DE60002679D1 - Co-kristallisationsprozess - Google Patents
Co-kristallisationsprozessInfo
- Publication number
- DE60002679D1 DE60002679D1 DE60002679T DE60002679T DE60002679D1 DE 60002679 D1 DE60002679 D1 DE 60002679D1 DE 60002679 T DE60002679 T DE 60002679T DE 60002679 T DE60002679 T DE 60002679T DE 60002679 D1 DE60002679 D1 DE 60002679D1
- Authority
- DE
- Germany
- Prior art keywords
- crystals
- crystallization
- enantiomers
- chiral
- crystal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002288 cocrystallisation Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000013078 crystal Substances 0.000 abstract 5
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 238000009738 saturating Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/42—Separation; Purification; Stabilisation; Use of additives
- C07C303/44—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99200648 | 1999-03-05 | ||
EP99200648A EP1034826A1 (de) | 1999-03-05 | 1999-03-05 | Co-Kristallisationsverfahren |
PCT/EP2000/001858 WO2000053283A1 (en) | 1999-03-05 | 2000-03-03 | Co-crystallization process |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60002679D1 true DE60002679D1 (de) | 2003-06-18 |
DE60002679T2 DE60002679T2 (de) | 2004-04-08 |
Family
ID=8239950
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60002679T Expired - Lifetime DE60002679T2 (de) | 1999-03-05 | 2000-03-03 | Co-kristallisationsprozess |
Country Status (8)
Country | Link |
---|---|
US (1) | US6570036B1 (de) |
EP (2) | EP1034826A1 (de) |
JP (1) | JP4896294B2 (de) |
AT (1) | ATE240139T1 (de) |
AU (1) | AU3285800A (de) |
DE (1) | DE60002679T2 (de) |
ES (1) | ES2199144T3 (de) |
WO (1) | WO2000053283A1 (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60036369T2 (de) * | 1999-03-17 | 2008-06-12 | Reuter Chemischer Apparatebau Kg | Emulsionskristallisation mit rückführung |
US20090088443A1 (en) * | 2002-02-15 | 2009-04-02 | Julius Remenar | Novel crystalline forms of conazoles and methods of making and using the same |
US7790905B2 (en) | 2002-02-15 | 2010-09-07 | Mcneil-Ppc, Inc. | Pharmaceutical propylene glycol solvate compositions |
US20100311701A1 (en) * | 2002-02-15 | 2010-12-09 | Transform Pharmaceuticals, Inc | Pharmaceutical Co-Crystal Compositions |
US7927613B2 (en) | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
AU2003213719A1 (en) | 2002-03-01 | 2003-09-16 | Regents Of The University Of Michigan | Multiple-component solid phases containing at least one active pharmaceutical ingredient |
US20070059356A1 (en) * | 2002-05-31 | 2007-03-15 | Almarsson Oern | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
CA2489984A1 (en) * | 2002-06-21 | 2003-12-31 | Transform Pharmaceuticals, Inc. | Pharmaceutical compositions with improved dissolution |
US20040110957A1 (en) * | 2002-12-05 | 2004-06-10 | Honeywell International, Inc. | Process for the synthesis of an antiviral compound |
US8183290B2 (en) * | 2002-12-30 | 2012-05-22 | Mcneil-Ppc, Inc. | Pharmaceutically acceptable propylene glycol solvate of naproxen |
TWI335227B (en) | 2004-02-25 | 2011-01-01 | Medical & Pharm Ind Tech & Dev | Pharmaceutical composition of taste masking and rapidly dissolving drug and method of preparing the same |
US20090246288A1 (en) * | 2004-02-25 | 2009-10-01 | Pharmaceutical Industry Technology And Development Center | Taste-masking oral dosage form and method of preparing the same |
US8601530B2 (en) * | 2006-09-19 | 2013-12-03 | The Invention Science Fund I, Llc | Evaluation systems and methods for coordinating software agents |
JP5901292B2 (ja) | 2008-07-29 | 2016-04-06 | ポクセル・エスアーエスPoxelsas | 粒子サイズ制御結晶化による鏡像異性体混合物からの鏡像異性体成分の単離方法 |
SI2413911T1 (sl) | 2009-03-31 | 2014-04-30 | Krka, D.D., Novo Mesto | Progresivna emulzijska kristalizacija |
US8716520B2 (en) | 2010-01-15 | 2014-05-06 | Lupin Limited | Method of resolution of (RS)- 1,1′-BI-2-naphthol for obtaining enantiomeric pure I.E. (S)-(−)-1,1′-BI-2-naphthol and/or (R)-(+)-1,1′-BI-2-naphthol via co-crystal formation with optically active derivatives of γ-amino acids |
EP2364977A1 (de) | 2010-01-26 | 2011-09-14 | Reuter Chemische Apparatebau KG | Verfahren zur Enantiomerenanreicherung von 3-Methyl-1-(2-Piperidinphenyl)-1-Butylamin |
AU2011227300A1 (en) | 2010-03-16 | 2012-11-15 | Imperial Sugar Company | Process for the manufacture of cocrystallized sucrose - polyol natural sweeteners and products thereof |
CN102633690B (zh) * | 2012-04-11 | 2014-04-09 | 上海康福赛尔医药科技有限公司 | 诱导结晶拆分外消旋樟脑磺酸制左旋和右旋樟脑磺酸方法 |
CN102633692B (zh) * | 2012-04-11 | 2014-04-09 | 上海康福赛尔医药科技有限公司 | 一种光学活性左旋和右旋3-溴樟脑-8-磺酸的制备方法 |
EP2671858A1 (de) | 2012-06-08 | 2013-12-11 | Université Catholique De Louvain | Verfahren zur Racematspaltung von Etiracetam |
WO2013186390A1 (en) | 2012-06-15 | 2013-12-19 | Farma Grs, D.O.O. | Selective crystallization processes using reverse micelle and w/o microemulsion systems - multitask emulsion crystallization (mec) |
JOP20190251A1 (ar) | 2017-05-31 | 2019-10-21 | Metys Pharmaceuticals AG | تركيبات تآزرية تشتمل على (r)-ديميراسيتام (1) و(s)-ديميراسيتام (2) بنسبة غير راسيمية |
US10414721B1 (en) | 2018-06-04 | 2019-09-17 | University Of Bern | Inhibitor of endocannabinoid cellular reuptake |
KR20210099566A (ko) | 2018-12-04 | 2021-08-12 | 메티스 파마슈티칼스 아게 | R-2-(치환된-술포닐)-헥사히드로-피롤로[1,2-a]피라진-6(2H)-온 및 S-2-(치환된-술포닐)-헥사히드로-피롤로[1,2-a]피라진-6(2H)-온을 비-라세미 비로 포함하는 상승작용적 조성물 |
HUE062575T2 (hu) | 2018-12-04 | 2023-11-28 | Metys Pharmaceuticals AG | (R)-2-(2-oxopirrolidin-1-il)-butánamidot és (S)-2-(2-oxopirrolidin-1-il)-butánamidot nem-racém arányban tartalmazó szinergetikus kompozíciók |
EP3898614A1 (de) | 2018-12-17 | 2021-10-27 | Tolremo Therapeutics AG | Heterocyclische derivate, pharmazeutische zusammensetzungen und deren verwendung in der behandlung, linderung oder vorbeugung von krebserkrankungen |
BR112021024125A2 (pt) | 2019-06-24 | 2022-03-22 | Philip Morris Products Sa | Composições e métodos para controle de parasitas |
EP4041399A1 (de) | 2019-10-02 | 2022-08-17 | Tolremo Therapeutics AG | Heterocyclische derivate, pharmazeutische zusammensetzungen und deren verwendung zur behandlung oder linderung von krebs |
WO2021064141A1 (en) | 2019-10-02 | 2021-04-08 | Tolremo Therapeutics Ag | Inhibitors of dual specificity tyrosine phosphorylation regulated kinase 1b |
EP4172156A1 (de) | 2020-06-24 | 2023-05-03 | Philip Morris Products S.A. | Zusammensetzungen und verfahren zur bekämpfung von parasiten |
CA3184062A1 (en) | 2020-06-25 | 2021-12-30 | Stefanie Fluckiger-Mangual | Heterocyclic derivatives, pharmaceutical compositions and their use in the treatment, amelioration or prevention of fibrotic disease |
EP3939578A1 (de) | 2020-07-13 | 2022-01-19 | Novaremed Ltd. | Verbindungen zur behandlung oder vorbeugung einer infektion, die aus einer coronavirus- und/oder einer coronavirusinduzierten erkrankung resultiert |
EP3964497A1 (de) | 2020-09-04 | 2022-03-09 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Substituierte vicinale diaminverbindungen und deren verwendung zur behandlung, linderung oder vorbeugung von schmerzen |
KR20230167092A (ko) | 2021-04-07 | 2023-12-07 | 톨레모 테라퓨틱스 아게 | 헤테로사이클릭 유도체, 약학 조성물, 및 암의 치료 또는 개선에서의 그들의 용도 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB865311A (en) * | 1958-09-28 | 1961-04-12 | Ajinomoto Kk | Process for continuous resolution of racemic amino acids |
JPS5655360A (en) * | 1979-10-15 | 1981-05-15 | Hiroyuki Nohira | Optical resolution of (+-)-phenylglycine and/or (+-)-camphor-sulfonic acid |
JPS5686138A (en) * | 1979-12-18 | 1981-07-13 | Hiroyuki Nohira | Optical resolution of (+-)phenylglycine and (+-)camphorsulfonic acid |
GB9126832D0 (en) * | 1991-12-18 | 1992-02-19 | Sandoz Ltd | Separation process |
AU3187495A (en) * | 1994-08-19 | 1996-03-14 | Chiroscience Limited | Process for the separation of the enantiomers of a bicyclic lactam |
US6383233B1 (en) | 1996-03-10 | 2002-05-07 | Reuter Chemicscher Apparatebau Kg | Separation process |
NL1004346C2 (nl) * | 1996-10-23 | 1998-04-24 | Dsm Nv | Werkwijze voor het scheiden van een mengsel van enantiomeren in een geschikt oplosmiddel. |
-
1999
- 1999-03-05 EP EP99200648A patent/EP1034826A1/de not_active Withdrawn
-
2000
- 2000-03-03 AT AT00910766T patent/ATE240139T1/de active IP Right Revival
- 2000-03-03 JP JP2000603771A patent/JP4896294B2/ja not_active Expired - Fee Related
- 2000-03-03 AU AU32858/00A patent/AU3285800A/en not_active Abandoned
- 2000-03-03 ES ES00910766T patent/ES2199144T3/es not_active Expired - Lifetime
- 2000-03-03 US US09/914,642 patent/US6570036B1/en not_active Expired - Lifetime
- 2000-03-03 EP EP00910766A patent/EP1156864B1/de not_active Expired - Lifetime
- 2000-03-03 WO PCT/EP2000/001858 patent/WO2000053283A1/en active Search and Examination
- 2000-03-03 DE DE60002679T patent/DE60002679T2/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1156864B1 (de) | 2003-05-14 |
JP4896294B2 (ja) | 2012-03-14 |
ES2199144T3 (es) | 2004-02-16 |
DE60002679T2 (de) | 2004-04-08 |
JP2002538228A (ja) | 2002-11-12 |
WO2000053283A1 (en) | 2000-09-14 |
EP1156864A1 (de) | 2001-11-28 |
AU3285800A (en) | 2000-09-28 |
EP1034826A1 (de) | 2000-09-13 |
ATE240139T1 (de) | 2003-05-15 |
US6570036B1 (en) | 2003-05-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |