BR0007613A - Aplicação de imidazo[1,5-a]-pirido[3,2-e]-pirazinonascomo medicamento - Google Patents

Aplicação de imidazo[1,5-a]-pirido[3,2-e]-pirazinonascomo medicamento

Info

Publication number
BR0007613A
BR0007613A BR0007613-9A BR0007613A BR0007613A BR 0007613 A BR0007613 A BR 0007613A BR 0007613 A BR0007613 A BR 0007613A BR 0007613 A BR0007613 A BR 0007613A
Authority
BR
Brazil
Prior art keywords
pyrazinones
pyrido
imidazo
medicine
application
Prior art date
Application number
BR0007613-9A
Other languages
English (en)
Inventor
Norbert Hoefgen
Stefan Szelenyi
Marx Degenhard
Ute Egerland
Original Assignee
Dresden Arzneimittel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999102082 external-priority patent/DE19902082A1/de
Priority claimed from DE1999161302 external-priority patent/DE19961302A1/de
Application filed by Dresden Arzneimittel filed Critical Dresden Arzneimittel
Publication of BR0007613A publication Critical patent/BR0007613A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Patente de Invenção: "APLICAçãO DEIMIDAZO[1,5-A]-PIRIDO[3,2-E]-PIRAZINONAS COMOMEDICAMENTO". A invenção refere-se ao emprego deimidazo[1,5-al-pirido[3,2-e]-pirazinonas da fórmula (1) comoinibidores da fosfodiesterase 5 para a terapia da disfunção erétil(impotência), ao emprego de imidazo[1,5-a]-pirido[3,2-e]-pirazinonasda fórmula (1) como inibidores duais da fosfodiesterase 3 e dafosfodiesterase 5 para a terapia da insuficiência cardíaca, dahipertonia pulmonar e doenças vasculares, que ocorrem junto comuma pequena hemorragia e processos para a sua preparação.
BR0007613-9A 1999-01-20 2000-01-14 Aplicação de imidazo[1,5-a]-pirido[3,2-e]-pirazinonascomo medicamento BR0007613A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1999102082 DE19902082A1 (de) 1999-01-20 1999-01-20 Verwendung von Imidazo[1,5-a]-pyrido[3,2-e]-pyrazinonen als Inhibitoren der Phosphodiesterase 5 zur Therapie von erectiler Dysfunktion und Verfahren zu deren Herstellung
DE1999161302 DE19961302A1 (de) 1999-12-18 1999-12-18 Verwendung von Imidazo(1,5-a)-pyrido(3,2-e)-pyrazinonen als duale Inhibitoren der Phosphodiesterase 5 und der Phosphodiesterase 3 zur Therapie der Herzinsuffizienz, von pulmonaler Hypertonie und Gefäßerkrankungen, die mit einer Minderdurchblutung einhergehen
PCT/EP2000/000260 WO2000043392A2 (de) 1999-01-20 2000-01-14 Verwendung von imidazo[1,5-a]-pyrido[3,2-e]-pyrazinonen als arzneimittel

Publications (1)

Publication Number Publication Date
BR0007613A true BR0007613A (pt) 2001-10-30

Family

ID=26051406

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0007613-9A BR0007613A (pt) 1999-01-20 2000-01-14 Aplicação de imidazo[1,5-a]-pirido[3,2-e]-pirazinonascomo medicamento

Country Status (23)

Country Link
EP (1) EP1144410A2 (pt)
JP (1) JP2002535330A (pt)
KR (1) KR20010101603A (pt)
CN (1) CN1344268A (pt)
AR (1) AR022318A1 (pt)
AU (1) AU2291200A (pt)
BG (1) BG105714A (pt)
BR (1) BR0007613A (pt)
CA (1) CA2296224A1 (pt)
CO (1) CO5190700A1 (pt)
CZ (1) CZ20012627A3 (pt)
EA (1) EA200100792A1 (pt)
EE (1) EE200100377A (pt)
HU (1) HUP0105132A3 (pt)
ID (1) ID29790A (pt)
IL (1) IL144156A0 (pt)
IS (1) IS5987A (pt)
LT (1) LT2001078A (pt)
LV (1) LV12793B (pt)
NO (1) NO20013334D0 (pt)
SK (1) SK10322001A3 (pt)
TR (1) TR200102121T2 (pt)
WO (1) WO2000043392A2 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403597B1 (en) 1997-10-28 2002-06-11 Vivus, Inc. Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation
US6548490B1 (en) * 1997-10-28 2003-04-15 Vivus, Inc. Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
JP2005513060A (ja) * 2001-12-17 2005-05-12 アルタナ　ファルマ　アクチエンゲゼルシャフト 選択的ｐｄｅ５阻害剤の新規使用
US6916345B2 (en) 2002-02-12 2005-07-12 L'oreal S.A. 6-alkoxy-2,3-diaminopyridine couplers for dyeing keratin fibres
FR2835741B1 (fr) * 2002-02-12 2006-05-05 Oreal Nouveaux coupleurs 6-alcoxy-2,3-diaminopyridine utiles pour la teinture des fibres keratiniques
DE10325813B4 (de) 2003-06-06 2007-12-20 Universitätsklinikum Freiburg Prophylaxe und/oder Therapie bei der portalen Hypertonie
EP1786428B1 (en) * 2004-08-17 2012-05-16 The Johns Hopkins University Pde5 inhibitor compositions and methods for treating cardiac indications
ES2536906T3 (es) 2006-12-13 2015-05-29 Aska Pharmaceutical Co., Ltd. Derivado de quinoxalina
WO2009070583A1 (en) * 2007-11-30 2009-06-04 Wyeth Pyrido[3,2-e]pyrazines, process for preparing the same, and their use as inhibitors of phosphodiesterase 10
KR20100110804A (ko) 2007-11-30 2010-10-13 와이어쓰 엘엘씨 포스포디에스테라제 10의 저해물질로서의 아릴 및 헤테로아릴 융합된 이미다조[1,5-ａ]피라진
US9643970B2 (en) 2011-10-10 2017-05-09 H. Lundbeck A/S Substituted imidazo [1,5-a]pyrazines as PDE9 inhibitors
AP2014007820A0 (en) 2012-01-26 2014-07-31 Lundbeck & Co As H PDE9 inhibitors with imidazo triazinone backbone
JP5842640B2 (ja) * 2012-01-31 2016-01-13 株式会社東洋新薬 ホスホジエステラーゼ３阻害剤
WO2016022825A1 (en) * 2014-08-07 2016-02-11 Intra-Cellular Therapies, Inc. Organic compounds
WO2016022836A1 (en) * 2014-08-07 2016-02-11 Intra-Cellular Therapies, Inc. Organic compounds
PT3865484T (pt) 2015-07-07 2024-01-30 H Lundbeck As Inibidor da pde9 com esqueleto de imidazo pirazinona para tratamento de doenças periféricas

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055465A (en) * 1989-05-31 1991-10-08 Berlex Laboratories, Inc. Imidazoquinoxalinones, their aza analogs and process for their preparation
DE19510965A1 (de) * 1995-03-24 1996-09-26 Asta Medica Ag Neue Pyrido/3,2-e/pyrazinone mit antiasthmatischer Wirksamkeit und Verfahren zu deren Herstellung

Also Published As

Publication number Publication date
EP1144410A2 (de) 2001-10-17
AR022318A1 (es) 2002-09-04
IS5987A (is) 2001-06-29
KR20010101603A (ko) 2001-11-14
IL144156A0 (en) 2002-05-23
CO5190700A1 (es) 2002-08-29
EA200100792A1 (ru) 2002-10-31
HUP0105132A3 (en) 2002-12-28
LV12793A (lv) 2002-02-20
NO20013334L (no) 2001-07-05
AU2291200A (en) 2000-08-07
HUP0105132A2 (hu) 2002-05-29
ID29790A (id) 2001-10-11
EE200100377A (et) 2002-10-15
NO20013334D0 (no) 2001-07-05
LV12793B (lv) 2002-05-20
BG105714A (en) 2002-02-28
WO2000043392A2 (de) 2000-07-27
CZ20012627A3 (cs) 2002-01-16
CN1344268A (zh) 2002-04-10
SK10322001A3 (sk) 2002-07-02
WO2000043392A3 (de) 2000-09-28
LT2001078A (en) 2002-08-26
TR200102121T2 (tr) 2002-01-21
JP2002535330A (ja) 2002-10-22
CA2296224A1 (en) 2000-07-20

Similar Documents

Publication Publication Date Title
BR0007613A (pt) Aplicação de imidazo[1,5-a]-pirido[3,2-e]-pirazinonascomo medicamento
MXPA04003668A (es) Inhibidores de fosfodiesteresa de tipo 4 y usos de los mismos.
ATE297208T1 (de) Tablette mit verlängerter wirkstoffabgabe zur behandlung der parkinsonkrankheit
BR9714363A (pt) Derivados de pirazol substituìdos para o tratamento de doenças circulatórias cardìacas
WO2003096990A3 (en) Protein cages for the delivery of medical imaging and therapy
MX2007004882A (es) Derivados de xantina con actividad de receptor de hm74a.
HK1104530A1 (en) Medicaments with hm74a receptor activity
HUP0401104A3 (en) Beta-aminoacyl tetrahydroimidazo[1,2-a]pyrazines and tetrahydrotriazolo[4,3-a]pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes and pharmaceutical compositions containing them
WO2001030381A3 (de) Verwendung von csf-1-inhibitoren
BR0211450A (pt) Método terapêutico
EP0249735A3 (en) Pharmaceutical preparations comprising as active agent 2-phenyl-1.2-benzisoselenazol-3(2h)-one, for the treatment of diseases caused by oxidative stress
BR0109163A (pt) Uso de pirido[3,2-e]-pirazinonas como inibidores da fosfodieterase 5, para terapia de disfunção erétil
WO2005016867A3 (en) Anthranilic acid derivatives and their use as activators of the hm74a receptor
MXPA05012302A (es) Composicion que comprende un inhibidor de pde4 y un inhibidor de pde5.
MY138883A (en) Use of asiatic acid for treatment of cencer
FR2795646B1 (fr) Article manufacture pour un usage pharmaceutique humain
WO2000072823A8 (en) Preparations for the application of anti-inflammatory agents
ES2191449T3 (es) Derivados de ciclopentabenzofurano y su uso.
AR029189A1 (es) Uso de un inhibidor de fosfodiesterasa 4 y un corticoesteroide antiinflamatorio en forma combinada, separadamente o separadamente secuencial para la preparacion de un medicamento
WO2003007876A3 (en) N-fatty acid-amino acid conjugates and therapeutic uses
HUP0301915A2 (hu) Sildenafil és egyéb PDE5 inhibitor hatású vegyületek alkalmazása korai magömlés kezelésére szolgáló gyógyszerkészítmény elżállítására
WO2001070951A3 (de) Mittel zur diagnose und therapie viraler erkrankungen
HN2001000204A (es) Amidas de acido fenilciclohexanocarboxilico sustituido y su uso
RS20050603A (en) New combinations and new application of pharmaceutically active compounds
WO2002003971A3 (en) Pharmaceutical composition and method for the treatment of retroviral infections

Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]