulina |
WO2023159248A1 (en) * | 2022-02-21 | 2023-08-24 | The Regents Of The University Of Colorado A Body Corporate | Re-sensitizing multidrug-resistant (mdr) gram-negative bacteria to colistin using ionophores |
WO2023192935A1 (en) * | 2022-03-30 | 2023-10-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods and compositions for the treatment for inflammation and fibrosis in retinal neovascular diseases |
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-
2006
- 2006-06-27 DE DE602006017849T patent/DE602006017849D1/de active Active
- 2006-06-27 AT AT06785619T patent/ATE486078T1/de not_active IP Right Cessation
- 2006-06-27 JP JP2008519469A patent/JP2009500328A/ja not_active Ceased
- 2006-06-27 ES ES06785619T patent/ES2353401T3/es active Active
- 2006-06-27 CN CN2006800315359A patent/CN101253180B/zh not_active Expired - Fee Related
- 2006-06-27 US US11/475,789 patent/US7897606B2/en not_active Expired - Fee Related
- 2006-06-27 MX MX2008000367A patent/MX2008000367A/es unknown
- 2006-06-27 EP EP06785619A patent/EP1907399B1/de active Active
- 2006-06-27 CA CA002613428A patent/CA2613428A1/en not_active Abandoned
- 2006-06-27 WO PCT/US2006/024908 patent/WO2007005403A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
CN101253180A (zh) | 2008-08-27 |
ES2353401T3 (es) | 2011-03-01 |
DE602006017849D1 (de) | 2010-12-09 |
JP2009500328A (ja) | 2009-01-08 |
US7897606B2 (en) | 2011-03-01 |
US20070015731A1 (en) | 2007-01-18 |
CN101253180B (zh) | 2011-08-03 |
EP1907399B1 (de) | 2010-10-27 |
CA2613428A1 (en) | 2007-01-11 |
WO2007005403A1 (en) | 2007-01-11 |
MX2008000367A (es) | 2008-03-07 |
EP1907399A1 (de) | 2008-04-09 |
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