ATE127472T1 - Zwischenverbindung für 2- alkynyladenosinherstellung, herstellung dieser zwischenverbindung, herstellung von 2- alkynyladenosin aus diesem zwischenprodukt sowie stabiles 2-alkynyladenosinderivat. - Google Patents

Zwischenverbindung für 2- alkynyladenosinherstellung, herstellung dieser zwischenverbindung, herstellung von 2- alkynyladenosin aus diesem zwischenprodukt sowie stabiles 2-alkynyladenosinderivat.

Info

Publication number
ATE127472T1
ATE127472T1 AT90909403T AT90909403T ATE127472T1 AT E127472 T1 ATE127472 T1 AT E127472T1 AT 90909403 T AT90909403 T AT 90909403T AT 90909403 T AT90909403 T AT 90909403T AT E127472 T1 ATE127472 T1 AT E127472T1
Authority
AT
Austria
Prior art keywords
alkynyladenosine
production
intermediate compound
derivative
compound
Prior art date
Application number
AT90909403T
Other languages
English (en)
Inventor
Toyofumi Heim Nishi- Yamaguchi
Takanori Miyashita
Shinji Sakata
Toichi Abiru
Akira - Minamishinkawa Matsuda
Nishi -Chome K Monbusho-Youchi
Tohru - Maruyamanishi-Mac Ueda
Kentaro Toa Eiyo Ltd Kenk Kogi
Machi
Original Assignee
Yamasa Shoyu Kk
Toa Eiyo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Shoyu Kk, Toa Eiyo Ltd filed Critical Yamasa Shoyu Kk
Application granted granted Critical
Publication of ATE127472T1 publication Critical patent/ATE127472T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Ladders (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT90909403T 1989-06-20 1990-06-20 Zwischenverbindung für 2- alkynyladenosinherstellung, herstellung dieser zwischenverbindung, herstellung von 2- alkynyladenosin aus diesem zwischenprodukt sowie stabiles 2-alkynyladenosinderivat. ATE127472T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15751789 1989-06-20
JP472790 1990-01-13

Publications (1)

Publication Number Publication Date
ATE127472T1 true ATE127472T1 (de) 1995-09-15

Family

ID=26338545

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90909403T ATE127472T1 (de) 1989-06-20 1990-06-20 Zwischenverbindung für 2- alkynyladenosinherstellung, herstellung dieser zwischenverbindung, herstellung von 2- alkynyladenosin aus diesem zwischenprodukt sowie stabiles 2-alkynyladenosinderivat.

Country Status (8)

Country Link
US (2) US5283327A (de)
EP (1) EP0429681B1 (de)
KR (1) KR920700218A (de)
AT (1) ATE127472T1 (de)
CA (1) CA2035038C (de)
DE (1) DE69022176T2 (de)
ES (1) ES2077070T3 (de)
WO (1) WO1990015812A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5189027A (en) 1990-11-30 1993-02-23 Yamasa Shoyu Kabushiki Kaisha 2-substituted adenosine derivatives and pharmaceutical compositions for circulatory diseases
JP2740362B2 (ja) * 1991-02-12 1998-04-15 ヤマサ醤油株式会社 安定な固体状２‐オクチニルアデノシンおよびその製造法
CZ296404B6 (cs) * 1999-02-01 2006-03-15 University Of Virginia Patent Foundation 2-Alkynyladenosinové deriváty
US6214807B1 (en) 1999-06-22 2001-04-10 Cv Therapeutics, Inc. C-pyrazole 2A A receptor agonists
US6180615B1 (en) * 1999-06-22 2001-01-30 Cv Therapeutics, Inc. Propargyl phenyl ether A2A receptor agonists
US6403567B1 (en) 1999-06-22 2002-06-11 Cv Therapeutics, Inc. N-pyrazole A2A adenosine receptor agonists
USRE47351E1 (en) 1999-06-22 2019-04-16 Gilead Sciences, Inc. 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists
CA2671940A1 (en) * 2000-02-23 2001-08-30 Cv Therapeutics, Inc. Identification of partial agonists of the a2a adenosine receptor
CA2492855C (en) * 2002-07-29 2012-09-18 Cv Therapeutics, Inc. Myocardial perfusion imaging using a2a receptor agonists
US20050020915A1 (en) * 2002-07-29 2005-01-27 Cv Therapeutics, Inc. Myocardial perfusion imaging methods and compositions
US8470801B2 (en) 2002-07-29 2013-06-25 Gilead Sciences, Inc. Myocardial perfusion imaging methods and compositions
KR20070083714A (ko) * 2004-10-20 2007-08-24 씨브이 쎄러퓨틱스, 인코포레이티드 Ａ2ａ 아데노신 수용체 작용제의 용도
NZ570239A (en) * 2006-02-03 2011-09-30 Gilead Palo Alto Inc Preparation of (1-{ 9-[(4S,2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminopurin-2-yl} pyrazol-4-yl)-N-methylcarboxamide monohydrate
EP2068850A1 (de) * 2006-06-22 2009-06-17 Cv Therapeutics, Inc. Verwendung von a2a-adenosin-rezeptoragonisten bei der behandlung von ischämie
JP2010502649A (ja) * 2006-09-01 2010-01-28 シーブイ・セラピューティクス・インコーポレイテッド 心筋層画像化法中の患者の耐性を増加させるための方法および組成物
US20090081120A1 (en) * 2006-09-01 2009-03-26 Cv Therapeutics, Inc. Methods and Compositions for Increasing Patient Tolerability During Myocardial Imaging Methods
CA2663361A1 (en) * 2006-09-29 2008-04-10 Cv Therapeutics, Inc. Methods for myocardial imaging in patients having a history of pulmonary disease
CA2673653A1 (en) * 2007-01-03 2008-07-17 Cv Therapeutics, Inc. Myocardial perfusion imaging
AU2009296235A1 (en) * 2008-09-29 2010-04-01 Gilead Sciences, Inc. Combinations of a rate control agent and an A-2-alpha receptor antagonist for use in multidetector computed tomography methods
US9822141B2 (en) 2012-08-01 2017-11-21 Lewis And Clark Pharmaceuticals, Inc. N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as A2A agonists
CN104582709A (zh) 2012-08-01 2015-04-29 路易斯与克拉克药品公司 作为a2a激动剂的n-烷基2-(双取代的)炔基腺苷-5’-糖醛酰胺

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6299395A (ja) * 1985-10-25 1987-05-08 Yamasa Shoyu Co Ltd ２−アルキニルアデノシンおよび抗高血圧剤
KR0137786B1 (ko) * 1988-11-15 1998-05-15 하마구찌 미찌오 심장 또는 뇌의 허혈성 질환의 치료, 예방제

Also Published As

Publication number Publication date
DE69022176D1 (de) 1995-10-12
US5283327A (en) 1994-02-01
EP0429681A1 (de) 1991-06-05
CA2035038A1 (en) 1990-12-21
US5459254A (en) 1995-10-17
EP0429681B1 (de) 1995-09-06
CA2035038C (en) 1998-12-29
KR920700218A (ko) 1992-02-19
WO1990015812A1 (fr) 1990-12-27
ES2077070T3 (es) 1995-11-16
EP0429681A4 (en) 1992-03-11
DE69022176T2 (de) 1996-02-15

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