BR0104355A - Taxanos substituìdos por c7 carbamoilóxi como agentes antitumor - Google Patents
Taxanos substituìdos por c7 carbamoilóxi como agentes antitumorInfo
- Publication number
- BR0104355A BR0104355A BR0104355-2A BR0104355A BR0104355A BR 0104355 A BR0104355 A BR 0104355A BR 0104355 A BR0104355 A BR 0104355A BR 0104355 A BR0104355 A BR 0104355A
- Authority
- BR
- Brazil
- Prior art keywords
- taxanes
- carbamoyloxy
- substituted
- antitumor agents
- agents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Patente de Invenção: "TAXANOS SUBSTITUìDOS POR C7 CARBAMOILóXI COMO AGENTES ANTITUMOR". Os taxanos tendo um substituinte de carbamoilóxi em C(7), um substituinte de hidróxi em C(10), e uma faixa de C(2), C(9), C(14), e substituintes de cadeia lateral.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17967000P | 2000-02-02 | 2000-02-02 | |
PCT/US2001/003592 WO2001057028A1 (en) | 2000-02-02 | 2001-02-02 | C7 carbamoyloxy substituted taxanes as antitumor agents |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0104355A true BR0104355A (pt) | 2002-01-02 |
Family
ID=22657498
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0104355-2A BR0104355A (pt) | 2000-02-02 | 2001-02-02 | Taxanos substituìdos por c7 carbamoilóxi como agentes antitumor |
Country Status (23)
Country | Link |
---|---|
US (3) | US6359154B2 (pt) |
EP (1) | EP1165549B1 (pt) |
JP (1) | JP2003522168A (pt) |
KR (1) | KR20020002417A (pt) |
CN (1) | CN1362956A (pt) |
AT (1) | ATE392422T1 (pt) |
AU (1) | AU778991B2 (pt) |
BR (1) | BR0104355A (pt) |
CA (1) | CA2368510A1 (pt) |
CZ (1) | CZ20013521A3 (pt) |
DE (1) | DE60133600T2 (pt) |
DK (1) | DK1165549T3 (pt) |
ES (1) | ES2305056T3 (pt) |
HK (1) | HK1047937A1 (pt) |
HU (1) | HUP0200752A3 (pt) |
IL (1) | IL145643A0 (pt) |
MX (1) | MXPA01009923A (pt) |
NO (1) | NO20014757L (pt) |
NZ (1) | NZ514410A (pt) |
PL (1) | PL350024A1 (pt) |
PT (1) | PT1165549E (pt) |
WO (1) | WO2001057028A1 (pt) |
ZA (1) | ZA200108056B (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6638973B2 (en) * | 2000-02-02 | 2003-10-28 | Fsu Research Foundation, Inc. | Taxane formulations |
AU778991B2 (en) * | 2000-02-02 | 2004-12-23 | Florida State University Research Foundation, Inc. | C7 carbamoyloxy substituted taxanes as antitumor agents |
CN100522955C (zh) * | 2002-08-02 | 2009-08-05 | 伊缪诺金公司 | 含有新型强效紫杉烷的细胞毒性剂及其治疗用途 |
US7390898B2 (en) | 2002-08-02 | 2008-06-24 | Immunogen Inc. | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
CN113952464A (zh) * | 2018-03-06 | 2022-01-21 | 江苏吉贝尔药业股份有限公司 | 含酮羰基的疏水性抗肿瘤药物及其应用 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4960790A (en) | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
US5175315A (en) | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
FR2679230B1 (fr) * | 1991-07-16 | 1993-11-19 | Rhone Poulenc Rorer Sa | Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent. |
US5430160A (en) | 1991-09-23 | 1995-07-04 | Florida State University | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
US5350866A (en) | 1991-09-23 | 1994-09-27 | Bristol-Myers Squibb Company | 10-desacetoxytaxol derivatives |
US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
US5721268A (en) | 1991-09-23 | 1998-02-24 | Florida State University | C7 taxane derivatives and pharmaceutical compositions containing them |
US5243045A (en) | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
US5227400A (en) | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
US5714513A (en) | 1991-09-23 | 1998-02-03 | Florida State University | C10 taxane derivatives and pharmaceutical compositions |
DE69329304T2 (de) | 1992-01-15 | 2001-01-04 | Squibb & Sons Inc | Enzymatische Verfahren zur Resolution von Enantiomeren-Mischungen nützlich wie Zwischenprodukte zur Herstellung von Taxanen |
US5272171A (en) | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
US5614549A (en) * | 1992-08-21 | 1997-03-25 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
CA2109861C (en) | 1992-12-04 | 1999-03-16 | Shu-Hui Chen | 6,7-modified paclitaxels |
EP1260507A1 (en) * | 1993-02-05 | 2002-11-27 | Bryn Mawr College | Synthesis of taxol, analogs and intermediates with variable A-nng side chains |
IL109926A (en) | 1993-06-15 | 2000-02-29 | Bristol Myers Squibb Co | Methods for the preparation of taxanes and microorganisms and enzymes utilized therein |
TW397866B (en) | 1993-07-14 | 2000-07-11 | Bristol Myers Squibb Co | Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes |
AU4133096A (en) | 1994-10-28 | 1996-05-23 | Research Foundation Of The State University Of New York, The | Taxoid derivatives, their preparation and their use as antitumor agents |
US6100411A (en) | 1994-10-28 | 2000-08-08 | The Research Foundation Of State University Of New York | Taxoid anti-tumor agents and pharmaceutical compositions thereof |
US5780653A (en) | 1995-06-07 | 1998-07-14 | Vivorx Pharmaceuticals, Inc. | Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers |
WO1997009979A1 (en) | 1995-09-13 | 1997-03-20 | Florida State University | Radiosensitizing taxanes and their pharmaceutical preparations |
WO1997042181A1 (en) | 1996-05-06 | 1997-11-13 | Florida State University | 1-deoxy baccatin iii, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof |
US5811452A (en) | 1997-01-08 | 1998-09-22 | The Research Foundation Of State University Of New York | Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof |
US5912264A (en) | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
US7288665B1 (en) | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
AU778991B2 (en) * | 2000-02-02 | 2004-12-23 | Florida State University Research Foundation, Inc. | C7 carbamoyloxy substituted taxanes as antitumor agents |
-
2001
- 2001-02-02 AU AU33302/01A patent/AU778991B2/en not_active Ceased
- 2001-02-02 ES ES01905421T patent/ES2305056T3/es not_active Expired - Lifetime
- 2001-02-02 JP JP2001557860A patent/JP2003522168A/ja not_active Withdrawn
- 2001-02-02 NZ NZ514410A patent/NZ514410A/en unknown
- 2001-02-02 EP EP01905421A patent/EP1165549B1/en not_active Expired - Lifetime
- 2001-02-02 MX MXPA01009923A patent/MXPA01009923A/es active IP Right Grant
- 2001-02-02 BR BR0104355-2A patent/BR0104355A/pt not_active IP Right Cessation
- 2001-02-02 PL PL01350024A patent/PL350024A1/xx not_active Application Discontinuation
- 2001-02-02 IL IL14564301A patent/IL145643A0/xx unknown
- 2001-02-02 DE DE60133600T patent/DE60133600T2/de not_active Expired - Fee Related
- 2001-02-02 CA CA002368510A patent/CA2368510A1/en not_active Withdrawn
- 2001-02-02 KR KR1020017012622A patent/KR20020002417A/ko active IP Right Grant
- 2001-02-02 WO PCT/US2001/003592 patent/WO2001057028A1/en active Application Filing
- 2001-02-02 DK DK01905421T patent/DK1165549T3/da active
- 2001-02-02 US US09/776,494 patent/US6359154B2/en not_active Expired - Fee Related
- 2001-02-02 HU HU0200752A patent/HUP0200752A3/hu unknown
- 2001-02-02 CN CN01800316A patent/CN1362956A/zh active Pending
- 2001-02-02 PT PT01905421T patent/PT1165549E/pt unknown
- 2001-02-02 CZ CZ20013521A patent/CZ20013521A3/cs unknown
- 2001-02-02 AT AT01905421T patent/ATE392422T1/de not_active IP Right Cessation
- 2001-10-01 NO NO20014757A patent/NO20014757L/no not_active Application Discontinuation
- 2001-10-01 ZA ZA200108056A patent/ZA200108056B/en unknown
-
2002
- 2002-02-06 US US10/071,924 patent/US6750245B2/en not_active Expired - Fee Related
-
2003
- 2003-01-07 HK HK03100171.8A patent/HK1047937A1/zh unknown
-
2004
- 2004-06-14 US US10/867,275 patent/US20050020635A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DK1165549T3 (da) | 2008-08-11 |
CA2368510A1 (en) | 2001-08-09 |
HUP0200752A3 (en) | 2005-02-28 |
IL145643A0 (en) | 2002-06-30 |
EP1165549B1 (en) | 2008-04-16 |
CN1362956A (zh) | 2002-08-07 |
ES2305056T3 (es) | 2008-11-01 |
AU3330201A (en) | 2001-08-14 |
JP2003522168A (ja) | 2003-07-22 |
CZ20013521A3 (cs) | 2002-03-13 |
US6750245B2 (en) | 2004-06-15 |
ZA200108056B (en) | 2003-12-01 |
MXPA01009923A (es) | 2003-08-01 |
NO20014757D0 (no) | 2001-10-01 |
US20030060638A1 (en) | 2003-03-27 |
PL350024A1 (en) | 2002-10-21 |
US20010051640A1 (en) | 2001-12-13 |
NO20014757L (no) | 2001-11-29 |
DE60133600T2 (de) | 2009-06-10 |
DE60133600D1 (de) | 2008-05-29 |
ATE392422T1 (de) | 2008-05-15 |
WO2001057028A1 (en) | 2001-08-09 |
AU778991B2 (en) | 2004-12-23 |
US6359154B2 (en) | 2002-03-19 |
PT1165549E (pt) | 2008-06-20 |
HK1047937A1 (zh) | 2003-03-14 |
NZ514410A (en) | 2005-01-28 |
KR20020002417A (ko) | 2002-01-09 |
HUP0200752A2 (en) | 2002-10-28 |
US20050020635A1 (en) | 2005-01-27 |
EP1165549A1 (en) | 2002-01-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE 8A., 9A., 10A. E 11A. ANUIDADE(S). |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2138 DE 27/12/2011. |