CO5130018A1 - Agonistas y antagonistas muscarinicos . - Google Patents
Agonistas y antagonistas muscarinicos .Info
- Publication number
- CO5130018A1 CO5130018A1 CO99052330A CO99052330A CO5130018A1 CO 5130018 A1 CO5130018 A1 CO 5130018A1 CO 99052330 A CO99052330 A CO 99052330A CO 99052330 A CO99052330 A CO 99052330A CO 5130018 A1 CO5130018 A1 CO 5130018A1
- Authority
- CO
- Colombia
- Prior art keywords
- independently
- alkyl
- halogen
- alkoxy
- branched
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto que consiste en un sistema de anillo azaciclico de fórmula (I) :<EMI FILE="99052330_1" ID="1" IMF=JPEG >incluyendo sus isómeros geométricos, enantiómeros, diastereómeros, racematos, sales de adición de ácido, sales de los mismos con un ácido farmacéuticamente aceptable y pro-drogas de los mismos, en donde Q es<EMI FILE="99052330_2" ID="2" IMF=JPEG >X es CH2, NH, O o S;V, W, y y Z son independientemente CH o N,n y m son independientemente O, 1, 2, 3 ó 4;R1 y R2 están en cualquier posición en el anillo azacíclico, incluyendo el punto de unión del heterociclo Q e, independientemente, son hidrógeno, -OH, halógeno, -NH2, carboxi, alquil C1-10 recto o ramificado, alquenil C1-10 o alquinil C1-10, alcoxi C1-10, recto o ramificado o alquil C1-10 recto o ramificado, substituido con -OH, -CO, -CHO, OR3, -SR3, -NH2, NHR3, NR3R4, -NO2, SOR3, SO2R3, -COR3, -CONH2, -CONHR3, CONR3R4 o -CH=NOR3; o R1 y R2 son independientemente fenil, fenoxi, benzoíl, bencil o benciloxicarbonil, cada uno de los cuales está no-substituido o substituido con halógeno, -CN, alquil C1-10, alcoxi C1-10 o alquiltio C1-10,R es hidrógeno o halógeno, -CN, -CHO, -OH, OR3, -SR3, -NH2, NHR3, NR3R4, -NO2, -SOR3, -SO2R3, -COR3, -CO2R3, CONH2, -CONHR3, CONR3R4 o -CH=NOR3, oR es fenil, fenoxi, benzoil, bencil, o benciloxicarbonil, cada uno de los cuales está no-substituido o substituido con halógeno, -CN, alquil C1-15, alcoxi C1-10, o alquiltio C 1-10; oR es un anillo heterocíclico, de 5 o 6 miembros, saturado, parcialmente saturado o aromático que contiene uno a tresheteroátomos; yR3 y R4 son independientemente alquil C1-15 recto, ramificado o ciclico, alquenil C2-15, alquinil C2-15 o combinaciones de los mismos, o R3 y R4 son independientemente grupos fenil, fenoxi, benzoil o benciloxicarbonil, cada uno de los cuales están no-substituidos o substituidos con H, halógeno, -CN, alquil C1-15, alcoxi C1-10, alquiltio C1-10 o aril; oR3 y R4 son independientemente anillos heterocíclicos de 5 o 6 miembros, saturados, parcialmente saturados o aromáticos, que contienen uno a tres heteroátomos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9697798P | 1998-08-18 | 1998-08-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5130018A1 true CO5130018A1 (es) | 2002-02-27 |
Family
ID=22260061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO99052330A CO5130018A1 (es) | 1998-08-18 | 1999-08-18 | Agonistas y antagonistas muscarinicos . |
Country Status (30)
| Country | Link |
|---|---|
| US (5) | US6093724A (es) |
| EP (1) | EP1112272B1 (es) |
| JP (1) | JP2002523416A (es) |
| KR (1) | KR20010072784A (es) |
| CN (1) | CN1312812A (es) |
| AR (1) | AR020199A1 (es) |
| AT (1) | ATE227724T1 (es) |
| AU (1) | AU750566B2 (es) |
| BG (1) | BG105256A (es) |
| BR (1) | BR9913072A (es) |
| CA (1) | CA2340946A1 (es) |
| CO (1) | CO5130018A1 (es) |
| DE (1) | DE69903961T2 (es) |
| EE (1) | EE200100096A (es) |
| ES (1) | ES2191455T3 (es) |
| HK (1) | HK1038918A1 (es) |
| HU (1) | HUP0103203A3 (es) |
| ID (1) | ID27544A (es) |
| IL (1) | IL141050A0 (es) |
| IS (1) | IS5827A (es) |
| NO (1) | NO20010804L (es) |
| NZ (1) | NZ509762A (es) |
| PE (1) | PE20000988A1 (es) |
| PL (1) | PL346247A1 (es) |
| RU (1) | RU2219179C2 (es) |
| SK (1) | SK1892001A3 (es) |
| TR (1) | TR200100462T2 (es) |
| WO (1) | WO2000011001A1 (es) |
| YU (1) | YU13301A (es) |
| ZA (1) | ZA200100978B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0301442A3 (en) * | 2000-10-19 | 2007-03-28 | Pfizer Prod Inc | Bridged piperazine derivatives and pharmaceutical compositions containing them |
| GB0117950D0 (en) * | 2001-02-16 | 2001-09-19 | Aventis Pharma Inc | Novel heterocyclic urea derivatives andd their use as dopamine D3 receptor ligands |
| WO2002094827A1 (en) * | 2001-05-23 | 2002-11-28 | Neurosearch A/S | Fused tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| US20030064979A1 (en) * | 2001-06-29 | 2003-04-03 | Hansen Thomas Kruse | Method of inhibiting PTP 1B and /or T-cell PTP and/or other PTPases with an Asp residue at position 48 |
| US6828328B1 (en) * | 2002-03-01 | 2004-12-07 | Ucb S.A. | Analgesic combination of muscarinic agonists |
| US7897766B2 (en) | 2005-09-23 | 2011-03-01 | Abbott Laboratories | Amino-aza-adamantane derivatives and methods of use |
| US8314119B2 (en) * | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
| US8076350B2 (en) | 2006-12-22 | 2011-12-13 | Abbott Laboratories | Spirocyclic azaadamantane derivatives and methods of use |
| MX2009010175A (es) * | 2007-03-23 | 2009-10-12 | Abbott Lab | Derivados de acetamida y carboxamida de aza-adamantano y metodos de uso de los mismos. |
| US8163915B2 (en) * | 2007-03-23 | 2012-04-24 | Abbott Laboratories | 4-substituted azaadamantane derivatives and methods of use thereof |
| RU2549551C2 (ru) * | 2009-06-19 | 2015-04-27 | Эббви Инк. | Производные диазагомоадамантана и способы их применения |
| US10265311B2 (en) | 2009-07-22 | 2019-04-23 | PureTech Health LLC | Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation |
| HUE044653T2 (hu) | 2009-07-22 | 2019-11-28 | PureTech Health LLC | Készítmények olyan rendellenességek kezelésére, amelyek muszkarin-receptor aktiválással enyhíthetõk |
| EP2560488B1 (en) | 2010-04-23 | 2015-10-28 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
| AR081331A1 (es) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
| AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
| WO2012040404A1 (en) * | 2010-09-23 | 2012-03-29 | Abbott Laboratories | Monohydrate of an azaadamantane derivative |
| US8759380B2 (en) | 2011-04-22 | 2014-06-24 | Cytokinetics, Inc. | Certain heterocycles, compositions thereof, and methods for their use |
| US11325896B2 (en) | 2017-12-20 | 2022-05-10 | Vanderbilt University | Antagonists of the muscarinic acetylcholine receptor M4 |
| SG11202102349PA (en) | 2018-09-28 | 2021-04-29 | Karuna Therapeutics Inc | Compositions and methods for treating disorders ameliorated by muscarnic receptor activation |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4739074A (en) * | 1986-01-22 | 1988-04-19 | Pennwalt Corporation | Adamantane spiro-pyrrolidine derivatives |
| IL88156A (en) * | 1987-11-13 | 1997-02-18 | Novo Nordisk As | Azacyclic compounds their preparation and pharmaceutical compositions containing them |
| US5527813A (en) * | 1990-08-21 | 1996-06-18 | Novo Nordisk A/S | Heterocyclic compounds and their preparation and use |
| EP0563036A1 (en) * | 1990-12-21 | 1993-10-06 | Merck Sharp & Dohme Ltd. | 4-azatricyclo 2.2.1.0?2,6 ]heptanes and pharmaceutical compositions |
| US5955470A (en) * | 1991-06-11 | 1999-09-21 | Merrell Pharmaceuticals, Inc. | Derivatives of amide analogs of certain methano bridged quinolizines |
| US5641791A (en) * | 1991-08-13 | 1997-06-24 | Novo Nordisk A.S | Heterocyclic compounds and their preparation and use |
| US5998405A (en) * | 1995-11-02 | 1999-12-07 | Neurosearch A/S | Fused tropane-derivatives as neurotransmitter reuptake inhibitors |
| US5914338A (en) * | 1996-04-02 | 1999-06-22 | Novo Nordisk | Heterocyclic compounds and their preparation and use |
| US6057446A (en) * | 1998-04-02 | 2000-05-02 | Crooks; Peter Anthony | Certain 1-aza-tricyclo [3.3.1-13,7 ] decane compounds |
| US5952339A (en) * | 1998-04-02 | 1999-09-14 | Bencherif; Merouane | Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release |
| US5986100A (en) * | 1998-04-02 | 1999-11-16 | Crooks; Peter Anthony | Pharmaceutical compositions and methods for use |
-
1999
- 1999-08-16 PL PL99346247A patent/PL346247A1/xx not_active Application Discontinuation
- 1999-08-16 AT AT99945064T patent/ATE227724T1/de not_active IP Right Cessation
- 1999-08-16 SK SK189-2001A patent/SK1892001A3/sk unknown
- 1999-08-16 EP EP99945064A patent/EP1112272B1/en not_active Expired - Lifetime
- 1999-08-16 ES ES99945064T patent/ES2191455T3/es not_active Expired - Lifetime
- 1999-08-16 KR KR1020017002128A patent/KR20010072784A/ko not_active Application Discontinuation
- 1999-08-16 TR TR2001/00462T patent/TR200100462T2/xx unknown
- 1999-08-16 CN CN99809775A patent/CN1312812A/zh active Pending
- 1999-08-16 CA CA002340946A patent/CA2340946A1/en not_active Abandoned
- 1999-08-16 DE DE69903961T patent/DE69903961T2/de not_active Expired - Fee Related
- 1999-08-16 NZ NZ509762A patent/NZ509762A/xx unknown
- 1999-08-16 BR BR9913072-6A patent/BR9913072A/pt not_active IP Right Cessation
- 1999-08-16 JP JP2000566274A patent/JP2002523416A/ja active Pending
- 1999-08-16 US US09/375,149 patent/US6093724A/en not_active Expired - Fee Related
- 1999-08-16 EE EEP200100096A patent/EE200100096A/xx unknown
- 1999-08-16 AU AU57758/99A patent/AU750566B2/en not_active Ceased
- 1999-08-16 RU RU2001107139/04A patent/RU2219179C2/ru not_active IP Right Cessation
- 1999-08-16 ID IDW20010377A patent/ID27544A/id unknown
- 1999-08-16 IL IL14105099A patent/IL141050A0/xx unknown
- 1999-08-16 WO PCT/US1999/018570 patent/WO2000011001A1/en not_active Application Discontinuation
- 1999-08-16 HU HU0103203A patent/HUP0103203A3/hu unknown
- 1999-08-16 YU YU13301A patent/YU13301A/sh unknown
- 1999-08-17 AR ARP990104100A patent/AR020199A1/es unknown
- 1999-08-18 PE PE1999000838A patent/PE20000988A1/es not_active Application Discontinuation
- 1999-08-18 CO CO99052330A patent/CO5130018A1/es unknown
-
2000
- 2000-05-09 US US09/567,785 patent/US6251916B1/en not_active Expired - Fee Related
- 2000-10-17 US US09/690,494 patent/US6323194B1/en not_active Expired - Fee Related
-
2001
- 2001-01-26 IS IS5827A patent/IS5827A/is unknown
- 2001-02-05 ZA ZA200100978A patent/ZA200100978B/xx unknown
- 2001-02-14 BG BG105256A patent/BG105256A/xx unknown
- 2001-02-16 NO NO20010804A patent/NO20010804L/no not_active Application Discontinuation
- 2001-10-05 US US09/972,415 patent/US6423842B1/en not_active Expired - Fee Related
-
2002
- 2002-01-18 HK HK02100409.3A patent/HK1038918A1/zh unknown
- 2002-03-27 US US10/108,046 patent/US6555550B1/en not_active Expired - Fee Related
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