DK1001036T3 - Enzymatiske fremgangsmåder til spaltning af enantiomerblandinger af forbindelser, der er nyttige som mellemprodukter ved fremstillingen af taxaner - Google Patents

Enzymatiske fremgangsmåder til spaltning af enantiomerblandinger af forbindelser, der er nyttige som mellemprodukter ved fremstillingen af taxaner

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Publication number
DK1001036T3
DK1001036T3 DK99124119T DK99124119T DK1001036T3 DK 1001036 T3 DK1001036 T3 DK 1001036T3 DK 99124119 T DK99124119 T DK 99124119T DK 99124119 T DK99124119 T DK 99124119T DK 1001036 T3 DK1001036 T3 DK 1001036T3
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DK
Denmark
Prior art keywords
taxanes
intermediates
preparation
cleavage
compounds useful
Prior art date
Application number
DK99124119T
Other languages
English (en)
Inventor
Laszlo J Szarka
Ramesh N Patel
Richard A Partyka
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Application granted granted Critical
Publication of DK1001036T3 publication Critical patent/DK1001036T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
DK99124119T 1992-01-15 1993-01-15 Enzymatiske fremgangsmåder til spaltning af enantiomerblandinger af forbindelser, der er nyttige som mellemprodukter ved fremstillingen af taxaner DK1001036T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82201592A 1992-01-15 1992-01-15
EP93300241A EP0552041B1 (en) 1992-01-15 1993-01-15 Enzymatic processes for resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes

Publications (1)

Publication Number Publication Date
DK1001036T3 true DK1001036T3 (da) 2004-11-29

Family

ID=25234887

Family Applications (2)

Application Number Title Priority Date Filing Date
DK99124119T DK1001036T3 (da) 1992-01-15 1993-01-15 Enzymatiske fremgangsmåder til spaltning af enantiomerblandinger af forbindelser, der er nyttige som mellemprodukter ved fremstillingen af taxaner
DK93300241T DK0552041T3 (da) 1992-01-15 1993-01-15 Enzymatiske fremgangsmåder til spaltning af enantiomerblandinger af forbindelser, der er nyttige som mellemprodukter ved fr

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK93300241T DK0552041T3 (da) 1992-01-15 1993-01-15 Enzymatiske fremgangsmåder til spaltning af enantiomerblandinger af forbindelser, der er nyttige som mellemprodukter ved fr

Country Status (11)

Country Link
US (2) US5567614A (da)
EP (2) EP1001036B1 (da)
JP (1) JP3184350B2 (da)
AT (2) ATE280240T1 (da)
CA (2) CA2087359A1 (da)
DE (2) DE69329304T2 (da)
DK (2) DK1001036T3 (da)
ES (2) ES2149800T3 (da)
GR (1) GR3034942T3 (da)
HK (1) HK1027130A1 (da)
PT (2) PT1001036E (da)

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US6649632B2 (en) * 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
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DE60136430D1 (de) * 2000-02-02 2008-12-18 Univ Florida State Res Found Heterosubstituierte c7-taxanacetate als antitumormittel
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DE10004926A1 (de) * 2000-02-04 2001-08-09 Gruenenthal Gmbh Verfahren zur enzymatischen Racematspaltung von Aminomethyl-Aryl-Cyclohexanol-Derivaten
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CN1960721A (zh) 2004-03-05 2007-05-09 佛罗里达州立大学研究基金有限公司 C7乳酰氧基取代的紫杉烷类
JP2008530122A (ja) * 2005-02-14 2008-08-07 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド Ｃ１０シクロプロピルエステル置換タキサン組成物
WO2009118750A1 (en) * 2008-03-26 2009-10-01 Council Of Scientific & Industrial Research Stereoselective hydrolysis for the resolution of racemic mixtures of (+/-) -cis-s-acetoxy-l- (4-methoxyphenyl) -4- (2-furyl) -2-azetidinone, (+/-) -cis-s-acetoxy-l- (4-methoxyphenyl) -4- (2-thienyl) -2-azetidinone, or
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Also Published As

Publication number Publication date
DE69333675D1 (de) 2004-11-25
EP0552041B1 (en) 2000-08-30
ES2230790T3 (es) 2005-05-01
JPH05308996A (ja) 1993-11-22
EP1001036B1 (en) 2004-10-20
DE69329304T2 (de) 2001-01-04
GR3034942T3 (en) 2001-02-28
EP0552041A3 (en) 1994-10-05
CA2087359A1 (en) 1993-07-16
EP0552041A2 (en) 1993-07-21
DK0552041T3 (da) 2000-10-09
DE69333675T2 (de) 2006-02-02
EP1001036A2 (en) 2000-05-17
DE69329304D1 (de) 2000-10-05
JP3184350B2 (ja) 2001-07-09
US5567614A (en) 1996-10-22
ATE280240T1 (de) 2004-11-15
ATE195973T1 (de) 2000-09-15
PT1001036E (pt) 2005-01-31
PT552041E (pt) 2000-12-29
HK1027130A1 (en) 2001-01-05
EP1001036A3 (en) 2000-08-02
CA2434312A1 (en) 1993-07-16
US5811292A (en) 1998-09-22
ES2149800T3 (es) 2000-11-16

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