MXPA01009923A - Taxanos sustituidos con carbamoiloxilo en c7 como agentes antitumorales. - Google Patents

Taxanos sustituidos con carbamoiloxilo en c7 como agentes antitumorales.

Info

Publication number
MXPA01009923A
MXPA01009923A MXPA01009923A MXPA01009923A MXPA01009923A MX PA01009923 A MXPA01009923 A MX PA01009923A MX PA01009923 A MXPA01009923 A MX PA01009923A MX PA01009923 A MXPA01009923 A MX PA01009923A MX PA01009923 A MXPA01009923 A MX PA01009923A
Authority
MX
Mexico
Prior art keywords
antitumor agents
substituted taxanes
carbamoyloxy substituted
carbamoyloxy
taxanes
Prior art date
Application number
MXPA01009923A
Other languages
English (en)
Inventor
Robert A Holton
Original Assignee
Univ Florida State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida State Res Found filed Critical Univ Florida State Res Found
Publication of MXPA01009923A publication Critical patent/MXPA01009923A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
MXPA01009923A 2000-02-02 2001-02-02 Taxanos sustituidos con carbamoiloxilo en c7 como agentes antitumorales. MXPA01009923A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17967000P 2000-02-02 2000-02-02
PCT/US2001/003592 WO2001057028A1 (en) 2000-02-02 2001-02-02 C7 carbamoyloxy substituted taxanes as antitumor agents

Publications (1)

Publication Number Publication Date
MXPA01009923A true MXPA01009923A (es) 2003-08-01

Family

ID=22657498

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA01009923A MXPA01009923A (es) 2000-02-02 2001-02-02 Taxanos sustituidos con carbamoiloxilo en c7 como agentes antitumorales.

Country Status (23)

Country Link
US (3) US6359154B2 (es)
EP (1) EP1165549B1 (es)
JP (1) JP2003522168A (es)
KR (1) KR20020002417A (es)
CN (1) CN1362956A (es)
AT (1) ATE392422T1 (es)
AU (1) AU778991B2 (es)
BR (1) BR0104355A (es)
CA (1) CA2368510A1 (es)
CZ (1) CZ20013521A3 (es)
DE (1) DE60133600T2 (es)
DK (1) DK1165549T3 (es)
ES (1) ES2305056T3 (es)
HK (1) HK1047937A1 (es)
HU (1) HUP0200752A3 (es)
IL (1) IL145643A0 (es)
MX (1) MXPA01009923A (es)
NO (1) NO20014757L (es)
NZ (1) NZ514410A (es)
PL (1) PL350024A1 (es)
PT (1) PT1165549E (es)
WO (1) WO2001057028A1 (es)
ZA (1) ZA200108056B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003521545A (ja) * 2000-02-02 2003-07-15 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド 改良された溶解性を有するタキサン製剤
WO2001057028A1 (en) * 2000-02-02 2001-08-09 Florida State University Research Foundation, Inc. C7 carbamoyloxy substituted taxanes as antitumor agents
US7390898B2 (en) 2002-08-02 2008-06-24 Immunogen Inc. Cytotoxic agents containing novel potent taxanes and their therapeutic use
CN100522955C (zh) 2002-08-02 2009-08-05 伊缪诺金公司 含有新型强效紫杉烷的细胞毒性剂及其治疗用途
CN113952464A (zh) * 2018-03-06 2022-01-21 江苏吉贝尔药业股份有限公司 含酮羰基的疏水性抗肿瘤药物及其应用

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4960790A (en) 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
FR2679230B1 (fr) 1991-07-16 1993-11-19 Rhone Poulenc Rorer Sa Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent.
US5430160A (en) 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5283253A (en) 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5714513A (en) 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5227400A (en) 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5350866A (en) 1991-09-23 1994-09-27 Bristol-Myers Squibb Company 10-desacetoxytaxol derivatives
US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
ES2230790T3 (es) 1992-01-15 2005-05-01 E.R. SQUIBB & SONS, INC. Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de compuestos utiles como intermedios en la preparacion de taxanos.
US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5614549A (en) * 1992-08-21 1997-03-25 Enzon, Inc. High molecular weight polymer-based prodrugs
CA2109861C (en) 1992-12-04 1999-03-16 Shu-Hui Chen 6,7-modified paclitaxels
DE69433297T2 (de) * 1993-02-05 2004-10-21 Bryn Mawr College Bryn Mawr Synthese von taxol, seinen analogen und intermediaten mit variablen a-ring seitenketten
IL109926A (en) 1993-06-15 2000-02-29 Bristol Myers Squibb Co Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
TW397866B (en) 1993-07-14 2000-07-11 Bristol Myers Squibb Co Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
AU4133096A (en) 1994-10-28 1996-05-23 Research Foundation Of The State University Of New York, The Taxoid derivatives, their preparation and their use as antitumor agents
US6100411A (en) 1994-10-28 2000-08-08 The Research Foundation Of State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
US5780653A (en) 1995-06-07 1998-07-14 Vivorx Pharmaceuticals, Inc. Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers
CA2231837A1 (en) 1995-09-13 1997-03-20 Florida State University Radiosensitizing taxanes and their pharmaceutical preparations
IL126856A0 (en) 1996-05-06 1999-09-22 Univ Florida State 1-Deoxy baccatin iii 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof
US5811452A (en) 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US5912264A (en) 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
WO2001057028A1 (en) * 2000-02-02 2001-08-09 Florida State University Research Foundation, Inc. C7 carbamoyloxy substituted taxanes as antitumor agents

Also Published As

Publication number Publication date
JP2003522168A (ja) 2003-07-22
ZA200108056B (en) 2003-12-01
IL145643A0 (en) 2002-06-30
NZ514410A (en) 2005-01-28
EP1165549A1 (en) 2002-01-02
AU3330201A (en) 2001-08-14
HUP0200752A2 (en) 2002-10-28
EP1165549B1 (en) 2008-04-16
US20030060638A1 (en) 2003-03-27
NO20014757D0 (no) 2001-10-01
DE60133600T2 (de) 2009-06-10
US20050020635A1 (en) 2005-01-27
DE60133600D1 (de) 2008-05-29
ES2305056T3 (es) 2008-11-01
PL350024A1 (en) 2002-10-21
US20010051640A1 (en) 2001-12-13
BR0104355A (pt) 2002-01-02
AU778991B2 (en) 2004-12-23
WO2001057028A1 (en) 2001-08-09
HUP0200752A3 (en) 2005-02-28
CZ20013521A3 (cs) 2002-03-13
KR20020002417A (ko) 2002-01-09
ATE392422T1 (de) 2008-05-15
NO20014757L (no) 2001-11-29
US6359154B2 (en) 2002-03-19
HK1047937A1 (zh) 2003-03-14
US6750245B2 (en) 2004-06-15
PT1165549E (pt) 2008-06-20
CN1362956A (zh) 2002-08-07
CA2368510A1 (en) 2001-08-09
DK1165549T3 (da) 2008-08-11

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