JPS5655360A - Optical resolution of (+-)-phenylglycine and/or (+-)-camphor-sulfonic acid - Google Patents

Optical resolution of (+-)-phenylglycine and/or (+-)-camphor-sulfonic acid

Info

Publication number
JPS5655360A
JPS5655360A JP13173579A JP13173579A JPS5655360A JP S5655360 A JPS5655360 A JP S5655360A JP 13173579 A JP13173579 A JP 13173579A JP 13173579 A JP13173579 A JP 13173579A JP S5655360 A JPS5655360 A JP S5655360A
Authority
JP
Japan
Prior art keywords
csa
phenylglycine
optical resolution
useful
camphorsulfonic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13173579A
Other languages
Japanese (ja)
Other versions
JPS641459B2 (en
Inventor
Hiroyuki Nohira
Hiroshi Fujii
Masami Yajima
Rieko Fujimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP13173579A priority Critical patent/JPS5655360A/en
Publication of JPS5655360A publication Critical patent/JPS5655360A/en
Publication of JPS641459B2 publication Critical patent/JPS641459B2/ja
Granted legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To carry out the optical resolution of phenylglycine and camphorsulfonic acid useful as synthetic raw materials of medicines, etc. simultaneously, in high efficiency, by the use of a mixture of optically active isomers and racemates of phenylglycine and camphorsulfonic acid as the resolving agent for each compound.
CONSTITUTION: A solution containing a mixture composed of optically active isomers and racemates of phenylglycine (PG) and camphorsulfonic acid (CSA) is prepared. After crystallizing (+)-PG-(-)-CSA salt or (-)-PG-(+)-CSA salt from the solution, (±)-PG and (±)-CSA are resolved to each optical isomers by the solid- liquied separation of the solution followed by the separation of PG from CSA. The amount of the recovered optical isomers is more than that of the used isomer, and the optical resolution can be carried out continuously. The D-(-)-PG is useful as a synthetic raw material of pennicillin, etc., and the L-(3)-PG and (+)- CSA are useful as resolving agents.
COPYRIGHT: (C)1981,JPO&Japio
JP13173579A 1979-10-15 1979-10-15 Optical resolution of (+-)-phenylglycine and/or (+-)-camphor-sulfonic acid Granted JPS5655360A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13173579A JPS5655360A (en) 1979-10-15 1979-10-15 Optical resolution of (+-)-phenylglycine and/or (+-)-camphor-sulfonic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13173579A JPS5655360A (en) 1979-10-15 1979-10-15 Optical resolution of (+-)-phenylglycine and/or (+-)-camphor-sulfonic acid

Publications (2)

Publication Number Publication Date
JPS5655360A true JPS5655360A (en) 1981-05-15
JPS641459B2 JPS641459B2 (en) 1989-01-11

Family

ID=15064962

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13173579A Granted JPS5655360A (en) 1979-10-15 1979-10-15 Optical resolution of (+-)-phenylglycine and/or (+-)-camphor-sulfonic acid

Country Status (1)

Country Link
JP (1) JPS5655360A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4896294B2 (en) * 1999-03-05 2012-03-14 ロイター・ヒェーミシェ・アパラーテバウ・コマンディート・ゲゼルシャフト Co-crystallization method

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4878137A (en) * 1972-01-29 1973-10-20

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4878137A (en) * 1972-01-29 1973-10-20

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4896294B2 (en) * 1999-03-05 2012-03-14 ロイター・ヒェーミシェ・アパラーテバウ・コマンディート・ゲゼルシャフト Co-crystallization method

Also Published As

Publication number Publication date
JPS641459B2 (en) 1989-01-11

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