NO974779L - FremgangsmÕte for separasjon av en blanding av enantiomere - Google Patents

FremgangsmÕte for separasjon av en blanding av enantiomere

Info

Publication number
NO974779L
NO974779L NO974779A NO974779A NO974779L NO 974779 L NO974779 L NO 974779L NO 974779 A NO974779 A NO 974779A NO 974779 A NO974779 A NO 974779A NO 974779 L NO974779 L NO 974779L
Authority
NO
Norway
Prior art keywords
enantiomers
diastereomer
mixture
optically active
active form
Prior art date
Application number
NO974779A
Other languages
English (en)
Other versions
NO974779D0 (no
Inventor
Ton Renu Vries
Hans Wijnberg
Erik Van Echten
Lambertus Albregt Hulshof
Quirinus Bernardus Broxterman
Original Assignee
Dsm Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Nv filed Critical Dsm Nv
Publication of NO974779D0 publication Critical patent/NO974779D0/no
Publication of NO974779L publication Critical patent/NO974779L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/023—Preparation; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/80—Preparation of compounds containing amino groups bound to a carbon skeleton by photochemical reactions; by using free radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C07C253/34—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Oppfinnelsen vedrører en fremgangsmåte ved separasjon av en blanding av enantiomerer, hvor det anvendes mer enn ett resolusjonsmiddel, av hvilke minst ett er optisk aktivt. Metoden gir et diastereomert kompleks som inneholder minst to resolusjonsmidler i optisk aktiv form. Oppfinnelsen vedrører også et diastereo- mert kompleks omfattende minst tre forbindelser, av hvilke minst en forbindelse er et resolusjonsmiddel i optisk aktiv form og minst en forbindelse er en enantiomer i optisk aktiv form.
NO974779A 1996-10-23 1997-10-16 FremgangsmÕte for separasjon av en blanding av enantiomere NO974779L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL1004346A NL1004346C2 (nl) 1996-10-23 1996-10-23 Werkwijze voor het scheiden van een mengsel van enantiomeren in een geschikt oplosmiddel.

Publications (2)

Publication Number Publication Date
NO974779D0 NO974779D0 (no) 1997-10-16
NO974779L true NO974779L (no) 1998-04-24

Family

ID=19763731

Family Applications (1)

Application Number Title Priority Date Filing Date
NO974779A NO974779L (no) 1996-10-23 1997-10-16 FremgangsmÕte for separasjon av en blanding av enantiomere

Country Status (11)

Country Link
US (1) US6235927B1 (no)
EP (1) EP0838448B1 (no)
JP (1) JPH10245368A (no)
CN (1) CN1182068A (no)
AT (1) ATE264826T1 (no)
CA (1) CA2218804A1 (no)
DE (1) DE69728730T9 (no)
IL (1) IL122012A (no)
IN (1) IN184142B (no)
NL (1) NL1004346C2 (no)
NO (1) NO974779L (no)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2320756C (en) * 1998-02-20 2009-02-17 Fine Chemicals Corporation (Proprietary) Limited Process for the production of optically enriched (r)- or (s)-albuterol
US6713627B2 (en) 1998-03-13 2004-03-30 Aventis Pharmaceuticals Inc. Processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
NL1008911C2 (nl) * 1998-04-17 1999-10-19 Dsm Nv Werkwijze voor het verhogen van de enantiomere overmaat van een chirale verbinding.
EP1034826A1 (en) * 1999-03-05 2000-09-13 Reuter Chemische Apparatebau Co-crystallization process
NL1012865C2 (nl) * 1999-08-19 2001-02-20 Dsm Nv 1-Fenyl-3-oxopropaan-1-sulfonzuren en -sulfonaten en zuivere enantiomeren daarvan.
WO2001030763A1 (fr) 1999-10-22 2001-05-03 Takeda Chemical Industries, Ltd. Procede de production de derive de naphtalene optiquement actif et son separateur optique
US7666588B2 (en) * 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
JP2005104895A (ja) * 2003-09-30 2005-04-21 Nippon Kayaku Co Ltd 光学活性なアミノアルコール化合物の製造法
JP4361094B2 (ja) * 2003-12-10 2009-11-11 エボニック デグサ ゲーエムベーハー エナンチオ濃縮されたアミノ酸の製造方法
WO2005082893A2 (en) 2004-02-25 2005-09-09 Eli Lilly And Company Histamine h3 receptor antagonists, preparation and therapeutic uses
WO2006006071A1 (en) * 2004-07-07 2006-01-19 Pfizer Products Inc. Resolution of an aryl-fused azapolycyclic compound
CA2607809A1 (en) * 2005-05-04 2007-01-11 Medichem, S.A. Process for the preparation of tamsulosin
CN101263112B (zh) 2005-07-01 2012-10-10 伊莱利利公司 组胺h3受体药物、其制备和治疗用途
WO2007123581A1 (en) 2005-11-17 2007-11-01 Eli Lilly And Company Glucagon receptor antagonists, preparation and therapeutic uses
ES2346246T3 (es) 2005-11-18 2010-10-13 ELI LILLY & COMPANY Antagonistas del receptor de glucagon, preparacion y usos terapeuticos.
UA99284C2 (ru) 2007-05-11 2012-08-10 Елі Ліллі Енд Компані ИНГИБИТОРЫ р70 S6-КИНАЗЫ
EA018508B1 (ru) * 2008-07-29 2013-08-30 Поксел Способ выделения энантиомерных компонентов из смеси энантиомеров в результате проведения кристаллизации, контролируемой по размеру частиц
AR075988A1 (es) 2009-04-09 2011-05-11 Lilly Co Eli Compuesto de piridiloxi - pirrolidina inhibidor de recaptacion de serotonina y norepinefrina, composicion farmaceutica que lo comprende y su uso para la manufactura de un medicamento util para el tratamiento de dolor cronico
EP2491032B1 (en) 2009-10-23 2014-04-16 Eli Lilly and Company Akt inhibitors
CN101792398B (zh) * 2010-03-09 2013-06-26 河北科技大学 一种拆分法制备光学纯对羟基苯甘氨酸的方法
CN104876856B (zh) * 2015-05-05 2017-11-21 河北凯力昂生物科技有限公司 一种拆分法制备(r)‑(+)‑3‑氨基哌啶二盐酸盐的方法
CN104829459B (zh) * 2015-05-06 2017-05-24 河北凯力昂生物科技有限公司 一种拆分法制备(r)‑(+)‑1‑萘乙胺的方法
KR102565407B1 (ko) * 2016-01-04 2023-08-10 (주)아모레퍼시픽 극성 비양자성 용매를 이용한 n-[4-(1-아미노에틸)-페닐]-술폰아미드 유도체의 카이랄 분할 방법
CN108658784B (zh) * 2018-04-26 2020-12-18 联化科技股份有限公司 (r)-1-(4-甲基苯基)乙胺的合成方法
CN109485561A (zh) * 2018-11-23 2019-03-19 江苏颖盛化工有限公司 一种dl-萘普生的合成工艺
WO2021074778A1 (en) * 2019-10-16 2021-04-22 Hikal Limited An industrial process for resolution of chlocyphos
WO2024014282A1 (ja) * 2022-07-14 2024-01-18 株式会社クレハ トリアゾール誘導体のエナンチオマー（ｒ）体の製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB656500A (en) * 1947-10-24 1951-08-22 Sterling Drug Inc Improvements in or relating to the preparation of l-arterenol and l-arterenol so prepared
US3862985A (en) * 1971-07-28 1975-01-28 Allied Chem Resolution of lysineamide
EP0174358A1 (en) * 1984-03-01 1986-03-19 ALKALOIDA VEGYéSZETI GYáR Novel diastereomer salts of phenylalanine and n-acyl derivatives thereof and process for the separation of optically active phenylalanine and n-acyl derivatives thereof

Also Published As

Publication number Publication date
NL1004346C2 (nl) 1998-04-24
US6235927B1 (en) 2001-05-22
NO974779D0 (no) 1997-10-16
DE69728730T9 (de) 2005-09-08
EP0838448B1 (en) 2004-04-21
JPH10245368A (ja) 1998-09-14
IL122012A (en) 2001-08-26
IL122012A0 (en) 1998-03-10
CA2218804A1 (en) 1998-04-23
CN1182068A (zh) 1998-05-20
ATE264826T1 (de) 2004-05-15
EP0838448A1 (en) 1998-04-29
DE69728730D1 (de) 2004-05-27
IN184142B (no) 2000-06-17
DE69728730T2 (de) 2005-03-31

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