ES2158840T3 - Nuevos analogos de adenosina carbociclicos utiles como inmunosupresores. - Google Patents

Nuevos analogos de adenosina carbociclicos utiles como inmunosupresores.

Info

Publication number
ES2158840T3
ES2158840T3 ES91115485T ES91115485T ES2158840T3 ES 2158840 T3 ES2158840 T3 ES 2158840T3 ES 91115485 T ES91115485 T ES 91115485T ES 91115485 T ES91115485 T ES 91115485T ES 2158840 T3 ES2158840 T3 ES 2158840T3
Authority
ES
Spain
Prior art keywords
sub
carbociclic
immunosuppressors
new useful
adenosine analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91115485T
Other languages
English (en)
Inventor
David R Borcherding
Iii Carl K Edwards
Ronald E Esser
Douglas L Cole
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Aventis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc filed Critical Aventis Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2158840T3 publication Critical patent/ES2158840T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

LA INVENCION SE REFIERE A NUEVOS COMPUESTOS DE ADENOSINA CARBOCICLICOS QUE TIENEN LA FORMULA (1) EN DONDE EL SUSTITUYENTE HIDROXI DEL ANILLO DE CICLOPENTANILO ESTA EN LA CONFIGURACION CIS RELATIVA AL SUSTITUYENTE BICICLICO, Y SUB 3, Y SUB 7, Y SUB 8 E Y SUB 9 SON CADA UNO INDEPENDIENTEMENTE NITROGENO O UN GRUPO DE CH, Q ES NH SUB 2, HALOGENO O HIDROGENO, Y Z ES HIDROGENO, HALOGENO O NH SUB 2; O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO Y A SU USO COMO INMUNOSUPRESORES.
ES91115485T 1990-09-14 1991-09-12 Nuevos analogos de adenosina carbociclicos utiles como inmunosupresores. Expired - Lifetime ES2158840T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58228090A 1990-09-14 1990-09-14
US74817291A 1991-08-23 1991-08-23

Publications (1)

Publication Number Publication Date
ES2158840T3 true ES2158840T3 (es) 2001-09-16

Family

ID=27078528

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91115485T Expired - Lifetime ES2158840T3 (es) 1990-09-14 1991-09-12 Nuevos analogos de adenosina carbociclicos utiles como inmunosupresores.

Country Status (19)

Country Link
EP (1) EP0475411B1 (es)
JP (1) JP3099280B2 (es)
KR (1) KR100249111B1 (es)
CN (1) CN1031132C (es)
AR (1) AR247566A1 (es)
AT (1) ATE202106T1 (es)
AU (1) AU647822B2 (es)
CA (1) CA2051012C (es)
DE (1) DE69132632T2 (es)
DK (1) DK0475411T3 (es)
ES (1) ES2158840T3 (es)
FI (1) FI102755B (es)
GR (1) GR3036577T3 (es)
HU (1) HU209304B (es)
IE (1) IE913247A1 (es)
IL (1) IL99466A (es)
NO (1) NO179908C (es)
NZ (1) NZ239750A (es)
PT (1) PT98943B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5470857A (en) * 1990-09-14 1995-11-28 Marion Merrell Dow Inc. Carbocyclic nucleoside analogs useful as immunosuppressants
AU642526B2 (en) * 1990-09-14 1993-10-21 Marion Merrell Dow Inc. Method of immunosuppression using cyclopentenyl substituted nucleoside analogs and compositions thereof
US5817660A (en) * 1991-12-06 1998-10-06 Hoechst Marion Roussel, Inc. Trans cyclopentanyl purine analogs useful as immunosuppressants
US5723466A (en) * 1991-12-06 1998-03-03 Hoechst Marion Roussel, Inc. Trans cyclopentanyl purine analogs useful as immunosuppressants
US5817672A (en) * 1991-12-06 1998-10-06 Hoechst Marion Roussel, Inc. Trans cyclopentanyl purine analogs useful as immunosuppressants
AU658698B2 (en) * 1991-12-06 1995-04-27 Aventis Pharmaceuticals Inc. Novel trans cyclopentanyl purine analogs useful as immunosuppressants
US5817661A (en) 1991-12-06 1998-10-06 Hoechst Marion Roussel, Inc. Trans cyclopentanyl purine analogs useful as immunosuppressants
US5292513A (en) * 1992-05-18 1994-03-08 Anthony G. Gristina Method for nonspecific cellular immune stimulation
WO1994013676A1 (en) * 1992-12-17 1994-06-23 Pfizer Inc. Pyrrolopyrimidines as crf antagonists
JP3479077B2 (ja) * 1993-06-21 2003-12-15 メレルファーマス−ティカルズ インコーポレイテッド プロ炎症性サイトカインの選択的抑制剤として有用な新規な炭素環式ヌクレオシド剤
KR960705825A (ko) * 1993-11-12 1996-11-08 게리 디. 스트리트 면역억제제로서 유용한 6-옥소-뉴클레오시드(6-Oxo-nucleosides useful as immunosuppressants)
TW282470B (es) * 1993-11-18 1996-08-01 Ajinomoto Kk
EP0682027B1 (de) * 1994-05-03 1997-10-15 Novartis AG Pyrrolopyrimidinderivate mit antiproliferativer Wirkung
TW574214B (en) * 1994-06-08 2004-02-01 Pfizer Corticotropin releasing factor antagonists
US6956047B1 (en) 1995-06-06 2005-10-18 Pfizer Inc. Corticotropin releasing factor antagonists
US7067664B1 (en) 1995-06-06 2006-06-27 Pfizer Inc. Corticotropin releasing factor antagonists
US6403599B1 (en) 1995-11-08 2002-06-11 Pfizer Inc Corticotropin releasing factor antagonists
KR20020063934A (ko) 2000-01-18 2002-08-07 화이자 프로덕츠 인코포레이티드 코르티코트로핀 방출 인자 길항제
PE20050347A1 (es) * 2003-08-26 2005-05-04 Teijin Pharma Ltd Derivados de pirrolopirimidina
US8945505B2 (en) 2007-02-02 2015-02-03 Panaphix, Inc. Use of arsenic compounds for treatment of pain and inflammation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3551428A (en) * 1956-02-10 1970-12-29 Ciba Geigy Corp New 1- (or 2-) substituted 4-mercapto-pyrazolo(3,4-d)pyrimidines
US3917837A (en) * 1974-10-21 1975-11-04 American Cyanamid Co Method of using trans-2-(6-amino-9H-purin-9-yl)-cyclopentanol
US4076711A (en) * 1976-04-05 1978-02-28 Schering Corporation Triazolo [4,5-d]-pyrimidines
US4221794A (en) * 1979-06-21 1980-09-09 Newport Pharmaceuticals International, Inc. Method of imparting immunomodulating and antiviral activity
US4386093A (en) * 1981-09-16 1983-05-31 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services (±)3-Deazaaristeromycin and uses
IN164556B (es) * 1986-03-06 1989-04-08 Takeda Chemical Industries Ltd
US4859677A (en) * 1987-04-17 1989-08-22 University Of Kansas Nucleoside analogues having antiviral activity
US4782062A (en) * 1987-05-11 1988-11-01 Merck & Co., Inc. 9-(2-hydroxymethyl)cycloalkylmethyl) guanines
IL86381A0 (en) * 1987-05-19 1988-11-15 Nippon Kayaku Kk Oxetanocins and pharmaceutical compositions containing the same
GB8826205D0 (en) * 1988-11-09 1988-12-14 Wellcome Found Heterocyclic compounds

Also Published As

Publication number Publication date
HU912961D0 (en) 1992-01-28
DE69132632T2 (de) 2002-04-18
CN1059909A (zh) 1992-04-01
DE69132632D1 (de) 2001-07-19
AU8372991A (en) 1992-03-19
GR3036577T3 (en) 2001-12-31
CA2051012A1 (en) 1992-03-15
DK0475411T3 (da) 2001-10-01
HUT59138A (en) 1992-04-28
CA2051012C (en) 2002-04-02
IL99466A (en) 1996-07-23
FI102755B1 (fi) 1999-02-15
NZ239750A (en) 1994-02-25
AR247566A1 (es) 1995-01-31
NO913625D0 (no) 1991-09-13
JPH04270282A (ja) 1992-09-25
NO179908C (no) 1997-01-08
HU209304B (en) 1994-04-28
FI102755B (fi) 1999-02-15
CN1031132C (zh) 1996-02-28
IL99466A0 (en) 1992-08-18
NO179908B (no) 1996-09-30
ATE202106T1 (de) 2001-06-15
EP0475411A1 (en) 1992-03-18
FI914319A0 (fi) 1991-09-13
IE913247A1 (en) 1992-02-25
KR100249111B1 (ko) 2000-08-01
EP0475411B1 (en) 2001-06-13
AU647822B2 (en) 1994-03-31
JP3099280B2 (ja) 2000-10-16
PT98943B (pt) 1999-02-26
KR920006357A (ko) 1992-04-27
FI914319A (fi) 1992-03-15
PT98943A (pt) 1992-07-31
NO913625L (no) 1992-03-16

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