DE60002679D1 - Co-kristallisationsprozess - Google Patents

Co-kristallisationsprozess

Info

Publication number
DE60002679D1
DE60002679D1 DE60002679T DE60002679T DE60002679D1 DE 60002679 D1 DE60002679 D1 DE 60002679D1 DE 60002679 T DE60002679 T DE 60002679T DE 60002679 T DE60002679 T DE 60002679T DE 60002679 D1 DE60002679 D1 DE 60002679D1
Authority
DE
Germany
Prior art keywords
crystals
crystallization
enantiomers
chiral
crystal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60002679T
Other languages
English (en)
Other versions
DE60002679T2 (de
Inventor
Karl Reuter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Reuter Chemischer Apparatebau GmbH
Original Assignee
Reuter Chemischer Apparatebau GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reuter Chemischer Apparatebau GmbH filed Critical Reuter Chemischer Apparatebau GmbH
Publication of DE60002679D1 publication Critical patent/DE60002679D1/de
Application granted granted Critical
Publication of DE60002679T2 publication Critical patent/DE60002679T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/42—Separation; Purification; Stabilisation; Use of additives
    • C07C303/44—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
DE60002679T 1999-03-05 2000-03-03 Co-kristallisationsprozess Expired - Lifetime DE60002679T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99200648 1999-03-05
EP99200648A EP1034826A1 (de) 1999-03-05 1999-03-05 Co-Kristallisationsverfahren
PCT/EP2000/001858 WO2000053283A1 (en) 1999-03-05 2000-03-03 Co-crystallization process

Publications (2)

Publication Number Publication Date
DE60002679D1 true DE60002679D1 (de) 2003-06-18
DE60002679T2 DE60002679T2 (de) 2004-04-08

Family

ID=8239950

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60002679T Expired - Lifetime DE60002679T2 (de) 1999-03-05 2000-03-03 Co-kristallisationsprozess

Country Status (8)

Country Link
US (1) US6570036B1 (de)
EP (2) EP1034826A1 (de)
JP (1) JP4896294B2 (de)
AT (1) ATE240139T1 (de)
AU (1) AU3285800A (de)
DE (1) DE60002679T2 (de)
ES (1) ES2199144T3 (de)
WO (1) WO2000053283A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1161290B1 (de) * 1999-03-17 2007-09-12 Reuter Chemische Apparatebau KG Emulsionskristallisation mit rückführung
WO2003074474A2 (en) * 2002-03-01 2003-09-12 University Of South Florida Multiple-component solid phases containing at least one active pharmaceutical ingredient
US7790905B2 (en) * 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
US20090088443A1 (en) * 2002-02-15 2009-04-02 Julius Remenar Novel crystalline forms of conazoles and methods of making and using the same
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US20100311701A1 (en) * 2002-02-15 2010-12-09 Transform Pharmaceuticals, Inc Pharmaceutical Co-Crystal Compositions
US20070059356A1 (en) * 2002-05-31 2007-03-15 Almarsson Oern Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
CN100360117C (zh) 2002-06-21 2008-01-09 转化医药公司 具有提高的溶出度的药物组合物
US20040110957A1 (en) * 2002-12-05 2004-06-10 Honeywell International, Inc. Process for the synthesis of an antiviral compound
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
TWI335227B (en) 2004-02-25 2011-01-01 Medical & Pharm Ind Tech & Dev Pharmaceutical composition of taste masking and rapidly dissolving drug and method of preparing the same
US20090246288A1 (en) * 2004-02-25 2009-10-01 Pharmaceutical Industry Technology And Development Center Taste-masking oral dosage form and method of preparing the same
US8601530B2 (en) * 2006-09-19 2013-12-03 The Invention Science Fund I, Llc Evaluation systems and methods for coordinating software agents
JP5901292B2 (ja) * 2008-07-29 2016-04-06 ポクセル・エスアーエスＰｏｘｅｌｓａｓ 粒子サイズ制御結晶化による鏡像異性体混合物からの鏡像異性体成分の単離方法
SI2413911T1 (sl) 2009-03-31 2014-04-30 Krka, D.D., Novo Mesto Progresivna emulzijska kristalizacija
US8716520B2 (en) 2010-01-15 2014-05-06 Lupin Limited Method of resolution of (RS)- 1,1′-BI-2-naphthol for obtaining enantiomeric pure I.E. (S)-(−)-1,1′-BI-2-naphthol and/or (R)-(+)-1,1′-BI-2-naphthol via co-crystal formation with optically active derivatives of γ-amino acids
EP2364977A1 (de) 2010-01-26 2011-09-14 Reuter Chemische Apparatebau KG Verfahren zur Enantiomerenanreicherung von 3-Methyl-1-(2-Piperidinphenyl)-1-Butylamin
PT2547220T (pt) 2010-03-16 2018-05-09 Imp Sugar Company Processo de fabrico de sacarose e edulcorantes naturais cocristalizados
CN102633692B (zh) * 2012-04-11 2014-04-09 上海康福赛尔医药科技有限公司 一种光学活性左旋和右旋3-溴樟脑-8-磺酸的制备方法
CN102633690B (zh) * 2012-04-11 2014-04-09 上海康福赛尔医药科技有限公司 诱导结晶拆分外消旋樟脑磺酸制左旋和右旋樟脑磺酸方法
EP2671858A1 (de) 2012-06-08 2013-12-11 Université Catholique De Louvain Verfahren zur Racematspaltung von Etiracetam
EP2861316B1 (de) 2012-06-15 2020-06-03 Farma GRS, d.o.o. Selektive kristallisationsverfahren mittels reverser mizellen und ohne mikroemulsionssysteme - multitask-emulsionskristallisierung (mec)
JOP20190251A1 (ar) 2017-05-31 2019-10-21 Metys Pharmaceuticals AG تركيبات تآزرية تشتمل على (r)-ديميراسيتام (1) و(s)-ديميراسيتام (2) بنسبة غير راسيمية
US10414721B1 (en) 2018-06-04 2019-09-17 University Of Bern Inhibitor of endocannabinoid cellular reuptake
MX2021006243A (es) 2018-12-04 2021-08-11 Metys Pharmaceuticals AG Composiciones sinergicas que comprenden (r)-2-(2-oxopirrolidin-1-i l)butanamida y (s)-2-(2-oxopirrolidin-1-il)butanamida en una proporcion no racemica.
EP3891150A1 (de) 2018-12-04 2021-10-13 Metys Pharmaceuticals AG Synergistische zusammensetzungen mit r-2-(substituiertem sulfonyl)-hexahydro-pyrrolo[1,2-a]pyrazin-6 (2h)-onen und s-2-(substituiertem sulfonyl)-hexahydro-pyrrolo[1,2-a]pyrazin-6(2h)-onen in einem nicht-racemischen verhältnis
EP3898614A1 (de) 2018-12-17 2021-10-27 Tolremo Therapeutics AG Heterocyclische derivate, pharmazeutische zusammensetzungen und deren verwendung in der behandlung, linderung oder vorbeugung von krebserkrankungen
JP2022537674A (ja) 2019-06-24 2022-08-29 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム 寄生虫防除のための組成物および方法
WO2021064142A1 (en) 2019-10-02 2021-04-08 Tolremo Therapeutics Ag Heterocyclic derivatives, pharmaceutical compositions and their use in the treatment or amelioration of cancer
WO2021064141A1 (en) 2019-10-02 2021-04-08 Tolremo Therapeutics Ag Inhibitors of dual specificity tyrosine phosphorylation regulated kinase 1b
CA3183706A1 (en) 2020-06-24 2021-12-30 Julia HOENG Compositions and methods for parasite control
KR20230027294A (ko) 2020-06-25 2023-02-27 톨레모 테라퓨틱스 아게 섬유성 질환의 치료, 개선 또는 예방을 위한 헤테로사이클릭 유도체, 약학 조성물 및 그들의 용도
EP3939578A1 (de) 2020-07-13 2022-01-19 Novaremed Ltd. Verbindungen zur behandlung oder vorbeugung einer infektion, die aus einer coronavirus- und/oder einer coronavirusinduzierten erkrankung resultiert
EP3964497A1 (de) 2020-09-04 2022-03-09 Friedrich-Alexander-Universität Erlangen-Nürnberg Substituierte vicinale diaminverbindungen und deren verwendung zur behandlung, linderung oder vorbeugung von schmerzen
BR112023020538A2 (pt) 2021-04-07 2024-01-23 Tolremo Therapeutics Ag Derivados heterocíclicos, composições farmacêuticas e seus usos no tratamento ou na melhoria de câncer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB865311A (en) * 1958-09-28 1961-04-12 Ajinomoto Kk Process for continuous resolution of racemic amino acids
JPS5655360A (en) * 1979-10-15 1981-05-15 Hiroyuki Nohira Optical resolution of (+-)-phenylglycine and/or (+-)-camphor-sulfonic acid
JPS5686138A (en) * 1979-12-18 1981-07-13 Hiroyuki Nohira Optical resolution of (+-)phenylglycine and (+-)camphorsulfonic acid
GB9126832D0 (en) * 1991-12-18 1992-02-19 Sandoz Ltd Separation process
JPH10506384A (ja) 1994-08-19 1998-06-23 カイロサイエンス・リミテッド 二環式ラクタム鏡像体の分離法
US6383233B1 (en) * 1996-03-10 2002-05-07 Reuter Chemicscher Apparatebau Kg Separation process
NL1004346C2 (nl) * 1996-10-23 1998-04-24 Dsm Nv Werkwijze voor het scheiden van een mengsel van enantiomeren in een geschikt oplosmiddel.

Also Published As

Publication number Publication date
EP1156864B1 (de) 2003-05-14
ATE240139T1 (de) 2003-05-15
JP4896294B2 (ja) 2012-03-14
JP2002538228A (ja) 2002-11-12
US6570036B1 (en) 2003-05-27
WO2000053283A1 (en) 2000-09-14
ES2199144T3 (es) 2004-02-16
DE60002679T2 (de) 2004-04-08
EP1034826A1 (de) 2000-09-13
AU3285800A (en) 2000-09-28
EP1156864A1 (de) 2001-11-28

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