HUP0103203A2 - Azaadamantánszármazékok és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Azaadamantánszármazékok és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0103203A2
HUP0103203A2 HU0103203A HUP0103203A HUP0103203A2 HU P0103203 A2 HUP0103203 A2 HU P0103203A2 HU 0103203 A HU0103203 A HU 0103203A HU P0103203 A HUP0103203 A HU P0103203A HU P0103203 A2 HUP0103203 A2 HU P0103203A2
Authority
HU
Hungary
Prior art keywords
pharmaceutical compositions
azaadamantane
azaadamantane derivatives
derivatives
compounds
Prior art date
Application number
HU0103203A
Other languages
English (en)
Inventor
Xiong Cai
Gurmit Grewal
George Mark Latham
Anna Toy-Palmer
Original Assignee
Ucb, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb, S.A. filed Critical Ucb, S.A.
Publication of HUP0103203A2 publication Critical patent/HUP0103203A2/hu
Publication of HUP0103203A3 publication Critical patent/HUP0103203A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

A találmány (I) általános képletű azaadamantán, azanoradamantán ésazahomoadamantán szerkezetű vegyületekre, ahol R1, R2 és Q jelentésekülönböző szerves csoport, n és m értéke egymástól függetlenül 0, 1,2, 3 vagy 4; és a vegyületeket tartalmazó gyógyszerkészítményekrevonatkozik, amelyek fájdalom kezelésére használhatók muszkarinagonista, illetve antagonista hatásuk révén. Ó
HU0103203A 1998-08-18 1999-08-16 Azaadamantane derivatives and pharmaceutical compositions thereof HUP0103203A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9697798P 1998-08-18 1998-08-18
PCT/US1999/018570 WO2000011001A1 (en) 1998-08-18 1999-08-16 Muscarinic agonists and antagonists

Publications (2)

Publication Number Publication Date
HUP0103203A2 true HUP0103203A2 (hu) 2002-01-28
HUP0103203A3 HUP0103203A3 (en) 2002-10-28

Family

ID=22260061

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0103203A HUP0103203A3 (en) 1998-08-18 1999-08-16 Azaadamantane derivatives and pharmaceutical compositions thereof

Country Status (30)

Country Link
US (5) US6093724A (hu)
EP (1) EP1112272B1 (hu)
JP (1) JP2002523416A (hu)
KR (1) KR20010072784A (hu)
CN (1) CN1312812A (hu)
AR (1) AR020199A1 (hu)
AT (1) ATE227724T1 (hu)
AU (1) AU750566B2 (hu)
BG (1) BG105256A (hu)
BR (1) BR9913072A (hu)
CA (1) CA2340946A1 (hu)
CO (1) CO5130018A1 (hu)
DE (1) DE69903961T2 (hu)
EE (1) EE200100096A (hu)
ES (1) ES2191455T3 (hu)
HK (1) HK1038918A1 (hu)
HU (1) HUP0103203A3 (hu)
ID (1) ID27544A (hu)
IL (1) IL141050A0 (hu)
IS (1) IS5827A (hu)
NO (1) NO20010804L (hu)
NZ (1) NZ509762A (hu)
PE (1) PE20000988A1 (hu)
PL (1) PL346247A1 (hu)
RU (1) RU2219179C2 (hu)
SK (1) SK1892001A3 (hu)
TR (1) TR200100462T2 (hu)
WO (1) WO2000011001A1 (hu)
YU (1) YU13301A (hu)
ZA (1) ZA200100978B (hu)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001292160A1 (en) * 2000-10-19 2002-04-29 Pfizer Products Inc. Bridged piperazine derivatives
GB0117950D0 (en) * 2001-02-16 2001-09-19 Aventis Pharma Inc Novel heterocyclic urea derivatives andd their use as dopamine D3 receptor ligands
WO2002094827A1 (en) * 2001-05-23 2002-11-28 Neurosearch A/S Fused tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US20030064979A1 (en) * 2001-06-29 2003-04-03 Hansen Thomas Kruse Method of inhibiting PTP 1B and /or T-cell PTP and/or other PTPases with an Asp residue at position 48
US6828328B1 (en) * 2002-03-01 2004-12-07 Ucb S.A. Analgesic combination of muscarinic agonists
US7897766B2 (en) 2005-09-23 2011-03-01 Abbott Laboratories Amino-aza-adamantane derivatives and methods of use
US8314119B2 (en) * 2006-11-06 2012-11-20 Abbvie Inc. Azaadamantane derivatives and methods of use
US8076350B2 (en) 2006-12-22 2011-12-13 Abbott Laboratories Spirocyclic azaadamantane derivatives and methods of use
JP5364878B2 (ja) * 2007-03-23 2013-12-11 アッヴィ・インコーポレイテッド アザアダマンタンのアセトアミドおよびカルボキサミド誘導体ならびにそれらの使用方法
CA2679876A1 (en) * 2007-03-23 2008-10-02 Abbott Laboratories 4-substituted azaadamantane derivatives and methods of use thereof
CA2765466A1 (en) * 2009-06-19 2010-12-23 Abbott Laboratories Diazahomoadamantane derivatives and methods of use thereof
WO2011011060A1 (en) 2009-07-22 2011-01-27 Puretech Ventures Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation
US10265311B2 (en) 2009-07-22 2019-04-23 PureTech Health LLC Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation
AR081626A1 (es) 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
EP2560488B1 (en) 2010-04-23 2015-10-28 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
NZ707955A (en) * 2010-09-23 2016-03-31 Abbvie Bahamas Ltd Monohydrate of an azaadamantane derivative
US8759380B2 (en) 2011-04-22 2014-06-24 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use
US11325896B2 (en) 2017-12-20 2022-05-10 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor M4
SG11202102349PA (en) 2018-09-28 2021-04-29 Karuna Therapeutics Inc Compositions and methods for treating disorders ameliorated by muscarnic receptor activation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4739074A (en) * 1986-01-22 1988-04-19 Pennwalt Corporation Adamantane spiro-pyrrolidine derivatives
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
US5527813A (en) * 1990-08-21 1996-06-18 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
JPH06502616A (ja) * 1990-12-21 1994-03-24 メルク　シヤープ　エンド　ドーム　リミテツド 治療用化合物
US5955470A (en) * 1991-06-11 1999-09-21 Merrell Pharmaceuticals, Inc. Derivatives of amide analogs of certain methano bridged quinolizines
US5641791A (en) * 1991-08-13 1997-06-24 Novo Nordisk A.S Heterocyclic compounds and their preparation and use
EE03566B1 (et) * 1995-11-02 2001-12-17 Neurosearch A/S Kondenseerunud tropaanderivaadid, nende valmistamine ja kasutamine
US5914338A (en) * 1996-04-02 1999-06-22 Novo Nordisk Heterocyclic compounds and their preparation and use
US5952339A (en) * 1998-04-02 1999-09-14 Bencherif; Merouane Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release
US6057446A (en) * 1998-04-02 2000-05-02 Crooks; Peter Anthony Certain 1-aza-tricyclo [3.3.1-13,7 ] decane compounds
US5986100A (en) * 1998-04-02 1999-11-16 Crooks; Peter Anthony Pharmaceutical compositions and methods for use

Also Published As

Publication number Publication date
CA2340946A1 (en) 2000-03-02
EP1112272B1 (en) 2002-11-13
PL346247A1 (en) 2002-01-28
WO2000011001A1 (en) 2000-03-02
HUP0103203A3 (en) 2002-10-28
NZ509762A (en) 2002-12-20
KR20010072784A (ko) 2001-07-31
BG105256A (en) 2001-11-30
US6323194B1 (en) 2001-11-27
US6251916B1 (en) 2001-06-26
EP1112272A1 (en) 2001-07-04
YU13301A (sh) 2005-06-10
HK1038918A1 (zh) 2002-04-04
RU2219179C2 (ru) 2003-12-20
ID27544A (id) 2001-04-12
ZA200100978B (en) 2002-02-05
NO20010804D0 (no) 2001-02-16
SK1892001A3 (en) 2001-11-06
IL141050A0 (en) 2002-02-10
DE69903961D1 (de) 2002-12-19
US6093724A (en) 2000-07-25
CO5130018A1 (es) 2002-02-27
DE69903961T2 (de) 2003-07-03
US20020045617A1 (en) 2002-04-18
ES2191455T3 (es) 2003-09-01
JP2002523416A (ja) 2002-07-30
ATE227724T1 (de) 2002-11-15
AR020199A1 (es) 2002-05-02
AU750566B2 (en) 2002-07-25
TR200100462T2 (tr) 2001-09-21
PE20000988A1 (es) 2000-09-30
CN1312812A (zh) 2001-09-12
EE200100096A (et) 2002-06-17
AU5775899A (en) 2000-03-14
NO20010804L (no) 2001-04-11
IS5827A (is) 2001-01-26
US6423842B1 (en) 2002-07-23
BR9913072A (pt) 2001-05-15
US6555550B1 (en) 2003-04-29

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