DE69333675D1 - Enzymatische Verfahren zur Aüftrennüng von Enantiomeren-Mischungen nützlich als Zwischenprodukte zur Herstellung von Taxanen - Google Patents

Enzymatische Verfahren zur Aüftrennüng von Enantiomeren-Mischungen nützlich als Zwischenprodukte zur Herstellung von Taxanen

Info

Publication number
DE69333675D1
DE69333675D1 DE69333675T DE69333675T DE69333675D1 DE 69333675 D1 DE69333675 D1 DE 69333675D1 DE 69333675 T DE69333675 T DE 69333675T DE 69333675 T DE69333675 T DE 69333675T DE 69333675 D1 DE69333675 D1 DE 69333675D1
Authority
DE
Germany
Prior art keywords
taxanes
intermediates
preparation
separation
enzymatic processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69333675T
Other languages
English (en)
Other versions
DE69333675T2 (de
Inventor
Ramesh N Patel
Laszlo J Szarka
Richard A Partyka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Application granted granted Critical
Publication of DE69333675D1 publication Critical patent/DE69333675D1/de
Publication of DE69333675T2 publication Critical patent/DE69333675T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Epoxy Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DE69333675T 1992-01-15 1993-01-15 Enzymatische Verfahren zur Trennung von Enantiomerengemischen von Verbindungen, die als Zwischenprodukte zur Herstellung von Taxanen nützlich sind Expired - Fee Related DE69333675T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82201592A 1992-01-15 1992-01-15
US822015 1992-01-15

Publications (2)

Publication Number Publication Date
DE69333675D1 true DE69333675D1 (de) 2004-11-25
DE69333675T2 DE69333675T2 (de) 2006-02-02

Family

ID=25234887

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69329304T Expired - Fee Related DE69329304T2 (de) 1992-01-15 1993-01-15 Enzymatische Verfahren zur Resolution von Enantiomeren-Mischungen nützlich wie Zwischenprodukte zur Herstellung von Taxanen
DE69333675T Expired - Fee Related DE69333675T2 (de) 1992-01-15 1993-01-15 Enzymatische Verfahren zur Trennung von Enantiomerengemischen von Verbindungen, die als Zwischenprodukte zur Herstellung von Taxanen nützlich sind

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69329304T Expired - Fee Related DE69329304T2 (de) 1992-01-15 1993-01-15 Enzymatische Verfahren zur Resolution von Enantiomeren-Mischungen nützlich wie Zwischenprodukte zur Herstellung von Taxanen

Country Status (11)

Country Link
US (2) US5567614A (de)
EP (2) EP1001036B1 (de)
JP (1) JP3184350B2 (de)
AT (2) ATE195973T1 (de)
CA (2) CA2434312A1 (de)
DE (2) DE69329304T2 (de)
DK (2) DK1001036T3 (de)
ES (2) ES2230790T3 (de)
GR (1) GR3034942T3 (de)
HK (1) HK1027130A1 (de)
PT (2) PT552041E (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6005138A (en) 1991-09-23 1999-12-21 Florida State University Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US6521660B2 (en) 1991-09-23 2003-02-18 Florida State University 3′-alkyl substituted taxanes and pharmaceutical compositions containing them
US6335362B1 (en) * 1991-09-23 2002-01-01 Florida State University Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
ATE195973T1 (de) * 1992-01-15 2000-09-15 Squibb & Sons Inc Enzymatische verfahren zur resolution von enantiomeren-mischungen nützlich wie zwischenprodukte zur herstellung von taxanen
US5646176A (en) 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
TW397866B (en) * 1993-07-14 2000-07-11 Bristol Myers Squibb Co Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
DE4420751A1 (de) * 1994-06-15 1995-12-21 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Lactamen
US5602272A (en) * 1994-06-21 1997-02-11 Bristol-Myers Squibb Company Reduction and resolution methods for the preparation of compounds useful as intemediates for preparing taxanes
US6201140B1 (en) 1994-07-28 2001-03-13 Bristol-Myers Squibb Company 7-0-ethers of taxane derivatives
US5523233A (en) * 1995-05-03 1996-06-04 Merck & Co., Inc. Enzymatic hydrolysis of 3,3-diethyl-4-[(4-carboxy)phenoxy]-2-azetidinone esters
US5635531A (en) * 1996-07-08 1997-06-03 Bristol-Myers Squibb Company 3'-aminocarbonyloxy paclitaxels
EP1308519B1 (de) * 1997-01-24 2006-04-19 Sumitomo Chemical Company, Limited Verfahren zur Verbesserung der optischen Aktivität von Azetidin-2-carbonsäure
GB9714877D0 (en) * 1997-07-15 1997-09-17 Chiroscience Ltd Microorganism and its use
EP0933360A1 (de) 1997-12-22 1999-08-04 Pharmachemie B.V. Synthese von Beta-lactamen
US5919672A (en) * 1998-10-02 1999-07-06 Schering Corporation Resolution of trans-2-(alkoxycarbonylethyl)-lactams useful in the synthesis of 1-(4-fluoro-phenyl)-3(R)- (S)-hydroxy-3-(4-fluorophenyl)-propyl!-4(S)-(4-hydroxyphenyl)-2-azetidinone
KR100567108B1 (ko) * 1999-07-16 2006-03-31 에스케이 주식회사 효소적 방법에 의한 트랜스-(1ｓ,2ｓ)-1-아지도 2-인단올 및 트랜스-(1ｒ,2ｒ)-1-아지도 2-인다닐 아세테이트의 제조방법
EP2289549A3 (de) 1999-10-01 2011-06-15 Immunogen, Inc. Immunokonjugate für Krebsbehandlung
US6548293B1 (en) 1999-10-18 2003-04-15 Fsu Research Foundation, Inc. Enzymatic process for the resolution of enantiomeric mixtures of β-lactams
ATE413397T1 (de) * 2000-02-02 2008-11-15 Univ Florida State Res Found Heterosubstituierte c7-taxanacetate als antitumormittel
AU776767B2 (en) 2000-02-02 2004-09-23 Florida State University Research Foundation, Inc. C10 heterosubstituted acetate taxanes as antitumor agents
AU776122B2 (en) 2000-02-02 2004-08-26 Florida State University Research Foundation, Inc. C7 carbonate substituted taxanes as antitumor agents
US6649632B2 (en) * 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
WO2001057033A1 (en) * 2000-02-02 2001-08-09 Florida State University Research Foundation, Inc. C10 carbamoyloxy substituted taxanes as antitumor agents
CO5280224A1 (es) * 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
ATE392422T1 (de) * 2000-02-02 2008-05-15 Univ Florida State Res Found C7-carbamoyloxysubstituierte taxane als antitumormittel
JP2003522171A (ja) 2000-02-02 2003-07-22 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド 抗腫瘍剤としてのｃ１０カーボネート置換タキサン
DE10004926A1 (de) 2000-02-04 2001-08-09 Gruenenthal Gmbh Verfahren zur enzymatischen Racematspaltung von Aminomethyl-Aryl-Cyclohexanol-Derivaten
ES2284613T3 (es) * 2000-02-11 2007-11-16 Shire Biochem Inc. Sintesis estereoselectiva de analogos de nucleosido.
DE50212728D1 (de) * 2001-03-07 2008-10-16 Daiichi Sankyo Co Ltd Verfahren zur herstellung von 2-azetidinonderivaten
US6653501B2 (en) 2001-06-27 2003-11-25 Napro Biotherapeutics, Inc. Chiral resolution method for producing compounds useful in the synthesis of taxanes
US7063977B2 (en) * 2001-08-21 2006-06-20 Bristol-Myers Squibb Company Enzymatic resolution of t-butyl taxane derivatives
HUP0600533A2 (en) 2001-11-30 2006-11-28 Bristol Myers Squibb Co Paclitaxel solvates
KR100433633B1 (ko) * 2002-04-18 2004-05-31 학교법인 포항공과대학교 무용매 이상계 시스템을 이용한 효소적 광학분할 방법
US7064980B2 (en) * 2003-09-17 2006-06-20 Sandisk Corporation Non-volatile memory and method with bit line coupled compensation
PE20050693A1 (es) * 2004-02-13 2005-09-27 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
CN1960721A (zh) 2004-03-05 2007-05-09 佛罗里达州立大学研究基金有限公司 C7乳酰氧基取代的紫杉烷类
TW200640447A (en) * 2005-02-14 2006-12-01 Univ Florida State Res Found C10 cyclopropyl ester substituted taxane compositions
WO2009118750A1 (en) * 2008-03-26 2009-10-01 Council Of Scientific & Industrial Research Stereoselective hydrolysis for the resolution of racemic mixtures of (+/-) -cis-s-acetoxy-l- (4-methoxyphenyl) -4- (2-furyl) -2-azetidinone, (+/-) -cis-s-acetoxy-l- (4-methoxyphenyl) -4- (2-thienyl) -2-azetidinone, or
WO2009145981A1 (en) * 2008-03-31 2009-12-03 Florida State University Research Foundation, Inc. C(10) ethyl ester and c(10) cyclopropyl ester substituted taxanes

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4492757A (en) * 1981-12-28 1985-01-08 Denki Kagaku Kogyo Kabushiki Kaisha Process for preparing L-threonine
JPS60248192A (ja) * 1984-05-23 1985-12-07 Sumitomo Chem Co Ltd 光学活性なスレオ−３−フエニルセリン誘導体の製造方法
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
US4876399A (en) * 1987-11-02 1989-10-24 Research Corporation Technologies, Inc. Taxols, their preparation and intermediates thereof
US4942184A (en) * 1988-03-07 1990-07-17 The United States Of America As Represented By The Department Of Health And Human Services Water soluble, antineoplastic derivatives of taxol
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
US4943528A (en) * 1988-11-22 1990-07-24 Nitto Chemical Industry Co., Ltd. Process for the production of optically active (R)-(-)-3-halo-1,2-propanediol
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
CA2012364A1 (en) * 1989-04-01 1990-10-01 Fumio Moriuchi Optically active compound and process for preparing the same
KR920701469A (ko) * 1989-05-15 1992-08-11 스테이너 브이. 캔스태드 향균성 화합물 및 이의 중간물질의 제조방법
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
EP0404586A3 (de) * 1989-06-21 1991-12-11 Merck & Co. Inc. Stickstoffungeschützte 4-Acyloxyazetidin-2-one
CA2023645C (fr) * 1989-08-23 2002-03-26 Jean-Noel Denis Procede pour la preparation enantioselective de derives de la phenylisoserine
US5241064A (en) * 1989-10-02 1993-08-31 Fujisawa Pharmaceutical Co., Ltd. Enzymatic process for preparing optically active 3-substituted azetidinones
US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
CA2071160A1 (en) * 1991-07-31 1993-02-01 Vittorio Farina Asymmetric synthesis of taxol side chain
ATE134610T1 (de) * 1991-08-22 1996-03-15 Lonza Ag Verfahren zur herstellung von optisch aktiven 4- amino-3-hydroxycarbonsäuren
US5243045A (en) * 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5227400A (en) * 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5250683A (en) * 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
ATE195973T1 (de) * 1992-01-15 2000-09-15 Squibb & Sons Inc Enzymatische verfahren zur resolution von enantiomeren-mischungen nützlich wie zwischenprodukte zur herstellung von taxanen
US5272171A (en) * 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5294637A (en) * 1992-07-01 1994-03-15 Bristol-Myers Squibb Company Fluoro taxols
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
EP0582469A2 (de) * 1992-08-06 1994-02-09 Wisconsin Alumni Research Foundation Verfahren zur Herstellung von Taxol-Typ-Verbindungen vom Beta-Laktam-Vorläufer
NO310238B1 (no) * 1992-12-24 2001-06-11 Bristol Myers Squibb Co Kjemiske forbindelser og farmasöytisk preparat samt anvendelse av slike preparater
US5516676A (en) * 1993-06-15 1996-05-14 Bristol-Myers Squibb Company Preparation of C-13 hydroxyl-bearing taxanes using nocardioides or a hydrolase isolated therefrom
US5523219A (en) * 1993-06-15 1996-06-04 Bristol-Myers Squibb Company Enzymatic hydrolysis method for the preparation of C-10 hydroxyl-bearing taxanes and enzymatic esterification method for the preparation of C-10 acyloxy-bearing

Also Published As

Publication number Publication date
EP0552041A2 (de) 1993-07-21
HK1027130A1 (en) 2001-01-05
PT552041E (pt) 2000-12-29
GR3034942T3 (en) 2001-02-28
US5567614A (en) 1996-10-22
JPH05308996A (ja) 1993-11-22
DE69333675T2 (de) 2006-02-02
PT1001036E (pt) 2005-01-31
EP1001036A3 (de) 2000-08-02
CA2087359A1 (en) 1993-07-16
DK1001036T3 (da) 2004-11-29
DE69329304D1 (de) 2000-10-05
ES2230790T3 (es) 2005-05-01
JP3184350B2 (ja) 2001-07-09
EP0552041A3 (en) 1994-10-05
ATE280240T1 (de) 2004-11-15
EP1001036A2 (de) 2000-05-17
EP0552041B1 (de) 2000-08-30
US5811292A (en) 1998-09-22
CA2434312A1 (en) 1993-07-16
EP1001036B1 (de) 2004-10-20
DK0552041T3 (da) 2000-10-09
ES2149800T3 (es) 2000-11-16
DE69329304T2 (de) 2001-01-04
ATE195973T1 (de) 2000-09-15

Similar Documents

Publication Publication Date Title
DE69333675D1 (de) Enzymatische Verfahren zur Aüftrennüng von Enantiomeren-Mischungen nützlich als Zwischenprodukte zur Herstellung von Taxanen
DE69201995T2 (de) Verfahren zur Herstellung von Nitrilen.
DE69431642D1 (de) Verfahren zur Herstellung von stabilisiertem Polycarbonat
DE69014707D1 (de) Verfahren zur Herstellung von CMOS-Feldeffekt-Transistoren.
DE69231815D1 (de) Verfahren zur Herstellung von Cephalosporinen und Zwischenprodukte in diesem Verfahren
DE59204480D1 (de) Verfahren zur Herstellung von tert.-Butoxycarbonyl-Gruppen tragenden organischen Verbindungen.
DE59400013D1 (de) Verfahren zur Herstellung von Methylchlorsilanen.
IT8922075A0 (it) Processo per l'inversione stereochimica di (2s,3s)-2-ammino-3-fenil-1 ,3-propandioli nei corrispondenti enantiomeri (2r,3r)
DE69107410D1 (de) Verfahren zur Herstellung von optischen aktiven Aminen.
DE69300551D1 (de) Verfahren zur Herstellung von (3R,4R)-3-Hydroxy-4-Hydroxymethyl-4-Butanolid.
DE68920351D1 (de) Verfahren zur Herstellung von Indigoverbindungen.
DE69402201D1 (de) Phosphorhaltiges, metallurgisches silizium zur herstellung von organohalosilanen
DE69007965D1 (de) Apparatur zur herstellung von alpha-beta-ungesättigten nitrilen.
DE69313411D1 (de) Verfahren zur O-Alkylierung von phenolischen Verbindungen
DE69410222T2 (de) Verfahren zur Herstellung von optisch aktiven Erythro-3-amino-1,2-epoxy-Verbindungen
FI102083B1 (fi) Menetelmä L-karnitiinin valmistamiseksi epäjatkuvasti mikrobiologista tietä
DE69008382T2 (de) Verfahren zur Herstellung von Organosiliziumverbindungen.
DE69114599D1 (de) Verfahren zur Herstellung von Esterase.
DE19983723T1 (de) Verfahren zur Herstellung von Bis-N-substituierten Perylentetracarboximiden über Bis(hydroxymethyl)perylentetracarboximid
DE59405085D1 (de) Verfahren zur Herstellung von Tetrachlor-1,4-benzochinon
DE69519564D1 (de) Verfahren zur herstellung von 4,4-dialkyl-6-halogen-chromanen oder -thiochromanen, welche als pharmazeutische zwischenprodukte brauchbar sind
DE59400715D1 (de) Diskontinuierliches katalytisches Verfahren zur Herstellung von Polyamid-6.6
DE59707130D1 (de) Verfahren zur destillativen Reinigung von Diurethanen
DE69404641D1 (de) Verfahren zur herstellung von 3,4-dihalogeno-1,2-epoxybutanen ausgehend von 3,4-epoxy-1-buten
DE68918226D1 (de) Verfahren zur Herstellung von Indigoverbindungen.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee