PE86698A1 - Derivados de indolina - Google Patents

Derivados de indolina

Info

Publication number
PE86698A1
PE86698A1 PE1997000510A PE00051097A PE86698A1 PE 86698 A1 PE86698 A1 PE 86698A1 PE 1997000510 A PE1997000510 A PE 1997000510A PE 00051097 A PE00051097 A PE 00051097A PE 86698 A1 PE86698 A1 PE 86698A1
Authority
PE
Peru
Prior art keywords
formula
compound
indolina
derivatives
halogen
Prior art date
Application number
PE1997000510A
Other languages
English (en)
Inventor
Steven Mark Bromidge
Ian Thomson Forbes
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of PE86698A1 publication Critical patent/PE86698A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DE FORMULA (I), EN DONDE: "X" ES CH o N; R1 ES H O ALQUILO C1-C6, DE PREFERENCIA METILO; R2 Y R3 SON HALOGENO, ALQUILO C1-C6 O CF3, SIENDO PREFERIDO QUE R2 SEA CF3 Y QUE R3 SEA METILO. TAMBIEN SE REFIERE AL PROCEDIMIENTO DE PREPARACION DEL COMPUESTO DE FORMULA (I), QUE COMPRENDE HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN DONDE: (i) "A" ES N=C=O Y "B" ES H; (ii) "A" ES NHCOL Y "B" ES H; (iii) "A" ES NH2 Y "B" ES COL; o (iv) "A" ES HALOGENO Y "B" ES CONH2; "L" ES UN GRUPO LABIL. LOS COMPUESTOS OBTENIDOS ACTUAN COMO ANTAGONISTAS DEL RECEPTOR DE SEROTONINA (5HT) 2C, POR LO QUE PUEDEN SER UTILES EN EL TRATAMIENTO DE LA ANSIEDAD Y/O LA DEPRESION, ENTRE OTROS
PE1997000510A 1996-06-20 1997-06-18 Derivados de indolina PE86698A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9612883.0A GB9612883D0 (en) 1996-06-20 1996-06-20 Novel compounds

Publications (1)

Publication Number Publication Date
PE86698A1 true PE86698A1 (es) 1999-01-28

Family

ID=10795575

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1997000510A PE86698A1 (es) 1996-06-20 1997-06-18 Derivados de indolina

Country Status (33)

Country Link
US (1) US6369060B1 (es)
EP (1) EP0912554B1 (es)
JP (1) JP2000512306A (es)
KR (1) KR20000022045A (es)
CN (1) CN1229408A (es)
AP (2) AP9801410A0 (es)
AR (1) AR008243A1 (es)
AT (1) ATE228514T1 (es)
AU (1) AU718597B2 (es)
BG (1) BG103089A (es)
BR (1) BR9709911A (es)
CA (1) CA2258240A1 (es)
CO (1) CO4890847A1 (es)
CZ (1) CZ420598A3 (es)
DE (1) DE69717449T2 (es)
DZ (1) DZ2250A1 (es)
EA (1) EA001780B1 (es)
ES (1) ES2187783T3 (es)
GB (1) GB9612883D0 (es)
HU (1) HUP9903439A3 (es)
ID (1) ID19433A (es)
IL (1) IL127417A0 (es)
MA (1) MA24214A1 (es)
NO (1) NO985972D0 (es)
NZ (1) NZ333229A (es)
OA (1) OA10944A (es)
PE (1) PE86698A1 (es)
PL (1) PL330796A1 (es)
SK (1) SK282706B6 (es)
TR (1) TR199802661T2 (es)
TW (1) TW382015B (es)
WO (1) WO1997048699A1 (es)
ZA (1) ZA975415B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3030899A (en) * 1998-02-25 1999-09-15 Smithkline Beecham Plc Process(es) for the preparation of 6-trifluoromethyl-indoline derivatives
GB0019950D0 (en) * 2000-08-12 2000-09-27 Smithkline Beecham Plc Compounds
JP2005535560A (ja) * 2001-11-28 2005-11-24 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 治療用の化合物
WO2003076426A2 (en) * 2002-03-04 2003-09-18 Pharmacia & Upjohn Company Pyridinyloxy derivatives as 5-ht receptor ligands
KR101062376B1 (ko) * 2008-04-10 2011-09-06 한국화학연구원 신규 인돌 카르복실산 비스피리딜 카르복사마이드 유도체,이의 제조방법 및 이를 유효성분으로 함유하는 조성물
CN102348798A (zh) 2009-01-16 2012-02-08 麻省理工学院 孤独症谱系障碍的诊断和治疗
EP2651403B1 (en) 2010-12-17 2020-12-02 Glaxo Group Limited Use of lp-pla2 inhibitors in the treatment and prevention of eye diseases
WO2014046544A1 (en) 2012-09-21 2014-03-27 Aapa B.V. Substituted 3-heteroaryloxy-3-(hetero)aryl-propylamines as serotonin transporter and serotonin ht2c receptor modulators

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001333A1 (en) 1987-08-07 1989-02-23 The Australian National University IMIDAZO[1,2-b]PYRIDAZINES
CA2142721A1 (en) 1992-08-20 1994-03-03 Ian T. Forbes Condensed indole derivatives as 5ht and 5ht antagonists
GB9313913D0 (en) * 1993-07-06 1993-08-18 Smithkline Beecham Plc Novel compounds
EA000304B1 (ru) * 1995-02-02 1999-04-29 Смитклайн Бичам Плс Производные индола как антагонисты рецептора 5-ht
GB9607219D0 (en) * 1996-04-04 1996-06-12 Smithkline Beecham Plc Novel compounds
GB9615767D0 (en) * 1996-07-26 1996-09-04 Smithkline Beecham Plc Novel treatment

Also Published As

Publication number Publication date
AP9701037A0 (en) 1997-07-31
WO1997048699A1 (en) 1997-12-24
SK175298A3 (en) 1999-05-07
CA2258240A1 (en) 1997-12-24
HUP9903439A2 (en) 2000-07-28
GB9612883D0 (en) 1996-08-21
TW382015B (en) 2000-02-11
ZA975415B (en) 1998-12-21
NO985972L (no) 1998-12-18
IL127417A0 (en) 1999-10-28
EA001780B1 (ru) 2001-08-27
ATE228514T1 (de) 2002-12-15
CZ420598A3 (cs) 1999-06-16
AP9801410A0 (en) 1998-12-31
CO4890847A1 (es) 2000-02-28
US6369060B1 (en) 2002-04-09
OA10944A (en) 2003-02-27
AP745A (en) 1999-04-28
AU3260297A (en) 1998-01-07
PL330796A1 (en) 1999-06-07
TR199802661T2 (xx) 1999-03-22
ES2187783T3 (es) 2003-06-16
HUP9903439A3 (en) 2002-12-28
AR008243A1 (es) 1999-12-29
DE69717449D1 (de) 2003-01-09
EA199900043A1 (ru) 1999-06-24
SK282706B6 (sk) 2002-11-06
BG103089A (en) 1999-09-30
EP0912554A1 (en) 1999-05-06
ID19433A (id) 1998-07-09
EP0912554B1 (en) 2002-11-27
MA24214A1 (fr) 1997-12-31
DZ2250A1 (fr) 2002-12-18
KR20000022045A (ko) 2000-04-25
NO985972D0 (no) 1998-12-18
AU718597B2 (en) 2000-04-20
BR9709911A (pt) 1999-08-10
NZ333229A (es) 2000-01-28
DE69717449T2 (de) 2003-10-02
CN1229408A (zh) 1999-09-22
JP2000512306A (ja) 2000-09-19

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed