ATE248153T1 - Neue benzoxazole - Google Patents

Neue benzoxazole

Info

Publication number
ATE248153T1
ATE248153T1 AT95940634T AT95940634T ATE248153T1 AT E248153 T1 ATE248153 T1 AT E248153T1 AT 95940634 T AT95940634 T AT 95940634T AT 95940634 T AT95940634 T AT 95940634T AT E248153 T1 ATE248153 T1 AT E248153T1
Authority
AT
Austria
Prior art keywords
pde
benzoxazoles
new
inhibition
new benzoxazoles
Prior art date
Application number
AT95940634T
Other languages
English (en)
Inventor
David John Cavalla
Mark Chasin
Peter Hofer
Lloyd Dolby
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08321730 external-priority patent/US5665737B1/en
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Application granted granted Critical
Publication of ATE248153T1 publication Critical patent/ATE248153T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57Aryl or substituted aryl radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT95940634T 1994-10-12 1995-10-11 Neue benzoxazole ATE248153T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08321730 US5665737B1 (en) 1994-10-12 1994-10-12 Substituted benzoxazoles
US46709195A 1995-06-06 1995-06-06
PCT/US1995/014399 WO1996011917A1 (en) 1994-10-12 1995-10-11 Novel benzoxazoles

Publications (1)

Publication Number Publication Date
ATE248153T1 true ATE248153T1 (de) 2003-09-15

Family

ID=26983104

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95940634T ATE248153T1 (de) 1994-10-12 1995-10-11 Neue benzoxazole

Country Status (12)

Country Link
EP (1) EP0785927B1 (de)
KR (1) KR100237962B1 (de)
AT (1) ATE248153T1 (de)
AU (1) AU699489B2 (de)
BG (1) BG101422A (de)
CA (1) CA2202273A1 (de)
DE (1) DE69531623T2 (de)
FI (1) FI971489A (de)
NO (1) NO971684L (de)
PL (1) PL319605A1 (de)
SK (1) SK45497A3 (de)
WO (1) WO1996011917A1 (de)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1283860B (de) * 1963-03-08 1968-11-28 Demag Ag Metallurgisches Schuettelgefaess, insbesondere Konverter, zur Frischbehandlung eines Roheisenbades mittels Sauerstoffblaslanzen
US5591776A (en) * 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
AU3102697A (en) * 1996-06-19 1998-01-07 Rhone-Poulenc Rorer Limited Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase
US5849774A (en) * 1996-07-03 1998-12-15 University Of Pittsburgh Treatment of sepsis-induced acute renal failure
US6172074B1 (en) 1996-11-11 2001-01-09 Byk Gulden Lomberg Chemische Fabrik Gmbh Imidazopyridines and oxazolopyridines
SK283534B6 (sk) 1996-11-15 2003-09-11 Darwin Discovery Limited Bicyklické arylkarboxamidy a farmaceutický prostriedok s ich obsahom
EP0998472A1 (de) 1997-07-14 2000-05-10 Basf Aktiengesellschaft Substituierte 2-(benzaryl)pyridine
FR2766822B1 (fr) * 1997-07-30 2001-02-23 Adir Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
HUP0101678A3 (en) 1998-05-05 2002-06-28 Altana Pharma Ag Novel benzimidazoles and benzoxazoles and pharmaceutical compositions containing the compounds
ZA200100088B (en) * 1998-07-06 2002-05-06 Byk Gulden Lomberg Chem Fab New benzoxazoles with PDE-inhibiting activity.
AU2942000A (en) * 1999-03-11 2000-09-28 Banyu Pharmaceutical Co., Ltd. Novel piperidine derivatives
IL147688A0 (en) 1999-08-21 2002-08-14 Byk Gulden Lomberg Chem Fab Synergistic combination
CO5261573A1 (es) 1999-11-19 2003-03-31 Novartis Ag Derivados de benzoxa y bezotiazol, compuesto y composicion farmaceutica que los contiene y proceso para la preparacion de la mencionada composicion
EP1160247A1 (de) * 2000-05-08 2001-12-05 Euro-Celtique S.A. 6,5 kondensierten, aromatischen, polycyclischen verbindung mit phosphodiesterase iv hemmender aktivität
EP1460067A4 (de) * 2001-11-26 2005-12-07 Takeda Pharmaceutical Bicyclische derivate, verfahren zu deren herstellung und deren verwendung
EP1478631A1 (de) * 2001-11-28 2004-11-24 AstraZeneca AB Therapeutische verbindungen
EP1453815A4 (de) * 2001-11-30 2005-04-06 Merck & Co Inc Modulatoren des metabotropen glutamatrezeptors-5
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
CA2516842A1 (en) * 2003-02-25 2004-09-10 Topotarget Uk Limited Hydroxamic acid compounds comprising a bicylic heteroaryl group as hdac inhibitors
ITTO20040125A1 (it) * 2004-03-01 2004-06-01 Rotta Research Lab Nuove amidine eterocicliche inibitrici la produzione di ossido d'azoto (no) ad attivita' antinfiammatoria ed analgesica
JP2008513426A (ja) 2004-09-20 2008-05-01 バイオリポックス エービー 炎症の治療に有用なピラゾール化合物
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
EP1852108A1 (de) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG Zusammensetzungen von DPP-IV-Inhibitoren
BRPI0711558A2 (pt) 2006-05-04 2011-11-08 Boeringer Ingelheim Internat Gmbh polimorfos
SI2035369T1 (sl) 2006-07-05 2014-11-28 Fibrotech Therapeutics Pty Ltd Terapevtske spojine
WO2008082003A1 (en) * 2006-12-29 2008-07-10 Takeda Pharmaceutical Company Limited Fused heterocyclic compounds having crf antagonistic activity
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2689575A1 (en) 2007-06-20 2008-12-24 Merck Sharp & Dohme Corp. Cetp inhibitors derived from benzoxazole arylamides
JP2010530418A (ja) * 2007-06-20 2010-09-09 メルク・シャープ・エンド・ドーム・コーポレイション ベンゾオキサゾールアリールアミドから誘導されたcetp阻害剤
US8436028B2 (en) 2007-06-20 2013-05-07 Merck Sharp & Dohme Corp CETP inhibitors derived from benzoxazole arylamides
PE20091730A1 (es) 2008-04-03 2009-12-10 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
AU2009256157B2 (en) 2008-06-04 2014-12-18 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2321341B1 (de) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Zur behandlung von erkrankungen des magen-darm-trakts, entzündlichen erkrankungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase
KR20190016601A (ko) 2008-08-06 2019-02-18 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
KR20110103968A (ko) 2008-12-23 2011-09-21 베링거 인겔하임 인터내셔날 게엠베하 유기 화합물의 염 형태
TW201036975A (en) 2009-01-07 2010-10-16 Boehringer Ingelheim Int Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy
CN105153188B (zh) 2009-10-22 2018-06-01 法博太科制药有限公司 抗纤维化剂的稠环类似物
MX364651B (es) 2009-11-27 2019-05-03 Boehringer Ingelheim Int Gmbh Star Inhibidores de dpp-iv, tales como la linagliptina, y composiciones farmacéuticas o combinaciones que comprenden los mismos, para usarse en el tratamiento de pacientes diabéticos tipificados genéticamente.
EP2566469B1 (de) 2010-05-05 2022-12-21 Boehringer Ingelheim International GmbH Kombinationstherapie
EP2585101A1 (de) 2010-06-24 2013-05-01 Boehringer Ingelheim International GmbH Diabetestherapie
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
EA201391254A1 (ru) 2011-03-01 2014-02-28 Синерджи Фармасьютикалз Инк. Способ получения агонистов гуанилатциклазы c
MX366629B (es) 2011-07-15 2019-07-17 Boehringer Ingelheim Int Quinazolinas sustituidas, su preparación y su uso en composiciones farmacéuticas.
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
EP3685839A1 (de) 2012-05-14 2020-07-29 Boehringer Ingelheim International GmbH Linagliptin zur verwendung in der behandlung von albuminuria und nierenbedingten erkrankungen
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
CA2902348C (en) 2013-02-25 2021-11-30 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014197720A2 (en) 2013-06-05 2014-12-11 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase c, method of making and using same
US20160184387A1 (en) 2013-08-09 2016-06-30 Dominique Charmot Compounds and methods for inhibiting phosphate transport
EP3110449B1 (de) 2014-02-28 2023-06-28 Boehringer Ingelheim International GmbH Medizinische verwendung eines dpp-4-inhibitors
WO2017211979A1 (en) 2016-06-10 2017-12-14 Boehringer Ingelheim International Gmbh Combinations of linagliptin and metformin
SG11201907139UA (en) 2017-02-03 2019-09-27 Certa Therapeutics Pty Ltd Anti-fibrotic compounds
CN114340631A (zh) 2019-05-21 2022-04-12 阿德利克斯股份有限公司 用于降低患者的血清磷酸盐的组合

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2320654A (en) * 1940-08-08 1943-06-01 Riester Oskar Sensitization of photographic emulsions
US3136771A (en) * 1962-03-09 1964-06-09 Ciba Ltd Bis-(2-benzoxazolyl) furylmethy-pyridinium chloride
US3491091A (en) * 1962-03-28 1970-01-20 Boehringer & Soehne Gmbh 5-nitrofuran derivatives
US3470164A (en) * 1962-05-04 1969-09-30 Dainippon Pharmaceutical Co 2-(2-(5-nitrofuryl)-vinyl)-azoles and process for producing thereof
US3494919A (en) * 1964-07-30 1970-02-10 American Cyanamid Co Preparation of styryloxazole compounds
CH465959A (de) * 1966-11-30 1969-01-15 Ciba Geigy Gebrauchsfertiges Mittel zur Bekämpfung von schädlichen Mikroorganismen auf textilem Material
CH542853A (de) * 1967-07-26 1973-10-15 Agripat Sa Verfahren zur Herstellung neuer Isothiocyano-benzazol-Derivate
US3541100A (en) * 1967-12-14 1970-11-17 American Cyanamid Co Benzheteroazolo(2,3-a)isoquinolium salts
US3669979A (en) * 1967-12-14 1972-06-13 Gaf Corp Novel process for the production of 2-benzothiazolyl-phenol and derivatives thereof employing phosphorus trichloride as a catalyst
US3491106A (en) * 1967-12-15 1970-01-20 Gaf Corp Sodium 3-(2-benzothiazolyl) - 4-hydroxy-benzenesulfonates and analogues thereof
CH516339A (de) * 1969-03-03 1971-12-15 Ciba Geigy Ag Verwendung von Azolverbindungen als Antioxydantien
US3647812A (en) * 1969-04-22 1972-03-07 Richard F Smith Halogenated 2(2'-hydroxyphenyl benzothiazoles
US3574218A (en) * 1969-08-11 1971-04-06 Egyt Gyogyszervegyeszeti Gyar 2-aryl- or aralkyl-substituted benzazole derivatives
US3666769A (en) * 1969-10-09 1972-05-30 Du Pont Thermally stable 2-perfluoro-substituted benzothiazoles
US3674781A (en) * 1970-09-15 1972-07-04 Hoechst Ag Optical brighteners of the benzoxazole series
US3895028A (en) * 1972-09-12 1975-07-15 Tokyo Tanabe Co Alpha-(2-phenylbenzothiazol-5-yl)propionic acid
US4025636A (en) * 1973-10-23 1977-05-24 Lilly Industries, Ltd. 2-(Optionally substituted)phenyl-5 or 6-substituted benzoxazoles
US4025637A (en) * 1973-10-23 1977-05-24 Lilly Industries, Ltd. 2,5 OR 2,6 Disubstituted benzoxazoles
US4020165A (en) * 1975-08-20 1977-04-26 Uniroyal Inc. Control of acarids using certain benzothiazoles or benzothiazolines
LU76467A1 (de) * 1976-12-23 1978-07-10
JPS5721375A (en) * 1980-07-14 1982-02-04 Yamanouchi Pharmaceut Co Ltd 2,6-di-tert-butyl-4-heterocyclic substituted phenolic derivative and its preparation
US4416892A (en) * 1981-04-23 1983-11-22 Lilly Industries Limited Method of treating hypersensitivity disease with benzoxazole derivatives
JPS615071A (ja) * 1984-06-15 1986-01-10 Fuji Photo Film Co Ltd ベンゾオキサゾ−ル誘導体
IT1177017B (it) * 1984-10-22 1987-08-26 Ravizza Spa Processo per la preparazione dell'acido 2(4-flurofenil)alfa-metil-5-benzox azoloacetico
US4732978A (en) * 1985-10-03 1988-03-22 American Home Products Corporation Novel substituted naphthyloxymethyl quinoline derivatives as anti-inflammatory and antiallergy agents
JPH0670025B2 (ja) * 1987-08-07 1994-09-07 鐘紡株式会社 ベンゾチアゾ−ル誘導体および該化合物を有効成分とする抗リウマチ剤
DE3808914A1 (de) * 1988-03-17 1989-10-05 Bayer Ag Neue 2-aryl-benzoxazole und neue 2'-hydroxybenzanilide
JPH03173874A (ja) * 1989-09-29 1991-07-29 Mitsubishi Kasei Corp 新規複素環化合物
US5190942A (en) * 1991-04-22 1993-03-02 E. R. Squibb & Sons, Inc. Benzoxazole and related heterocyclic substituted imidazole and benzimidazole derivatives
US5322847A (en) * 1992-11-05 1994-06-21 Pfizer Inc. Azabenzimidazoles in the treatment of asthma, arthritis and related diseases

Also Published As

Publication number Publication date
BG101422A (en) 1997-11-28
EP0785927A1 (de) 1997-07-30
FI971489A0 (fi) 1997-04-10
SK45497A3 (en) 1997-10-08
DE69531623T2 (de) 2004-06-17
FI971489A (fi) 1997-06-05
PL319605A1 (en) 1997-08-18
AU4231796A (en) 1996-05-06
CA2202273A1 (en) 1996-04-25
WO1996011917A1 (en) 1996-04-25
AU699489B2 (en) 1998-12-03
NO971684L (no) 1997-06-12
DE69531623D1 (de) 2003-10-02
KR100237962B1 (ko) 2000-02-01
EP0785927A4 (de) 1997-12-29
EP0785927B1 (de) 2003-08-27
NO971684D0 (no) 1997-04-11

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