DK0912537T3 - Fremgangsmåde til fremstilling af phenylheterocykliske forbindelser, der er anvendelige som cox-2-inhibitorer - Google Patents
Fremgangsmåde til fremstilling af phenylheterocykliske forbindelser, der er anvendelige som cox-2-inhibitorerInfo
- Publication number
- DK0912537T3 DK0912537T3 DK97932424T DK97932424T DK0912537T3 DK 0912537 T3 DK0912537 T3 DK 0912537T3 DK 97932424 T DK97932424 T DK 97932424T DK 97932424 T DK97932424 T DK 97932424T DK 0912537 T3 DK0912537 T3 DK 0912537T3
- Authority
- DK
- Denmark
- Prior art keywords
- cox
- inhibitors
- preparation
- compounds useful
- phenylheterocyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2120096P | 1996-07-03 | 1996-07-03 | |
GBGB9615867.0A GB9615867D0 (en) | 1996-07-03 | 1996-07-29 | Process of preparing phenyl heterocycles useful as cox-2 inhibitors |
PCT/US1997/011466 WO1998000416A1 (en) | 1996-07-03 | 1997-06-27 | Process of preparing phenyl heterocycles useful as cox-2 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0912537T3 true DK0912537T3 (da) | 2004-08-30 |
Family
ID=26309770
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97932424T DK0912537T3 (da) | 1996-07-03 | 1997-06-27 | Fremgangsmåde til fremstilling af phenylheterocykliske forbindelser, der er anvendelige som cox-2-inhibitorer |
Country Status (26)
Country | Link |
---|---|
US (1) | US5840924A (da) |
EP (1) | EP0912537B1 (da) |
JP (1) | JP3071472B2 (da) |
CN (1) | CN1097046C (da) |
AR (1) | AR007695A1 (da) |
AT (1) | ATE266651T1 (da) |
AU (1) | AU717835B2 (da) |
BR (1) | BR9710099A (da) |
CA (1) | CA2258048C (da) |
CZ (1) | CZ297257B6 (da) |
DE (1) | DE69729096T2 (da) |
DK (1) | DK0912537T3 (da) |
EA (1) | EA001629B1 (da) |
ES (1) | ES2218691T3 (da) |
GB (1) | GB9615867D0 (da) |
HK (1) | HK1017355A1 (da) |
HR (1) | HRP970351B1 (da) |
HU (1) | HU224840B1 (da) |
NZ (1) | NZ333379A (da) |
PL (1) | PL195025B1 (da) |
PT (1) | PT912537E (da) |
RS (1) | RS49591B (da) |
SK (1) | SK283997B6 (da) |
TW (1) | TW419474B (da) |
UA (1) | UA57029C2 (da) |
WO (1) | WO1998000416A1 (da) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040072889A1 (en) * | 1997-04-21 | 2004-04-15 | Pharmacia Corporation | Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia |
JP2002506024A (ja) * | 1998-03-13 | 2002-02-26 | メルク エンド カムパニー インコーポレーテッド | 急性冠動脈虚血症候群および関連状態に対する併用療法および組成物 |
US6031108A (en) * | 1998-09-16 | 2000-02-29 | Bayer Corporation | Process for the preparation of 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole (TDA sulfone) |
US6649645B1 (en) * | 1998-12-23 | 2003-11-18 | Pharmacia Corporation | Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia |
CN1443180A (zh) * | 2000-05-22 | 2003-09-17 | 雷迪实验室有限公司 | 具有抗炎活性的新的化合物:它们的制备方法和含有它们的药物组合物 |
DE10129320A1 (de) * | 2001-06-19 | 2003-04-10 | Norbert Mueller | Verwendung von COX-2 Inhibitoren zur Behandlung von Schizophrenie, wahnhaften Störungen, affektiven Störungen oder Ticstörungen |
US20060167074A1 (en) * | 2001-06-19 | 2006-07-27 | Norbert Muller | Methods and compositions for the treatment of psychiatric disorders |
AU2002214243A1 (en) * | 2001-10-10 | 2003-04-22 | Shasun Chemicals And Drugs Limited | 1-((4-methyl thio)phenyl)-2-(phenyl acetoxy)-1-ethanone and a process for preparing the same |
KR20040072720A (ko) * | 2002-01-10 | 2004-08-18 | 파마시아 앤드 업존 캄파니 | 항바이러스제와 함께 사용되는 유두종 바이러스 감염의치료를 위한 cox-2 억제제의 용도 |
TW200403072A (en) * | 2002-01-23 | 2004-03-01 | Upjohn Co | Combination therapy for the treatment of bacterial infections |
US20040147581A1 (en) * | 2002-11-18 | 2004-07-29 | Pharmacia Corporation | Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy |
US20040220155A1 (en) * | 2003-03-28 | 2004-11-04 | Pharmacia Corporation | Method of providing a steroid-sparing benefit with a cyclooxygenase-2 inhibitor and compositions therewith |
PL1745791T3 (pl) * | 2003-05-07 | 2013-11-29 | Osteologix As | Leczenie chorób chrząstki/kości za pomocą rozpuszczalnych w wodzie soli strontu |
ES2394782T3 (es) * | 2003-05-07 | 2013-02-05 | Osteologix A/S | Composición con estroncio y vitamina D para la profilaxis y/o tratamiento de afecciones de cartílagos y/o huesos |
US20050014729A1 (en) * | 2003-07-16 | 2005-01-20 | Pharmacia Corporation | Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith |
US20050119262A1 (en) * | 2003-08-21 | 2005-06-02 | Pharmacia Corporation | Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent |
WO2005023189A2 (en) * | 2003-09-03 | 2005-03-17 | Pharmacia Corporation | Method of cox-2 selective inhibitor and nitric oxide-donating agent |
WO2006137839A2 (en) | 2004-08-24 | 2006-12-28 | Merck & Co., Inc. | Combination therapy for treating cyclooxygenase-2 mediated diseases or conditions in patients at risk of thrombotic cardiovascular events |
AU2006244393B2 (en) * | 2005-05-05 | 2012-06-21 | Cook Biotech Incorporated | Implantable materials and methods for inhibiting tissue adhesion formation |
CN104774186A (zh) * | 2015-04-28 | 2015-07-15 | 江苏中旗作物保护股份有限公司 | 农药除草剂异恶唑草酮的合成方法 |
CA3119728A1 (en) | 2018-11-21 | 2020-05-28 | Tremeau Pharmaceuticals, Inc. | Purified forms of rofecoxib, methods of manufacture and use |
US10945992B1 (en) | 2019-11-13 | 2021-03-16 | Tremeau Pharmaceuticals, Inc. | Dosage forms of rofecoxib and related methods |
US11161833B1 (en) | 2021-04-09 | 2021-11-02 | Tremeau Pharmaceuticals, Inc. | Deuterated etoricoxib, methods of manufacture, and use thereof |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5916884A (ja) * | 1982-07-19 | 1984-01-28 | Fujisawa Pharmaceut Co Ltd | 新規フラン化合物 |
US4968817A (en) * | 1984-07-27 | 1990-11-06 | National Distillers And Chemical Corporation | Manufacture of gamma-crotonolactone by carbonylation of glycidol |
DE3615157A1 (de) * | 1986-05-05 | 1987-11-12 | Schwabe Willmar Gmbh & Co | 5-arylalkyl-4-alkoxy-2(5h)-furanone, zwischenprodukte und verfahren zu ihrer herstellung sowie ihre anwendung als therapeutische wirkstoffe |
DE3718527A1 (de) * | 1987-06-03 | 1988-12-15 | Basf Ag | Verfahren zur herstellung von 2(5h)-furanonen |
DE4014420A1 (de) * | 1989-09-23 | 1991-04-04 | Bayer Ag | 5h-furan-2-on-derivate |
US5207817A (en) * | 1989-09-23 | 1993-05-04 | Bayer Aktiengesellschaft | Herbicidal 5H-furan-2-one derivatives |
WO1991016055A1 (en) * | 1990-04-17 | 1991-10-31 | Allergan, Inc. | 2(5h)-furanones substituted in the 5 and or in the 4 position, as anti-inflammatory agents |
US5393150A (en) * | 1991-09-05 | 1995-02-28 | Fort; Chris | Bifurcated keyboard arrangement |
IT1254558B (it) * | 1992-03-26 | 1995-09-25 | Mini Ricerca Scient Tecnolog | Composti a base di 3,4-diaril-(5h)-furan-2-one ad attivita' fungicida 3 |
EP0759432A1 (en) * | 1993-01-15 | 1997-02-26 | G.D. Searle & Co. | Use of medicaments containing 3,4-diaryl furans and analogs thereof for treating a skin-related condition |
US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
SK20396A3 (en) * | 1993-08-19 | 1997-03-05 | Warner Lambert Co | Substituted 2(5h)furanone, 2(5h)thiophenone or 2(5h)pyrrolone derivatives and pharmaceutical compositions on their base |
CA2180651A1 (en) * | 1994-01-10 | 1995-07-13 | Yves Ducharme | Phenyl heterocycles as cox-2 inhibitors |
US5475995A (en) * | 1994-05-16 | 1995-12-19 | Livingston; George G. | Truck spare tire locking rod |
-
1996
- 1996-07-29 GB GBGB9615867.0A patent/GB9615867D0/en active Pending
-
1997
- 1997-06-16 US US08/876,894 patent/US5840924A/en not_active Expired - Fee Related
- 1997-06-27 PT PT97932424T patent/PT912537E/pt unknown
- 1997-06-27 DE DE69729096T patent/DE69729096T2/de not_active Expired - Lifetime
- 1997-06-27 ES ES97932424T patent/ES2218691T3/es not_active Expired - Lifetime
- 1997-06-27 SK SK1793-98A patent/SK283997B6/sk not_active IP Right Cessation
- 1997-06-27 PL PL97330750A patent/PL195025B1/pl not_active IP Right Cessation
- 1997-06-27 AT AT97932424T patent/ATE266651T1/de active
- 1997-06-27 HU HU9903836A patent/HU224840B1/hu not_active IP Right Cessation
- 1997-06-27 UA UA99020607A patent/UA57029C2/uk unknown
- 1997-06-27 RS YUP-592/98A patent/RS49591B/sr unknown
- 1997-06-27 CA CA002258048A patent/CA2258048C/en not_active Expired - Fee Related
- 1997-06-27 EP EP97932424A patent/EP0912537B1/en not_active Expired - Lifetime
- 1997-06-27 HR HR970351A patent/HRP970351B1/xx not_active IP Right Cessation
- 1997-06-27 AU AU35886/97A patent/AU717835B2/en not_active Ceased
- 1997-06-27 CN CN97196133A patent/CN1097046C/zh not_active Expired - Fee Related
- 1997-06-27 EA EA199900079A patent/EA001629B1/ru not_active IP Right Cessation
- 1997-06-27 WO PCT/US1997/011466 patent/WO1998000416A1/en active IP Right Grant
- 1997-06-27 JP JP10504411A patent/JP3071472B2/ja not_active Expired - Fee Related
- 1997-06-27 CZ CZ0436898A patent/CZ297257B6/cs not_active IP Right Cessation
- 1997-06-27 DK DK97932424T patent/DK0912537T3/da active
- 1997-06-27 BR BR9710099A patent/BR9710099A/pt not_active IP Right Cessation
- 1997-06-27 NZ NZ333379A patent/NZ333379A/xx not_active IP Right Cessation
- 1997-06-28 TW TW086109096A patent/TW419474B/zh not_active IP Right Cessation
- 1997-07-01 AR ARP970102940A patent/AR007695A1/es active IP Right Grant
-
1999
- 1999-06-08 HK HK99102482A patent/HK1017355A1/xx not_active IP Right Cessation
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