ATE186728T1 - Imidazochinoxalinone, ihre azaanaloge und verfahren zu ihrer herstellung - Google Patents
Imidazochinoxalinone, ihre azaanaloge und verfahren zu ihrer herstellungInfo
- Publication number
- ATE186728T1 ATE186728T1 AT90110191T AT90110191T ATE186728T1 AT E186728 T1 ATE186728 T1 AT E186728T1 AT 90110191 T AT90110191 T AT 90110191T AT 90110191 T AT90110191 T AT 90110191T AT E186728 T1 ATE186728 T1 AT E186728T1
- Authority
- AT
- Austria
- Prior art keywords
- imidazochinoxalinones
- azanalogues
- production
- venodilatory
- inodilatory
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/359,182 US5055465A (en) | 1989-05-31 | 1989-05-31 | Imidazoquinoxalinones, their aza analogs and process for their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE186728T1 true ATE186728T1 (de) | 1999-12-15 |
Family
ID=23412679
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90110191T ATE186728T1 (de) | 1989-05-31 | 1990-05-29 | Imidazochinoxalinone, ihre azaanaloge und verfahren zu ihrer herstellung |
Country Status (7)
Country | Link |
---|---|
US (1) | US5055465A (de) |
EP (1) | EP0400583B1 (de) |
AT (1) | ATE186728T1 (de) |
DE (1) | DE69033355T2 (de) |
DK (1) | DK0400583T3 (de) |
ES (1) | ES2138956T3 (de) |
GR (1) | GR3032611T3 (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5854419A (en) * | 1989-11-17 | 1998-12-29 | Schering Aktiengesellschaft | Tricyclic pteridinones and a process for their preparation |
US5602252A (en) * | 1989-11-17 | 1997-02-11 | Berlex Laboratories, Inc. | Tricyclic pteridinones and a process for their preparation |
US5182386A (en) * | 1991-08-27 | 1993-01-26 | Neurogen Corporation | Certain imidazoquinoxalinones; a new class of gaba brain receptor ligands |
DE69334237D1 (de) * | 1992-06-22 | 2008-09-25 | State Of Oregon Through Oregon | Glycinrezeptorantagonisten und ihre verwendung |
DE4228095A1 (de) * | 1992-08-24 | 1994-03-03 | Asta Medica Ag | Neue 4,5-Dihydro-4-oxo-pyrrolo[1,2-a]chinoxaline und entsprechende Aza-analoga und Verfahren zu deren Herstellung |
US5306819A (en) * | 1992-08-27 | 1994-04-26 | Neurogen Corporation | Certain aryl a cycloalkyl fused imidazopyrazinols; and new class of GABA brain receptor ligands |
DE4310523A1 (de) * | 1993-03-31 | 1994-10-06 | Basf Ag | Imidazolo-chinoxalinone zur Behandlung zentralnervöser Erkrankungen |
US5631373A (en) * | 1993-11-05 | 1997-05-20 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon | Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones |
JPH09510695A (ja) * | 1994-01-03 | 1997-10-28 | エイシア・ファーマシュウティカルズ,インコーポレイテッド | 8−アザ、6−アザ、および6,8−ジアザ−1,4−ジヒドロキノキサリン−2,3−ジオン類およびそのグリシン/nmdaリセプターに対するアンタゴニストとしての使用 |
ATE214069T1 (de) * | 1994-02-11 | 2002-03-15 | Novo Nordisk As | Heterocyclische verbindungen und ihre herstellung und verwendung |
BR9509055A (pt) * | 1994-09-30 | 1998-06-23 | Basf Ag | Imidazoloquinoxalinona uso da mesma e composiçao farmacêutica |
US5801183A (en) * | 1995-01-27 | 1998-09-01 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Aza and aza (N-oxy) analogs of glycine/NMDA receptor antagonists |
DE19510965A1 (de) * | 1995-03-24 | 1996-09-26 | Asta Medica Ag | Neue Pyrido/3,2-e/pyrazinone mit antiasthmatischer Wirksamkeit und Verfahren zu deren Herstellung |
DE19611476A1 (de) * | 1996-03-22 | 1997-09-25 | Basf Ag | Neue heterocyclische substituierte Imidazolo-chinoxalinone, ihre Herstellung und Verwendung |
DE19961302A1 (de) * | 1999-12-18 | 2001-06-21 | Dresden Arzneimittel | Verwendung von Imidazo(1,5-a)-pyrido(3,2-e)-pyrazinonen als duale Inhibitoren der Phosphodiesterase 5 und der Phosphodiesterase 3 zur Therapie der Herzinsuffizienz, von pulmonaler Hypertonie und Gefäßerkrankungen, die mit einer Minderdurchblutung einhergehen |
EE200100377A (et) * | 1999-01-20 | 2002-10-15 | Arzneimittelwerk Dresden Gmbh | Imidaso[1,5-a]-pürido[3,2-e]-pürasinoonide kasutamine arstimitena |
WO2000056719A1 (en) * | 1999-03-22 | 2000-09-28 | Bristol-Myers Squibb Company | FUSED PYRIDOPYRIDAZINE INHIBITORS OF cGMP PHOSPHODIESTERASE |
US6465465B1 (en) * | 2000-03-14 | 2002-10-15 | Arzneimittelwerk Dresden Gmbh | Process for the treatment of erectile dysfunction and product therefor |
DE10012373A1 (de) * | 2000-03-14 | 2001-09-20 | Dresden Arzneimittel | Verwendung von Pyrido[3,2-e]-pyrazinonen als Inhibitoren der Phosphodiesterase 5 zur Therapie von erektiler Dysfunktion |
EP1312363A1 (de) * | 2001-09-28 | 2003-05-21 | Pfizer Products Inc. | Behandlungsverfahren und kits bestehend aus Wachstumshormonsekretionsförderern |
US7342884B2 (en) * | 2002-03-13 | 2008-03-11 | Harmonic, Inc. | Method and apparatus for one directional communications in bidirectional communications channel |
GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
TW200817400A (en) * | 2006-05-30 | 2008-04-16 | Elbion Ag | Pyrido [3,2-e] pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them |
KR101563103B1 (ko) * | 2006-12-13 | 2015-10-23 | 아스카 세이야쿠 가부시키가이샤 | 퀴녹살린 유도체 |
US20090143361A1 (en) * | 2007-11-30 | 2009-06-04 | Elbion Gmbh | Pyrido[3,2-E]Pyrazines, Process For Preparing The Same, And Their Use As Inhibitors Of Phosphodiesterase 10 |
CN101918408A (zh) * | 2007-11-30 | 2010-12-15 | 惠氏有限责任公司 | 作为磷酸二酯酶10的抑制剂的芳基和杂芳基稠合的咪唑并[1,5-a]吡嗪 |
AU2008329072A1 (en) * | 2007-11-30 | 2009-06-04 | Elbion Gmbh | Aryl and heteroaryl fused imidazo (1,5-A) pyrazines as inhibitors of phosphodiesterase 10 |
WO2010085570A1 (en) | 2009-01-23 | 2010-07-29 | Takeda Pharmaceutical Company Limited | Poly (ADP-Ribose) Polymerase (PARP) Inhibitors |
WO2011014681A1 (en) | 2009-07-30 | 2011-02-03 | Takeda Pharmaceutical Company Limited | Poly (ADP-Ribose) Polymerase (PARP) INHIBITORS |
US20110190192A1 (en) * | 2009-12-15 | 2011-08-04 | Cebix Inc. | Methods for treating erectile dysfunction in patients with insulin-dependent diabetes |
ES2747423T3 (es) | 2010-09-07 | 2020-03-10 | Astellas Pharma Inc | Compuesto de quinoxalina |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4138564A (en) * | 1977-08-03 | 1979-02-06 | American Home Products Corporation | Tetrahydro[1H]pyrazino[1,2-a]azaquinoxalin-5(6H)-ones and derivatives thereof |
SE441449B (sv) * | 1979-02-09 | 1985-10-07 | Roussel Uclaf | Heterocykliska derivat och farmaceutiska kompositioner innehallande dessa derivat |
US4333394A (en) * | 1979-12-31 | 1982-06-08 | Brown Stanford M | Method for handling and baling metallic scrap material |
US4440929A (en) * | 1981-07-16 | 1984-04-03 | Usv Pharmaceutical Corporation | Imidazoquinoxaline compounds |
US4761414A (en) * | 1986-08-19 | 1988-08-02 | G. D. Searle & Co. | Substituted 1H-pyrimido[1,2-a-]-pyrido[3,4-e]pyrazine 6 oxides |
-
1989
- 1989-05-31 US US07/359,182 patent/US5055465A/en not_active Expired - Fee Related
-
1990
- 1990-05-29 DK DK90110191T patent/DK0400583T3/da active
- 1990-05-29 EP EP90110191A patent/EP0400583B1/de not_active Expired - Lifetime
- 1990-05-29 DE DE69033355T patent/DE69033355T2/de not_active Expired - Fee Related
- 1990-05-29 AT AT90110191T patent/ATE186728T1/de not_active IP Right Cessation
- 1990-05-29 ES ES90110191T patent/ES2138956T3/es not_active Expired - Lifetime
-
2000
- 2000-02-09 GR GR20000400310T patent/GR3032611T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2138956T3 (es) | 2000-02-01 |
US5055465A (en) | 1991-10-08 |
DE69033355D1 (de) | 1999-12-23 |
DK0400583T3 (da) | 2000-03-13 |
GR3032611T3 (en) | 2000-05-31 |
EP0400583B1 (de) | 1999-11-17 |
EP0400583A1 (de) | 1990-12-05 |
DE69033355T2 (de) | 2000-05-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |