ATE381328T1 - Heterosubstituierte taxan-c10-acetate als antitumormittel - Google Patents

Heterosubstituierte taxan-c10-acetate als antitumormittel

Info

Publication number
ATE381328T1
ATE381328T1 AT01906951T AT01906951T ATE381328T1 AT E381328 T1 ATE381328 T1 AT E381328T1 AT 01906951 T AT01906951 T AT 01906951T AT 01906951 T AT01906951 T AT 01906951T AT E381328 T1 ATE381328 T1 AT E381328T1
Authority
AT
Austria
Prior art keywords
heterosubstituted
acetate
taxan
tumor agent
substituent
Prior art date
Application number
AT01906951T
Other languages
English (en)
Inventor
Robert A Holton
Original Assignee
Univ Florida State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida State Res Found filed Critical Univ Florida State Res Found
Application granted granted Critical
Publication of ATE381328T1 publication Critical patent/ATE381328T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT01906951T 2000-02-02 2001-02-02 Heterosubstituierte taxan-c10-acetate als antitumormittel ATE381328T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17966900P 2000-02-02 2000-02-02

Publications (1)

Publication Number Publication Date
ATE381328T1 true ATE381328T1 (de) 2008-01-15

Family

ID=22657495

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01906951T ATE381328T1 (de) 2000-02-02 2001-02-02 Heterosubstituierte taxan-c10-acetate als antitumormittel

Country Status (21)

Country Link
US (4) US6664275B2 (de)
EP (1) EP1165068B1 (de)
JP (1) JP2003521514A (de)
KR (1) KR20020002488A (de)
CN (1) CN1362876A (de)
AT (1) ATE381328T1 (de)
AU (1) AU776767B2 (de)
BR (1) BR0104350A (de)
CA (1) CA2368502A1 (de)
CZ (1) CZ20013523A3 (de)
DE (1) DE60131927D1 (de)
HK (1) HK1047896A1 (de)
HU (1) HUP0200750A3 (de)
IL (1) IL145639A (de)
MX (1) MXPA01009924A (de)
NO (1) NO20014756L (de)
NZ (1) NZ514406A (de)
PL (1) PL350027A1 (de)
TW (1) TWI257390B (de)
WO (1) WO2001056564A1 (de)
ZA (1) ZA200108052B (de)

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JP2003521514A (ja) * 2000-02-02 2003-07-15 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド 抗腫瘍剤としてのc10ヘテロ置換アセテートタキサン
JP2003521545A (ja) * 2000-02-02 2003-07-15 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド 改良された溶解性を有するタキサン製剤
KR20050032110A (ko) * 2002-08-02 2005-04-06 이뮤노젠 아이엔씨 신규의 효능을 갖는 탁산을 포함하는 세포독성제 및 그치료용도
US7390898B2 (en) 2002-08-02 2008-06-24 Immunogen Inc. Cytotoxic agents containing novel potent taxanes and their therapeutic use
EP1894921A3 (de) * 2003-09-25 2008-03-12 Tapestry Pharmaceuticals, Inc. 9, 10-Alpha, Alpha-OH-Taxan-Analoga und Herstellungsverfahren dafür
ATE377593T1 (de) 2003-09-25 2007-11-15 Tapestry Pharmaceuticals Inc 9,10-alpha,alpha-oh-taxananaloga und verfahren zu deren herstellung
CN1712399B (zh) * 2004-06-24 2010-08-11 中国医学科学院药物研究所 紫杉醇和免疫增强剂胞壁酰二肽共轭物的制备及用途
KR100627436B1 (ko) * 2005-10-18 2006-09-22 주식회사 시드컴 차량용 요일체킹장치
WO2008106621A1 (en) 2007-02-28 2008-09-04 Tapestry Pharmaceuticals, Inc Taxane analogs for the treatment of brain cancer
US11786504B2 (en) 2006-09-28 2023-10-17 Tapestry Pharmaceuticals, Inc. Taxane analogs for the treatment of brain cancer
WO2008121476A1 (en) 2007-03-28 2008-10-09 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
US11873308B2 (en) 2006-11-06 2024-01-16 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
US20080233135A1 (en) * 2007-03-19 2008-09-25 Gebhard John R Cobalamin taxane bioconjugates
CA2721153C (en) * 2008-04-10 2018-10-02 Abraxis Bioscience, Llc Compositions of hydrophobic taxane derivatives and uses thereof
KR20150136137A (ko) * 2008-04-10 2015-12-04 아브락시스 바이오사이언스, 엘엘씨 소수성 탁산 유도체의 조성물 및 그의 용도
CN102740976B (zh) 2010-01-29 2016-04-20 精密公司 取样-应答微流体盒
EP3239139B1 (de) 2010-05-27 2020-10-28 Ningbo Combireg Pharmaceutical Technology Co. Ltd Chemische synthese sowie antitumor- und antimetastasewirkung eines konjugats mit doppelfunktion
KR20150097764A (ko) 2012-12-21 2015-08-26 마이크로닉스 인코포레이티드. 휴대형 형광 검출 시스템 및 미량분석 카트리지
WO2014100732A1 (en) 2012-12-21 2014-06-26 Micronics, Inc. Fluidic circuits and related manufacturing methods
EP3549674B1 (de) 2012-12-21 2020-08-12 PerkinElmer Health Sciences, Inc. Filme mit geringere elastizität zur mikrofluidischen verwendung
WO2014182847A1 (en) 2013-05-07 2014-11-13 Micronics, Inc. Device for preparation and analysis of nucleic acids
WO2014182831A1 (en) 2013-05-07 2014-11-13 Micronics, Inc. Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions
US10386377B2 (en) 2013-05-07 2019-08-20 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
EP3516401A1 (de) 2016-09-19 2019-07-31 Genmark Diagnostics Inc. Instrument zur verarbeitung einer kassette zur durchführung von tests in einem geschlossenen probenvorbereitungs- und -reaktionssystem

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US4960790A (en) 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5283253A (en) 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
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US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
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US5430160A (en) 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
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ATE249448T1 (de) 1993-06-11 2003-09-15 Upjohn Co Delta 6,7-taxol derivate antineoplastische verbindungen und diese enthaltende pharmazeutische zusammenstellungen
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WO1996013495A1 (en) 1994-10-28 1996-05-09 The Research Foundation Of State University Of New York Taxoid derivatives, their preparation and their use as antitumor agents
MA23823A1 (fr) 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
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JP2003521514A (ja) * 2000-02-02 2003-07-15 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド 抗腫瘍剤としてのc10ヘテロ置換アセテートタキサン
BR0104358A (pt) 2000-02-02 2002-01-02 Univ Florida State Res Found Formulações de taxana tendo solubilidade aperfeiçoada

Also Published As

Publication number Publication date
PL350027A1 (en) 2002-10-21
IL145639A (en) 2007-02-11
NO20014756D0 (no) 2001-10-01
WO2001056564A1 (en) 2001-08-09
KR20020002488A (ko) 2002-01-09
TWI257390B (en) 2006-07-01
US20020068755A1 (en) 2002-06-06
EP1165068A1 (de) 2002-01-02
CN1362876A (zh) 2002-08-07
IL145639A0 (en) 2002-06-30
AU3479201A (en) 2001-08-14
HUP0200750A3 (en) 2005-02-28
US20050143447A1 (en) 2005-06-30
DE60131927D1 (de) 2008-01-31
HUP0200750A2 (hu) 2002-07-29
US20070249707A1 (en) 2007-10-25
NO20014756L (no) 2001-11-29
NZ514406A (en) 2005-01-28
CA2368502A1 (en) 2001-08-09
MXPA01009924A (es) 2003-08-01
EP1165068B1 (de) 2007-12-19
US20040024051A1 (en) 2004-02-05
ZA200108052B (en) 2003-12-01
US6664275B2 (en) 2003-12-16
AU776767B2 (en) 2004-09-23
US6872837B2 (en) 2005-03-29
HK1047896A1 (zh) 2003-03-14
CZ20013523A3 (cs) 2002-03-13
JP2003521514A (ja) 2003-07-15
BR0104350A (pt) 2002-01-02
US7157474B2 (en) 2007-01-02

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