ATE381328T1 - Heterosubstituierte taxan-c10-acetate als antitumormittel - Google Patents

Heterosubstituierte taxan-c10-acetate als antitumormittel

Info

Publication number
ATE381328T1
ATE381328T1 AT01906951T AT01906951T ATE381328T1 AT E381328 T1 ATE381328 T1 AT E381328T1 AT 01906951 T AT01906951 T AT 01906951T AT 01906951 T AT01906951 T AT 01906951T AT E381328 T1 ATE381328 T1 AT E381328T1
Authority
AT
Austria
Prior art keywords
heterosubstituted
acetate
taxan
tumor agent
substituent
Prior art date
Application number
AT01906951T
Other languages
English (en)
Inventor
Robert A Holton
Original Assignee
Univ Florida State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida State Res Found filed Critical Univ Florida State Res Found
Application granted granted Critical
Publication of ATE381328T1 publication Critical patent/ATE381328T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT01906951T 2000-02-02 2001-02-02 Heterosubstituierte taxan-c10-acetate als antitumormittel ATE381328T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17966900P 2000-02-02 2000-02-02

Publications (1)

Publication Number Publication Date
ATE381328T1 true ATE381328T1 (de) 2008-01-15

Family

ID=22657495

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01906951T ATE381328T1 (de) 2000-02-02 2001-02-02 Heterosubstituierte taxan-c10-acetate als antitumormittel

Country Status (21)

Country Link
US (4) US6664275B2 (de)
EP (1) EP1165068B1 (de)
JP (1) JP2003521514A (de)
KR (1) KR20020002488A (de)
CN (1) CN1362876A (de)
AT (1) ATE381328T1 (de)
AU (1) AU776767B2 (de)
BR (1) BR0104350A (de)
CA (1) CA2368502A1 (de)
CZ (1) CZ20013523A3 (de)
DE (1) DE60131927D1 (de)
HK (1) HK1047896A1 (de)
HU (1) HUP0200750A3 (de)
IL (1) IL145639A (de)
MX (1) MXPA01009924A (de)
NO (1) NO20014756L (de)
NZ (1) NZ514406A (de)
PL (1) PL350027A1 (de)
TW (1) TWI257390B (de)
WO (1) WO2001056564A1 (de)
ZA (1) ZA200108052B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6638973B2 (en) * 2000-02-02 2003-10-28 Fsu Research Foundation, Inc. Taxane formulations
ATE381328T1 (de) * 2000-02-02 2008-01-15 Univ Florida State Res Found Heterosubstituierte taxan-c10-acetate als antitumormittel
US7390898B2 (en) * 2002-08-02 2008-06-24 Immunogen Inc. Cytotoxic agents containing novel potent taxanes and their therapeutic use
WO2004013093A2 (en) * 2002-08-02 2004-02-12 Immunogen, Inc. Cytotoxic agents containing novel potent taxanes and their therapeutic use
WO2005030150A2 (en) 2003-09-25 2005-04-07 Tapestry Pharmaceuticals, Inc. 9,10-α,α-OH-TAXANE ANALOGS AND METHODS FOR PRODUCTION THEREOF
EP1894921A3 (de) * 2003-09-25 2008-03-12 Tapestry Pharmaceuticals, Inc. 9, 10-Alpha, Alpha-OH-Taxan-Analoga und Herstellungsverfahren dafür
CN1712399B (zh) * 2004-06-24 2010-08-11 中国医学科学院药物研究所 紫杉醇和免疫增强剂胞壁酰二肽共轭物的制备及用途
KR100627436B1 (ko) * 2005-10-18 2006-09-22 주식회사 시드컴 차량용 요일체킹장치
US11786504B2 (en) 2006-09-28 2023-10-17 Tapestry Pharmaceuticals, Inc. Taxane analogs for the treatment of brain cancer
WO2008106621A1 (en) 2007-02-28 2008-09-04 Tapestry Pharmaceuticals, Inc Taxane analogs for the treatment of brain cancer
US11873308B2 (en) 2006-11-06 2024-01-16 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
WO2008121476A1 (en) 2007-03-28 2008-10-09 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
KR20100021403A (ko) * 2007-03-19 2010-02-24 인플라블록 팔라큐티칼스, 인크. 코발라민 탁산 생체접합체
KR20150136137A (ko) * 2008-04-10 2015-12-04 아브락시스 바이오사이언스, 엘엘씨 소수성 탁산 유도체의 조성물 및 그의 용도
WO2009126401A1 (en) * 2008-04-10 2009-10-15 Abraxis Bioscience, Llc Compositions of hydrophobic taxane derivatives and uses thereof
KR101851117B1 (ko) 2010-01-29 2018-04-23 마이크로닉스 인코포레이티드. 샘플-투-앤서 마이크로유체 카트리지
WO2011147330A1 (zh) 2010-05-27 2011-12-01 中国医学科学院药物研究所 双功能共缀物的化学合成及抗肿瘤与抗肿瘤转移作用
EP3549674B1 (de) 2012-12-21 2020-08-12 PerkinElmer Health Sciences, Inc. Filme mit geringere elastizität zur mikrofluidischen verwendung
WO2014100725A1 (en) 2012-12-21 2014-06-26 Micronics, Inc. Portable fluorescence detection system and microassay cartridge
US10065186B2 (en) 2012-12-21 2018-09-04 Micronics, Inc. Fluidic circuits and related manufacturing methods
JP6472788B2 (ja) 2013-05-07 2019-02-20 マイクロニクス, インコーポレイテッド 粘土鉱物およびアルカリ性溶液を使用して核酸含有試料を調製するための方法
JP6484222B2 (ja) 2013-05-07 2019-03-13 マイクロニクス, インコーポレイテッド 核酸の調製および分析のためのデバイス
EP2994750B1 (de) 2013-05-07 2020-08-12 PerkinElmer Health Sciences, Inc. Mikrofluidische vorrichtungen und verfahren zur durchführung von serumtrennung und blutkreuzproben
CA3036572A1 (en) 2016-09-19 2018-03-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4960790A (en) 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5430160A (en) 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5227400A (en) 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5283253A (en) 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5714513A (en) 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
SG46582A1 (en) 1991-09-23 1998-02-20 Univ Florida State 10-Desacetoxytaxol derivatives
DK1001036T3 (da) 1992-01-15 2004-11-29 Squibb & Sons Inc Enzymatiske fremgangsmåder til spaltning af enantiomerblandinger af forbindelser, der er nyttige som mellemprodukter ved fremstillingen af taxaner
US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5939561A (en) 1992-03-10 1999-08-17 Rhone-Poulence Rorer S.A. Process for the preparation of β-phenylisoserine and β-lactam and their analogues
US5200534A (en) 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
FR2702212B1 (fr) * 1993-03-02 1995-04-07 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5703247A (en) 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
DK0703909T3 (da) 1993-06-11 2000-09-11 Upjohn Co Delta6,7-taxoler, antineoplastisk anvendelse og farmaceutiske præparater indeholdende dem
IL109926A (en) 1993-06-15 2000-02-29 Bristol Myers Squibb Co Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
TW397866B (en) 1993-07-14 2000-07-11 Bristol Myers Squibb Co Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
FR2711369B1 (fr) 1993-10-20 1995-11-17 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions qui les contiennent.
AU4133096A (en) 1994-10-28 1996-05-23 Research Foundation Of The State University Of New York, The Taxoid derivatives, their preparation and their use as antitumor agents
MA23823A1 (fr) 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
US5780653A (en) 1995-06-07 1998-07-14 Vivorx Pharmaceuticals, Inc. Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers
WO1997009979A1 (en) 1995-09-13 1997-03-20 Florida State University Radiosensitizing taxanes and their pharmaceutical preparations
TW338042B (en) * 1995-10-31 1998-08-11 Clary Kk Process for producing all trans-form polyprenols
US5756536A (en) * 1995-11-03 1998-05-26 Purdue Research Foundation Microbial transformation of taxol and cephalomannine
US5899043A (en) * 1995-12-18 1999-05-04 Engineering Certifiers Ltd. Ductile-failure anchors for concrete elements
US5767297A (en) * 1997-02-05 1998-06-16 Ensuiko Sugar Refining Co., Ltd. Taxoid derivative and method of producing thereof
AU724499B2 (en) 1996-05-06 2000-09-21 Florida State University 1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof
BR9710366A (pt) * 1996-07-15 1999-08-17 Yakult Honsha Kk Derivados de taxane e drogas que os contêm
US5811452A (en) 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US5912264A (en) 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
CA2206739C (en) 1997-06-03 2006-10-10 Ensuiko Sugar Refining Co., Ltd. Taxoid derivative and method of producing thereof
SE9702776D0 (sv) * 1997-07-22 1997-07-22 Pharmacia & Upjohn Ab Method of preparing pharmaceutical compositions
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
ATE381328T1 (de) * 2000-02-02 2008-01-15 Univ Florida State Res Found Heterosubstituierte taxan-c10-acetate als antitumormittel
NZ514073A (en) 2000-02-02 2004-02-27 Univ Florida State Res Found Taxane formulations having improved solubility

Also Published As

Publication number Publication date
US7157474B2 (en) 2007-01-02
CZ20013523A3 (cs) 2002-03-13
US20050143447A1 (en) 2005-06-30
IL145639A (en) 2007-02-11
CN1362876A (zh) 2002-08-07
US6664275B2 (en) 2003-12-16
NZ514406A (en) 2005-01-28
IL145639A0 (en) 2002-06-30
US20070249707A1 (en) 2007-10-25
KR20020002488A (ko) 2002-01-09
EP1165068B1 (de) 2007-12-19
AU776767B2 (en) 2004-09-23
HK1047896A1 (zh) 2003-03-14
HUP0200750A3 (en) 2005-02-28
HUP0200750A2 (hu) 2002-07-29
ZA200108052B (en) 2003-12-01
BR0104350A (pt) 2002-01-02
US20040024051A1 (en) 2004-02-05
US20020068755A1 (en) 2002-06-06
DE60131927D1 (de) 2008-01-31
TWI257390B (en) 2006-07-01
NO20014756D0 (no) 2001-10-01
AU3479201A (en) 2001-08-14
NO20014756L (no) 2001-11-29
EP1165068A1 (de) 2002-01-02
WO2001056564A1 (en) 2001-08-09
PL350027A1 (en) 2002-10-21
CA2368502A1 (en) 2001-08-09
US6872837B2 (en) 2005-03-29
JP2003521514A (ja) 2003-07-15
MXPA01009924A (es) 2003-08-01

Similar Documents

Publication Publication Date Title
ATE381328T1 (de) Heterosubstituierte taxan-c10-acetate als antitumormittel
MY137637A (en) C7 ester substituted taxanes
NO20014758L (no) C(7)-heterosubstituerte acetattaxaner som antitumormidler
BG105964A (en) C(10) carbonate substituted taxanes and their use as antitumor agents
DE60134814D1 (de) C10-carbamoyloxysubstituierte taxane als antitumormittel
DE60138853D1 (de) C10-taxanester als antitumormittel
DE60133600D1 (de) C7-carbamoyloxysubstituierte taxane als antitumormittel
ATE282611T1 (de) Stolonoxide
MXPA01007972A (es) Esteres de taxanos c10 sustituidos.
SG125888A1 (en) C10 carbonate substituted taxanes

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties