JPS5655360A - Optical resolution of (+-)-phenylglycine and/or (+-)-camphor-sulfonic acid - Google Patents
Optical resolution of (+-)-phenylglycine and/or (+-)-camphor-sulfonic acidInfo
- Publication number
- JPS5655360A JPS5655360A JP13173579A JP13173579A JPS5655360A JP S5655360 A JPS5655360 A JP S5655360A JP 13173579 A JP13173579 A JP 13173579A JP 13173579 A JP13173579 A JP 13173579A JP S5655360 A JPS5655360 A JP S5655360A
- Authority
- JP
- Japan
- Prior art keywords
- csa
- phenylglycine
- optical resolution
- useful
- camphorsulfonic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To carry out the optical resolution of phenylglycine and camphorsulfonic acid useful as synthetic raw materials of medicines, etc. simultaneously, in high efficiency, by the use of a mixture of optically active isomers and racemates of phenylglycine and camphorsulfonic acid as the resolving agent for each compound.
CONSTITUTION: A solution containing a mixture composed of optically active isomers and racemates of phenylglycine (PG) and camphorsulfonic acid (CSA) is prepared. After crystallizing (+)-PG-(-)-CSA salt or (-)-PG-(+)-CSA salt from the solution, (±)-PG and (±)-CSA are resolved to each optical isomers by the solid- liquied separation of the solution followed by the separation of PG from CSA. The amount of the recovered optical isomers is more than that of the used isomer, and the optical resolution can be carried out continuously. The D-(-)-PG is useful as a synthetic raw material of pennicillin, etc., and the L-(3)-PG and (+)- CSA are useful as resolving agents.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13173579A JPS5655360A (en) | 1979-10-15 | 1979-10-15 | Optical resolution of (+-)-phenylglycine and/or (+-)-camphor-sulfonic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13173579A JPS5655360A (en) | 1979-10-15 | 1979-10-15 | Optical resolution of (+-)-phenylglycine and/or (+-)-camphor-sulfonic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5655360A true JPS5655360A (en) | 1981-05-15 |
JPS641459B2 JPS641459B2 (en) | 1989-01-11 |
Family
ID=15064962
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13173579A Granted JPS5655360A (en) | 1979-10-15 | 1979-10-15 | Optical resolution of (+-)-phenylglycine and/or (+-)-camphor-sulfonic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5655360A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4896294B2 (en) * | 1999-03-05 | 2012-03-14 | ロイター・ヒェーミシェ・アパラーテバウ・コマンディート・ゲゼルシャフト | Co-crystallization method |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4878137A (en) * | 1972-01-29 | 1973-10-20 |
-
1979
- 1979-10-15 JP JP13173579A patent/JPS5655360A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4878137A (en) * | 1972-01-29 | 1973-10-20 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4896294B2 (en) * | 1999-03-05 | 2012-03-14 | ロイター・ヒェーミシェ・アパラーテバウ・コマンディート・ゲゼルシャフト | Co-crystallization method |
Also Published As
Publication number | Publication date |
---|---|
JPS641459B2 (en) | 1989-01-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP930428B1 (en) | Process for the preparation of omeprazole new salts | |
KR890002030A (en) | D and 1 enantiomer of medetomidine, separation method thereof and pharmaceutical composition comprising the same | |
ATE38988T1 (en) | IMIDAZOLYLPHENYL-TETRAHYDROPYRIDAZINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM. | |
ES551434A0 (en) | PROCESS FOR THE MANUFACTURE OF SPYRO-HYDANTOIN COMPOUNDS | |
IL52227A (en) | Process for the preparation of 10,19-dihydro-vitamin d derivatives and some novel 10,19-dihydro-1alpha-hydroxy and 1 alpha,25-dihydroxy-vitamin d3 compounds and pharmaceutical compositions containing them | |
JPS5655360A (en) | Optical resolution of (+-)-phenylglycine and/or (+-)-camphor-sulfonic acid | |
JPS6413024A (en) | Pharmaceutical composition | |
JPS5686138A (en) | Optical resolution of (+-)phenylglycine and (+-)camphorsulfonic acid | |
ES483087A1 (en) | 5(6)-(2-Amino-5-thiazoloyl)benzimidazole-2-carbamic acid esters and their salts, their preparation and use, and pharmaceutical compositions containing them. | |
EP0023355A3 (en) | Medicinal solutions and process for their preparation | |
JPS5223037A (en) | Process for preparation of optical active amino acid | |
DE2966607D1 (en) | Medicines containing as active ingredients compounds of the benzene-sulfone type; compounds of this type and process for their preparation | |
JPS51131847A (en) | Process for preparation of 2,2'- dithiobisbenzamide compounds | |
JPS5212143A (en) | Process for preparation of alpha-(4' -isobutylphenyl)alkylacetic acid | |
PT76949A (en) | Process for the preparation of racemic and optically active apovincaminic acid derivatives and pharmaceutical compositions containing them | |
JPS5275580A (en) | Process for the preparation of feed | |
JPS5239622A (en) | Process for preparation of methacrylic acid | |
JPS5439036A (en) | Isolatin of alkoxyformylphenols | |
DE2965912D1 (en) | Medicines containing as active ingredients compounds of the benzene-sulfone type; compounds of this type and process for their preparation | |
ES449432A1 (en) | Pyrrolo(2,1-b)(3)benzazepines methods of preparing them pharmaceutical compositions containing them and their use for treatment of non-human animals | |
JPS51142093A (en) | A process for manufacturing polyion complex | |
JPS51149212A (en) | Process for separating mixture of benzen and alcohols | |
JPS5259141A (en) | Process for preparation of optical active organic thiophosphoric acid | |
JPS5219654A (en) | Preparation of ng-substituted-n2- substituted-alginamides and acid add ition salts thereof | |
ATE65390T1 (en) | TABLET IN CAPSULE FORM, PROCESS AND APPARATUS FOR THEIR PRODUCTION. |