DE69033355D1 - Imidazochinoxalinone, ihre Azaanaloge und Verfahren zu ihrer Herstellung - Google Patents

Imidazochinoxalinone, ihre Azaanaloge und Verfahren zu ihrer Herstellung

Info

Publication number
DE69033355D1
DE69033355D1 DE69033355T DE69033355T DE69033355D1 DE 69033355 D1 DE69033355 D1 DE 69033355D1 DE 69033355 T DE69033355 T DE 69033355T DE 69033355 T DE69033355 T DE 69033355T DE 69033355 D1 DE69033355 D1 DE 69033355D1
Authority
DE
Germany
Prior art keywords
imidazoquinoxalinones
preparation
processes
aza analogues
aza
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69033355T
Other languages
English (en)
Other versions
DE69033355T2 (de
Inventor
David Daniel Davey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Berlex Laboratories Inc
Original Assignee
Berlex Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berlex Laboratories Inc filed Critical Berlex Laboratories Inc
Application granted granted Critical
Publication of DE69033355D1 publication Critical patent/DE69033355D1/de
Publication of DE69033355T2 publication Critical patent/DE69033355T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69033355T 1989-05-31 1990-05-29 Imidazochinoxalinone, ihre Azaanaloge und Verfahren zu ihrer Herstellung Expired - Fee Related DE69033355T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/359,182 US5055465A (en) 1989-05-31 1989-05-31 Imidazoquinoxalinones, their aza analogs and process for their preparation

Publications (2)

Publication Number Publication Date
DE69033355D1 true DE69033355D1 (de) 1999-12-23
DE69033355T2 DE69033355T2 (de) 2000-05-11

Family

ID=23412679

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69033355T Expired - Fee Related DE69033355T2 (de) 1989-05-31 1990-05-29 Imidazochinoxalinone, ihre Azaanaloge und Verfahren zu ihrer Herstellung

Country Status (7)

Country Link
US (1) US5055465A (de)
EP (1) EP0400583B1 (de)
AT (1) ATE186728T1 (de)
DE (1) DE69033355T2 (de)
DK (1) DK0400583T3 (de)
ES (1) ES2138956T3 (de)
GR (1) GR3032611T3 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602252A (en) * 1989-11-17 1997-02-11 Berlex Laboratories, Inc. Tricyclic pteridinones and a process for their preparation
US5854419A (en) * 1989-11-17 1998-12-29 Schering Aktiengesellschaft Tricyclic pteridinones and a process for their preparation
US5182386A (en) * 1991-08-27 1993-01-26 Neurogen Corporation Certain imidazoquinoxalinones; a new class of gaba brain receptor ligands
DK0647137T3 (da) * 1992-06-22 2008-12-08 State Of Oregon Through Oregon Glycinreceptorantagonister og anvendelse deraf
DE4228095A1 (de) * 1992-08-24 1994-03-03 Asta Medica Ag Neue 4,5-Dihydro-4-oxo-pyrrolo[1,2-a]chinoxaline und entsprechende Aza-analoga und Verfahren zu deren Herstellung
US5306819A (en) * 1992-08-27 1994-04-26 Neurogen Corporation Certain aryl a cycloalkyl fused imidazopyrazinols; and new class of GABA brain receptor ligands
DE4310523A1 (de) * 1993-03-31 1994-10-06 Basf Ag Imidazolo-chinoxalinone zur Behandlung zentralnervöser Erkrankungen
US5631373A (en) * 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
CA2180122A1 (en) * 1994-01-03 1995-07-13 Sui Xiong Cai 8-aza, 6-aza and 6,8-diaza-1,4-dihydroquinoxaline-2,3-diones and the usethereof as antagonists for the glycine/nmda receptor
ATE214069T1 (de) * 1994-02-11 2002-03-15 Novo Nordisk As Heterocyclische verbindungen und ihre herstellung und verwendung
SI9520108A (en) * 1994-09-30 1997-10-31 Basf Ag New heterocyclic substituted imidazoloquinoxalinones, their preparation and their use
US5801183A (en) * 1995-01-27 1998-09-01 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Aza and aza (N-oxy) analogs of glycine/NMDA receptor antagonists
DE19510965A1 (de) * 1995-03-24 1996-09-26 Asta Medica Ag Neue Pyrido/3,2-e/pyrazinone mit antiasthmatischer Wirksamkeit und Verfahren zu deren Herstellung
DE19611476A1 (de) * 1996-03-22 1997-09-25 Basf Ag Neue heterocyclische substituierte Imidazolo-chinoxalinone, ihre Herstellung und Verwendung
DE19961302A1 (de) * 1999-12-18 2001-06-21 Dresden Arzneimittel Verwendung von Imidazo(1,5-a)-pyrido(3,2-e)-pyrazinonen als duale Inhibitoren der Phosphodiesterase 5 und der Phosphodiesterase 3 zur Therapie der Herzinsuffizienz, von pulmonaler Hypertonie und Gefäßerkrankungen, die mit einer Minderdurchblutung einhergehen
HUP0105132A3 (en) * 1999-01-20 2002-12-28 Dresden Arzneimittel Process for preparing imidazo[1,5-a]-pyrido[3,2-e]-pyrazinones and the use of the same for preparing pharmaceutical compositions
ID30182A (id) * 1999-03-22 2001-11-08 Bristol Myers Squibb Co PENGHAMBAT-PENGHAMBAT PIRIDOPIRIDAZINA LEBURAN DARI cGMP FOSFODIESTERASE
DE10012373A1 (de) * 2000-03-14 2001-09-20 Dresden Arzneimittel Verwendung von Pyrido[3,2-e]-pyrazinonen als Inhibitoren der Phosphodiesterase 5 zur Therapie von erektiler Dysfunktion
US6465465B1 (en) * 2000-03-14 2002-10-15 Arzneimittelwerk Dresden Gmbh Process for the treatment of erectile dysfunction and product therefor
EP1312363A1 (de) * 2001-09-28 2003-05-21 Pfizer Products Inc. Behandlungsverfahren und kits bestehend aus Wachstumshormonsekretionsförderern
US7342884B2 (en) * 2002-03-13 2008-03-11 Harmonic, Inc. Method and apparatus for one directional communications in bidirectional communications channel
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
TW200817400A (en) * 2006-05-30 2008-04-16 Elbion Ag Pyrido [3,2-e] pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them
KR101563103B1 (ko) * 2006-12-13 2015-10-23 아스카 세이야쿠 가부시키가이샤 퀴녹살린 유도체
WO2009068320A1 (en) * 2007-11-30 2009-06-04 Elbion Gmbh Aryl and heteroaryl fused imidazo (1,5-a) pyrazines as inhibitors of phosphodiesterase 10
WO2009070583A1 (en) * 2007-11-30 2009-06-04 Wyeth Pyrido[3,2-e]pyrazines, process for preparing the same, and their use as inhibitors of phosphodiesterase 10
JP2011505366A (ja) * 2007-11-30 2011-02-24 ワイス・エルエルシー ホスホエステラーゼ１０の阻害剤としてのアリールおよびヘテロアリール縮合イミダゾ［１，５−ａ］ピラジン
MY152386A (en) 2009-01-23 2014-09-15 Takeda Pharmaceutical Substituted 6a,7,8,9-tetrahydropyrido[3,2-e] pyrrolo[1,2-a]pyrazin-6(5h)-ones
WO2011014681A1 (en) 2009-07-30 2011-02-03 Takeda Pharmaceutical Company Limited Poly (ADP-Ribose) Polymerase (PARP) INHIBITORS
WO2011081915A2 (en) * 2009-12-15 2011-07-07 Cebix Inc. Methods for treating erectile dysfunction in patients with insulin-dependent diabetes
PL2615096T3 (pl) * 2010-09-07 2019-12-31 Astellas Pharma Inc. Związki chinoksalinowe

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4138564A (en) * 1977-08-03 1979-02-06 American Home Products Corporation Tetrahydro[1H]pyrazino[1,2-a]azaquinoxalin-5(6H)-ones and derivatives thereof
IL59104A (en) * 1979-02-09 1984-02-29 Roussel Uclaf Heterotricyclic derivatives,process for their preparation and pharmaceutical compositions incorporating them
US4333394A (en) * 1979-12-31 1982-06-08 Brown Stanford M Method for handling and baling metallic scrap material
US4440929A (en) * 1981-07-16 1984-04-03 Usv Pharmaceutical Corporation Imidazoquinoxaline compounds
US4761414A (en) * 1986-08-19 1988-08-02 G. D. Searle & Co. Substituted 1H-pyrimido[1,2-a-]-pyrido[3,4-e]pyrazine 6 oxides

Also Published As

Publication number Publication date
EP0400583B1 (de) 1999-11-17
ES2138956T3 (es) 2000-02-01
DK0400583T3 (da) 2000-03-13
ATE186728T1 (de) 1999-12-15
GR3032611T3 (en) 2000-05-31
DE69033355T2 (de) 2000-05-11
US5055465A (en) 1991-10-08
EP0400583A1 (de) 1990-12-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee