IT1254915B - Derivati di adenosina ad attivita' a2 agonista - Google Patents
Derivati di adenosina ad attivita' a2 agonistaInfo
- Publication number
- IT1254915B IT1254915B ITMI920973A ITMI920973A IT1254915B IT 1254915 B IT1254915 B IT 1254915B IT MI920973 A ITMI920973 A IT MI920973A IT MI920973 A ITMI920973 A IT MI920973A IT 1254915 B IT1254915 B IT 1254915B
- Authority
- IT
- Italy
- Prior art keywords
- agonist
- activity
- adenosine derivatives
- formula
- diseases
- Prior art date
Links
- 150000003835 adenosine derivatives Chemical class 0.000 title abstract 2
- 239000000556 agonist Substances 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000000653 nervous system Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Derivati d'adenosina ad attività A2 agonista di formula I (FORMULA I) processo per la loro preparazione e composizioni farmaceutiche che li contengono.I composti dell'invenzione sono utili per il trattamento di patologie cardiovascolari e malattie del sistema nervoso.
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI920973A IT1254915B (it) | 1992-04-24 | 1992-04-24 | Derivati di adenosina ad attivita' a2 agonista |
DE69328722T DE69328722T2 (de) | 1992-04-24 | 1993-04-21 | Adenosinderivate mit a2 agonistwirkung |
PCT/EP1993/000972 WO1993022328A1 (en) | 1992-04-24 | 1993-04-21 | Adenosine derivatives having a2 agonist activity |
ES93911492T ES2145774T3 (es) | 1992-04-24 | 1993-04-21 | Derivados de adenosina que tienen actividad agonista en a2. |
JP5518886A JPH07508718A (ja) | 1992-04-24 | 1993-04-21 | A↓2アゴニスト活性を有するアデノシン誘導体 |
AT93911492T ATE193299T1 (de) | 1992-04-24 | 1993-04-21 | Adenosinderivate mit a2 agonistwirkung |
EP93911492A EP0637315B1 (en) | 1992-04-24 | 1993-04-21 | Adenosine derivatives having a2 agonist activity |
US08/325,201 US5593975A (en) | 1992-04-24 | 1993-04-21 | Adenosine derivatives having A2 agonist activity |
CA002134067A CA2134067A1 (en) | 1992-04-24 | 1993-04-21 | Adenosine derivatives having a2 agonist activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI920973A IT1254915B (it) | 1992-04-24 | 1992-04-24 | Derivati di adenosina ad attivita' a2 agonista |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI920973A0 ITMI920973A0 (it) | 1992-04-24 |
ITMI920973A1 ITMI920973A1 (it) | 1993-10-24 |
IT1254915B true IT1254915B (it) | 1995-10-11 |
Family
ID=11363039
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI920973A IT1254915B (it) | 1992-04-24 | 1992-04-24 | Derivati di adenosina ad attivita' a2 agonista |
Country Status (9)
Country | Link |
---|---|
US (1) | US5593975A (it) |
EP (1) | EP0637315B1 (it) |
JP (1) | JPH07508718A (it) |
AT (1) | ATE193299T1 (it) |
CA (1) | CA2134067A1 (it) |
DE (1) | DE69328722T2 (it) |
ES (1) | ES2145774T3 (it) |
IT (1) | IT1254915B (it) |
WO (1) | WO1993022328A1 (it) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5646156A (en) * | 1994-04-25 | 1997-07-08 | Merck & Co., Inc. | Inhibition of eosinophil activation through A3 adenosine receptor antagonism |
US6448235B1 (en) | 1994-07-11 | 2002-09-10 | University Of Virginia Patent Foundation | Method for treating restenosis with A2A adenosine receptor agonists |
US6514949B1 (en) | 1994-07-11 | 2003-02-04 | University Of Virginia Patent Foundation | Method compositions for treating the inflammatory response |
YU44900A (sh) | 1998-01-31 | 2003-01-31 | Glaxo Group Limited | Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola |
US6117878A (en) * | 1998-02-24 | 2000-09-12 | University Of Virginia | 8-phenyl- or 8-cycloalkyl xanthine antagonists of A2B human adenosine receptors |
GB9813540D0 (en) * | 1998-06-23 | 1998-08-19 | Glaxo Group Ltd | Chemical compounds |
JP2002173427A (ja) * | 1998-09-01 | 2002-06-21 | Yamasa Shoyu Co Ltd | 眼疾患治療用医薬組成物 |
DE60009665T2 (de) * | 1999-02-01 | 2004-08-19 | The University Of Virginia Patent Foundation | Zusammensetzungen zur behandlung von entzündungsreaktionen |
US6232297B1 (en) | 1999-02-01 | 2001-05-15 | University Of Virginia Patent Foundation | Methods and compositions for treating inflammatory response |
US7378400B2 (en) | 1999-02-01 | 2008-05-27 | University Of Virginia Patent Foundation | Method to reduce an inflammatory response from arthritis |
US7427606B2 (en) * | 1999-02-01 | 2008-09-23 | University Of Virginia Patent Foundation | Method to reduce inflammatory response in transplanted tissue |
US6322771B1 (en) * | 1999-06-18 | 2001-11-27 | University Of Virginia Patent Foundation | Induction of pharmacological stress with adenosine receptor agonists |
US6214807B1 (en) * | 1999-06-22 | 2001-04-10 | Cv Therapeutics, Inc. | C-pyrazole 2A A receptor agonists |
US6403567B1 (en) * | 1999-06-22 | 2002-06-11 | Cv Therapeutics, Inc. | N-pyrazole A2A adenosine receptor agonists |
USRE47351E1 (en) | 1999-06-22 | 2019-04-16 | Gilead Sciences, Inc. | 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists |
US6180615B1 (en) | 1999-06-22 | 2001-01-30 | Cv Therapeutics, Inc. | Propargyl phenyl ether A2A receptor agonists |
GB0003960D0 (en) * | 2000-02-18 | 2000-04-12 | Pfizer Ltd | Purine derivatives |
US20020012946A1 (en) | 2000-02-23 | 2002-01-31 | Luiz Belardinelli | Method of identifying partial agonists of the A2A receptor |
WO2002020539A1 (fr) * | 2000-09-08 | 2002-03-14 | Toa Eiyo Ltd. | Derives d'adenosine et leur utilisation |
US6670334B2 (en) | 2001-01-05 | 2003-12-30 | University Of Virginia Patent Foundation | Method and compositions for treating the inflammatory response |
AP2003002828A0 (en) * | 2001-01-16 | 2003-09-30 | Vascular Therapies Llc | Implantable device containing resorbable matrix material and anti-proliferative drugs for preventing or treating failure of hemodialysis vascular access and other vascular grafts. |
AU2002362443B2 (en) * | 2001-10-01 | 2008-05-15 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof |
GB0129273D0 (en) * | 2001-12-06 | 2002-01-23 | Pfizer Ltd | Crystalline drug form |
US20050020915A1 (en) * | 2002-07-29 | 2005-01-27 | Cv Therapeutics, Inc. | Myocardial perfusion imaging methods and compositions |
NZ537975A (en) * | 2002-07-29 | 2007-08-31 | Cv Therapeutics Inc | Method of producing coronary vasodilation without peripheral vasodilation comprising administering at least 10 mcg of at least one A2A receptor agonist |
US8470801B2 (en) | 2002-07-29 | 2013-06-25 | Gilead Sciences, Inc. | Myocardial perfusion imaging methods and compositions |
US20050033044A1 (en) | 2003-05-19 | 2005-02-10 | Bristol-Myers Squibb Pharma Company | Methods for preparing 2-alkynyladenosine derivatives |
DE602004018808D1 (de) * | 2003-10-31 | 2009-02-12 | Cv Therapeutics Inc | Antagonisten des a2b-adenosinrezeptors |
TWI346109B (en) * | 2004-04-30 | 2011-08-01 | Otsuka Pharma Co Ltd | 4-amino-5-cyanopyrimidine derivatives |
NZ585697A (en) | 2004-08-02 | 2011-12-22 | Univ Virginia Patent Found | 2-propynyl adenosine analogs with modified 5'-ribose groups having A2A agonist activity |
US7576069B2 (en) | 2004-08-02 | 2009-08-18 | University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs having A2A agonist activity |
WO2006023272A1 (en) | 2004-08-02 | 2006-03-02 | University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs having a2a agonist activity |
CN101076343A (zh) * | 2004-10-20 | 2007-11-21 | Cv医药有限公司 | A2a腺苷受体激动剂的应用 |
GT200500281A (es) | 2004-10-22 | 2006-04-24 | Novartis Ag | Compuestos organicos. |
GB0500785D0 (en) | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
US7732595B2 (en) | 2006-02-03 | 2010-06-08 | Gilead Palo Alto, Inc. | Process for preparing an A2A-adenosine receptor agonist and its polymorphs |
WO2007092936A2 (en) * | 2006-02-08 | 2007-08-16 | University Of Virginia Patent Foundation | Method to treat gastric lesions |
WO2007120972A2 (en) | 2006-02-10 | 2007-10-25 | University Of Virginia Patent Foundation | Method to treat sickle cell disease |
JP5373599B2 (ja) | 2006-04-21 | 2013-12-18 | ノバルティス アーゲー | アデノシンa2a受容体アゴニストとして使用するためのプリン誘導体 |
GB0607950D0 (en) | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
US8188063B2 (en) * | 2006-06-19 | 2012-05-29 | University Of Virginia Patent Foundation | Use of adenosine A2A modulators to treat spinal cord injury |
MX2008016254A (es) * | 2006-06-22 | 2009-01-15 | Cv Therapeutics Inc | Uso de agonistas del receptor de adenosina a2a en el tratamiento de isquemia. |
EP1889846A1 (en) | 2006-07-13 | 2008-02-20 | Novartis AG | Purine derivatives as A2a agonists |
US20090081120A1 (en) * | 2006-09-01 | 2009-03-26 | Cv Therapeutics, Inc. | Methods and Compositions for Increasing Patient Tolerability During Myocardial Imaging Methods |
KR20090047499A (ko) * | 2006-09-01 | 2009-05-12 | 씨브이 쎄러퓨틱스, 인코포레이티드 | 심근 조영법 동안에 환자의 순응성을 증가시키기 위한 방법및 조성물 |
EP1903044A1 (en) | 2006-09-14 | 2008-03-26 | Novartis AG | Adenosine Derivatives as A2A Receptor Agonists |
JP2011502101A (ja) * | 2006-09-29 | 2011-01-20 | ギリアード・パロ・アルト・インコーポレイテッド | 肺疾患の病歴を有する患者における心筋画像化法 |
WO2008086096A2 (en) * | 2007-01-03 | 2008-07-17 | Cv Therapeutics, Inc. | Myocardial perfusion imaging |
US8058259B2 (en) * | 2007-12-20 | 2011-11-15 | University Of Virginia Patent Foundation | Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists |
CN102014959B (zh) | 2008-03-10 | 2016-01-20 | 康奈尔大学 | 血脑屏障通透性的调节 |
CA2737077A1 (en) * | 2008-09-29 | 2010-04-01 | Gilead Sciences, Inc. | Combinations of a rate control agent and an a-2-alpha receptor antagonist for use in multidetector computed tomography methods |
JP2012532140A (ja) | 2009-06-30 | 2012-12-13 | フォレスト・ラボラトリーズ・ホールディングス・リミテッド | A2ar作動薬としてのアルコキシ−カルボニル−アミノ−アルキニル−アデノシン化合物及びその誘導体 |
US9822141B2 (en) | 2012-08-01 | 2017-11-21 | Lewis And Clark Pharmaceuticals, Inc. | N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as A2A agonists |
KR20150036767A (ko) | 2012-08-01 | 2015-04-07 | 루이스 앤드 클라크 파마슈티컬스, 인코포레이티드 | A2a 효능제로서의 n-알킬 2-(이치환된)알키닐아데노신-5-유론아미드 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6299395A (ja) * | 1985-10-25 | 1987-05-08 | Yamasa Shoyu Co Ltd | 2−アルキニルアデノシンおよび抗高血圧剤 |
IL84414A0 (en) * | 1986-11-14 | 1988-04-29 | Ciba Geigy Ag | N9-cyclopentyl-substituted adenine derivatives |
FI880405A (fi) * | 1987-02-04 | 1988-08-05 | Ciba Geigy Ag | Adenosin-5'-karboxamidderivat. |
LU87181A1 (fr) * | 1987-04-06 | 1988-11-17 | Sandoz Sa | Nouveaux derives de l'acide furannuronique,leur preparation et leur utilisation comme medicaments |
US5034381A (en) * | 1988-01-07 | 1991-07-23 | Ciba-Geigy Corporation | 2-(substituted amino) adenosines as antihypertensives |
ZA902280B (en) * | 1989-03-29 | 1990-12-28 | Merrell Dow Pharma | Selective adenosine receptor agents |
-
1992
- 1992-04-24 IT ITMI920973A patent/IT1254915B/it active IP Right Grant
-
1993
- 1993-04-21 WO PCT/EP1993/000972 patent/WO1993022328A1/en active IP Right Grant
- 1993-04-21 ES ES93911492T patent/ES2145774T3/es not_active Expired - Lifetime
- 1993-04-21 AT AT93911492T patent/ATE193299T1/de active
- 1993-04-21 JP JP5518886A patent/JPH07508718A/ja active Pending
- 1993-04-21 DE DE69328722T patent/DE69328722T2/de not_active Expired - Fee Related
- 1993-04-21 EP EP93911492A patent/EP0637315B1/en not_active Expired - Lifetime
- 1993-04-21 CA CA002134067A patent/CA2134067A1/en not_active Abandoned
- 1993-04-21 US US08/325,201 patent/US5593975A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH07508718A (ja) | 1995-09-28 |
ATE193299T1 (de) | 2000-06-15 |
CA2134067A1 (en) | 1993-11-11 |
EP0637315A1 (en) | 1995-02-08 |
ES2145774T3 (es) | 2000-07-16 |
EP0637315B1 (en) | 2000-05-24 |
DE69328722D1 (de) | 2000-06-29 |
US5593975A (en) | 1997-01-14 |
WO1993022328A1 (en) | 1993-11-11 |
ITMI920973A0 (it) | 1992-04-24 |
ITMI920973A1 (it) | 1993-10-24 |
DE69328722T2 (de) | 2000-12-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970329 |