HUP0200750A3 - C10 heterosubstituted acetate taxanes as antitumor agents and pharmaceutical compositions containing them and their use - Google Patents
C10 heterosubstituted acetate taxanes as antitumor agents and pharmaceutical compositions containing them and their useInfo
- Publication number
- HUP0200750A3 HUP0200750A3 HU0200750A HUP0200750A HUP0200750A3 HU P0200750 A3 HUP0200750 A3 HU P0200750A3 HU 0200750 A HU0200750 A HU 0200750A HU P0200750 A HUP0200750 A HU P0200750A HU P0200750 A3 HUP0200750 A3 HU P0200750A3
- Authority
- HU
- Hungary
- Prior art keywords
- pharmaceutical compositions
- compositions containing
- antitumor agents
- taxanes
- heterosubstituted acetate
- Prior art date
Links
- 229940123237 Taxane Drugs 0.000 title 1
- 150000001242 acetic acid derivatives Chemical class 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Epoxy Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17966900P | 2000-02-02 | 2000-02-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0200750A2 HUP0200750A2 (hu) | 2002-07-29 |
| HUP0200750A3 true HUP0200750A3 (en) | 2005-02-28 |
Family
ID=22657495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0200750A HUP0200750A3 (en) | 2000-02-02 | 2001-02-02 | C10 heterosubstituted acetate taxanes as antitumor agents and pharmaceutical compositions containing them and their use |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US6664275B2 (hu) |
| EP (1) | EP1165068B1 (hu) |
| JP (1) | JP2003521514A (hu) |
| KR (1) | KR20020002488A (hu) |
| CN (1) | CN1362876A (hu) |
| AT (1) | ATE381328T1 (hu) |
| AU (1) | AU776767B2 (hu) |
| BR (1) | BR0104350A (hu) |
| CA (1) | CA2368502A1 (hu) |
| CZ (1) | CZ20013523A3 (hu) |
| DE (1) | DE60131927D1 (hu) |
| HK (1) | HK1047896A1 (hu) |
| HU (1) | HUP0200750A3 (hu) |
| IL (1) | IL145639A (hu) |
| MX (1) | MXPA01009924A (hu) |
| NO (1) | NO20014756L (hu) |
| NZ (1) | NZ514406A (hu) |
| PL (1) | PL350027A1 (hu) |
| TW (1) | TWI257390B (hu) |
| WO (1) | WO2001056564A1 (hu) |
| ZA (1) | ZA200108052B (hu) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6638973B2 (en) * | 2000-02-02 | 2003-10-28 | Fsu Research Foundation, Inc. | Taxane formulations |
| BR0104350A (pt) * | 2000-02-02 | 2002-01-02 | Univ Florida State Res Found | Taxanos de c10 acetato heterossubstituìdo como agentes antitumor |
| EP1534674A4 (en) | 2002-08-02 | 2007-11-28 | Immunogen Inc | CYTOTOXIC AGENTS CONTAINING NEW, EFFECTIVE TAXANES AND THEIR THERAPEUTIC USE |
| US7390898B2 (en) * | 2002-08-02 | 2008-06-24 | Immunogen Inc. | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
| CA2539975C (en) * | 2003-09-25 | 2012-11-20 | Tapestry Pharmaceuticals, Inc. | 9,10-.alpha.,.alpha.-oh-taxane analogs and methods for production thereof |
| SI1664033T1 (sl) * | 2003-09-25 | 2008-04-30 | Tapestry Pharmaceuticals Inc | Analogi 9,10-alfa,alfa-oh-taksana in postopki za proizvodnjo le-teh |
| CN1712399B (zh) * | 2004-06-24 | 2010-08-11 | 中国医学科学院药物研究所 | 紫杉醇和免疫增强剂胞壁酰二肽共轭物的制备及用途 |
| KR100627436B1 (ko) * | 2005-10-18 | 2006-09-22 | 주식회사 시드컴 | 차량용 요일체킹장치 |
| WO2008106621A1 (en) | 2007-02-28 | 2008-09-04 | Tapestry Pharmaceuticals, Inc | Taxane analogs for the treatment of brain cancer |
| US11786504B2 (en) | 2006-09-28 | 2023-10-17 | Tapestry Pharmaceuticals, Inc. | Taxane analogs for the treatment of brain cancer |
| WO2008121476A1 (en) | 2007-03-28 | 2008-10-09 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| US11873308B2 (en) | 2006-11-06 | 2024-01-16 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| US20080233135A1 (en) * | 2007-03-19 | 2008-09-25 | Gebhard John R | Cobalamin taxane bioconjugates |
| WO2009126401A1 (en) * | 2008-04-10 | 2009-10-15 | Abraxis Bioscience, Llc | Compositions of hydrophobic taxane derivatives and uses thereof |
| KR20150136137A (ko) * | 2008-04-10 | 2015-12-04 | 아브락시스 바이오사이언스, 엘엘씨 | 소수성 탁산 유도체의 조성물 및 그의 용도 |
| WO2011094577A2 (en) | 2010-01-29 | 2011-08-04 | Micronics, Inc. | Sample-to-answer microfluidic cartridge |
| KR101477194B1 (ko) | 2010-05-27 | 2014-12-29 | 심천 사루브리스 퍼머수티칼스 컴퍼니 리미티드 | 이중기능 복합체의 화학합성 및 항 종양과 항 종양 전이 작용 |
| EP3549674B1 (en) | 2012-12-21 | 2020-08-12 | PerkinElmer Health Sciences, Inc. | Low elasticity films for microfluidic use |
| JP2016509206A (ja) | 2012-12-21 | 2016-03-24 | マイクロニクス， インコーポレイテッド | 携帯型蛍光検出システムおよびマイクロアッセイカートリッジ |
| US10065186B2 (en) | 2012-12-21 | 2018-09-04 | Micronics, Inc. | Fluidic circuits and related manufacturing methods |
| AU2014262710B2 (en) | 2013-05-07 | 2019-09-12 | Perkinelmer Health Sciences, Inc. | Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions |
| US10386377B2 (en) | 2013-05-07 | 2019-08-20 | Micronics, Inc. | Microfluidic devices and methods for performing serum separation and blood cross-matching |
| JP6484222B2 (ja) | 2013-05-07 | 2019-03-13 | マイクロニクス， インコーポレイテッド | 核酸の調製および分析のためのデバイス |
| CA3036572A1 (en) | 2016-09-19 | 2018-03-22 | Genmark Diagnostics, Inc. | Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4960790A (en) | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
| US5175315A (en) | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
| SG46582A1 (en) | 1991-09-23 | 1998-02-20 | Univ Florida State | 10-Desacetoxytaxol derivatives |
| US5227400A (en) | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
| US5243045A (en) | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
| US5721268A (en) | 1991-09-23 | 1998-02-24 | Florida State University | C7 taxane derivatives and pharmaceutical compositions containing them |
| US5430160A (en) | 1991-09-23 | 1995-07-04 | Florida State University | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
| US5714513A (en) | 1991-09-23 | 1998-02-03 | Florida State University | C10 taxane derivatives and pharmaceutical compositions |
| US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
| CA2434312A1 (en) | 1992-01-15 | 1993-07-16 | Ramesh N. Patel | Enzymatic processes for resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes |
| US5272171A (en) | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
| US5939561A (en) | 1992-03-10 | 1999-08-17 | Rhone-Poulence Rorer S.A. | Process for the preparation of β-phenylisoserine and β-lactam and their analogues |
| US5200534A (en) | 1992-03-13 | 1993-04-06 | University Of Florida | Process for the preparation of taxol and 10-deacetyltaxol |
| FR2702212B1 (fr) * | 1993-03-02 | 1995-04-07 | Rhone Poulenc Rorer Sa | Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| US5703247A (en) | 1993-03-11 | 1997-12-30 | Virginia Tech Intellectual Properties, Inc. | 2-Debenzoyl-2-acyl taxol derivatives and methods for making same |
| ES2145829T3 (es) | 1993-06-11 | 2000-07-16 | Upjohn Co | Uso antineoplasico de delta 6,7-taxoles y composiciones farmaceuticas que los contienen. |
| IL109926A (en) | 1993-06-15 | 2000-02-29 | Bristol Myers Squibb Co | Methods for the preparation of taxanes and microorganisms and enzymes utilized therein |
| TW397866B (en) | 1993-07-14 | 2000-07-11 | Bristol Myers Squibb Co | Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes |
| FR2711369B1 (fr) * | 1993-10-20 | 1995-11-17 | Rhone Poulenc Rorer Sa | Nouveaux taxoïdes, leur préparation et les compositions qui les contiennent. |
| AU4133096A (en) | 1994-10-28 | 1996-05-23 | Research Foundation Of The State University Of New York, The | Taxoid derivatives, their preparation and their use as antitumor agents |
| MA23823A1 (fr) | 1995-03-27 | 1996-10-01 | Aventis Pharma Sa | Nouveaux taxoides, leur preparation et les compositions qui les contiennent |
| US5780653A (en) | 1995-06-07 | 1998-07-14 | Vivorx Pharmaceuticals, Inc. | Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers |
| WO1997009979A1 (en) | 1995-09-13 | 1997-03-20 | Florida State University | Radiosensitizing taxanes and their pharmaceutical preparations |
| US5714645A (en) * | 1995-10-31 | 1998-02-03 | Kuraray Co., Ltd. | Process for producing all trans-form polyprenols |
| US5756536A (en) * | 1995-11-03 | 1998-05-26 | Purdue Research Foundation | Microbial transformation of taxol and cephalomannine |
| AU702826B2 (en) * | 1995-12-18 | 1999-03-04 | Engineering Certifiers Limited | Ductile-failure anchors for concrete elements |
| US5767297A (en) * | 1997-02-05 | 1998-06-16 | Ensuiko Sugar Refining Co., Ltd. | Taxoid derivative and method of producing thereof |
| JP2000510470A (ja) | 1996-05-06 | 2000-08-15 | フロリダ・ステイト・ユニバーシティ | １―デオキシバッカチンｉｉｉ、１―デオキシタキソールおよび１―デオキシタキソール類似体、ならびにこれらの製造方法 |
| WO1998002426A1 (fr) * | 1996-07-15 | 1998-01-22 | Kabushiki Kaisha Yakult Honsha | Derives de taxane et medicaments les contenant |
| US5811452A (en) | 1997-01-08 | 1998-09-22 | The Research Foundation Of State University Of New York | Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof |
| US5912264A (en) | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
| HU224589B1 (hu) * | 1997-06-03 | 2005-11-28 | Ensuiko Sugar Refining Co., Ltd. | Taxoidszármazékok és eljárás előállításukra |
| SE9702776D0 (sv) * | 1997-07-22 | 1997-07-22 | Pharmacia & Upjohn Ab | Method of preparing pharmaceutical compositions |
| US7288665B1 (en) | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
| BR0104350A (pt) * | 2000-02-02 | 2002-01-02 | Univ Florida State Res Found | Taxanos de c10 acetato heterossubstituìdo como agentes antitumor |
| KR20010111580A (ko) | 2000-02-02 | 2001-12-19 | 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 | 개선된 용해도를 갖는 탁산 제형물 |
-
2001
- 2001-02-02 BR BR0104350-1A patent/BR0104350A/pt not_active IP Right Cessation
- 2001-02-02 CA CA002368502A patent/CA2368502A1/en not_active Abandoned
- 2001-02-02 AT AT01906951T patent/ATE381328T1/de not_active IP Right Cessation
- 2001-02-02 DE DE60131927T patent/DE60131927D1/de not_active Expired - Lifetime
- 2001-02-02 PL PL01350027A patent/PL350027A1/xx not_active Application Discontinuation
- 2001-02-02 CZ CZ20013523A patent/CZ20013523A3/cs unknown
- 2001-02-02 MX MXPA01009924A patent/MXPA01009924A/es active IP Right Grant
- 2001-02-02 NZ NZ514406A patent/NZ514406A/en unknown
- 2001-02-02 IL IL145639A patent/IL145639A/en not_active IP Right Cessation
- 2001-02-02 EP EP01906951A patent/EP1165068B1/en not_active Expired - Lifetime
- 2001-02-02 WO PCT/US2001/003553 patent/WO2001056564A1/en active IP Right Grant
- 2001-02-02 US US09/775,912 patent/US6664275B2/en not_active Expired - Fee Related
- 2001-02-02 AU AU34792/01A patent/AU776767B2/en not_active Ceased
- 2001-02-02 CN CN01800315A patent/CN1362876A/zh active Pending
- 2001-02-02 HU HU0200750A patent/HUP0200750A3/hu unknown
- 2001-02-02 JP JP2001556255A patent/JP2003521514A/ja not_active Withdrawn
- 2001-02-02 KR KR1020017012585A patent/KR20020002488A/ko active IP Right Grant
- 2001-03-27 TW TW090102213A patent/TWI257390B/zh not_active IP Right Cessation
- 2001-10-01 NO NO20014756A patent/NO20014756L/no not_active Application Discontinuation
- 2001-10-01 ZA ZA200108052A patent/ZA200108052B/en unknown
-
2003
- 2003-01-07 HK HK03100167.4A patent/HK1047896A1/zh unknown
- 2003-06-27 US US10/609,301 patent/US6872837B2/en not_active Expired - Fee Related
-
2005
- 2005-02-28 US US11/068,166 patent/US7157474B2/en not_active Expired - Fee Related
-
2006
- 2006-12-04 US US11/566,439 patent/US20070249707A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1165068B1 (en) | 2007-12-19 |
| CA2368502A1 (en) | 2001-08-09 |
| US6664275B2 (en) | 2003-12-16 |
| KR20020002488A (ko) | 2002-01-09 |
| US20040024051A1 (en) | 2004-02-05 |
| BR0104350A (pt) | 2002-01-02 |
| ZA200108052B (en) | 2003-12-01 |
| NZ514406A (en) | 2005-01-28 |
| US7157474B2 (en) | 2007-01-02 |
| EP1165068A1 (en) | 2002-01-02 |
| IL145639A0 (en) | 2002-06-30 |
| AU776767B2 (en) | 2004-09-23 |
| NO20014756D0 (no) | 2001-10-01 |
| US20020068755A1 (en) | 2002-06-06 |
| TWI257390B (en) | 2006-07-01 |
| US6872837B2 (en) | 2005-03-29 |
| ATE381328T1 (de) | 2008-01-15 |
| NO20014756L (no) | 2001-11-29 |
| CZ20013523A3 (cs) | 2002-03-13 |
| HUP0200750A2 (hu) | 2002-07-29 |
| HK1047896A1 (zh) | 2003-03-14 |
| MXPA01009924A (es) | 2003-08-01 |
| US20050143447A1 (en) | 2005-06-30 |
| AU3479201A (en) | 2001-08-14 |
| DE60131927D1 (de) | 2008-01-31 |
| IL145639A (en) | 2007-02-11 |
| JP2003521514A (ja) | 2003-07-15 |
| US20070249707A1 (en) | 2007-10-25 |
| CN1362876A (zh) | 2002-08-07 |
| WO2001056564A1 (en) | 2001-08-09 |
| PL350027A1 (en) | 2002-10-21 |
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