UY26601A1 - Antagonistas de los receptores de il-8 - Google Patents

Antagonistas de los receptores de il-8

Info

Publication number
UY26601A1
UY26601A1 UY26601A UY26601A UY26601A1 UY 26601 A1 UY26601 A1 UY 26601A1 UY 26601 A UY26601 A UY 26601A UY 26601 A UY26601 A UY 26601A UY 26601 A1 UY26601 A1 UY 26601A1
Authority
UY
Uruguay
Prior art keywords
receptor antagonists
squarates
dianilino
treatment
relates
Prior art date
Application number
UY26601A
Other languages
English (en)
Inventor
Michael Robert Palovich
Katherine Widdowson
Joseph Weinstock
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of UY26601A1 publication Critical patent/UY26601A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)

Abstract

Esta invención se refiere al nuevo uso de dianilino escuaratos en el tratamiento de estados de enfermedades mediados por la quimioquina interleuquina-8 (IL-8).
UY26601A 2000-03-01 2001-03-01 Antagonistas de los receptores de il-8 UY26601A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18618300P 2000-03-01 2000-03-01

Publications (1)

Publication Number Publication Date
UY26601A1 true UY26601A1 (es) 2001-08-27

Family

ID=22683958

Family Applications (1)

Application Number Title Priority Date Filing Date
UY26601A UY26601A1 (es) 2000-03-01 2001-03-01 Antagonistas de los receptores de il-8

Country Status (28)

Country Link
EP (1) EP1261328B1 (es)
JP (1) JP2003525242A (es)
KR (1) KR20020080460A (es)
CN (1) CN1416339A (es)
AP (1) AP2002002605A0 (es)
AR (1) AR033803A1 (es)
AT (1) ATE299698T1 (es)
AU (1) AU2001239970A1 (es)
BG (1) BG107014A (es)
BR (1) BR0108866A (es)
CA (1) CA2401659A1 (es)
CZ (1) CZ20022932A3 (es)
DE (1) DE60112051T2 (es)
DZ (1) DZ3309A1 (es)
EA (1) EA200200933A1 (es)
ES (1) ES2245976T3 (es)
HU (1) HUP0300599A3 (es)
IL (1) IL151429A0 (es)
MA (1) MA25657A1 (es)
MX (1) MXPA02008589A (es)
NO (1) NO20024133L (es)
OA (1) OA12184A (es)
PE (1) PE20011190A1 (es)
PL (1) PL358540A1 (es)
SK (1) SK12352002A3 (es)
UY (1) UY26601A1 (es)
WO (1) WO2001064208A1 (es)
ZA (1) ZA200206988B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02011868A (es) * 2000-05-30 2003-04-10 Smithkline Beecham Corp Antagonistas de receptor de interleucina 8.
WO2002067919A1 (en) * 2001-01-16 2002-09-06 Smithkline Beecham Corporation Il-8 receptor antagonists
EP1355875A1 (en) * 2001-02-02 2003-10-29 Schering Corporation 3,4-di-substituted cyclobutene-1, 2-diones as cxc chemokine receptor antagonists
US20040106794A1 (en) 2001-04-16 2004-06-03 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
US7132445B2 (en) 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
MY149050A (en) * 2001-04-16 2013-07-15 Merck Sharp & Dohme 3,4 di-substituted cyclobutene-1,2-diones as cxc-chemokine receptor ligands
EP1434775A1 (en) 2001-10-12 2004-07-07 Schering Corporation 3,4-di-substituted maleimide compounds as cxc-chemokine receptor antagonists
US6878709B2 (en) 2002-01-04 2005-04-12 Schering Corporation 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
WO2003080053A1 (en) 2002-03-18 2003-10-02 Schering Corporation Combination treatments for chemokine-mediated diseases
CN1720240B (zh) * 2002-10-09 2010-10-27 先灵公司 作为cxc-和cc-趋化因子受体配体的噻二唑二氧化物和噻二唑氧化物
CN1918138B (zh) 2003-12-19 2011-05-04 先灵公司 作为cxc-和cc-趋化因子受体配体的噻二唑化合物
MXPA06007205A (es) * 2003-12-22 2006-08-31 Schering Corp Dioxidos de isotiazol como ligandos del receptor cxc y cc-quimiocina.
EP1907399B1 (en) 2005-06-29 2010-10-27 Schering Corporation 5,6-di-substituted oxadiazolopyrazines and thiadiazolopyrazines as cxc-chemokine receptor ligands
JP2009500334A (ja) 2005-06-29 2009-01-08 シェーリング コーポレイション Ｃｘｃ−ケモカインレセプターリガンドとしてのジ置換オキサジアゾール
TWI724056B (zh) 2015-11-19 2021-04-11 美商卡默森屈有限公司 Ｃｘｃｒ２抑制劑
TWI734715B (zh) 2015-11-19 2021-08-01 美商卡默森屈有限公司 趨化因子受體調節劑
CN111867579B (zh) 2018-01-08 2023-11-24 凯莫森特里克斯股份有限公司 Ccr6或cxcr2拮抗剂治疗泛发性脓疱型银屑病的方法
CN112851635B (zh) * 2019-11-28 2022-09-16 中国医学科学院药物研究所 环状砜类化合物及其制备方法、用途和药物组合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5780483A (en) * 1995-02-17 1998-07-14 Smithkline Beecham Corporation IL-8 receptor antagonists

Also Published As

Publication number Publication date
AR033803A1 (es) 2004-01-07
DZ3309A1 (en) 2001-09-07
EA200200933A1 (ru) 2003-02-27
EP1261328A4 (en) 2003-05-28
PE20011190A1 (es) 2002-01-06
MXPA02008589A (es) 2003-02-24
PL358540A1 (en) 2004-08-09
HUP0300599A2 (hu) 2003-07-28
CN1416339A (zh) 2003-05-07
CA2401659A1 (en) 2001-09-07
WO2001064208A1 (en) 2001-09-07
EP1261328B1 (en) 2005-07-20
IL151429A0 (en) 2003-04-10
EP1261328A1 (en) 2002-12-04
NO20024133D0 (no) 2002-08-30
DE60112051D1 (de) 2005-08-25
KR20020080460A (ko) 2002-10-23
DE60112051T2 (de) 2006-04-27
HUP0300599A3 (en) 2003-09-29
AP2002002605A0 (en) 2002-09-30
ES2245976T3 (es) 2006-02-01
MA25657A1 (fr) 2002-12-31
ZA200206988B (en) 2003-10-16
JP2003525242A (ja) 2003-08-26
NO20024133L (no) 2002-10-31
AU2001239970A1 (en) 2001-09-12
SK12352002A3 (sk) 2003-02-04
BR0108866A (pt) 2004-02-25
ATE299698T1 (de) 2005-08-15
OA12184A (en) 2006-05-09
BG107014A (bg) 2003-05-30
CZ20022932A3 (cs) 2003-05-14

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