BR0007864A - Composto, e, uso de um composto - Google Patents

Composto, e, uso de um composto

Info

Publication number
BR0007864A
BR0007864A BR0007864-6A BR0007864A BR0007864A BR 0007864 A BR0007864 A BR 0007864A BR 0007864 A BR0007864 A BR 0007864A BR 0007864 A BR0007864 A BR 0007864A
Authority
BR
Brazil
Prior art keywords
compound
compounds
methods
certain
receptor antagonists
Prior art date
Application number
BR0007864-6A
Other languages
English (en)
Inventor
Joel M Linden
Gail W Sullivan
Ian J Sarembock
Timothy Macdonald
Mark Okusa
Irving L Kron
W Michael Scheld
Original Assignee
Univ Virginia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/333,387 external-priority patent/US6232297B1/en
Application filed by Univ Virginia filed Critical Univ Virginia
Publication of BR0007864A publication Critical patent/BR0007864A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Abstract

"COMPOSTO, E, USO DE UM COMPOSTO". Compostos e métodos são fornecidos para tratar condições inflamatórias com certos antagonistas do receptor de adenosina A~ 2A~.
BR0007864-6A 1999-02-01 2000-01-31 Composto, e, uso de um composto BR0007864A (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US11802999P 1999-02-01 1999-02-01
US12431699P 1999-03-12 1999-03-12
US13337499P 1999-05-10 1999-05-10
US13557399P 1999-05-24 1999-05-24
US09/333,387 US6232297B1 (en) 1999-02-01 1999-06-15 Methods and compositions for treating inflammatory response
US15141299P 1999-08-30 1999-08-30
PCT/US2000/002324 WO2000044763A2 (en) 1999-02-01 2000-01-31 Compositions for treating inflammatory response

Publications (1)

Publication Number Publication Date
BR0007864A true BR0007864A (pt) 2001-11-06

Family

ID=27557920

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0007864-6A BR0007864A (pt) 1999-02-01 2000-01-31 Composto, e, uso de um composto

Country Status (26)

Country Link
EP (1) EP1150991B1 (pt)
JP (1) JP4837831B2 (pt)
KR (1) KR100668006B1 (pt)
CN (1) CN1191266C (pt)
AR (1) AR029332A1 (pt)
AT (1) ATE263777T1 (pt)
AU (2) AU778870B2 (pt)
BR (1) BR0007864A (pt)
CA (1) CA2361614C (pt)
CZ (1) CZ296404B6 (pt)
DE (1) DE60009665T2 (pt)
DK (1) DK1150991T3 (pt)
EE (1) EE05185B1 (pt)
ES (1) ES2215609T3 (pt)
HK (1) HK1047288A1 (pt)
HU (1) HU228937B1 (pt)
IL (2) IL144188A0 (pt)
MX (1) MXPA01007850A (pt)
MY (1) MY129445A (pt)
NO (1) NO321216B1 (pt)
NZ (1) NZ513096A (pt)
PL (1) PL199953B1 (pt)
PT (1) PT1150991E (pt)
SK (1) SK284877B6 (pt)
UA (1) UA72912C2 (pt)
WO (1) WO2000044763A2 (pt)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8178509B2 (en) 2006-02-10 2012-05-15 University Of Virginia Patent Foundation Method to treat sickle cell disease
US8188063B2 (en) 2006-06-19 2012-05-29 University Of Virginia Patent Foundation Use of adenosine A2A modulators to treat spinal cord injury

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6514949B1 (en) 1994-07-11 2003-02-04 University Of Virginia Patent Foundation Method compositions for treating the inflammatory response
US6448235B1 (en) 1994-07-11 2002-09-10 University Of Virginia Patent Foundation Method for treating restenosis with A2A adenosine receptor agonists
US7427606B2 (en) 1999-02-01 2008-09-23 University Of Virginia Patent Foundation Method to reduce inflammatory response in transplanted tissue
US7378400B2 (en) 1999-02-01 2008-05-27 University Of Virginia Patent Foundation Method to reduce an inflammatory response from arthritis
US6232297B1 (en) 1999-02-01 2001-05-15 University Of Virginia Patent Foundation Methods and compositions for treating inflammatory response
US6322771B1 (en) 1999-06-18 2001-11-27 University Of Virginia Patent Foundation Induction of pharmacological stress with adenosine receptor agonists
IL133680A0 (en) 1999-09-10 2001-04-30 Can Fite Technologies Ltd Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist
NZ545787A (en) 2001-10-01 2007-12-21 Univ Virginia 2-Propynyl adenosine analogs having A2A agonist activity and compositions thereof
US20050033044A1 (en) 2003-05-19 2005-02-10 Bristol-Myers Squibb Pharma Company Methods for preparing 2-alkynyladenosine derivatives
EP1740587A4 (en) * 2004-04-02 2009-07-15 Adenosine Therapeutics Llc SELECTIVE ANTAGONISTS OF A2A ADENOSINE RECEPTORS
EP1746885A4 (en) * 2004-05-03 2010-09-08 Univ Virginia ADENOSINE A2A RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETIC NEPHROPATHY
WO2006028618A1 (en) 2004-08-02 2006-03-16 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
US7442687B2 (en) 2004-08-02 2008-10-28 The University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having A2A agonist activity
JP5046930B2 (ja) 2004-08-02 2012-10-10 ユニバーシティ オブ バージニア パテント ファウンデーション Ａ２ａアゴニスト活性を有する修飾５’−リボース基を備えた２−プロピニルアデノシン類似体
US20100048501A1 (en) 2006-03-21 2010-02-25 Heinrich-Heine-Universitat Dusseldorf Phosphorylated A2A Receptor Agonists
US8058259B2 (en) 2007-12-20 2011-11-15 University Of Virginia Patent Foundation Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists
EP2306971B1 (en) 2008-07-03 2015-02-25 University Of Virginia Patent Foundation Unit dosage of apadenoson
WO2011002917A1 (en) 2009-06-30 2011-01-06 Pgxhealth, Llc Alkoxy-carbonyl-amino-alkynyl-adenosine compounds and derivatives thereof as a2a r agonists
FR2960876B1 (fr) 2010-06-03 2012-07-27 Sanofi Aventis Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique.
WO2020253867A1 (zh) * 2019-06-21 2020-12-24 中国人民解放军军事科学院军事医学研究院 具有a2a腺苷受体拮抗作用的小分子化合物

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
DE3537228A1 (de) * 1985-10-19 1987-04-23 Huels Chemische Werke Ag Verfahren zur herstellung von cyclohexylverbindungen
JPS6299330A (ja) * 1985-10-25 1987-05-08 Yamasa Shoyu Co Ltd 抗高血圧剤
DE68916036T2 (de) * 1988-11-15 1994-09-29 Yamasa Shoyu Kk Mittel zur behandlung und prophylaxe koronarer und zerebraler ischämischer erkrankungen.
CA2035038C (en) * 1989-06-20 1998-12-29 Toyofumi Yamaguchi Synthetic intermediates of 2-alkynyladenosines, processes for preparing the synthetic intermediates, processes for preparing 2-alkynyladenosines utilizing the synthetic intermediates, and stable 2-alkynyladenosine derivatives
WO1991009864A1 (en) * 1990-01-04 1991-07-11 Yamasa Shoyu Kabushiki Kaisha Drug for treating or preventing ischemic diseases of heart or brain
JPH03287537A (ja) * 1990-03-31 1991-12-18 Yamasa Shoyu Co Ltd 抗動脈硬化症剤
JP3025559B2 (ja) * 1990-07-19 2000-03-27 ヤマサ醤油株式会社 アデノシン誘導体
JP3053908B2 (ja) * 1991-06-28 2000-06-19 ヤマサ醤油株式会社 ２‐アルキニルアデノシン誘導体
JP3025557B2 (ja) * 1991-06-28 2000-03-27 ヤマサ醤油株式会社 ２‐アルキニルアデノシン誘導体
IT1254915B (it) * 1992-04-24 1995-10-11 Gloria Cristalli Derivati di adenosina ad attivita' a2 agonista
EP0983768A1 (en) * 1997-05-23 2000-03-08 Nippon Shinyaku Co., Ltd. Medicinal composition for prevention or treatment of hepatopathy
JP2002505687A (ja) * 1997-06-18 2002-02-19 ディスカバリー セラピューティクス，インコーポレイテッド 脈管再生手順の後の再狭窄を防止するための組成物および方法
JPH11335302A (ja) * 1998-05-26 1999-12-07 Toa Eiyo Ltd 安定な医薬組成物
JP3619017B2 (ja) * 1998-06-24 2005-02-09 日本臓器製薬株式会社 新規アラビノシルアデニン誘導体
JP2002173427A (ja) * 1998-09-01 2002-06-21 Yamasa Shoyu Co Ltd 眼疾患治療用医薬組成物

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8178509B2 (en) 2006-02-10 2012-05-15 University Of Virginia Patent Foundation Method to treat sickle cell disease
US8188063B2 (en) 2006-06-19 2012-05-29 University Of Virginia Patent Foundation Use of adenosine A2A modulators to treat spinal cord injury

Also Published As

Publication number Publication date
CA2361614A1 (en) 2000-08-03
DK1150991T3 (da) 2004-06-07
CZ296404B6 (cs) 2006-03-15
NO20013507D0 (no) 2001-07-13
WO2000044763A3 (en) 2000-12-14
EE05185B1 (et) 2009-06-15
UA72912C2 (uk) 2005-05-16
MXPA01007850A (es) 2002-08-20
ES2215609T3 (es) 2004-10-16
EP1150991B1 (en) 2004-04-07
HU228937B1 (en) 2013-06-28
JP2002536300A (ja) 2002-10-29
NO20013507L (no) 2001-09-18
WO2000044763A2 (en) 2000-08-03
HUP0200224A2 (en) 2002-06-29
AU2005201255A1 (en) 2005-04-21
NO321216B1 (no) 2006-04-03
MY129445A (en) 2007-04-30
AU778870B2 (en) 2004-12-23
EP1150991A2 (en) 2001-11-07
HK1047288A1 (en) 2003-02-14
NZ513096A (en) 2003-01-31
CA2361614C (en) 2008-08-26
CN1357002A (zh) 2002-07-03
DE60009665D1 (de) 2004-05-13
JP4837831B2 (ja) 2011-12-14
KR20020013494A (ko) 2002-02-20
DE60009665T2 (de) 2004-08-19
IL144188A0 (en) 2002-05-23
SK284877B6 (sk) 2006-01-05
IL144188A (en) 2008-12-29
AU2005201255B2 (en) 2008-02-28
CZ20012781A3 (cs) 2002-01-16
AR029332A1 (es) 2003-06-25
ATE263777T1 (de) 2004-04-15
CN1191266C (zh) 2005-03-02
KR100668006B1 (ko) 2007-01-15
EE200100397A (et) 2002-08-15
SK10972001A3 (sk) 2002-01-07
AU2745400A (en) 2000-08-18
PT1150991E (pt) 2004-08-31
PL199953B1 (pl) 2008-11-28
CA2361614E (en) 2000-08-03
HUP0200224A3 (en) 2005-02-28

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements