MX9306606A - Procedimiento para la preparacion de derivados de taxano. - Google Patents

Procedimiento para la preparacion de derivados de taxano.

Info

Publication number
MX9306606A
MX9306606A MX9306606A MX9306606A MX9306606A MX 9306606 A MX9306606 A MX 9306606A MX 9306606 A MX9306606 A MX 9306606A MX 9306606 A MX9306606 A MX 9306606A MX 9306606 A MX9306606 A MX 9306606A
Authority
MX
Mexico
Prior art keywords
radical
phenyl
general formula
preparation
protecting group
Prior art date
Application number
MX9306606A
Other languages
English (en)
Inventor
Jean-Noel Denis
Andrew Greene
Alice Kanazawa
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of MX9306606A publication Critical patent/MX9306606A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se describe un procedimiento de preparación de derivados de taxano de la fórmula general (I) mediante la esterificación de la bacatina III protegida o de la 10-desacetil-bacatina III protegida, por medio de un ácido de la fórmula general (II). En las fórmulas generales (I) y (II), Ar representa un radical arilo, R1 y R2, idénticos o diferentes, representan un átomo de hidrógeno, un radical alquilo , fenilalquilo, fenilo, alcoxifenilo, o bien R1 y R2 forman conjuntamente con el átomo de carbono al cual están unidos, un ciclo que tiene de 4 a 7 enlaces o eslabones. R3 representa un radical acetilo o un grupo protector de la función hidroxi y R4 representa un grupo protector de la función hidroxi, R representa un radical fenilo o un radical de la fórmula R5-0-, en la cual R5- representa un radical alquilo, alquenilo, alquinilo, cicloalquilo, cicloalquenilo, fenilo, heterociclilo nitrogenado, saturado o no saturado. Los productos de la fórmula general (I) son particularmente útiles para preparar el taxol, el Taxótero y sus análogos, que presentan las propiedades antitumorales notables.
MX9306606A 1992-10-30 1993-10-25 Procedimiento para la preparacion de derivados de taxano. MX9306606A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9213000A FR2697522B1 (fr) 1992-10-30 1992-10-30 Procédé de préparation de dérivés du taxane.

Publications (1)

Publication Number Publication Date
MX9306606A true MX9306606A (es) 1994-04-29

Family

ID=9435013

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9306606A MX9306606A (es) 1992-10-30 1993-10-25 Procedimiento para la preparacion de derivados de taxano.

Country Status (24)

Country Link
US (3) US5686623A (es)
EP (1) EP0666857B1 (es)
JP (1) JP3030088B2 (es)
KR (1) KR100255460B1 (es)
AT (1) ATE180258T1 (es)
AU (1) AU679947B2 (es)
CA (1) CA2148103C (es)
CZ (1) CZ287805B6 (es)
DE (1) DE69325031T2 (es)
DK (1) DK0666857T3 (es)
ES (1) ES2133418T3 (es)
FI (1) FI109798B (es)
FR (1) FR2697522B1 (es)
GR (1) GR3030268T3 (es)
HU (1) HUT73780A (es)
MX (1) MX9306606A (es)
NO (2) NO304114B1 (es)
NZ (1) NZ257578A (es)
PL (1) PL177746B1 (es)
RU (2) RU2118958C1 (es)
SK (1) SK281045B6 (es)
TW (1) TW427988B (es)
WO (1) WO1994010169A1 (es)
ZA (1) ZA938012B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL107950A (en) 1992-12-15 2001-04-30 Upjohn Co b 7, b 8 - Matano - Taxols, their preparation and pharmaceutical preparations against malignant tumors containing them
EP0703909B1 (en) * 1993-06-11 2000-04-26 PHARMACIA & UPJOHN COMPANY Delta 6,7 -taxols antineoplastic use and pharmaceutical compositions containing them
IL127598A (en) * 1994-01-28 2003-04-10 Upjohn Co Process for preparing isotaxol analogs
CA2170661A1 (en) 1995-03-22 1996-09-23 John K. Thottathil Novel methods for the preparation of taxanes using oaxzolidine intermediates
EP1099696A3 (en) * 1995-06-06 2001-05-23 Dr. Reddy's Research Foundation Preparation of oxazolidine
US6410756B1 (en) 1996-10-24 2002-06-25 Institut National De La Recherche Scientifique Family of Canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof
US6150537A (en) * 1997-12-12 2000-11-21 Emory University Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents
EP0982028A1 (en) * 1998-08-20 2000-03-01 Aventis Pharma S.A. New use of taxoid derivatives
HUP0104000A3 (en) * 1998-08-20 2003-01-28 Aventis Pharma Sa New use of taxoid derivatives
JP4502338B2 (ja) * 1999-09-17 2010-07-14 株式会社横浜国際バイオ研究所 タキソイド化合物の製造法
EP2266607A3 (en) 1999-10-01 2011-04-20 Immunogen, Inc. Immunoconjugates for treating cancer
AU2000261768A1 (en) * 2000-08-08 2002-02-18 Dr. Reddy's Research Foundation An improved process for the preparation of docetaxel
JP2002088935A (ja) 2000-09-14 2002-03-27 Nichiha Corp 外装材の縦目地ジョイナー
US8338617B2 (en) 2004-11-19 2012-12-25 Dr. Reddy's Laboratories Limited Process for preparing oxazolidine derivatives
CZ298332B6 (cs) * 2005-09-26 2007-08-29 Zentiva, A. S Zpusob prípravy kyseliny (4S,5R)-2,4-difenyloxazolin-4,5-dihydro-5-karboxylové
MX2008008119A (es) * 2005-12-21 2008-09-24 Tapestry Pharmaceuticals Inc Procesos para derivados de taxano y compuestos intermedios utiles en los mismos.
WO2008074178A1 (fr) * 2006-11-23 2008-06-26 Shanghai Bailing Pharmaceutical Technology Co., Ltd Nouveau procédé de préparation de paclitaxel semi-synthétique
CN101020672B (zh) * 2006-12-28 2010-08-25 上海百灵医药科技有限公司 多烯紫杉醇的合成方法
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
KR101379694B1 (ko) * 2011-09-30 2014-03-31 주식회사 삼양바이오팜 탁산유도체의 제조방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
FR2696464B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III.
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696459B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696458B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
EP0703909B1 (en) * 1993-06-11 2000-04-26 PHARMACIA & UPJOHN COMPANY Delta 6,7 -taxols antineoplastic use and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
SK281045B6 (sk) 2000-11-07
RU2118958C1 (ru) 1998-09-20
NO951587L (no) 1995-04-26
ES2133418T3 (es) 1999-09-16
HUT73780A (en) 1996-09-30
CZ287805B6 (en) 2001-02-14
TW427988B (en) 2001-04-01
WO1994010169A1 (fr) 1994-05-11
FI952059A (fi) 1995-04-28
NO304114B1 (no) 1998-10-26
EP0666857A1 (fr) 1995-08-16
KR950704307A (ko) 1995-11-17
SK55795A3 (en) 1995-10-11
RU2188198C2 (ru) 2002-08-27
GR3030268T3 (en) 1999-08-31
FI952059A0 (fi) 1995-04-28
FI109798B (fi) 2002-10-15
DK0666857T3 (da) 1999-11-08
ZA938012B (en) 1994-06-09
JP3030088B2 (ja) 2000-04-10
JPH08502507A (ja) 1996-03-19
EP0666857B1 (fr) 1999-05-19
HU9501235D0 (en) 1995-06-28
NO306062B1 (no) 1999-09-13
US5686623A (en) 1997-11-11
CA2148103A1 (fr) 1994-05-11
AU5423794A (en) 1994-05-24
US6433180B1 (en) 2002-08-13
DE69325031D1 (de) 1999-06-24
DE69325031T2 (de) 1999-10-07
NZ257578A (en) 1996-06-25
NO981813L (no) 1995-04-26
KR100255460B1 (ko) 2000-05-01
FR2697522B1 (fr) 1994-11-25
US20030013889A1 (en) 2003-01-16
PL177746B1 (pl) 2000-01-31
RU95111381A (ru) 1996-12-27
NO981813D0 (no) 1998-04-22
AU679947B2 (en) 1997-07-17
CZ109295A3 (en) 1995-10-18
NO951587D0 (no) 1995-04-26
FR2697522A1 (fr) 1994-05-06
PL308638A1 (en) 1995-08-21
ATE180258T1 (de) 1999-06-15
CA2148103C (fr) 2002-11-26

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Legal Events

Date Code Title Description
FG Grant or registration
HC Change of company name or juridical status

Owner name: EMERSON ENERGY SYSTEMS AB

MM Annulment or lapse due to non-payment of fees