AR247566A1 - Procedimiento para preparar nuevos analogos carbociclicos de adenosina utiles como inmunosupresores - Google Patents

Procedimiento para preparar nuevos analogos carbociclicos de adenosina utiles como inmunosupresores

Info

Publication number
AR247566A1
AR247566A1 AR91320625A AR32062591A AR247566A1 AR 247566 A1 AR247566 A1 AR 247566A1 AR 91320625 A AR91320625 A AR 91320625A AR 32062591 A AR32062591 A AR 32062591A AR 247566 A1 AR247566 A1 AR 247566A1
Authority
AR
Argentina
Prior art keywords
immunosuppressants
analogs useful
adenosine analogs
carbocyclic adenosine
novel carbocyclic
Prior art date
Application number
AR91320625A
Other languages
English (en)
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of AR247566A1 publication Critical patent/AR247566A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

PREPARACION DE ANALOGOS CARBOCICLICOS DE ADENOSINA UTILES COMO INMUNOSUPRESORES, DE FORMULA (I), DONDE EL SUSTITUYENTE HIDROXI EN EL ANILLO CICLOPENTANILICO ESTA EN CONFIGURACION CIS CON RESPECTO AL SUSTITUYENTE BICICLICO, CADA UNO DE Y3, Y7, Y8 E Y9, ES NITROGENO O UN GRUPO CH, Q ES NH2, HALOGENO O HIDROGENO, Y Z ES HIDROGENO, HALOGENO O NH2; O UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES, QUE COMPRENDE SOMETER EL CORRESPONDIENTE DERIVADO CICLOPENTENILICO A HIDROGENACION CATALITICA.
AR91320625A 1990-09-14 1991-09-10 Procedimiento para preparar nuevos analogos carbociclicos de adenosina utiles como inmunosupresores AR247566A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58228090A 1990-09-14 1990-09-14
US74817291A 1991-08-23 1991-08-23

Publications (1)

Publication Number Publication Date
AR247566A1 true AR247566A1 (es) 1995-01-31

Family

ID=27078528

Family Applications (1)

Application Number Title Priority Date Filing Date
AR91320625A AR247566A1 (es) 1990-09-14 1991-09-10 Procedimiento para preparar nuevos analogos carbociclicos de adenosina utiles como inmunosupresores

Country Status (19)

Country Link
EP (1) EP0475411B1 (es)
JP (1) JP3099280B2 (es)
KR (1) KR100249111B1 (es)
CN (1) CN1031132C (es)
AR (1) AR247566A1 (es)
AT (1) ATE202106T1 (es)
AU (1) AU647822B2 (es)
CA (1) CA2051012C (es)
DE (1) DE69132632T2 (es)
DK (1) DK0475411T3 (es)
ES (1) ES2158840T3 (es)
FI (1) FI102755B (es)
GR (1) GR3036577T3 (es)
HU (1) HU209304B (es)
IE (1) IE913247A1 (es)
IL (1) IL99466A (es)
NO (1) NO179908C (es)
NZ (1) NZ239750A (es)
PT (1) PT98943B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU642526B2 (en) * 1990-09-14 1993-10-21 Marion Merrell Dow Inc. Method of immunosuppression using cyclopentenyl substituted nucleoside analogs and compositions thereof
US5470857A (en) * 1990-09-14 1995-11-28 Marion Merrell Dow Inc. Carbocyclic nucleoside analogs useful as immunosuppressants
US5723466A (en) * 1991-12-06 1998-03-03 Hoechst Marion Roussel, Inc. Trans cyclopentanyl purine analogs useful as immunosuppressants
US5817661A (en) * 1991-12-06 1998-10-06 Hoechst Marion Roussel, Inc. Trans cyclopentanyl purine analogs useful as immunosuppressants
US5817672A (en) * 1991-12-06 1998-10-06 Hoechst Marion Roussel, Inc. Trans cyclopentanyl purine analogs useful as immunosuppressants
AU658698B2 (en) * 1991-12-06 1995-04-27 Aventis Pharmaceuticals Inc. Novel trans cyclopentanyl purine analogs useful as immunosuppressants
US5817660A (en) * 1991-12-06 1998-10-06 Hoechst Marion Roussel, Inc. Trans cyclopentanyl purine analogs useful as immunosuppressants
US5292513A (en) * 1992-05-18 1994-03-08 Anthony G. Gristina Method for nonspecific cellular immune stimulation
KR19990067704A (ko) 1992-12-17 1999-08-25 디. 제이. 우드, 스피겔 알렌 제이 부신피질자극호르몬 유리인자 길항제로서의 피롤로피리미딘을함유하는 약학 조성물
DK0705263T3 (da) * 1993-06-21 1997-05-05 Merrell Pharma Inc Carbocycliske nukleoside midler anvendelige som selektive inhibitorer af proinflammatoriske cytokiner
AU677732B2 (en) * 1993-11-12 1997-05-01 Merrell Pharmaceuticals Inc. 6-oxo-nucleosides useful as immunosuppressants
TW282470B (es) * 1993-11-18 1996-08-01 Ajinomoto Kk
EP0682027B1 (de) * 1994-05-03 1997-10-15 Novartis AG Pyrrolopyrimidinderivate mit antiproliferativer Wirkung
TW530047B (en) * 1994-06-08 2003-05-01 Pfizer Corticotropin releasing factor antagonists
US6403599B1 (en) 1995-11-08 2002-06-11 Pfizer Inc Corticotropin releasing factor antagonists
US6956047B1 (en) 1995-06-06 2005-10-18 Pfizer Inc. Corticotropin releasing factor antagonists
US7125880B1 (en) 1995-06-06 2006-10-24 Pfizer Inc. Corticotropin releasing factor antagonists
YU54402A (sh) 2000-01-18 2005-11-28 Pfizer Products Inc. Antagonisti faktora otpuštanja kortikotropina
WO2005019218A1 (ja) * 2003-08-26 2005-03-03 Teijin Pharma Limited ピロロピリミジンチオン誘導体
US8945505B2 (en) 2007-02-02 2015-02-03 Panaphix, Inc. Use of arsenic compounds for treatment of pain and inflammation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3551428A (en) * 1956-02-10 1970-12-29 Ciba Geigy Corp New 1- (or 2-) substituted 4-mercapto-pyrazolo(3,4-d)pyrimidines
US3917837A (en) * 1974-10-21 1975-11-04 American Cyanamid Co Method of using trans-2-(6-amino-9H-purin-9-yl)-cyclopentanol
US4076711A (en) * 1976-04-05 1978-02-28 Schering Corporation Triazolo [4,5-d]-pyrimidines
US4221794A (en) * 1979-06-21 1980-09-09 Newport Pharmaceuticals International, Inc. Method of imparting immunomodulating and antiviral activity
US4386093A (en) * 1981-09-16 1983-05-31 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services (±)3-Deazaaristeromycin and uses
IN164556B (es) * 1986-03-06 1989-04-08 Takeda Chemical Industries Ltd
US4859677A (en) * 1987-04-17 1989-08-22 University Of Kansas Nucleoside analogues having antiviral activity
US4782062A (en) * 1987-05-11 1988-11-01 Merck & Co., Inc. 9-(2-hydroxymethyl)cycloalkylmethyl) guanines
IL86381A0 (en) * 1987-05-19 1988-11-15 Nippon Kayaku Kk Oxetanocins and pharmaceutical compositions containing the same
GB8826205D0 (en) * 1988-11-09 1988-12-14 Wellcome Found Heterocyclic compounds

Also Published As

Publication number Publication date
HUT59138A (en) 1992-04-28
AU8372991A (en) 1992-03-19
CN1059909A (zh) 1992-04-01
ATE202106T1 (de) 2001-06-15
NO913625L (no) 1992-03-16
NO179908B (no) 1996-09-30
FI102755B1 (fi) 1999-02-15
DK0475411T3 (da) 2001-10-01
KR920006357A (ko) 1992-04-27
ES2158840T3 (es) 2001-09-16
JP3099280B2 (ja) 2000-10-16
HU209304B (en) 1994-04-28
NZ239750A (en) 1994-02-25
DE69132632T2 (de) 2002-04-18
AU647822B2 (en) 1994-03-31
EP0475411A1 (en) 1992-03-18
IL99466A (en) 1996-07-23
KR100249111B1 (ko) 2000-08-01
GR3036577T3 (en) 2001-12-31
IE913247A1 (en) 1992-02-25
NO179908C (no) 1997-01-08
FI102755B (fi) 1999-02-15
CA2051012A1 (en) 1992-03-15
PT98943A (pt) 1992-07-31
EP0475411B1 (en) 2001-06-13
NO913625D0 (no) 1991-09-13
PT98943B (pt) 1999-02-26
DE69132632D1 (de) 2001-07-19
CA2051012C (en) 2002-04-02
IL99466A0 (en) 1992-08-18
JPH04270282A (ja) 1992-09-25
HU912961D0 (en) 1992-01-28
CN1031132C (zh) 1996-02-28
FI914319A (fi) 1992-03-15
FI914319A0 (fi) 1991-09-13

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