ES2073396T3 - Nuevos derivados ciclicos del acido antranilico y procedimiento para su preparacion. - Google Patents
Nuevos derivados ciclicos del acido antranilico y procedimiento para su preparacion.Info
- Publication number
- ES2073396T3 ES2073396T3 ES88116141T ES88116141T ES2073396T3 ES 2073396 T3 ES2073396 T3 ES 2073396T3 ES 88116141 T ES88116141 T ES 88116141T ES 88116141 T ES88116141 T ES 88116141T ES 2073396 T3 ES2073396 T3 ES 2073396T3
- Authority
- ES
- Spain
- Prior art keywords
- grupo
- group
- atom
- carbon
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
DERIVADOS DEL ACIDO ANTRANILICO CICLICOS DE LA FORMULA(I) EN DONDE R1, R2 Y R3 INDICAN INDEPENDIENTEMENTE CADA UNO UN ATOMO DE H, UN GRUPO ALQUILO INFERIOR TENIENDO 1 A 3 ATOMOS DE CARBONO, UN GRUPO ALCOXI TENIENDO DE 1 A 3 ATOMOS DE CARBONO, GRUPO AMINO, GRUPO NITRO, GRUPO HIDROXI, GRUPO SULFONAMIDA, GRUPO TRIFLUOROMETIL, GRUPO BENZOILMETILO EL CUAL PUEDE SER SUSTITUIDO, GRUPO ALCANOILAMINO TENIENDO DE 1 A 3 ATOMOS DE CARBONO, GRUPO BENZOILAMINO QUE PUEDE SER SUSTITUIDO, GRUPO ALQUILSULFONILAMINO TENIENDO DE 1 A 3 ATOMOS DE CARBONO O GRUPO FENILSULFONILAMINO QUE PUEDE SER SUSTITUIDO; R4 Y R5 INDICAN CADA UNO INDEPENDIENTEMENTE UN ATOMO DE H U OTROS GRUPOS; R6 INDICA UN ATOMO DE H U OTRA SUSTITUCION, X INDICA UN GRUPO METILENO U OTROS COMPUESTOS, SUS ACIDOS O SALES ALCALINOS DE ESTOS SON UTILES COMO AGENTES ANTIRREUMATICOS.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP24960887 | 1987-10-02 | ||
JP879388 | 1988-01-19 | ||
JP63236295A JPH01279867A (ja) | 1987-10-02 | 1988-09-22 | 新規環状アントラニル酸誘導体及びその製造法 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2073396T3 true ES2073396T3 (es) | 1995-08-16 |
Family
ID=27278180
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88116141T Expired - Lifetime ES2073396T3 (es) | 1987-10-02 | 1988-09-29 | Nuevos derivados ciclicos del acido antranilico y procedimiento para su preparacion. |
Country Status (8)
Country | Link |
---|---|
US (3) | US4956372A (es) |
EP (1) | EP0310096B1 (es) |
KR (1) | KR960010350B1 (es) |
CN (1) | CN1032788A (es) |
CA (1) | CA1317294C (es) |
DE (1) | DE3853608T2 (es) |
ES (1) | ES2073396T3 (es) |
HU (1) | HU204802B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0317061A (ja) * | 1989-06-13 | 1991-01-25 | Kyorin Pharmaceut Co Ltd | 新規環状アントラニル酸酢酸誘導体 |
US5124325A (en) * | 1989-06-13 | 1992-06-23 | Kyorin Pharmaceutical Co., Ltd. | Therapeutic agents of metabolic bone disease |
US5112836A (en) * | 1989-06-19 | 1992-05-12 | Kyorin Pharmaceutical Co., Ltd. | Cyclic anthranililc acid carboxylic acid derivatives and medical therapeutic use thereof |
JPH0327357A (ja) * | 1989-06-26 | 1991-02-05 | Kyorin Pharmaceut Co Ltd | 新規環状アントラニル酸誘導体及びその製造法 |
US5248777A (en) * | 1989-09-19 | 1993-09-28 | Allergan, Inc. | Process and intermediates for preparing compounds having a disubstituted acetylene moiety and retinoic acid-like biological activity |
JP3209568B2 (ja) * | 1991-04-16 | 2001-09-17 | 杏林製薬株式会社 | 新規環状アミノフェニル酢酸誘導体、その製造法及びそれらを有効成分とする免疫応答の修飾剤 |
FR2714381B1 (fr) * | 1993-12-29 | 1996-02-02 | Pharmascience Lab | Dérivés de la benzoxazine, leurs procédés d'obtention et leur utilisation en tant que médicaments . |
US6696459B1 (en) | 1994-12-22 | 2004-02-24 | Ligand Pharmaceuticals Inc. | Steroid receptor modulator compounds and methods |
US5688808A (en) * | 1994-12-22 | 1997-11-18 | Ligand Pharmaceuticals Incorporated | Steroid receptor modulator compounds and methods |
DK0866059T3 (da) * | 1995-10-05 | 2002-03-25 | Kyoto Pharma Ind | Nye heterocykliske derivater og medicinsk anvendelse deraf |
US5776482A (en) * | 1996-03-29 | 1998-07-07 | University Of Iowa Research Foundation | Tetrahydroquinoline analogues for use in glaucoma treatment |
GB9724586D0 (en) * | 1997-11-20 | 1998-01-21 | Rhone Poulenc Agriculture | New herbicides |
FR2779144B1 (fr) * | 1998-05-29 | 2000-06-30 | Adir | Nouveaux composes 8-amino-1,4-benzoxaziniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
AU4583599A (en) | 1998-06-25 | 2000-01-10 | Sepracor, Inc. | Di- and tetra-hydroquinoline-indole antimicrobial agents, uses and compositions related thereto |
EP1541553B1 (en) * | 2002-07-17 | 2010-06-02 | Kyoto Pharmaceutical Industries, Ltd. | Indoline compound and medicinal use thereof |
ATE500250T1 (de) | 2006-08-15 | 2011-03-15 | Actelion Pharmaceuticals Ltd | Azetidinverbindungen als orexin-rezeptor- antagonisten |
WO2013076590A1 (en) * | 2011-11-23 | 2013-05-30 | Oxygen Healthcare Research Pvt. Ltd | Benzothiazine compounds as h3 receptor ligands |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2733371A (en) * | 1970-04-14 | 1972-10-12 | A. H. Robins Company, Incorporated | 5, 7-DISUBSTITUTED-l, 9-ALKYLENE-l, 4-BENZODIAZEPIN-2 ONES |
US4843082A (en) * | 1986-05-05 | 1989-06-27 | E. R. Squibb & Sons, Inc. | 1,2,3,4-tetrahydro-8-quinolinol derivatives and anti-allergic use thereof |
-
1988
- 1988-09-27 US US07/249,996 patent/US4956372A/en not_active Expired - Fee Related
- 1988-09-29 EP EP88116141A patent/EP0310096B1/en not_active Expired - Lifetime
- 1988-09-29 DE DE3853608T patent/DE3853608T2/de not_active Expired - Fee Related
- 1988-09-29 ES ES88116141T patent/ES2073396T3/es not_active Expired - Lifetime
- 1988-09-30 KR KR1019880012730A patent/KR960010350B1/ko not_active IP Right Cessation
- 1988-09-30 CN CN88109044A patent/CN1032788A/zh active Pending
- 1988-09-30 HU HU885098A patent/HU204802B/hu not_active IP Right Cessation
- 1988-09-30 CA CA000578918A patent/CA1317294C/en not_active Expired - Fee Related
-
1990
- 1990-07-31 US US07/560,775 patent/US5147874A/en not_active Expired - Fee Related
-
1992
- 1992-08-14 US US07/929,526 patent/US5281600A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR890006604A (ko) | 1989-06-14 |
CA1317294C (en) | 1993-05-04 |
DE3853608T2 (de) | 1996-01-04 |
KR960010350B1 (ko) | 1996-07-30 |
EP0310096A2 (en) | 1989-04-05 |
US5147874A (en) | 1992-09-15 |
CN1032788A (zh) | 1989-05-10 |
DE3853608D1 (de) | 1995-05-24 |
US4956372A (en) | 1990-09-11 |
US5281600A (en) | 1994-01-25 |
EP0310096A3 (en) | 1990-10-31 |
HUT50459A (en) | 1990-02-28 |
HU204802B (en) | 1992-02-28 |
EP0310096B1 (en) | 1995-04-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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