DE68916036T2 - Mittel zur behandlung und prophylaxe koronarer und zerebraler ischämischer erkrankungen. - Google Patents

Mittel zur behandlung und prophylaxe koronarer und zerebraler ischämischer erkrankungen.

Info

Publication number
DE68916036T2
DE68916036T2 DE68916036T DE68916036T DE68916036T2 DE 68916036 T2 DE68916036 T2 DE 68916036T2 DE 68916036 T DE68916036 T DE 68916036T DE 68916036 T DE68916036 T DE 68916036T DE 68916036 T2 DE68916036 T2 DE 68916036T2
Authority
DE
Germany
Prior art keywords
prophylaxis
coronary
agent
treatment
ischemic diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68916036T
Other languages
English (en)
Other versions
DE68916036D1 (de
Inventor
Kentaro Toa Eiyo Ltd Kenk Kogi
Toichi Abiru
Toyofumi Yamaguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toa Eiyo Ltd
Yamasa Shoyu KK
Original Assignee
Toa Eiyo Ltd
Yamasa Shoyu KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toa Eiyo Ltd, Yamasa Shoyu KK filed Critical Toa Eiyo Ltd
Publication of DE68916036D1 publication Critical patent/DE68916036D1/de
Application granted granted Critical
Publication of DE68916036T2 publication Critical patent/DE68916036T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE68916036T 1988-11-15 1989-11-15 Mittel zur behandlung und prophylaxe koronarer und zerebraler ischämischer erkrankungen. Expired - Fee Related DE68916036T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP28851388 1988-11-15
PCT/JP1989/001158 WO1990005526A1 (en) 1988-11-15 1989-11-15 Agent for treatment and prophylaxis of ischemic disease of heart or brain

Publications (2)

Publication Number Publication Date
DE68916036D1 DE68916036D1 (de) 1994-07-14
DE68916036T2 true DE68916036T2 (de) 1994-09-29

Family

ID=17731205

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68916036T Expired - Fee Related DE68916036T2 (de) 1988-11-15 1989-11-15 Mittel zur behandlung und prophylaxe koronarer und zerebraler ischämischer erkrankungen.

Country Status (5)

Country Link
US (1) US5270304A (de)
EP (1) EP0444196B1 (de)
KR (1) KR0137786B1 (de)
DE (1) DE68916036T2 (de)
WO (1) WO1990005526A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE127472T1 (de) * 1989-06-20 1995-09-15 Yamasa Shoyu Kk Zwischenverbindung für 2- alkynyladenosinherstellung, herstellung dieser zwischenverbindung, herstellung von 2- alkynyladenosin aus diesem zwischenprodukt sowie stabiles 2-alkynyladenosinderivat.
JP2740362B2 (ja) * 1991-02-12 1998-04-15 ヤマサ醤油株式会社 安定な固体状２‐オクチニルアデノシンおよびその製造法
US5589467A (en) * 1993-09-17 1996-12-31 Novo Nordisk A/S 2,5',N6-trisubstituted adenosine derivatives
EP0704215A3 (de) * 1994-06-02 1998-04-01 Takeda Chemical Industries, Ltd. Hemmer der Erhöhung vaskulärer Permeabilität
US5817641A (en) * 1994-07-21 1998-10-06 Thomas Jefferson University Treatment of enterotoxigenic diarrhea with 2-substituted adenosine derivatives
JP2002173427A (ja) * 1998-09-01 2002-06-21 Yamasa Shoyu Co Ltd 眼疾患治療用医薬組成物
KR100668006B1 (ko) * 1999-02-01 2007-01-15 유니버시티 오브 버지니아 페이턴트 파운데이션 염증 반응을 치료하기 위한 조성물
USRE47351E1 (en) 1999-06-22 2019-04-16 Gilead Sciences, Inc. 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists
US6214807B1 (en) * 1999-06-22 2001-04-10 Cv Therapeutics, Inc. C-pyrazole 2A A receptor agonists
US6403567B1 (en) 1999-06-22 2002-06-11 Cv Therapeutics, Inc. N-pyrazole A2A adenosine receptor agonists
US6180615B1 (en) * 1999-06-22 2001-01-30 Cv Therapeutics, Inc. Propargyl phenyl ether A2A receptor agonists
CA2439222C (en) * 2000-02-23 2009-07-14 Cv Therapeutics, Inc. Identification of partial agonists of the a2a adenosine receptor
WO2002020539A1 (fr) 2000-09-08 2002-03-14 Toa Eiyo Ltd. Derives d'adenosine et leur utilisation
US8470801B2 (en) 2002-07-29 2013-06-25 Gilead Sciences, Inc. Myocardial perfusion imaging methods and compositions
NZ537975A (en) * 2002-07-29 2007-08-31 Cv Therapeutics Inc Method of producing coronary vasodilation without peripheral vasodilation comprising administering at least 10 mcg of at least one A2A receptor agonist
US20050020915A1 (en) * 2002-07-29 2005-01-27 Cv Therapeutics, Inc. Myocardial perfusion imaging methods and compositions
US7980784B2 (en) * 2003-10-24 2011-07-19 Amec Geomatrix, Inc. Drainage management systems and methods
TWI346109B (en) * 2004-04-30 2011-08-01 Otsuka Pharma Co Ltd 4-amino-5-cyanopyrimidine derivatives
JP2008517063A (ja) * 2004-10-20 2008-05-22 シーブイ・セラピューティクス・インコーポレイテッド Ａ２ａアデノシンレセプターアゴニストの使用
KR101340078B1 (ko) * 2005-02-22 2013-12-11 치히로 야베 허혈 또는 허혈 재관류에 의해 발생하는 심기능 장해 혹은심근 장해의 예방 또는 치료제
CA2640089C (en) 2006-02-03 2013-07-23 Cv Therapeutics, Inc. Process for preparing an a2a-adenosine receptor agonist and its polymorphs
CA2655310A1 (en) * 2006-06-22 2008-05-29 Cv Therapeutics, Inc. Use of a2a adenosine receptor agonists in the treatment of ischemia
BRPI0716174A2 (pt) * 2006-09-01 2013-09-24 Cv Therapeutics Inc mÉtodos e composiÇÕes para aumentar a tolerabilidade de paciente durante mÉtodos de imagem do miocÁrdio.
US20090081120A1 (en) * 2006-09-01 2009-03-26 Cv Therapeutics, Inc. Methods and Compositions for Increasing Patient Tolerability During Myocardial Imaging Methods
CA2663361A1 (en) * 2006-09-29 2008-04-10 Cv Therapeutics, Inc. Methods for myocardial imaging in patients having a history of pulmonary disease
JP2010515081A (ja) * 2007-01-03 2010-05-06 ギリアード・パロ・アルト・インコーポレイテッド 心筋灌流画像化
AU2009296235A1 (en) * 2008-09-29 2010-04-01 Gilead Sciences, Inc. Combinations of a rate control agent and an A-2-alpha receptor antagonist for use in multidetector computed tomography methods
JP6545618B2 (ja) 2012-08-01 2019-07-17 ルイス アンド クラーク ファーマスーティカルズ，インコーポレイテッドＬｅｗｉｓ ａｎｄ Ｃｌａｒｋ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． Ａ２ａアゴニストとしてのｎ−アルキル２−（二置換）アルキニルアデノシン−５’−ウロンアミド
US9822141B2 (en) 2012-08-01 2017-11-21 Lewis And Clark Pharmaceuticals, Inc. N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as A2A agonists

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56152437U (de) * 1980-04-14 1981-11-14
JPS6299395A (ja) * 1985-10-25 1987-05-08 Yamasa Shoyu Co Ltd ２−アルキニルアデノシンおよび抗高血圧剤
JPS62219876A (ja) * 1986-03-20 1987-09-28 Fujitsu Ltd 画信号の記録方法
EP0290496B2 (de) * 1986-10-06 1995-12-20 The University Of Virginia Alumni Patents Foundation Verwendung einer adenosin, hypoxanthin und ribose enthaltender lösung zur schonung des herzens während chirurgischer eingriffe

Also Published As

Publication number Publication date
DE68916036D1 (de) 1994-07-14
KR0137786B1 (ko) 1998-05-15
KR900701282A (ko) 1990-12-01
US5270304A (en) 1993-12-14
WO1990005526A1 (en) 1990-05-31
EP0444196A1 (de) 1991-09-04
EP0444196A4 (en) 1991-11-27
EP0444196B1 (de) 1994-06-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee