BR0104350A - Taxanos de c10 acetato heterossubstituìdo como agentes antitumor - Google Patents

Taxanos de c10 acetato heterossubstituìdo como agentes antitumor

Info

Publication number
BR0104350A
BR0104350A BR0104350-1A BR0104350A BR0104350A BR 0104350 A BR0104350 A BR 0104350A BR 0104350 A BR0104350 A BR 0104350A BR 0104350 A BR0104350 A BR 0104350A
Authority
BR
Brazil
Prior art keywords
heterosubstituted
acetate
antitumor agents
taxanes
acetate taxanes
Prior art date
Application number
BR0104350-1A
Other languages
English (en)
Inventor
Robert A Holton
Original Assignee
Univ Florida State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida State Res Found filed Critical Univ Florida State Res Found
Publication of BR0104350A publication Critical patent/BR0104350A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Patente de Invenção: "TAXANOS DE C10 ACETATO HETEROSSUBSTITUìDO COMO AGENTES ANTITUMOR". Taxanos tendo um substituinte de acetato heterossubstituído em C(10), um substituinte hidróxi em C(7), e uma faixa de C(2), C(9), C(14), e substituintes de cadeia lateral.
BR0104350-1A 2000-02-02 2001-02-02 Taxanos de c10 acetato heterossubstituìdo como agentes antitumor BR0104350A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17966900P 2000-02-02 2000-02-02
PCT/US2001/003553 WO2001056564A1 (en) 2000-02-02 2001-02-02 C10 heterosubstituted acetate taxanes as antitumor agents

Publications (1)

Publication Number Publication Date
BR0104350A true BR0104350A (pt) 2002-01-02

Family

ID=22657495

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0104350-1A BR0104350A (pt) 2000-02-02 2001-02-02 Taxanos de c10 acetato heterossubstituìdo como agentes antitumor

Country Status (21)

Country Link
US (4) US6664275B2 (pt)
EP (1) EP1165068B1 (pt)
JP (1) JP2003521514A (pt)
KR (1) KR20020002488A (pt)
CN (1) CN1362876A (pt)
AT (1) ATE381328T1 (pt)
AU (1) AU776767B2 (pt)
BR (1) BR0104350A (pt)
CA (1) CA2368502A1 (pt)
CZ (1) CZ20013523A3 (pt)
DE (1) DE60131927D1 (pt)
HK (1) HK1047896A1 (pt)
HU (1) HUP0200750A3 (pt)
IL (1) IL145639A (pt)
MX (1) MXPA01009924A (pt)
NO (1) NO20014756L (pt)
NZ (1) NZ514406A (pt)
PL (1) PL350027A1 (pt)
TW (1) TWI257390B (pt)
WO (1) WO2001056564A1 (pt)
ZA (1) ZA200108052B (pt)

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US6638973B2 (en) * 2000-02-02 2003-10-28 Fsu Research Foundation, Inc. Taxane formulations
BR0104350A (pt) * 2000-02-02 2002-01-02 Univ Florida State Res Found Taxanos de c10 acetato heterossubstituìdo como agentes antitumor
EP1534674A4 (en) 2002-08-02 2007-11-28 Immunogen Inc CYTOTOXIC AGENTS CONTAINING NEW, EFFECTIVE TAXANES AND THEIR THERAPEUTIC USE
US7390898B2 (en) * 2002-08-02 2008-06-24 Immunogen Inc. Cytotoxic agents containing novel potent taxanes and their therapeutic use
CA2539975C (en) * 2003-09-25 2012-11-20 Tapestry Pharmaceuticals, Inc. 9,10-.alpha.,.alpha.-oh-taxane analogs and methods for production thereof
SI1664033T1 (sl) * 2003-09-25 2008-04-30 Tapestry Pharmaceuticals Inc Analogi 9,10-alfa,alfa-oh-taksana in postopki za proizvodnjo le-teh
CN1712399B (zh) * 2004-06-24 2010-08-11 中国医学科学院药物研究所 紫杉醇和免疫增强剂胞壁酰二肽共轭物的制备及用途
KR100627436B1 (ko) * 2005-10-18 2006-09-22 주식회사 시드컴 차량용 요일체킹장치
WO2008106621A1 (en) 2007-02-28 2008-09-04 Tapestry Pharmaceuticals, Inc Taxane analogs for the treatment of brain cancer
US11786504B2 (en) 2006-09-28 2023-10-17 Tapestry Pharmaceuticals, Inc. Taxane analogs for the treatment of brain cancer
WO2008121476A1 (en) 2007-03-28 2008-10-09 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
US11873308B2 (en) 2006-11-06 2024-01-16 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
US20080233135A1 (en) * 2007-03-19 2008-09-25 Gebhard John R Cobalamin taxane bioconjugates
WO2009126401A1 (en) * 2008-04-10 2009-10-15 Abraxis Bioscience, Llc Compositions of hydrophobic taxane derivatives and uses thereof
KR20150136137A (ko) * 2008-04-10 2015-12-04 아브락시스 바이오사이언스, 엘엘씨 소수성 탁산 유도체의 조성물 및 그의 용도
WO2011094577A2 (en) 2010-01-29 2011-08-04 Micronics, Inc. Sample-to-answer microfluidic cartridge
KR101477194B1 (ko) 2010-05-27 2014-12-29 심천 사루브리스 퍼머수티칼스 컴퍼니 리미티드 이중기능 복합체의 화학합성 및 항 종양과 항 종양 전이 작용
EP3549674B1 (en) 2012-12-21 2020-08-12 PerkinElmer Health Sciences, Inc. Low elasticity films for microfluidic use
JP2016509206A (ja) 2012-12-21 2016-03-24 マイクロニクス， インコーポレイテッド 携帯型蛍光検出システムおよびマイクロアッセイカートリッジ
US10065186B2 (en) 2012-12-21 2018-09-04 Micronics, Inc. Fluidic circuits and related manufacturing methods
AU2014262710B2 (en) 2013-05-07 2019-09-12 Perkinelmer Health Sciences, Inc. Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions
US10386377B2 (en) 2013-05-07 2019-08-20 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
JP6484222B2 (ja) 2013-05-07 2019-03-13 マイクロニクス， インコーポレイテッド 核酸の調製および分析のためのデバイス
CA3036572A1 (en) 2016-09-19 2018-03-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system

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US4960790A (en) 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
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US5227400A (en) 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
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US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
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AU4133096A (en) 1994-10-28 1996-05-23 Research Foundation Of The State University Of New York, The Taxoid derivatives, their preparation and their use as antitumor agents
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BR0104350A (pt) * 2000-02-02 2002-01-02 Univ Florida State Res Found Taxanos de c10 acetato heterossubstituìdo como agentes antitumor
KR20010111580A (ko) 2000-02-02 2001-12-19 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 개선된 용해도를 갖는 탁산 제형물

Also Published As

Publication number Publication date
EP1165068B1 (en) 2007-12-19
CA2368502A1 (en) 2001-08-09
US6664275B2 (en) 2003-12-16
KR20020002488A (ko) 2002-01-09
US20040024051A1 (en) 2004-02-05
ZA200108052B (en) 2003-12-01
NZ514406A (en) 2005-01-28
US7157474B2 (en) 2007-01-02
EP1165068A1 (en) 2002-01-02
IL145639A0 (en) 2002-06-30
AU776767B2 (en) 2004-09-23
NO20014756D0 (no) 2001-10-01
US20020068755A1 (en) 2002-06-06
TWI257390B (en) 2006-07-01
US6872837B2 (en) 2005-03-29
ATE381328T1 (de) 2008-01-15
NO20014756L (no) 2001-11-29
CZ20013523A3 (cs) 2002-03-13
HUP0200750A2 (hu) 2002-07-29
HK1047896A1 (zh) 2003-03-14
MXPA01009924A (es) 2003-08-01
US20050143447A1 (en) 2005-06-30
AU3479201A (en) 2001-08-14
DE60131927D1 (de) 2008-01-31
IL145639A (en) 2007-02-11
JP2003521514A (ja) 2003-07-15
HUP0200750A3 (en) 2005-02-28
US20070249707A1 (en) 2007-10-25
CN1362876A (zh) 2002-08-07
WO2001056564A1 (en) 2001-08-09
PL350027A1 (en) 2002-10-21

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 8A., 9A., 10A. E 11A. ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2138 DE 27/12/2011.