ATE186728T1 - Imidazochinoxalinone, ihre azaanaloge und verfahren zu ihrer herstellung - Google Patents

Imidazochinoxalinone, ihre azaanaloge und verfahren zu ihrer herstellung

Info

Publication number
ATE186728T1
ATE186728T1 AT90110191T AT90110191T ATE186728T1 AT E186728 T1 ATE186728 T1 AT E186728T1 AT 90110191 T AT90110191 T AT 90110191T AT 90110191 T AT90110191 T AT 90110191T AT E186728 T1 ATE186728 T1 AT E186728T1
Authority
AT
Austria
Prior art keywords
imidazochinoxalinones
azanalogues
production
venodilatory
inodilatory
Prior art date
Application number
AT90110191T
Other languages
English (en)
Inventor
David Daniel Davey
Original Assignee
Berlex Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berlex Lab filed Critical Berlex Lab
Application granted granted Critical
Publication of ATE186728T1 publication Critical patent/ATE186728T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT90110191T 1989-05-31 1990-05-29 Imidazochinoxalinone, ihre azaanaloge und verfahren zu ihrer herstellung ATE186728T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/359,182 US5055465A (en) 1989-05-31 1989-05-31 Imidazoquinoxalinones, their aza analogs and process for their preparation

Publications (1)

Publication Number Publication Date
ATE186728T1 true ATE186728T1 (de) 1999-12-15

Family

ID=23412679

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90110191T ATE186728T1 (de) 1989-05-31 1990-05-29 Imidazochinoxalinone, ihre azaanaloge und verfahren zu ihrer herstellung

Country Status (7)

Country Link
US (1) US5055465A (de)
EP (1) EP0400583B1 (de)
AT (1) ATE186728T1 (de)
DE (1) DE69033355T2 (de)
DK (1) DK0400583T3 (de)
ES (1) ES2138956T3 (de)
GR (1) GR3032611T3 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5854419A (en) * 1989-11-17 1998-12-29 Schering Aktiengesellschaft Tricyclic pteridinones and a process for their preparation
US5602252A (en) * 1989-11-17 1997-02-11 Berlex Laboratories, Inc. Tricyclic pteridinones and a process for their preparation
US5182386A (en) * 1991-08-27 1993-01-26 Neurogen Corporation Certain imidazoquinoxalinones; a new class of gaba brain receptor ligands
ES2313714T3 (es) * 1992-06-22 2009-03-01 The Regents Of The University Of California Antagonistas de receptores de glicina y uso de los mismos.
DE4228095A1 (de) * 1992-08-24 1994-03-03 Asta Medica Ag Neue 4,5-Dihydro-4-oxo-pyrrolo[1,2-a]chinoxaline und entsprechende Aza-analoga und Verfahren zu deren Herstellung
US5306819A (en) * 1992-08-27 1994-04-26 Neurogen Corporation Certain aryl a cycloalkyl fused imidazopyrazinols; and new class of GABA brain receptor ligands
DE4310523A1 (de) * 1993-03-31 1994-10-06 Basf Ag Imidazolo-chinoxalinone zur Behandlung zentralnervöser Erkrankungen
US5631373A (en) * 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
EP0743855A1 (de) * 1994-01-03 1996-11-27 Acea Pharmaceuticals, Inc. 8-Aza,6-Aza und 6,8-Diaza - 1,4 dihydrochinoxalin -2,3-dione und deren Verwendung als Glycin/NMDARezeptor Antagonisten
HUT76323A (en) * 1994-02-11 1997-08-28 Novo Nordisk As Imidazo[1,2-a]quinoxalinone derivatives, process for their preparation and pharmaceutical compositions containing them
SI9520108A (en) * 1994-09-30 1997-10-31 Basf Ag New heterocyclic substituted imidazoloquinoxalinones, their preparation and their use
US5801183A (en) * 1995-01-27 1998-09-01 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Aza and aza (N-oxy) analogs of glycine/NMDA receptor antagonists
DE19510965A1 (de) * 1995-03-24 1996-09-26 Asta Medica Ag Neue Pyrido/3,2-e/pyrazinone mit antiasthmatischer Wirksamkeit und Verfahren zu deren Herstellung
DE19611476A1 (de) * 1996-03-22 1997-09-25 Basf Ag Neue heterocyclische substituierte Imidazolo-chinoxalinone, ihre Herstellung und Verwendung
DE19961302A1 (de) * 1999-12-18 2001-06-21 Dresden Arzneimittel Verwendung von Imidazo(1,5-a)-pyrido(3,2-e)-pyrazinonen als duale Inhibitoren der Phosphodiesterase 5 und der Phosphodiesterase 3 zur Therapie der Herzinsuffizienz, von pulmonaler Hypertonie und Gefäßerkrankungen, die mit einer Minderdurchblutung einhergehen
BR0007613A (pt) * 1999-01-20 2001-10-30 Dresden Arzneimittel Aplicação de imidazo[1,5-a]-pirido[3,2-e]-pirazinonascomo medicamento
EP1165521A4 (de) * 1999-03-22 2002-05-22 Bristol Myers Squibb Co Kondensierte pyridopyridazine als inhibitoren der cgmp-phosphodiesterase
US6465465B1 (en) * 2000-03-14 2002-10-15 Arzneimittelwerk Dresden Gmbh Process for the treatment of erectile dysfunction and product therefor
DE10012373A1 (de) * 2000-03-14 2001-09-20 Dresden Arzneimittel Verwendung von Pyrido[3,2-e]-pyrazinonen als Inhibitoren der Phosphodiesterase 5 zur Therapie von erektiler Dysfunktion
EP1312363A1 (de) * 2001-09-28 2003-05-21 Pfizer Products Inc. Behandlungsverfahren und kits bestehend aus Wachstumshormonsekretionsförderern
US7342884B2 (en) * 2002-03-13 2008-03-11 Harmonic, Inc. Method and apparatus for one directional communications in bidirectional communications channel
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
TW200817400A (en) * 2006-05-30 2008-04-16 Elbion Ag Pyrido [3,2-e] pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them
CA2671980C (en) * 2006-12-13 2015-05-05 Aska Pharmaceutical Co., Ltd. Quinoxaline derivatives
AU2008329072A1 (en) * 2007-11-30 2009-06-04 Elbion Gmbh Aryl and heteroaryl fused imidazo (1,5-A) pyrazines as inhibitors of phosphodiesterase 10
US20090143361A1 (en) * 2007-11-30 2009-06-04 Elbion Gmbh Pyrido[3,2-E]Pyrazines, Process For Preparing The Same, And Their Use As Inhibitors Of Phosphodiesterase 10
US7875618B2 (en) * 2007-11-30 2011-01-25 Wyeth Substituted imidazo[1,5-a]quinoxalines useful as inhibitors of phosphodiesterase 10 for the treatment of neurological and other disorders
MX2011007741A (es) * 2009-01-23 2011-09-06 Takeda Pharmaceutical Inhibidores de poli(adenosina difosfato plaquetaria (adp)-ribosa) polimerasa poli adenosina difosfato plaquetaria ribosa (parp).
EP2459561A1 (de) 2009-07-30 2012-06-06 Takeda Pharmaceutical Company Limited Poly(adp-ribose)-polymerase (parp)-hemmer
WO2011081915A2 (en) * 2009-12-15 2011-07-07 Cebix Inc. Methods for treating erectile dysfunction in patients with insulin-dependent diabetes
JP5822080B2 (ja) 2010-09-07 2015-11-24 アステラス製薬株式会社 キノキサリン化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4138564A (en) * 1977-08-03 1979-02-06 American Home Products Corporation Tetrahydro[1H]pyrazino[1,2-a]azaquinoxalin-5(6H)-ones and derivatives thereof
SE441449B (sv) * 1979-02-09 1985-10-07 Roussel Uclaf Heterocykliska derivat och farmaceutiska kompositioner innehallande dessa derivat
US4333394A (en) * 1979-12-31 1982-06-08 Brown Stanford M Method for handling and baling metallic scrap material
US4440929A (en) * 1981-07-16 1984-04-03 Usv Pharmaceutical Corporation Imidazoquinoxaline compounds
US4761414A (en) * 1986-08-19 1988-08-02 G. D. Searle & Co. Substituted 1H-pyrimido[1,2-a-]-pyrido[3,4-e]pyrazine 6 oxides

Also Published As

Publication number Publication date
DE69033355D1 (de) 1999-12-23
EP0400583B1 (de) 1999-11-17
ES2138956T3 (es) 2000-02-01
DK0400583T3 (da) 2000-03-13
EP0400583A1 (de) 1990-12-05
GR3032611T3 (en) 2000-05-31
DE69033355T2 (de) 2000-05-11
US5055465A (en) 1991-10-08

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee