WO2001070951A3 - Mittel zur diagnose und therapie viraler erkrankungen - Google Patents
Mittel zur diagnose und therapie viraler erkrankungen Download PDFInfo
- Publication number
- WO2001070951A3 WO2001070951A3 PCT/DE2001/001068 DE0101068W WO0170951A3 WO 2001070951 A3 WO2001070951 A3 WO 2001070951A3 DE 0101068 W DE0101068 W DE 0101068W WO 0170951 A3 WO0170951 A3 WO 0170951A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- diagnosis
- therapy
- agent
- viral diseases
- medicine
- Prior art date
Links
- 238000003745 diagnosis Methods 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 title abstract 2
- 230000003612 virological effect Effects 0.000 title abstract 2
- 230000001413 cellular effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Die Erfindung betrifft ein Mittel zur Diagnose und Therapie viraler Erkrankungen. Die erfinderische Lösung macht sich dabei spezielle Eigenschaften des zellulären Proteins YB-1 zu nutze. Anwendungsgebiete sind die Medizin und die pharmazeutische Industrie.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU56117/01A AU5611701A (en) | 2000-03-23 | 2001-03-21 | Agent for the diagnosis and therapy of viral diseases |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10015413A DE10015413A1 (de) | 2000-03-23 | 2000-03-23 | Mittel zur Diagnose und Therapie viraler Erkrankungen |
DE10015413.1 | 2000-03-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001070951A2 WO2001070951A2 (de) | 2001-09-27 |
WO2001070951A3 true WO2001070951A3 (de) | 2002-05-02 |
Family
ID=7636714
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DE2001/001068 WO2001070951A2 (de) | 2000-03-23 | 2001-03-21 | Mittel zur diagnose und therapie viraler erkrankungen |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU5611701A (de) |
DE (1) | DE10015413A1 (de) |
WO (1) | WO2001070951A2 (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002216500A1 (en) * | 2000-11-28 | 2002-06-11 | Genesis Research And Development Corporation Limited | Methods for modulating apoptotic cell death |
DE10150984A1 (de) * | 2001-10-16 | 2003-04-17 | Holm Per Sonne | Verwendung des adenoviralen E2-late-Promotors |
JP5213298B2 (ja) | 2002-05-27 | 2013-06-19 | ホルム,ペル・ゾンネ | アデノウイルスおよびそれをコードしている核酸の新たな使用 |
PL219321B1 (pl) * | 2002-10-15 | 2015-04-30 | Per Sonne Holm | Adenowirus, kodujący go kwas nukleinowy, zawierający je układ replikacyjny, wektor, komórka i organizm, ich zastosowanie oraz środek farmaceutyczny |
WO2005051430A1 (de) | 2003-11-14 | 2005-06-09 | Per Sonne Holm | Neue verwendung von adenoviren und dafür codierenden nukleinsäuren |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997016547A1 (en) * | 1995-10-31 | 1997-05-09 | The Board Of Regents, The University Of Texas System | ADENOVIRUS-ANTISENSE K-ras EXPRESSION VECTORS AND THEIR APPLICATION IN CANCER THERAPY |
WO2000003027A1 (de) * | 1998-07-10 | 2000-01-20 | Max-Delbrück-Centrum für Molekulare Medizin | Verfahren zur verbesserung des gentransfers von genetischem material in säugerzellen durch die verwendung von p21 (waf-1) |
US6140126A (en) * | 1999-10-26 | 2000-10-31 | Isis Pharmaceuticals Inc. | Antisense modulation of Y-box binding protein 1 expression |
WO2001002556A2 (de) * | 1999-06-30 | 2001-01-11 | Max-Delbrück-Centrum für Molekulare Medizin | Mittel zur diagnose, prognose und therapie maligner erkrankungen |
-
2000
- 2000-03-23 DE DE10015413A patent/DE10015413A1/de not_active Withdrawn
-
2001
- 2001-03-21 WO PCT/DE2001/001068 patent/WO2001070951A2/de active Application Filing
- 2001-03-21 AU AU56117/01A patent/AU5611701A/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997016547A1 (en) * | 1995-10-31 | 1997-05-09 | The Board Of Regents, The University Of Texas System | ADENOVIRUS-ANTISENSE K-ras EXPRESSION VECTORS AND THEIR APPLICATION IN CANCER THERAPY |
WO2000003027A1 (de) * | 1998-07-10 | 2000-01-20 | Max-Delbrück-Centrum für Molekulare Medizin | Verfahren zur verbesserung des gentransfers von genetischem material in säugerzellen durch die verwendung von p21 (waf-1) |
WO2001002556A2 (de) * | 1999-06-30 | 2001-01-11 | Max-Delbrück-Centrum für Molekulare Medizin | Mittel zur diagnose, prognose und therapie maligner erkrankungen |
US6140126A (en) * | 1999-10-26 | 2000-10-31 | Isis Pharmaceuticals Inc. | Antisense modulation of Y-box binding protein 1 expression |
Non-Patent Citations (7)
Title |
---|
ANSARI SAMEER A ET AL: "Interaction of YB-1 with human immunodeficiency virus type 1 Tat and TAR RNA modulates viral promoter activity.", JOURNAL OF GENERAL VIROLOGY, vol. 80, no. 10, October 1999 (1999-10-01), pages 2629 - 2638, XP002177053, ISSN: 0022-1317 * |
CHENG, S. ET AL.: "The tumor metastasis suppressor, NDPK-beta, inhibits gelatinase A gene transcription by interference with transactivator YB-1", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 10, no. PROGRAM AND ABSTR. ISSUE, September 1999 (1999-09-01), pages 569A, XP000978754, ISSN: 1046-6673 * |
KOIKE, K. ET AL.: "Nuclear translocation of the Y-box binding protein by ultraviolet irradiation", FEBS LETTERS, vol. 417, no. 3, 17 November 1997 (1997-11-17), pages 390 - 394, XP002177054, ISSN: 0014-5793 * |
OHGA, T. ET AL.: "Role of the human Y box-binding protein YB-1 in cellular sensitivity to the DNA damaging agents cisplatin, mitomycin C, and ultraviolet light", CANCER RESEARCH, vol. 56, no. 18, 1996, pages 4224 - 4228, XP002157301, ISSN: 0008-5472 * |
SAFAK MAHMUT ET AL: "Physical and functional interaction between the Y-box binding protein YB-1 and human polyomavirus JC virus large T antigen.", JOURNAL OF VIROLOGY, vol. 73, no. 12, December 1999 (1999-12-01), pages 10146 - 10157, XP002177057, ISSN: 0022-538X * |
TANGE THOMAS OSTERGAARD ET AL: "In vitro interaction between human immunodeficiency virus type 1 Rev protein and splicing factor ASF/SF2-associated protein, p32.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 17, 1996, pages 10066 - 10072, XP002177056, ISSN: 0021-9258 * |
WANG YILONG ET AL: "P32/TAP, a cellular protein that interacts with EBNA-1 of Epstein-Barr virus.", VIROLOGY, vol. 236, no. 1, 1997, pages 18 - 29, XP002177055, ISSN: 0042-6822 * |
Also Published As
Publication number | Publication date |
---|---|
AU5611701A (en) | 2001-10-03 |
DE10015413A1 (de) | 2001-09-27 |
WO2001070951A2 (de) | 2001-09-27 |
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