ES2260933T3 - Derivados del acido de tiazolina. - Google Patents

Derivados del acido de tiazolina.

Info

Publication number
ES2260933T3
ES2260933T3 ES99945267T ES99945267T ES2260933T3 ES 2260933 T3 ES2260933 T3 ES 2260933T3 ES 99945267 T ES99945267 T ES 99945267T ES 99945267 T ES99945267 T ES 99945267T ES 2260933 T3 ES2260933 T3 ES 2260933T3
Authority
ES
Spain
Prior art keywords
alkyl
carbon atoms
acid
tiazolina
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99945267T
Other languages
English (en)
Inventor
Raymond J Bergeron Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Florida
University of Florida Research Foundation Inc
Original Assignee
University of Florida
University of Florida Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Florida, University of Florida Research Foundation Inc filed Critical University of Florida
Application granted granted Critical
Publication of ES2260933T3 publication Critical patent/ES2260933T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Game Rules And Presentations Of Slot Machines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Un compuesto de la fórmula: en la cual: Z es CH o N; R es H o acilo; R1, R2, R3 y R5 pueden ser iguales o diferentes y representan a H, alquilo o hidrocarbilo arilalquilo teniendo hasta 14 átomos de carbono; R4 es H o alquilo teniendo de 1-4 átomos de carbono; y antípodas ópticas, racimadas y sus sales con un ácido aceptable en términos farmacéuticos o un complejo del mismo aceptable en términos farmacéuticos, con la condición de que; R4 es un alquilo que tiene 1-4 átomos de carbono, cuando Z es CH; y R, R1, R2, R3 y R5 son H cada uno.
ES99945267T 1998-08-31 1999-08-31 Derivados del acido de tiazolina. Expired - Lifetime ES2260933T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/144,103 US6083966A (en) 1998-08-31 1998-08-31 Thiazoline acid derivatives

Publications (1)

Publication Number Publication Date
ES2260933T3 true ES2260933T3 (es) 2006-11-01

Family

ID=22507049

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99945267T Expired - Lifetime ES2260933T3 (es) 1998-08-31 1999-08-31 Derivados del acido de tiazolina.

Country Status (24)

Country Link
US (9) US6083966A (es)
EP (1) EP1109795B1 (es)
JP (3) JP4817498B2 (es)
KR (1) KR20010074907A (es)
CN (1) CN100455574C (es)
AT (1) ATE317392T1 (es)
AU (1) AU759851B2 (es)
BR (1) BR9913441B1 (es)
CA (1) CA2342210C (es)
CZ (1) CZ2001711A3 (es)
DE (1) DE69929807T2 (es)
EA (1) EA200100261A1 (es)
ES (1) ES2260933T3 (es)
HK (1) HK1035720A1 (es)
HU (1) HUP0103165A3 (es)
IL (2) IL141611A0 (es)
NO (1) NO321028B1 (es)
NZ (1) NZ509899A (es)
PL (1) PL346852A1 (es)
PT (1) PT1109795E (es)
TR (1) TR200100541T2 (es)
UA (1) UA57161C2 (es)
WO (1) WO2000012493A1 (es)
YU (1) YU21801A (es)

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US6083966A (en) * 1998-08-31 2000-07-04 University Of Florida Thiazoline acid derivatives
NZ526880A (en) * 1998-09-21 2005-05-27 Univ Florida Antimalarial agents
EP1488791A3 (en) * 1998-09-21 2005-04-06 University Of Florida Research Foundation, Inc. Antimalarial agents
US6806363B1 (en) * 1999-04-16 2004-10-19 Mayo Foundation For Medical Education & Research Cobalamin conjugates useful as antitumor agents
EP1239887A1 (en) 1999-10-15 2002-09-18 Mayo Foundation For Medical Education And Research Cobalamin conjugates useful as imaging and therapeutic agents
US6689788B1 (en) * 2000-08-25 2004-02-10 University Of Florida Method and composition for treatment of inflammatory bowel disease
WO2002055530A2 (en) * 2000-10-25 2002-07-18 Mayo Foundation Transcobalamin binding conjugates useful for treating abnormal cellular proliferation
US6875883B2 (en) * 2002-05-15 2005-04-05 Genzyme Corporation Synthesis of benzonitriles from substituted benzaldehyde
US20040132789A1 (en) * 2002-08-22 2004-07-08 University Of Florida Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin
US20040044220A1 (en) * 2002-08-22 2004-03-04 University Of Florida Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin
AU2003268706A1 (en) * 2002-10-01 2004-04-23 Kaneka Corporation PROCESS FOR PRODUCING OPTICALLY ACTIVE Alpha-SUBSTITUTED CYSTEINE OR SALT THEREOF, INTERMEDIATE THEREFOR, AND PROCESS FOR PRODUCING THE SAME
US20040185028A1 (en) * 2003-03-19 2004-09-23 Zhenze Hu Antimicrobial compositions containing ethanolamine buffer and biguanide disinfectant
AU2003270473A1 (en) * 2003-09-09 2005-04-27 University Of Florida Desferrithiocin derivatives and their use as iron chelators
CA2538159A1 (en) * 2003-09-09 2005-03-17 University Of Florida Research Foundation, Inc. Polyamine-metal chelator conjugates
EP1694325A4 (en) * 2003-12-03 2009-03-25 Univ New Jersey Med METHOD FOR PREVENTING SURVIVAL OF RETROVIRAL CELLS AND FORMATION OF INFECTIOUS RETROVIRUSES
EP1714966A4 (en) * 2004-02-04 2008-01-02 Shionogi & Co NAPHTHYLIDINE DERIVATIVE HAVING HIGH INTEGRASE HIV INHIBITING ACTIVITY
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US7365371B2 (en) 2005-08-04 2008-04-29 Cree, Inc. Packages for semiconductor light emitting devices utilizing dispensed encapsulants
EP2101764A4 (en) * 2006-12-12 2010-02-17 Univ Florida ACTINIDE DECORPORATION AGENTS ANALOGUES OF DESFERRITHIOCIN
NZ579994A (en) * 2007-03-15 2011-09-30 Univ Florida Desferrithiocin polyether analogues useful in the treatment of pathological conditions responsive to chelation or sequestration of trivalent metal
NZ590302A (en) 2008-07-14 2013-02-22 Ferrokin Biosciences Inc Novel salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents
AU2011248158A1 (en) 2010-05-04 2012-12-20 Ferrokin Biosciences, Inc. Desazadesferrothiocin and desazadesferrothiocin polyether analogues as metal chelation agents
CN103562379A (zh) * 2011-05-19 2014-02-05 国立大学法人德岛大学 细胞分化诱导剂以及分化诱导方法
AU2012352025B2 (en) 2011-12-16 2018-01-18 University Of Florida Research Foundation, Inc. Uses of 4'-desferrithiocin analogs
JP6353751B2 (ja) * 2013-09-25 2018-07-04 国立大学法人電気通信大学 新規複素環式化合物及びその塩、並びに、発光基質組成物
EP3071201A4 (en) * 2013-11-22 2017-04-26 University of Florida Research Foundation, Inc. Desferrithiocin analogs and uses thereof
KR20170140306A (ko) 2015-04-27 2017-12-20 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 대사적으로 프로그램화된 금속 킬레이트화제 및 그의 용도

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AU2003270473A1 (en) * 2003-09-09 2005-04-27 University Of Florida Desferrithiocin derivatives and their use as iron chelators
CA2538159A1 (en) 2003-09-09 2005-03-17 University Of Florida Research Foundation, Inc. Polyamine-metal chelator conjugates
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BRPI0610644B8 (pt) 2005-04-04 2021-05-25 Univ Florida composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável.
EP2101764A4 (en) * 2006-12-12 2010-02-17 Univ Florida ACTINIDE DECORPORATION AGENTS ANALOGUES OF DESFERRITHIOCIN
NZ579994A (en) * 2007-03-15 2011-09-30 Univ Florida Desferrithiocin polyether analogues useful in the treatment of pathological conditions responsive to chelation or sequestration of trivalent metal

Also Published As

Publication number Publication date
BR9913441B1 (pt) 2013-10-29
YU21801A (sh) 2005-07-19
KR20010074907A (ko) 2001-08-09
UA57161C2 (uk) 2003-06-16
US6521652B1 (en) 2003-02-18
US20070238767A1 (en) 2007-10-11
WO2000012493A9 (en) 2002-04-11
US7531563B2 (en) 2009-05-12
ATE317392T1 (de) 2006-02-15
BR9913441A (pt) 2001-10-23
NO321028B1 (no) 2006-02-27
EP1109795A4 (en) 2002-01-16
HUP0103165A2 (hu) 2002-01-28
EP1109795A1 (en) 2001-06-27
US6525080B1 (en) 2003-02-25
PT1109795E (pt) 2006-06-30
NO20011003L (no) 2001-02-27
CN1313856A (zh) 2001-09-19
DE69929807D1 (de) 2006-04-20
CA2342210A1 (en) 2000-03-09
EA200100261A1 (ru) 2001-10-22
JP5520875B2 (ja) 2014-06-11
PL346852A1 (en) 2002-03-11
US6559315B1 (en) 2003-05-06
US8008502B2 (en) 2011-08-30
US6083966A (en) 2000-07-04
IL141611A0 (en) 2002-03-10
NZ509899A (en) 2003-12-19
TR200100541T2 (tr) 2001-11-21
AU5789799A (en) 2000-03-21
HUP0103165A3 (en) 2003-03-28
DE69929807T2 (de) 2006-11-02
NO20011003D0 (no) 2001-02-27
CZ2001711A3 (cs) 2001-09-12
JP2002523500A (ja) 2002-07-30
JP2011178797A (ja) 2011-09-15
IL141611A (en) 2006-12-31
USRE39132E1 (en) 2006-06-13
US20100094016A1 (en) 2010-04-15
WO2000012493A1 (en) 2000-03-09
US7126004B2 (en) 2006-10-24
US20050033057A1 (en) 2005-02-10
JP2014065730A (ja) 2014-04-17
EP1109795B1 (en) 2006-02-08
CA2342210C (en) 2009-03-10
JP4817498B2 (ja) 2011-11-16
HK1035720A1 (en) 2003-04-24
AU759851B2 (en) 2003-05-01
CN100455574C (zh) 2009-01-28
US20030236417A1 (en) 2003-12-25

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