MX9205309A - Nuevos taxanos substituidos con furilo y tienilo y composiciones farmaceuticas que los contienen - Google Patents

Nuevos taxanos substituidos con furilo y tienilo y composiciones farmaceuticas que los contienen

Info

Publication number
MX9205309A
MX9205309A MX9205309A MX9205309A MX9205309A MX 9205309 A MX9205309 A MX 9205309A MX 9205309 A MX9205309 A MX 9205309A MX 9205309 A MX9205309 A MX 9205309A MX 9205309 A MX9205309 A MX 9205309A
Authority
MX
Mexico
Prior art keywords
substituted
furile
tenyl
contain
pharmaceutical compositions
Prior art date
Application number
MX9205309A
Other languages
English (en)
Inventor
Robert A Holton
Ronald J Biediger
Hossain Nadizadeh
Original Assignee
Univ Florida State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida State filed Critical Univ Florida State
Publication of MX9205309A publication Critical patent/MX9205309A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/003—Compounds containing elements of Groups 4 or 14 of the Periodic Table without C-Metal linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Polyethers (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Esta invención se refiere a un derivado del taxano en donde: R1 es un heterociclo de cinco miembros en que el heteroátomo es O o S Z es -OT1 T1 es hidrógeno, un grupo protector de hidroxilo, o-COT2, -COT(2) T2 es H, alquilo, alquelino, alquinilo o arilo monocíclico R3 es benzoilo, benzoilo sustituido o alcoxicarbonilo Ac es acetilo E1 y E2 se seleccionan independientemente de hidrógeno y grupos funcionales, tales derivados son útiles como agentes antitumor.
MX9205309A 1991-09-23 1992-09-18 Nuevos taxanos substituidos con furilo y tienilo y composiciones farmaceuticas que los contienen MX9205309A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76380591A 1991-09-23 1991-09-23
US07/862,819 US5227400A (en) 1991-09-23 1992-04-03 Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
MX9205309A true MX9205309A (es) 1993-07-01

Family

ID=27117340

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9205309A MX9205309A (es) 1991-09-23 1992-09-18 Nuevos taxanos substituidos con furilo y tienilo y composiciones farmaceuticas que los contienen

Country Status (14)

Country Link
US (1) US5227400A (es)
EP (1) EP0534708B1 (es)
JP (1) JP3217156B2 (es)
AT (1) ATE128134T1 (es)
AU (1) AU649875B2 (es)
CA (1) CA2077621C (es)
DE (1) DE69204951T2 (es)
DK (1) DK0534708T3 (es)
FI (1) FI113267B (es)
GR (1) GR3018481T3 (es)
HU (1) HU215839B (es)
MX (1) MX9205309A (es)
NO (1) NO301070B1 (es)
NZ (1) NZ244455A (es)

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US7074945B2 (en) * 1991-09-23 2006-07-11 Florida State University Metal alkoxide taxane derivatives
US5284865A (en) 1991-09-23 1994-02-08 Holton Robert A Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
US6028205A (en) * 1991-09-23 2000-02-22 Florida State University C2 tricyclic taxanes
US5998656A (en) * 1991-09-23 1999-12-07 Florida State University C10 tricyclic taxanes
US5710287A (en) * 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US6335362B1 (en) 1991-09-23 2002-01-01 Florida State University Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
US6005138A (en) * 1991-09-23 1999-12-21 Florida State University Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
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US5739362A (en) * 1991-09-23 1998-04-14 Florida State University Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
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US5721268A (en) * 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US6018073A (en) * 1991-09-23 2000-01-25 Florida State University Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
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Also Published As

Publication number Publication date
US5227400A (en) 1993-07-13
JP3217156B2 (ja) 2001-10-09
HU9203017D0 (en) 1992-12-28
NO301070B1 (no) 1997-09-08
DK0534708T3 (da) 1996-02-05
JPH05239055A (ja) 1993-09-17
HU215839B (hu) 2001-06-28
FI924226A (fi) 1993-03-24
DE69204951T2 (de) 1996-02-08
NO923677D0 (no) 1992-09-22
AU2212292A (en) 1993-03-25
FI113267B (fi) 2004-03-31
CA2077621A1 (en) 1993-03-24
GR3018481T3 (en) 1996-03-31
EP0534708A1 (en) 1993-03-31
HUT62886A (en) 1993-06-28
DE69204951D1 (de) 1995-10-26
CA2077621C (en) 1999-11-02
NZ244455A (en) 1995-04-27
NO923677L (no) 1993-03-24
EP0534708B1 (en) 1995-09-20
FI924226A0 (fi) 1992-09-21
AU649875B2 (en) 1994-06-02
ATE128134T1 (de) 1995-10-15

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