ATE392422T1 - C7-carbamoyloxysubstituierte taxane als antitumormittel - Google Patents
C7-carbamoyloxysubstituierte taxane als antitumormittelInfo
- Publication number
- ATE392422T1 ATE392422T1 AT01905421T AT01905421T ATE392422T1 AT E392422 T1 ATE392422 T1 AT E392422T1 AT 01905421 T AT01905421 T AT 01905421T AT 01905421 T AT01905421 T AT 01905421T AT E392422 T1 ATE392422 T1 AT E392422T1
- Authority
- AT
- Austria
- Prior art keywords
- tumor agents
- substituted taxanes
- carbamoyloxy substituted
- carbamoyloxy
- taxanes
- Prior art date
Links
- 229940123237 Taxane Drugs 0.000 title abstract 2
- 239000002246 antineoplastic agent Substances 0.000 title 1
- -1 carbamoyloxy substituent Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17967000P | 2000-02-02 | 2000-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE392422T1 true ATE392422T1 (de) | 2008-05-15 |
Family
ID=22657498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01905421T ATE392422T1 (de) | 2000-02-02 | 2001-02-02 | C7-carbamoyloxysubstituierte taxane als antitumormittel |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US6359154B2 (de) |
| EP (1) | EP1165549B1 (de) |
| JP (1) | JP2003522168A (de) |
| KR (1) | KR20020002417A (de) |
| CN (1) | CN1362956A (de) |
| AT (1) | ATE392422T1 (de) |
| AU (1) | AU778991B2 (de) |
| BR (1) | BR0104355A (de) |
| CA (1) | CA2368510A1 (de) |
| CZ (1) | CZ20013521A3 (de) |
| DE (1) | DE60133600T2 (de) |
| DK (1) | DK1165549T3 (de) |
| ES (1) | ES2305056T3 (de) |
| HK (1) | HK1047937A1 (de) |
| HU (1) | HUP0200752A3 (de) |
| IL (1) | IL145643A0 (de) |
| MX (1) | MXPA01009923A (de) |
| NO (1) | NO20014757L (de) |
| NZ (1) | NZ514410A (de) |
| PL (1) | PL350024A1 (de) |
| PT (1) | PT1165549E (de) |
| WO (1) | WO2001057028A1 (de) |
| ZA (1) | ZA200108056B (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1165549B1 (de) * | 2000-02-02 | 2008-04-16 | Florida State University Research Foundation, Inc. | C7-carbamoyloxysubstituierte taxane als antitumormittel |
| JP2003521545A (ja) * | 2000-02-02 | 2003-07-15 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | 改良された溶解性を有するタキサン製剤 |
| US7390898B2 (en) | 2002-08-02 | 2008-06-24 | Immunogen Inc. | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
| JP2005539009A (ja) | 2002-08-02 | 2005-12-22 | イミュノジェン・インコーポレーテッド | 新規の効力のあるタキサンを含む細胞毒性物質、および、それらの治療用途 |
| CN113952464B (zh) * | 2018-03-06 | 2024-10-15 | 江苏吉贝尔药业股份有限公司 | 含酮羰基的疏水性抗肿瘤药物及其应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4960790A (en) | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
| US5175315A (en) | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
| FR2679230B1 (fr) | 1991-07-16 | 1993-11-19 | Rhone Poulenc Rorer Sa | Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent. |
| US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
| US5227400A (en) | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
| US5721268A (en) | 1991-09-23 | 1998-02-24 | Florida State University | C7 taxane derivatives and pharmaceutical compositions containing them |
| SG46582A1 (en) | 1991-09-23 | 1998-02-20 | Univ Florida State | 10-Desacetoxytaxol derivatives |
| US5243045A (en) | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
| US5714513A (en) | 1991-09-23 | 1998-02-03 | Florida State University | C10 taxane derivatives and pharmaceutical compositions |
| US5430160A (en) | 1991-09-23 | 1995-07-04 | Florida State University | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
| PT1001036E (pt) | 1992-01-15 | 2005-01-31 | Squibb & Sons Inc | Processos enzimaticos para o desdobramento de misturas enantiomericas de compostos uteis como intermediarios na preparacao de taxanos |
| US5272171A (en) | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
| US5614549A (en) * | 1992-08-21 | 1997-03-25 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| CA2109861C (en) | 1992-12-04 | 1999-03-16 | Shu-Hui Chen | 6,7-modified paclitaxels |
| JP3031715B2 (ja) * | 1993-02-05 | 2000-04-10 | ブリン モーアー カレッジ | 様々なａ環側鎖を有するタキソール、類似体及び中間体の合成 |
| IL109926A (en) | 1993-06-15 | 2000-02-29 | Bristol Myers Squibb Co | Methods for the preparation of taxanes and microorganisms and enzymes utilized therein |
| TW397866B (en) | 1993-07-14 | 2000-07-11 | Bristol Myers Squibb Co | Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes |
| AU4133096A (en) | 1994-10-28 | 1996-05-23 | Research Foundation Of The State University Of New York, The | Taxoid derivatives, their preparation and their use as antitumor agents |
| US6100411A (en) | 1994-10-28 | 2000-08-08 | The Research Foundation Of State University Of New York | Taxoid anti-tumor agents and pharmaceutical compositions thereof |
| US5780653A (en) | 1995-06-07 | 1998-07-14 | Vivorx Pharmaceuticals, Inc. | Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers |
| CA2231837A1 (en) | 1995-09-13 | 1997-03-20 | Florida State University | Radiosensitizing taxanes and their pharmaceutical preparations |
| EP0927175A4 (de) | 1996-05-06 | 2002-05-22 | Univ Florida State | 1-deoxybaccatin iii, 1-deoxytaxol und 1-deoxytaxol-analoge und verfahren zu ihrer herstellung |
| US5811452A (en) | 1997-01-08 | 1998-09-22 | The Research Foundation Of State University Of New York | Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof |
| US5912264A (en) | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
| US7288665B1 (en) | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
| EP1165549B1 (de) * | 2000-02-02 | 2008-04-16 | Florida State University Research Foundation, Inc. | C7-carbamoyloxysubstituierte taxane als antitumormittel |
-
2001
- 2001-02-02 EP EP01905421A patent/EP1165549B1/de not_active Expired - Lifetime
- 2001-02-02 KR KR1020017012622A patent/KR20020002417A/ko not_active Abandoned
- 2001-02-02 IL IL14564301A patent/IL145643A0/xx unknown
- 2001-02-02 BR BR0104355-2A patent/BR0104355A/pt not_active IP Right Cessation
- 2001-02-02 HU HU0200752A patent/HUP0200752A3/hu unknown
- 2001-02-02 NZ NZ514410A patent/NZ514410A/en unknown
- 2001-02-02 US US09/776,494 patent/US6359154B2/en not_active Expired - Fee Related
- 2001-02-02 HK HK03100171.8A patent/HK1047937A1/zh unknown
- 2001-02-02 ES ES01905421T patent/ES2305056T3/es not_active Expired - Lifetime
- 2001-02-02 JP JP2001557860A patent/JP2003522168A/ja not_active Withdrawn
- 2001-02-02 DE DE60133600T patent/DE60133600T2/de not_active Expired - Fee Related
- 2001-02-02 CA CA002368510A patent/CA2368510A1/en not_active Withdrawn
- 2001-02-02 PL PL01350024A patent/PL350024A1/xx not_active Application Discontinuation
- 2001-02-02 CZ CZ20013521A patent/CZ20013521A3/cs unknown
- 2001-02-02 MX MXPA01009923A patent/MXPA01009923A/es active IP Right Grant
- 2001-02-02 DK DK01905421T patent/DK1165549T3/da active
- 2001-02-02 AT AT01905421T patent/ATE392422T1/de not_active IP Right Cessation
- 2001-02-02 WO PCT/US2001/003592 patent/WO2001057028A1/en not_active Ceased
- 2001-02-02 AU AU33302/01A patent/AU778991B2/en not_active Ceased
- 2001-02-02 PT PT01905421T patent/PT1165549E/pt unknown
- 2001-02-02 CN CN01800316A patent/CN1362956A/zh active Pending
- 2001-10-01 NO NO20014757A patent/NO20014757L/no not_active Application Discontinuation
- 2001-10-01 ZA ZA200108056A patent/ZA200108056B/en unknown
-
2002
- 2002-02-06 US US10/071,924 patent/US6750245B2/en not_active Expired - Fee Related
-
2004
- 2004-06-14 US US10/867,275 patent/US20050020635A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0200752A3 (en) | 2005-02-28 |
| MXPA01009923A (es) | 2003-08-01 |
| NZ514410A (en) | 2005-01-28 |
| BR0104355A (pt) | 2002-01-02 |
| KR20020002417A (ko) | 2002-01-09 |
| PT1165549E (pt) | 2008-06-20 |
| AU778991B2 (en) | 2004-12-23 |
| EP1165549B1 (de) | 2008-04-16 |
| ES2305056T3 (es) | 2008-11-01 |
| CA2368510A1 (en) | 2001-08-09 |
| US6750245B2 (en) | 2004-06-15 |
| DE60133600T2 (de) | 2009-06-10 |
| CN1362956A (zh) | 2002-08-07 |
| HK1047937A1 (zh) | 2003-03-14 |
| NO20014757L (no) | 2001-11-29 |
| US6359154B2 (en) | 2002-03-19 |
| US20030060638A1 (en) | 2003-03-27 |
| HUP0200752A2 (en) | 2002-10-28 |
| AU3330201A (en) | 2001-08-14 |
| US20050020635A1 (en) | 2005-01-27 |
| DK1165549T3 (da) | 2008-08-11 |
| PL350024A1 (en) | 2002-10-21 |
| US20010051640A1 (en) | 2001-12-13 |
| ZA200108056B (en) | 2003-12-01 |
| EP1165549A1 (de) | 2002-01-02 |
| WO2001057028A1 (en) | 2001-08-09 |
| CZ20013521A3 (cs) | 2002-03-13 |
| JP2003522168A (ja) | 2003-07-22 |
| DE60133600D1 (de) | 2008-05-29 |
| IL145643A0 (en) | 2002-06-30 |
| NO20014757D0 (no) | 2001-10-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1165549 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |