ATE248153T1 - Neue benzoxazole - Google Patents
Neue benzoxazoleInfo
- Publication number
- ATE248153T1 ATE248153T1 AT95940634T AT95940634T ATE248153T1 AT E248153 T1 ATE248153 T1 AT E248153T1 AT 95940634 T AT95940634 T AT 95940634T AT 95940634 T AT95940634 T AT 95940634T AT E248153 T1 ATE248153 T1 AT E248153T1
- Authority
- AT
- Austria
- Prior art keywords
- pde
- benzoxazoles
- new
- inhibition
- new benzoxazoles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08321730 US5665737B1 (en) | 1994-10-12 | 1994-10-12 | Substituted benzoxazoles |
US46709195A | 1995-06-06 | 1995-06-06 | |
PCT/US1995/014399 WO1996011917A1 (en) | 1994-10-12 | 1995-10-11 | Novel benzoxazoles |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE248153T1 true ATE248153T1 (de) | 2003-09-15 |
Family
ID=26983104
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95940634T ATE248153T1 (de) | 1994-10-12 | 1995-10-11 | Neue benzoxazole |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0785927B1 (de) |
KR (1) | KR100237962B1 (de) |
AT (1) | ATE248153T1 (de) |
AU (1) | AU699489B2 (de) |
BG (1) | BG101422A (de) |
CA (1) | CA2202273A1 (de) |
DE (1) | DE69531623T2 (de) |
FI (1) | FI971489A (de) |
NO (1) | NO971684L (de) |
PL (1) | PL319605A1 (de) |
SK (1) | SK45497A3 (de) |
WO (1) | WO1996011917A1 (de) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1283860B (de) * | 1963-03-08 | 1968-11-28 | Demag Ag | Metallurgisches Schuettelgefaess, insbesondere Konverter, zur Frischbehandlung eines Roheisenbades mittels Sauerstoffblaslanzen |
US5591776A (en) * | 1994-06-24 | 1997-01-07 | Euro-Celtique, S.A. | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV |
AU3102697A (en) * | 1996-06-19 | 1998-01-07 | Rhone-Poulenc Rorer Limited | Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase |
US5849774A (en) * | 1996-07-03 | 1998-12-15 | University Of Pittsburgh | Treatment of sepsis-induced acute renal failure |
US6172074B1 (en) | 1996-11-11 | 2001-01-09 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Imidazopyridines and oxazolopyridines |
SK283534B6 (sk) | 1996-11-15 | 2003-09-11 | Darwin Discovery Limited | Bicyklické arylkarboxamidy a farmaceutický prostriedok s ich obsahom |
EP0998472A1 (de) | 1997-07-14 | 2000-05-10 | Basf Aktiengesellschaft | Substituierte 2-(benzaryl)pyridine |
FR2766822B1 (fr) * | 1997-07-30 | 2001-02-23 | Adir | Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
HUP0101678A3 (en) | 1998-05-05 | 2002-06-28 | Altana Pharma Ag | Novel benzimidazoles and benzoxazoles and pharmaceutical compositions containing the compounds |
ZA200100088B (en) * | 1998-07-06 | 2002-05-06 | Byk Gulden Lomberg Chem Fab | New benzoxazoles with PDE-inhibiting activity. |
AU2942000A (en) * | 1999-03-11 | 2000-09-28 | Banyu Pharmaceutical Co., Ltd. | Novel piperidine derivatives |
IL147688A0 (en) | 1999-08-21 | 2002-08-14 | Byk Gulden Lomberg Chem Fab | Synergistic combination |
CO5261573A1 (es) | 1999-11-19 | 2003-03-31 | Novartis Ag | Derivados de benzoxa y bezotiazol, compuesto y composicion farmaceutica que los contiene y proceso para la preparacion de la mencionada composicion |
EP1160247A1 (de) * | 2000-05-08 | 2001-12-05 | Euro-Celtique S.A. | 6,5 kondensierten, aromatischen, polycyclischen verbindung mit phosphodiesterase iv hemmender aktivität |
EP1460067A4 (de) * | 2001-11-26 | 2005-12-07 | Takeda Pharmaceutical | Bicyclische derivate, verfahren zu deren herstellung und deren verwendung |
EP1478631A1 (de) * | 2001-11-28 | 2004-11-24 | AstraZeneca AB | Therapeutische verbindungen |
EP1453815A4 (de) * | 2001-11-30 | 2005-04-06 | Merck & Co Inc | Modulatoren des metabotropen glutamatrezeptors-5 |
US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
CA2516842A1 (en) * | 2003-02-25 | 2004-09-10 | Topotarget Uk Limited | Hydroxamic acid compounds comprising a bicylic heteroaryl group as hdac inhibitors |
ITTO20040125A1 (it) * | 2004-03-01 | 2004-06-01 | Rotta Research Lab | Nuove amidine eterocicliche inibitrici la produzione di ossido d'azoto (no) ad attivita' antinfiammatoria ed analgesica |
JP2008513426A (ja) | 2004-09-20 | 2008-05-01 | バイオリポックス エービー | 炎症の治療に有用なピラゾール化合物 |
DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
EP1852108A1 (de) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | Zusammensetzungen von DPP-IV-Inhibitoren |
BRPI0711558A2 (pt) | 2006-05-04 | 2011-11-08 | Boeringer Ingelheim Internat Gmbh | polimorfos |
SI2035369T1 (sl) | 2006-07-05 | 2014-11-28 | Fibrotech Therapeutics Pty Ltd | Terapevtske spojine |
WO2008082003A1 (en) * | 2006-12-29 | 2008-07-10 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds having crf antagonistic activity |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
WO2008151257A2 (en) | 2007-06-04 | 2008-12-11 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
CA2689575A1 (en) | 2007-06-20 | 2008-12-24 | Merck Sharp & Dohme Corp. | Cetp inhibitors derived from benzoxazole arylamides |
JP2010530418A (ja) * | 2007-06-20 | 2010-09-09 | メルク・シャープ・エンド・ドーム・コーポレイション | ベンゾオキサゾールアリールアミドから誘導されたcetp阻害剤 |
US8436028B2 (en) | 2007-06-20 | 2013-05-07 | Merck Sharp & Dohme Corp | CETP inhibitors derived from benzoxazole arylamides |
PE20091730A1 (es) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
AU2009256157B2 (en) | 2008-06-04 | 2014-12-18 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
EP2321341B1 (de) | 2008-07-16 | 2017-02-22 | Synergy Pharmaceuticals Inc. | Zur behandlung von erkrankungen des magen-darm-trakts, entzündlichen erkrankungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase |
KR20190016601A (ko) | 2008-08-06 | 2019-02-18 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
KR20110103968A (ko) | 2008-12-23 | 2011-09-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 유기 화합물의 염 형태 |
TW201036975A (en) | 2009-01-07 | 2010-10-16 | Boehringer Ingelheim Int | Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy |
CN105153188B (zh) | 2009-10-22 | 2018-06-01 | 法博太科制药有限公司 | 抗纤维化剂的稠环类似物 |
MX364651B (es) | 2009-11-27 | 2019-05-03 | Boehringer Ingelheim Int Gmbh Star | Inhibidores de dpp-iv, tales como la linagliptina, y composiciones farmacéuticas o combinaciones que comprenden los mismos, para usarse en el tratamiento de pacientes diabéticos tipificados genéticamente. |
EP2566469B1 (de) | 2010-05-05 | 2022-12-21 | Boehringer Ingelheim International GmbH | Kombinationstherapie |
EP2585101A1 (de) | 2010-06-24 | 2013-05-01 | Boehringer Ingelheim International GmbH | Diabetestherapie |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
EA201391254A1 (ru) | 2011-03-01 | 2014-02-28 | Синерджи Фармасьютикалз Инк. | Способ получения агонистов гуанилатциклазы c |
MX366629B (es) | 2011-07-15 | 2019-07-17 | Boehringer Ingelheim Int | Quinazolinas sustituidas, su preparación y su uso en composiciones farmacéuticas. |
US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
EP3685839A1 (de) | 2012-05-14 | 2020-07-29 | Boehringer Ingelheim International GmbH | Linagliptin zur verwendung in der behandlung von albuminuria und nierenbedingten erkrankungen |
WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
CA2902348C (en) | 2013-02-25 | 2021-11-30 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
WO2014151206A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
WO2014197720A2 (en) | 2013-06-05 | 2014-12-11 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
US20160184387A1 (en) | 2013-08-09 | 2016-06-30 | Dominique Charmot | Compounds and methods for inhibiting phosphate transport |
EP3110449B1 (de) | 2014-02-28 | 2023-06-28 | Boehringer Ingelheim International GmbH | Medizinische verwendung eines dpp-4-inhibitors |
WO2017211979A1 (en) | 2016-06-10 | 2017-12-14 | Boehringer Ingelheim International Gmbh | Combinations of linagliptin and metformin |
SG11201907139UA (en) | 2017-02-03 | 2019-09-27 | Certa Therapeutics Pty Ltd | Anti-fibrotic compounds |
CN114340631A (zh) | 2019-05-21 | 2022-04-12 | 阿德利克斯股份有限公司 | 用于降低患者的血清磷酸盐的组合 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2320654A (en) * | 1940-08-08 | 1943-06-01 | Riester Oskar | Sensitization of photographic emulsions |
US3136771A (en) * | 1962-03-09 | 1964-06-09 | Ciba Ltd | Bis-(2-benzoxazolyl) furylmethy-pyridinium chloride |
US3491091A (en) * | 1962-03-28 | 1970-01-20 | Boehringer & Soehne Gmbh | 5-nitrofuran derivatives |
US3470164A (en) * | 1962-05-04 | 1969-09-30 | Dainippon Pharmaceutical Co | 2-(2-(5-nitrofuryl)-vinyl)-azoles and process for producing thereof |
US3494919A (en) * | 1964-07-30 | 1970-02-10 | American Cyanamid Co | Preparation of styryloxazole compounds |
CH465959A (de) * | 1966-11-30 | 1969-01-15 | Ciba Geigy | Gebrauchsfertiges Mittel zur Bekämpfung von schädlichen Mikroorganismen auf textilem Material |
CH542853A (de) * | 1967-07-26 | 1973-10-15 | Agripat Sa | Verfahren zur Herstellung neuer Isothiocyano-benzazol-Derivate |
US3541100A (en) * | 1967-12-14 | 1970-11-17 | American Cyanamid Co | Benzheteroazolo(2,3-a)isoquinolium salts |
US3669979A (en) * | 1967-12-14 | 1972-06-13 | Gaf Corp | Novel process for the production of 2-benzothiazolyl-phenol and derivatives thereof employing phosphorus trichloride as a catalyst |
US3491106A (en) * | 1967-12-15 | 1970-01-20 | Gaf Corp | Sodium 3-(2-benzothiazolyl) - 4-hydroxy-benzenesulfonates and analogues thereof |
CH516339A (de) * | 1969-03-03 | 1971-12-15 | Ciba Geigy Ag | Verwendung von Azolverbindungen als Antioxydantien |
US3647812A (en) * | 1969-04-22 | 1972-03-07 | Richard F Smith | Halogenated 2(2'-hydroxyphenyl benzothiazoles |
US3574218A (en) * | 1969-08-11 | 1971-04-06 | Egyt Gyogyszervegyeszeti Gyar | 2-aryl- or aralkyl-substituted benzazole derivatives |
US3666769A (en) * | 1969-10-09 | 1972-05-30 | Du Pont | Thermally stable 2-perfluoro-substituted benzothiazoles |
US3674781A (en) * | 1970-09-15 | 1972-07-04 | Hoechst Ag | Optical brighteners of the benzoxazole series |
US3895028A (en) * | 1972-09-12 | 1975-07-15 | Tokyo Tanabe Co | Alpha-(2-phenylbenzothiazol-5-yl)propionic acid |
US4025636A (en) * | 1973-10-23 | 1977-05-24 | Lilly Industries, Ltd. | 2-(Optionally substituted)phenyl-5 or 6-substituted benzoxazoles |
US4025637A (en) * | 1973-10-23 | 1977-05-24 | Lilly Industries, Ltd. | 2,5 OR 2,6 Disubstituted benzoxazoles |
US4020165A (en) * | 1975-08-20 | 1977-04-26 | Uniroyal Inc. | Control of acarids using certain benzothiazoles or benzothiazolines |
LU76467A1 (de) * | 1976-12-23 | 1978-07-10 | ||
JPS5721375A (en) * | 1980-07-14 | 1982-02-04 | Yamanouchi Pharmaceut Co Ltd | 2,6-di-tert-butyl-4-heterocyclic substituted phenolic derivative and its preparation |
US4416892A (en) * | 1981-04-23 | 1983-11-22 | Lilly Industries Limited | Method of treating hypersensitivity disease with benzoxazole derivatives |
JPS615071A (ja) * | 1984-06-15 | 1986-01-10 | Fuji Photo Film Co Ltd | ベンゾオキサゾ−ル誘導体 |
IT1177017B (it) * | 1984-10-22 | 1987-08-26 | Ravizza Spa | Processo per la preparazione dell'acido 2(4-flurofenil)alfa-metil-5-benzox azoloacetico |
US4732978A (en) * | 1985-10-03 | 1988-03-22 | American Home Products Corporation | Novel substituted naphthyloxymethyl quinoline derivatives as anti-inflammatory and antiallergy agents |
JPH0670025B2 (ja) * | 1987-08-07 | 1994-09-07 | 鐘紡株式会社 | ベンゾチアゾ−ル誘導体および該化合物を有効成分とする抗リウマチ剤 |
DE3808914A1 (de) * | 1988-03-17 | 1989-10-05 | Bayer Ag | Neue 2-aryl-benzoxazole und neue 2'-hydroxybenzanilide |
JPH03173874A (ja) * | 1989-09-29 | 1991-07-29 | Mitsubishi Kasei Corp | 新規複素環化合物 |
US5190942A (en) * | 1991-04-22 | 1993-03-02 | E. R. Squibb & Sons, Inc. | Benzoxazole and related heterocyclic substituted imidazole and benzimidazole derivatives |
US5322847A (en) * | 1992-11-05 | 1994-06-21 | Pfizer Inc. | Azabenzimidazoles in the treatment of asthma, arthritis and related diseases |
-
1995
- 1995-10-11 DE DE69531623T patent/DE69531623T2/de not_active Expired - Fee Related
- 1995-10-11 AT AT95940634T patent/ATE248153T1/de not_active IP Right Cessation
- 1995-10-11 EP EP95940634A patent/EP0785927B1/de not_active Expired - Lifetime
- 1995-10-11 AU AU42317/96A patent/AU699489B2/en not_active Ceased
- 1995-10-11 CA CA002202273A patent/CA2202273A1/en not_active Abandoned
- 1995-10-11 KR KR1019970702390A patent/KR100237962B1/ko not_active IP Right Cessation
- 1995-10-11 SK SK454-97A patent/SK45497A3/sk unknown
- 1995-10-11 WO PCT/US1995/014399 patent/WO1996011917A1/en active IP Right Grant
- 1995-10-11 PL PL95319605A patent/PL319605A1/xx unknown
-
1997
- 1997-04-10 FI FI971489A patent/FI971489A/fi unknown
- 1997-04-11 NO NO971684A patent/NO971684L/no not_active Application Discontinuation
- 1997-04-18 BG BG101422A patent/BG101422A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
BG101422A (en) | 1997-11-28 |
EP0785927A1 (de) | 1997-07-30 |
FI971489A0 (fi) | 1997-04-10 |
SK45497A3 (en) | 1997-10-08 |
DE69531623T2 (de) | 2004-06-17 |
FI971489A (fi) | 1997-06-05 |
PL319605A1 (en) | 1997-08-18 |
AU4231796A (en) | 1996-05-06 |
CA2202273A1 (en) | 1996-04-25 |
WO1996011917A1 (en) | 1996-04-25 |
AU699489B2 (en) | 1998-12-03 |
NO971684L (no) | 1997-06-12 |
DE69531623D1 (de) | 2003-10-02 |
KR100237962B1 (ko) | 2000-02-01 |
EP0785927A4 (de) | 1997-12-29 |
EP0785927B1 (de) | 2003-08-27 |
NO971684D0 (no) | 1997-04-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69531623D1 (de) | Neue benzoxazole | |
ATE217865T1 (de) | Verbindungen zur hemmung von phosphodiesrerase iv | |
TR199902400T2 (xx) | Fungusit etkinlik g�steren terkiplerin birle�imleri. | |
DE69612003T2 (de) | Substituierte benzolaktamverbindungen als substanz-p-antagonisten | |
DE69516866D1 (de) | Stereochemische wortmanninderivate | |
CO4780028A1 (es) | Procedimiento para la preparacion de sildenafil | |
TR200000782T2 (tr) | Resorsinol türevleri. | |
EA200300528A1 (ru) | 1-арил-или 1-алкилсульфонилгетероциклилбензазолы в качестве лигандов 5-гидрокситриптамина-6 | |
EA200300566A1 (ru) | Применение cci-779 в качестве противоопухолевого средства | |
CR6540A (es) | Trifluorobutenos nematicidas | |
EA200300716A1 (ru) | Гетероциклилалкилиндольные или -азаиндольные соединения в качестве лиганд 5-гидрокситриптамина-6 | |
DK0912537T3 (da) | Fremgangsmåde til fremstilling af phenylheterocykliske forbindelser, der er anvendelige som cox-2-inhibitorer | |
PE20011085A1 (es) | Compuestos isoxazolquinolin o imidazolquinolin como inhibidores de la proteina resistente a multifarmacos | |
SE9901077D0 (sv) | Novel use | |
SE9801494D0 (sv) | Novel use | |
ATE184604T1 (de) | Neue 2-substituierte tricyclische derivate von indan-2-mercaptoacetylamid verwendbar als enkephalinase inhibitoren | |
TR199800243T1 (xx) | Prolil endopeptidaz inhibit�rleri. | |
PT1206452E (pt) | Processo de preparacao de compostos benzoper-hidroisoindole | |
SE9604582D0 (sv) | Novel compounds | |
DK0915858T3 (da) | Mellemprodukter til fremstilling af 2-imidazolin-5-oner | |
TR200001080T2 (tr) | 2 ile ikame edilmiş 1,2-Benisotiyazol türevleri ve bunların serrotonın antagonistleri | |
EE200000024A (et) | Meetod alküüloksüfuranooni amiinderivaatide valmistamiseks, sel meetodil saadud ühendid ja nende kasutamine | |
EA199801084A1 (ru) | Спосб получения фенилгетероциклических соединений, используемых в качестве ингибиторов циклооксигеназы-2 | |
EA200001153A1 (ru) | Очистка карбоксальдегида | |
NO912985D0 (no) | Forbedret system for transdermal applikasjon av farmasoeytisk aktive forbindelser ved regulert ph. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 0785927 Country of ref document: EP |
|
REN | Ceased due to non-payment of the annual fee |