AR033803A1 - Compuestos de dianilino escuarano, composiciones farmaceuticas que los comprenden, y el uso de los mismos en la fabricacion de medicamentos para tratar enfermedades mediadas por quimioquinas - Google Patents

Compuestos de dianilino escuarano, composiciones farmaceuticas que los comprenden, y el uso de los mismos en la fabricacion de medicamentos para tratar enfermedades mediadas por quimioquinas

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Publication number
AR033803A1
AR033803A1 ARP010100889A ARP010100889A AR033803A1 AR 033803 A1 AR033803 A1 AR 033803A1 AR P010100889 A ARP010100889 A AR P010100889A AR P010100889 A ARP010100889 A AR P010100889A AR 033803 A1 AR033803 A1 AR 033803A1
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AR
Argentina
Prior art keywords
alkyl
cr8r8
optionally substituted
heterocyclic
alkenyl
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ARP010100889A
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English (en)
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Smithkline Beecham Corp
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Publication of AR033803A1 publication Critical patent/AR033803A1/es

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Abstract

Compuestos de dianilino escuarano que tienen la fórmula (1), en la que: R se selecciona del grupo que consta de OH, SH y NHSO2Rd; Rd se selecciona del grupo que consta de NR6R7, alquilo, arilalquilo C1-4, arilalquenilo C2-4, heteroarilo, heteroarilalquilo C1-4, heteroarilalquenilo C2-4, heterocíclico y heterocíclico-alquilo C1-4, en el que los anillos arilo, heteroarilo y heterocíclico están todos opcionalmente sustituidos; R6 y R7 son independientemente hidrógeno, o un grupo alquilo C1-4, o R6 y R7 junto con el nitrógeno al que están unidos forman un anillo de 5 a 7 miembros, cuyo anillo contiene opcionalmente un heteroátomo adicional que se selecciona de oxígeno, nitrógeno o azufre, y cuyo anillo puede estar opcionalmente sustituido;R1 se selecciona independientemente del grupo que consta de hidrógeno, halógeno, nitro, ciano, alquilo C1-10 halosustituido, alquilo C1-10, alquenilo C2-10, alcoxi C1-10, alcoxi C1-10 halosustituido, azido, (CR8R8)qS(O)tR4, hidroxi, hidroxialquilo C1-4, arilo, arilalquilo C1-4, ariloxi, arilalquil C1-4-oxi, heteroarilo, heteroarilalquilo, heterocíclico, heterocíclico-alquilo C1-4, heteroarilalquil C1-4-oxi, aril-alquenilo C2-10, heteroaril-alquenilo C2-10, heterocíclico-alquenilo C2-10, (CR8R8)qNR4R5, alquenil C2-10-C(O)NR4R5, (CR8R8)qC(O)NR4R5, (CR8R8)qC(O)NR4R10, S(O)3H, S(O)3R8, (CR8R8)qC(O)R11, alquenil C2-10-C(O)R11, alquenil C2-10-C(O)OR11(CR8R8)q-C(O)OR12, (CR8R8)qOC(O)R11, (CR8R8)qNR4C(O)R11, (CR8R8)qNHS(O)2R17, (CR8R8)qS(O)2NR4R5, o dos restos R1 juntos pueden formar O-(CH2)s-O- o un anillo insaturado de 5 a 6 miembros; q es 0, o un número entero que tiene un valor de 1 a 10; t es 0, o un número entero que tiene un valor de 1 ó 2; s es un número entero que tiene un valor de 1 a 3; R4 y R5 se seleccionan independientemente del grupo que consta de hidrógeno, alquilo C1-4 opcionalmente sustituido, arilo opcionalmente sustituido, arilalquilo C1-4 opcionalmente sustituido, heteroarilo opcionalmente sustituido, heteroaril-alquilo C1-4 opcionalmente sustituido, heterocíclico y heterocíclico-alquilo C1-4, o R4 y R5, junto con el nitrógeno al que están unidos, forman un anillo de 5 a 7 miembros que opcionalmente comprende un heteroátomo adicional seleccionado de oxígeno, nitrógeno y azufre; Y se selecciona independientemente del grupo que consta de hidrógeno, halógeno, nitro, ciano, alquilo C1-10 halosustituido, alquilo C1-10, alquenilo C2-10, alcoxi C1-10, alcoxi C1-10 halosustituido, azido, (CR8R8)qS(O)tR4, hidroxi, hidroxialquilo C1-4, arilo, arilalquilo C1-4, ariloxi, arilalquil C1-4-oxi, heteroarilo, heteroarilalquilo, heteroaril-alquil C1-4-oxi, heterocíclico, heterocíclico-alquilo C1-4, aril-alquenilo C2-10, heteroaril-alquenilo C2-10, heterocíclico-alquenilo C2-10, (CR8R8)qNR4R5, alquenil C2-10-C(O)NR4R5, (CR8R8)qC(O)NR4R5, (CR8R8)qC(O)NR4R10, S(O)3H, S(O)3R8, (CR8R8)qC(O)R11, alquenil C2-10-C(O)R11, alquenil C2-10-C(O)OR11, C(O)R11, (CR8R8)q-C(O)OR12, (CR8R8)qOC(O)R11, (CR8R8)qNR4C(O)R11, (CR8R8)qNHS(O)2Rd, y (CR8R8)qS(O)2NR4R5, o dos restos Y juntos forman O-(CH2)s-O- o un anillo insaturado de 5 a 6 miembros; n es un número entero que tiene un valor de 1 a 5; m es un número entero que tiene un valor de 1 a 4; R8 es hidrógeno o alquilo C1-4; R10 es alquil C1-10-C(O)2R8; R11 se selecciona del grupo que consta de hidrógeno, alquilo C1-4, arilo opcionalmente sustituido, arilalquilo C1-4 opcionalmente sustituido, heteroarilo opcionalmente sustituido, heteroarilalquilo C1-4 opcionalmente sustituido, heterocíclico opcionalmente sustituido o heterocíclico-alquilo C1-4 opcionalmente sustituido; R12 se selecciona de hidrógeno, alquilo C1-10, arilo opcionalmente sustituido y arilalquilo opcionalmente sustituido; y R17 se selecciona del grupo que consta de alquilo C1-4, arilo, arilalquilo, heteroarilo, heteroaril-alquilo C1-4, heterocíclico y heterocíclico-alquilo C1-4, en el que los anillos que contienen arilo, heteroarilo y heterocíclico pueden estar todos ellos opcionalmente sustituidos. Estos compuestos son útiles para el tratamiento de enfermedades mediadas por quimioquinas. También se dan a conocer: composiciones farmacéuticas que los comprenden y el uso de dichos compuestos en la producción de medicamentos.
ARP010100889A 2000-03-01 2001-02-27 Compuestos de dianilino escuarano, composiciones farmaceuticas que los comprenden, y el uso de los mismos en la fabricacion de medicamentos para tratar enfermedades mediadas por quimioquinas AR033803A1 (es)

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US18618300P 2000-03-01 2000-03-01

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US20040132694A1 (en) * 2001-01-16 2004-07-08 Palovich Michael R. Il-8 receptor antagonists
SK9782003A3 (en) * 2001-02-02 2004-01-08 Schering Corp 3,4-Di-substituted cyclobutene-1,2-diones as CXC chemokine receptor antagonists
US7132445B2 (en) 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
US20040106794A1 (en) 2001-04-16 2004-06-03 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
SI1818325T1 (sl) * 2001-04-16 2010-06-30 Schering Corp DI substituirani ciklobuten dioni kot ligandi CXC kemokinskega receptorja
US6903131B2 (en) 2001-10-12 2005-06-07 Schering Corporation 3,4-di-substituted maleimide compounds as CXC chemokine receptor antagonists
US6878709B2 (en) 2002-01-04 2005-04-12 Schering Corporation 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
US20040053953A1 (en) * 2002-03-18 2004-03-18 Schering Corporation Treatment of chemokine mediated diseases
MXPA05003867A (es) 2002-10-09 2005-11-23 Schering Corp Tiadiazoldioxidos y tiadiazoloxidos como ligandos de receptor cxc-y cc-quimiocina.
TW200528450A (en) 2003-12-19 2005-09-01 Schering Corp Thiadiazoles as cxc-and cc-chemokine receptor ligands
JP4851943B2 (ja) * 2003-12-22 2012-01-11 シェーリング コーポレイション Ｃｘｃ−ケモカインレセプターリガンドおよびｃｃ−ケモカインレセプターリガンドとしてのイソチアゾールジオキシド
WO2007002764A2 (en) 2005-06-29 2007-01-04 Schering Corporation Di-substituted oxadiazoles as cxc-chemokine receptor ligands
WO2007005403A1 (en) 2005-06-29 2007-01-11 Schering Corporation 5,6-di-substituted oxadiazolopyrazines and thiadiazolopyrazines as cxc-chemokine receptor ligands
TWI734715B (zh) 2015-11-19 2021-08-01 美商卡默森屈有限公司 趨化因子受體調節劑
TWI724056B (zh) 2015-11-19 2021-04-11 美商卡默森屈有限公司 Ｃｘｃｒ２抑制劑
EP3737366A4 (en) 2018-01-08 2022-07-27 ChemoCentryx, Inc. METHOD OF TREATMENT OF GENERALIZED PUSTULOUS PSORIASIS WITH AN ANTAGONIST OF CCR6 OR CXCR2
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NO20024133L (no) 2002-10-31
CN1416339A (zh) 2003-05-07
CA2401659A1 (en) 2001-09-07
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ZA200206988B (en) 2003-10-16
JP2003525242A (ja) 2003-08-26
CZ20022932A3 (cs) 2003-05-14
EP1261328A4 (en) 2003-05-28
EP1261328A1 (en) 2002-12-04
SK12352002A3 (sk) 2003-02-04
MXPA02008589A (es) 2003-02-24
NO20024133D0 (no) 2002-08-30
OA12184A (en) 2006-05-09
KR20020080460A (ko) 2002-10-23
AP2002002605A0 (en) 2002-09-30
AU2001239970A1 (en) 2001-09-12
DE60112051T2 (de) 2006-04-27
HUP0300599A2 (hu) 2003-07-28
PE20011190A1 (es) 2002-01-06
DZ3309A1 (en) 2001-09-07
HUP0300599A3 (en) 2003-09-29
MA25657A1 (fr) 2002-12-31
UY26601A1 (es) 2001-08-27
BR0108866A (pt) 2004-02-25
DE60112051D1 (de) 2005-08-25
EP1261328B1 (en) 2005-07-20
ATE299698T1 (de) 2005-08-15
EA200200933A1 (ru) 2003-02-27
IL151429A0 (en) 2003-04-10
ES2245976T3 (es) 2006-02-01
WO2001064208A1 (en) 2001-09-07

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