TR200102121T2 - İmidazo [1,5-a]pirido [3,2-e]pirazinonların hazır ilaçlar olarak kulanımı - Google Patents

İmidazo [1,5-a]pirido [3,2-e]pirazinonların hazır ilaçlar olarak kulanımı

Info

Publication number
TR200102121T2
TR200102121T2 TR2001/02121T TR200102121T TR200102121T2 TR 200102121 T2 TR200102121 T2 TR 200102121T2 TR 2001/02121 T TR2001/02121 T TR 2001/02121T TR 200102121 T TR200102121 T TR 200102121T TR 200102121 T2 TR200102121 T2 TR 200102121T2
Authority
TR
Turkey
Prior art keywords
pyrazinones
pyrido
imidazo
preparations
phosphodiesterase
Prior art date
Application number
TR2001/02121T
Other languages
English (en)
Turkish (tr)
Inventor
Hofgen Norbert
Szelenyi Stefan
Degenhard Marx
Egerland Ute
Original Assignee
Arzneimittelwerk Dresden Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999102082 external-priority patent/DE19902082A1/de
Priority claimed from DE1999161302 external-priority patent/DE19961302A1/de
Application filed by Arzneimittelwerk Dresden Gmbh filed Critical Arzneimittelwerk Dresden Gmbh
Publication of TR200102121T2 publication Critical patent/TR200102121T2/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TR2001/02121T 1999-01-20 2000-01-14 İmidazo [1,5-a]pirido [3,2-e]pirazinonların hazır ilaçlar olarak kulanımı TR200102121T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1999102082 DE19902082A1 (de) 1999-01-20 1999-01-20 Verwendung von Imidazo[1,5-a]-pyrido[3,2-e]-pyrazinonen als Inhibitoren der Phosphodiesterase 5 zur Therapie von erectiler Dysfunktion und Verfahren zu deren Herstellung
DE1999161302 DE19961302A1 (de) 1999-12-18 1999-12-18 Verwendung von Imidazo(1,5-a)-pyrido(3,2-e)-pyrazinonen als duale Inhibitoren der Phosphodiesterase 5 und der Phosphodiesterase 3 zur Therapie der Herzinsuffizienz, von pulmonaler Hypertonie und Gefäßerkrankungen, die mit einer Minderdurchblutung einhergehen

Publications (1)

Publication Number Publication Date
TR200102121T2 true TR200102121T2 (tr) 2002-01-21

Family

ID=26051406

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/02121T TR200102121T2 (tr) 1999-01-20 2000-01-14 İmidazo [1,5-a]pirido [3,2-e]pirazinonların hazır ilaçlar olarak kulanımı

Country Status (23)

Country Link
EP (1) EP1144410A2 (xx)
JP (1) JP2002535330A (xx)
KR (1) KR20010101603A (xx)
CN (1) CN1344268A (xx)
AR (1) AR022318A1 (xx)
AU (1) AU2291200A (xx)
BG (1) BG105714A (xx)
BR (1) BR0007613A (xx)
CA (1) CA2296224A1 (xx)
CO (1) CO5190700A1 (xx)
CZ (1) CZ20012627A3 (xx)
EA (1) EA200100792A1 (xx)
EE (1) EE200100377A (xx)
HU (1) HUP0105132A3 (xx)
ID (1) ID29790A (xx)
IL (1) IL144156A0 (xx)
IS (1) IS5987A (xx)
LT (1) LT2001078A (xx)
LV (1) LV12793B (xx)
NO (1) NO20013334L (xx)
SK (1) SK10322001A3 (xx)
TR (1) TR200102121T2 (xx)
WO (1) WO2000043392A2 (xx)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6548490B1 (en) 1997-10-28 2003-04-15 Vivus, Inc. Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
US6403597B1 (en) 1997-10-28 2002-06-11 Vivus, Inc. Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation
JP2005513060A (ja) * 2001-12-17 2005-05-12 アルタナ ファルマ アクチエンゲゼルシャフト 選択的pde5阻害剤の新規使用
US6916345B2 (en) 2002-02-12 2005-07-12 L'oreal S.A. 6-alkoxy-2,3-diaminopyridine couplers for dyeing keratin fibres
FR2835741B1 (fr) * 2002-02-12 2006-05-05 Oreal Nouveaux coupleurs 6-alcoxy-2,3-diaminopyridine utiles pour la teinture des fibres keratiniques
DE10325813B4 (de) 2003-06-06 2007-12-20 Universitätsklinikum Freiburg Prophylaxe und/oder Therapie bei der portalen Hypertonie
CN101106997A (zh) * 2004-08-17 2008-01-16 约翰·霍普金斯大学 Pde5抑制剂组合物及治疗心脏病征候的方法
EP2103613B1 (en) * 2006-12-13 2016-02-17 ASKA Pharmaceutical Co., Ltd. Quinoxaline derivative
JP2011505366A (ja) 2007-11-30 2011-02-24 ワイス・エルエルシー ホスホエステラーゼ10の阻害剤としてのアリールおよびヘテロアリール縮合イミダゾ[1,5−a]ピラジン
US20090143361A1 (en) * 2007-11-30 2009-06-04 Elbion Gmbh Pyrido[3,2-E]Pyrazines, Process For Preparing The Same, And Their Use As Inhibitors Of Phosphodiesterase 10
CN106905324B (zh) 2011-10-10 2018-09-25 H.隆德贝克有限公司 具有咪唑并吡嗪酮骨架的pde9抑制剂
EP2807163B1 (en) 2012-01-26 2017-03-22 H. Lundbeck A/S Pde9 inhibitors with imidazo triazinone backbone
JP5842640B2 (ja) * 2012-01-31 2016-01-13 株式会社東洋新薬 ホスホジエステラーゼ3阻害剤
WO2016022836A1 (en) * 2014-08-07 2016-02-11 Intra-Cellular Therapies, Inc. Organic compounds
WO2016022825A1 (en) * 2014-08-07 2016-02-11 Intra-Cellular Therapies, Inc. Organic compounds
DK3303339T3 (da) 2015-07-07 2021-04-12 H Lundbeck As Pde9-inhibitorer med imidazotriazinonskelet og imidazopyrazinonskelet til behandling af perifere sygdomme
JP2021526134A (ja) 2018-05-25 2021-09-30 イマラ インク. 6−[(3S,4S)−4−メチル−l−(ピリミジン−2−イルメチル)ピロリジン−3−イル]−3−テトラヒドロピラン−4−イル−7H−イミダゾ[l,5−A]ピラジン−8−オンの一水和物および結晶形態

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055465A (en) * 1989-05-31 1991-10-08 Berlex Laboratories, Inc. Imidazoquinoxalinones, their aza analogs and process for their preparation
DE19510965A1 (de) * 1995-03-24 1996-09-26 Asta Medica Ag Neue Pyrido/3,2-e/pyrazinone mit antiasthmatischer Wirksamkeit und Verfahren zu deren Herstellung

Also Published As

Publication number Publication date
ID29790A (id) 2001-10-11
EP1144410A2 (de) 2001-10-17
KR20010101603A (ko) 2001-11-14
LV12793B (lv) 2002-05-20
CO5190700A1 (es) 2002-08-29
CZ20012627A3 (cs) 2002-01-16
EA200100792A1 (ru) 2002-10-31
LT2001078A (en) 2002-08-26
BR0007613A (pt) 2001-10-30
IL144156A0 (en) 2002-05-23
SK10322001A3 (sk) 2002-07-02
LV12793A (lv) 2002-02-20
JP2002535330A (ja) 2002-10-22
NO20013334D0 (no) 2001-07-05
CA2296224A1 (en) 2000-07-20
CN1344268A (zh) 2002-04-10
AU2291200A (en) 2000-08-07
AR022318A1 (es) 2002-09-04
HUP0105132A2 (hu) 2002-05-29
NO20013334L (no) 2001-07-05
EE200100377A (et) 2002-10-15
BG105714A (en) 2002-02-28
WO2000043392A3 (de) 2000-09-28
HUP0105132A3 (en) 2002-12-28
WO2000043392A2 (de) 2000-07-27
IS5987A (is) 2001-06-29

Similar Documents

Publication Publication Date Title
TR200102121T2 (tr) İmidazo [1,5-a]pirido [3,2-e]pirazinonların hazır ilaçlar olarak kulanımı
ATE327756T1 (de) Verwendung von cgmp-phosphodiesterase hemmer zur behandlung von impotenz
BR0014698A (pt) Derivados de pirazolo [4,3-d] pirimidina
ATE297208T1 (de) Tablette mit verlängerter wirkstoffabgabe zur behandlung der parkinsonkrankheit
PL373414A1 (en) 8-methoxy-(1,2,4)triazolo(1,5-a)pyridine derivatives and their use as adenosine receptor ligands
HUP0004350A2 (hu) Vegyületek női szexuális diszfunkció kezelésére
EP0995751A3 (en) Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction
CA2287552A1 (en) Pyrazolopyrimidinone cgmp pde5 inhibitors for the treatment of sexual dysfunction
WO2002064590A3 (en) Carboline derivatives
NO20024364D0 (no) Anvendelse av pyrido [3,2-E]-pyrazinoner som inhibitorer av fosfodiesterase 5 for behandling av erektil dysfunksjon
ATE250602T1 (de) Pyrimido(6,1-a)isochinolinonderivate
WO2002064591A3 (en) Carboline derivatives
WO2003101919A3 (en) Scorpionate-like pendant macrocyclic ligands, complexes and compositions thereof, and methods of using same
DK1315731T3 (da) 2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-on og 7-pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)on-derivater
LV12560A (en) Articles of manufacture
NO20013645D0 (no) Anvendelse av pyridazino[4,5-b]indol-1-acetamid-derivater for fremstilling av medisiner for behandling av sykdommer relatert tildysfunksjonen av perifere benzodiazepinreseptorer
ZA200007019B (en) Use of prostaglandin agonists to treat erectile dysfunction or impotence.
WO2001080860A3 (en) Daily treatment for erectile dysfunction using a pde5 inhibitor
TR200103237T2 (tr) İmidazodiazepin türevi
MY131573A (en) Use of pde5 inhibitors for the treatment of premature ejaculation
WO2003053973A8 (de) Pyrazolyl-substituierte triazolochinoxaline
RS20050603A (xx) NOVE KOMBINACIJE I NOVA PRIMENA FARMACEUTSKIH AKTIVNIH JEDINjENjA
BR0011912A (pt) Hexaidropirrolo[1,2-c]pirimidinas como agentes anti-viróticos, anti-fúngicos e/ou anti-tumorais