SI2413911T1 - Progresivna emulzijska kristalizacija - Google Patents

Progresivna emulzijska kristalizacija

Info

Publication number
SI2413911T1
SI2413911T1 SI201030540T SI201030540T SI2413911T1 SI 2413911 T1 SI2413911 T1 SI 2413911T1 SI 201030540 T SI201030540 T SI 201030540T SI 201030540 T SI201030540 T SI 201030540T SI 2413911 T1 SI2413911 T1 SI 2413911T1
Authority
SI
Slovenia
Prior art keywords
progressive
emulsion crystallization
crystallization
emulsion
progressive emulsion
Prior art date
Application number
SI201030540T
Other languages
English (en)
Inventor
Alen Kljajic
Rok Zupez
Original Assignee
Krka, D.D., Novo Mesto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Krka, D.D., Novo Mesto filed Critical Krka, D.D., Novo Mesto
Publication of SI2413911T1 publication Critical patent/SI2413911T1/sl

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0004—Crystallisation cooling by heat exchange
    • B01D9/0013—Crystallisation cooling by heat exchange by indirect heat exchange
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI201030540T 2009-03-31 2010-03-31 Progresivna emulzijska kristalizacija SI2413911T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SI200900087 2009-03-31
EP10712359.8A EP2413911B1 (en) 2009-03-31 2010-03-31 Progressive emulsion crystallization
PCT/EP2010/002078 WO2010112222A1 (en) 2009-03-31 2010-03-31 Progressive emulsion crystallization

Publications (1)

Publication Number Publication Date
SI2413911T1 true SI2413911T1 (sl) 2014-04-30

Family

ID=42307187

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201030540T SI2413911T1 (sl) 2009-03-31 2010-03-31 Progresivna emulzijska kristalizacija

Country Status (3)

Country Link
EP (1) EP2413911B1 (sl)
SI (1) SI2413911T1 (sl)
WO (1) WO2010112222A1 (sl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9388440B2 (en) 2009-04-01 2016-07-12 Mylan Laboratories Limited Enzymatic process for the preparation of (S)-5-(4-fluoro-phenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-one, an intermediate of Ezetimibe and further conversion to Ezetimibe
EP2500072A1 (en) * 2011-03-15 2012-09-19 LEK Pharmaceuticals d.d. A novel process of residual solvent removal
WO2013186390A1 (en) 2012-06-15 2013-12-19 Farma Grs, D.O.O. Selective crystallization processes using reverse micelle and w/o microemulsion systems - multitask emulsion crystallization (mec)
CN110066260B (zh) * 2019-04-19 2022-05-24 大邦(湖南)生物制药有限公司 一种纯化利普斯他汀的方法
CN110734420A (zh) * 2019-12-04 2020-01-31 重庆植恩药业有限公司 一种奥利司他杂质f及其制备方法和用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9126832D0 (en) * 1991-12-18 1992-02-19 Sandoz Ltd Separation process
JP4157602B2 (ja) 1996-03-10 2008-10-01 ロイター・ヒェーミシェ・アパラーテバウ・コマンディート・ゲゼルシャフト 分離方法
US6428583B1 (en) 1997-09-06 2002-08-06 Reuter Chemische Apparatebau Kg Separation process
EP1034826A1 (en) 1999-03-05 2000-09-13 Reuter Chemische Apparatebau Co-crystallization process
ES2292432T3 (es) 1999-03-17 2008-03-16 Reuter Chemische Apparatebau Kg Cristalizacion de emulsiones con reciclaje.
US20040197275A1 (en) * 2002-10-17 2004-10-07 Ecole Polytechnique Federale De Lausanne Process for the manufacture of powders of inhalable medicaments
WO2005026140A1 (en) 2003-09-12 2005-03-24 Ranbaxy Laboratories Limited Process for the preparation of crystalline forms of orlistat
EP1708708A1 (en) 2004-01-30 2006-10-11 Teva Pharmaceutical Industries Ltd. Montelukast free acid polymorphs
SI21745A (sl) 2004-04-09 2005-10-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Polimorfi derivata 1-pirol-1-heptanojske kisline, intermediata za pripravo atorvastatina
WO2007069254A2 (en) 2005-12-14 2007-06-21 Makhteshim Chemical Works Ltd. POLYMORPHS AND AMORPHOUS FORMS OF 5-AMINO-l-[2,6- DICHLORO-4-(TRIFLUOROMETHYL)PHENYL]-4- [(TRIFLUOROMETHYL)SULFINYL]-IH-PYRAZOLE-3-CARBONITRILE
KR20080105070A (ko) * 2006-02-21 2008-12-03 케마지스 리미티드 몬테루카스트 암모늄염의 신규한 다형체 및 그 제조 방법
UA110598C2 (uk) 2006-11-10 2016-01-25 Басф Се Спосіб одержання кристалічної модифікації фіпронілу
CN102285906B (zh) 2007-01-24 2014-11-19 克尔克公司 依泽替米贝的制备方法和其的衍生物
EP2030973A1 (en) 2007-08-31 2009-03-04 KRKA, tovarna zdravil, d.d., Novo mesto Process for preparing 2-sulfinyl-1H-benzimidazoles

Also Published As

Publication number Publication date
EP2413911A1 (en) 2012-02-08
WO2010112222A1 (en) 2010-10-07
EP2413911B1 (en) 2014-02-19

Similar Documents

Publication Publication Date Title
EP2393493A4 (en) LINKS
EP2491025A4 (en) AZA-AZULENE COMPOUNDS
GB0907515D0 (en) Compounds
GB0914856D0 (en) Compounds
GB0922626D0 (en) Double emulsions
GB0905641D0 (en) Compounds
GB0909671D0 (en) Compounds
SI2413911T1 (sl) Progresivna emulzijska kristalizacija
AP2909A (en) Pyrazinoisoquinoline Compounds
GB201003063D0 (en) Fixings
GB0911000D0 (en) Compounds
GB0909672D0 (en) Compounds
EP2443115A4 (en) COMPOUNDS
GB0906053D0 (en) Co-crystals
GB0904772D0 (en) Emulsion
GB0912236D0 (en) Co-crystals
GB0912235D0 (en) Co-crystals
GB0906054D0 (en) Co-crystals
GB0906052D0 (en) Co-crystals
GB0906050D0 (en) Co-crystals
GB0905054D0 (en) Compounds
GB0908941D0 (en) Compounds
GB0904729D0 (en) Compounds
GB0904746D0 (en) Compounds
GB0903492D0 (en) Compounds